Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Download or read book Biochips as Pathways to Drug Discovery written by Andrew Carmen and published by CRC Press. This book was released on 2006-10-19 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as bioc

Download or read book Metallointercalators written by Janice Aldrich-Wright and published by Springer. This book was released on 2011-04-06 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Download or read book Advances in Applied Microbiology written by and published by Academic Press. This book was released on 2009-02-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2006: 1.96. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field - Reference and guide for scientists and specialists involved in advancements in applied microbiology

Download or read book Globins and Other Nitric Oxide Reactive Proteins Part B written by Robert K. Poole and published by Academic Press. This book was released on 2011-09-02 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/bookseries/ This volume is the second of two planned volumes on the topic of globin and other nitric oxide-reactive proteins.

Download or read book Transcriptomics in Health and Disease written by Geraldo A. Passos and published by Springer Nature. This book was released on 2022-03-07 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of transcriptomics is key to understanding complex diseases. This new edition will build on the foundation of the first edition while incorporating the progress that has been made in the field of transcriptomics in the past six years, including bioinformatics for data analysis. Written by leading experts, chapters address new subjects such as methodological advances in large-scale sequencing, the sequencing of single-cells, and spatial transcriptomics. The new edition will address how transcriptomics may be used in combination with genetic strategies to identify causative genes in monogenic and complex genetic diseases. Coverage will also explore transcriptomics in challenging groups of diseases, such as cancer, inflammation, bacterial infection, and autoimmune diseases. The updated volume will be useful for geneticists, genome biologists, biomedical researchers, molecular biologists, bioinformaticians, and students, among others.

Download or read book CorpTech Directory of Technology Companies written by and published by . This book was released on 1997 with total page 1714 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multi-volume directory which lists more than 40,000 companies is indexed by company name, geographic area, non-U.S. parent companies, technology, product code, CorpTech code, and SIC code. Profiles are provided for each company listed, and company rankings given under each industry.

Download or read book Genomics in Endocrinology written by Stuart Handwerger and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The text provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed include the methodology of DNA microarrays and general methods for the analysis of microarray data.

Download or read book Genomic Selection in Plants written by Ani A. Elias and published by CRC Press. This book was released on 2022-08-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic selection (GS) is a promising tool in the field of breeding especially in the era where genomic data is becoming cheaper. The potential of this tool has not been realized due to its limited adaptation in various crops. Marker Assisted Selection (MAS) has been the method of choice for plant breeders while using the genomic information in the breeding pipeline. MAS, however, fails to capture vital minor gene effects while focusing only on the major genes, which is not ideal for breeding advancement especially for quantitative traits such as yield. The main aim of statistical methodologies coming under the umbrella of GS on using the whole genome information is to predict potential candidates for breeding advancement while optimizing the use of resources such as land, manpower, and most importantly time. Lack of proper understanding of the methods and their applications is one of the reasons why breeders shy away from this tool. The book is meant for biologists, especially breeders, and provides a comprehensive idea of the statistical methodologies used in GS, guidance on the choice of models, and design of datasets. The book also encourages the readers to adopt GS by demonstrating the current scenarios of these models in some of the important crops among oilseeds, vegetables, legumes, tuber crops, and cereals. For ease of implementation of GS, the book also provides hands-on scripts on GS data design and modeling in a popular open-source statistical program. Additionally, prospective in GS model development and thereby enhancement in crop improvement programs is discussed.

Download or read book Encyclopedia of Biomedical Engineering written by and published by Elsevier. This book was released on 2018-09-01 with total page 2069 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Biomedical Engineering, Three Volume Set is a unique source for rapidly evolving updates on topics that are at the interface of the biological sciences and engineering. Biomaterials, biomedical devices and techniques play a significant role in improving the quality of health care in the developed world. The book covers an extensive range of topics related to biomedical engineering, including biomaterials, sensors, medical devices, imaging modalities and imaging processing. In addition, applications of biomedical engineering, advances in cardiology, drug delivery, gene therapy, orthopedics, ophthalmology, sensing and tissue engineering are explored. This important reference work serves many groups working at the interface of the biological sciences and engineering, including engineering students, biological science students, clinicians, and industrial researchers. Provides students with a concise description of the technologies at the interface of the biological sciences and engineering Covers all aspects of biomedical engineering, also incorporating perspectives from experts working within the domains of biomedicine, medical engineering, biology, chemistry, physics, electrical engineering, and more Contains reputable, multidisciplinary content from domain experts Presents a ‘one-stop’ resource for access to information written by world-leading scholars in the field

Download or read book Microarray Technology in Practice written by Steve Russell and published by Academic Press. This book was released on 2008-11-21 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using chips composed of thousands of spots, each with the capability of holding DNA molecules corresponding to a given gene, DNA microarray technology has enabled researchers to measure simultaneously gene expression across the genome. As with other large-scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This guide is designed to demystify the technology and inform more biologists about this critically important experimental technique. - Cohesive overview of the technology and available platforms, followed by detailed discussion of experimental design and analysis of microarray experiments - Up-to-date description of normalization methods and current methods for sample amplification and labeling - Deep focus on oligonucleotide design, printing, labeling and hybridization, data acquisition, normalization, and meta-analysis - Additional uses of microarray technology such as ChIP (chromatin immunoprecipitation) with hybridization to DNA arrays, microarray-based comparative genomic hybridization (CGH), and cell and tissue arrays

Download or read book The Economist written by and published by . This book was released on 2006 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The SAGE Handbook of Healthcare written by Decision Resources Inc and published by SAGE. This book was released on 2008-05-22 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: With escalating healthcare costs, changes to the regulatory control on pharmaceutical industries and the inevitable adjustments made in policies and investment in healthcare there is enormous interest in the commercial as well as the scientific aspects of today′s healthcare industry. The SAGE Handbook of Healthcare provides an authoritative analysis of the current (and anticipated) developments in the global healthcare industries. Providing a unique perspective that interfaces between the science and business aspects, it combines information on the latest scientific developments with applied, commercial business data from the global marketplace. The Handbook focuses on the aspects of paramount importance in the healthcare sector: - Pharmacoeconomics - Pharmacogenomics - Therapeutics - Diagnostics Areas covered include: - The role of nanotechnology, genomics and cell therapy in medicine - Diagnostics; Biomarkers and technological advances - Case studies in oncology and cardiovascular and CNS therapeutics

Download or read book Gene Technology and Economy written by Susanne Lundin and published by . This book was released on 2002 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the late 1990s, few areas of science have been able to compete with genetics when it comes to attracting public interest. The mapping of the entire human gene pool, the Hugo project, makes clear that genetics and gene technology concern life itself. The analysis of the human DNA means that new medicines can be designed, but also that human genetic material can be patented and commercialized. In this volume scholars shed light on the links between biotechnology and economics from a multidisciplinary perspective. Patent on genes, national and global power (im)balance, as well as human and plant genomics, are discussed.

Download or read book Reproductomics written by José A. Horcajadas and published by Academic Press. This book was released on 2018-07-13 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. - Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine - Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data - Features chapter contributions by leading international experts

Download or read book New Technology Based Firms in the New Millennium written by Ray Oakey and published by Emerald Group Publishing. This book was released on 2008-05-26 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the question of whether providing work experience within courses of study in higher education affects entrepreneurial attitudes and behaviour, important given government imperatives to foster entrepreneurship through the education system.

Download or read book Tracing Technologies written by Helena Machado and published by Routledge. This book was released on 2016-02-24 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The real heroes of television crime shows in the twenty-first century are no longer police detectives but forensic technologies. The immense popularity of high-tech crime television shows has changed the way in which crime scene work is viewed. The term 'CSI-effect' was coined to signify a situation where people's views and practices have been influenced by such media representations, e.g. judges and jurors putting more weight on forensic evidence that has been produced with high-tech tools - in particular, DNA evidence - than on other kinds of evidence. While considerable scholarly attention has been paid to examining the CSI effect on publics, jurors, judges, and police investigators, prisoners' views on forensic technologies and policing have been under-explored. Drawing on a research sample of over 50 interviews carried out with prisoners in Portugal and Austria, this groundbreaking book shows how prisoners view crime scene traces, how they understand crime scene technologies, and what effect they attribute to the existence of large police databases on their own lives, careers, and futures. Through critically engaging with STS, sociological and criminological perspectives on the use of DNA technologies within the criminal justice system, this work provides the reader with valuable insights into the effect of different legal, political, discursive, and historical configurations on how crime scene technologies are utilized by the police and related to by convicted offenders.