Download or read book Cold Springs written by Rick Riordan and published by Bantam. This book was released on 2004-03-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the #1 New York Times bestselling author of the Percy Jackson and the Olympians series The Edgar, Shamus, and Anthony award-winning Rick Riordan delivers a spellbinding novel of a man on an edge so extreme that his fall will destroy not only him—but all that he holds dear. Cold Springs Chadwick’s life was balanced on a knife’s edge—his career, his marriage, his relationship with his dangerously troubled daughter. And then one autumn night, the worst possible thing happened…. Now, a decade later, Chadwick’s heart is on the mend. Working for an old military buddy, he saves kids for a living, escorting troubled teens to a Texas wilderness school that specializes in the toughest brand of love. Until he gets a phone call that threatens to shatter his new life. Mallory Zedman is taking the same terrible path Chadwick’s own daughter once took. Defiant and out of control, Mallory is determined to destroy herself and anyone who tries to stop her. No sooner does Chadwick snatch her off the streets than he discovers she is wanted for questioning in a brutal murder—a slaying that seems directly linked to Chadwick’s past.To save Mallory, tough love will not be enough. Chadwick must find the truth behind the murder—and in doing so revisit the infidelities, shattered promises, and violent passions that cracked his world apart. And he must jeopardize the one thing he still has left to lose—a slim hope of redemption.

Download or read book The Road to Discovery written by Jan Anthony Witkowski and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Road to Discovery: A Short History of Cold Spring Harbor Laboratory was published in 2015 to mark the 125th anniversary of Cold Spring Harbor Laboratory. At Cold Spring Harbor, in a bucolic setting on the north shore of New York's Long Island, two interdependent research centers in biology were founded as Charles Darwin's insights into heredity and evolution shook the world of science. Fifty years later, those centers would emerge as a single institution that would cradle another revolution, the new science of molecular biology, and advance to world renown in research and professional education. It is a remarkable story, with a path of progress that was neither simple nor assured. The Road to Discovery traces half a century of changes in name, leadership, governance, and financial fortune. And scientific missteps, most notoriously in eugenics, were triumphed by innovative work in genetics, human metabolism, and cancer. From the 1940s through the 1960s, the Laboratory was home to fundamental discoveries about the nature of genetic material and a cauldron of critical assessment of ideas about genes by sharp-tongued summer visitors. James D. Watson, a junior member of that group, would go on to deduce the structure of DNA with Francis Crick in 1953 and help create the new field of molecular genetics before returning to Cold Spring Harbor as Director 15 years later. As the book shows, his "Bold Plan" would inspire, cajole, and goad into existence an era of expansion, new research directions, and initiatives in conferences, courses, publishing, and education that redefined the scope of the Laboratory. Under Bruce Stillman's leadership, that scope has grown still more, making the Laboratory unique among research institutions worldwide--envied, imitated, but not reproduced. The book's author is the science historian Jan Witkowski. His knowledge of the subject is wide and his affection for it deep. He brings to his task insights that only a decades-long career as a staff member can provide. For over a century, the Laboratory has been influenced by exceptional personalities, outstanding achievements, and dramatic events. The Road to Discovery captures that history in a lively narrative illuminated by vignettes on the importance of individual scientists and their discoveries. Abundantly documented with material from the Laboratory's archives, it is an accessible book that will appeal to anyone interested in the development of biomedical science and biotechnology through the 20th century to the present day.

Download or read book Prion Biology written by Stanley B. Prusiner and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology.

Download or read book Scooby Doo written by Scott Cunningham and published by ABDO. This book was released on 2010 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mystery, Inc. team investigates a monster threatening a film star at an exclusive spa, and travel to Tokyo in search of the shards of the powerful gem known as the Dragon's Eye.

Download or read book Live Cell Imaging written by Robert D. Goldman and published by CSHL Press. This book was released on 2005 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in imaging technology reveal, in real time and great detail, critical changes in living cells and organisms. This manual is a compendium of emerging techniques, organized into two parts: specific methods such as fluorescent labeling, and delivery and detection of labeled molecules in cells; and experimental approaches ranging from the detection of single molecules to the study of dynamic processes in organelles, organs, and whole animals. Although presented primarily as a laboratory manual, the book includes introductory and background material and could be used as a textbook in advanced courses. It also includes a DVD containing movies of living cells in action, created by investigators using the imaging techniques discussed in the book. The editors, David Spector and Robert Goldman, whose previous book was Cells: A Laboratory Manual,are highly respected investigators who have taught microscopy courses at Cold Spring Harbor Laboratory, the Marine Biology Laboratory at Woods Hole, and Northwestern University.

Download or read book Cold Spring Harbor written by Richard Yates and published by Random House. This book was released on 2010-12-23 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evan Shepard is a young man with a chequered past when he first meets the Drakes, after his car breaks down outside their house. Behind him, he has a troubled adolescence, a failed marriage and a little daughter, but his meeting with the quiet and beautiful Rachel heralds a new start. However, after their swift marriage, things don't work out quite as planned and the stresses of living with Rachel's family, in their shared house in Cold Spring Harbor, begin to take their toll on the new couple.

Download or read book Phage Display written by Carlos F. Barbas and published by CSHL Press. This book was released on 2001 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.

Download or read book So Cold the River written by Michael Koryta and published by Little, Brown. This book was released on 2010-06-09 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now a major motion picture: So Cold the River is a chilling, supernatural tale "guaranteed to put the cold finger down your spine" (Michael Connelly). It started with a beautiful woman and a challenge. As a gift for her husband, Alyssa Bradford approaches Eric Shaw to make a documentary about her father-in-law, Campbell Bradford, a 95-year-old billionaire whose past is wrapped in mystery. Eric grabs the job even though there are few clues to the man's past -- just the name of his hometown and an antique water bottle he's kept his entire life. In Bradford's hometown, Eric discovers an extraordinary history -- a glorious domed hotel where movie stars, presidents, athletes, and mobsters once mingled, and hot springs whose miraculous mineral water cured everything from insomnia to malaria. Neglected for years, the resort has been restored to its former grandeur just in time for Eric's stay. Just hours after his arrival, Eric experiences a frighteningly vivid vision. As the days pass, the frequency and intensity of his hallucinations increase and draw Eric deeper into the town's dark history. He discovers that something besides the hotel has been restored -- a long-forgotten evil that will stop at nothing to regain its lost glory. Brilliantly imagined and terrifyingly real, So Cold the River is a tale of irresistible suspense with a racing, unstoppable current.

Download or read book Experimental Design for Biologists written by David J. Glass and published by CSHL Press. This book was released on 2007 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.

Download or read book Lab Dynamics written by Carl M. Cohen and published by CSHL Press. This book was released on 2005 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Lab Dynamics is a book about the challenges to doing science and dealing with the individuals involved, including oneself. The authors, a scientist and a psychotherapist, draw on principles of group and behavioral psychology but speak to scientists in their own language about their own experiences. They offer in-depth, practical advice, real-life examples, and exercises tailored to scientific and technical workplaces on topics as diverse as conflict resolution, negotiation, dealing with supervision, working with competing peers, and making the transition from academia to industry." "This is a uniquely valuable contribution to the scientific literature, on a subject of direct importance to lab heads, postdocs, and students. It is also required reading for senior staff concerned about improving efficiency and effectiveness in academic and industrial research."--BOOK JACKET

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Download or read book Antibodies written by Edward Harlow and published by CSHL Press. This book was released on 1988 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to immunochemistry for molecular biologists and other nonspecialists. Spiral.

Download or read book Don t Hug Doug written by Carrie Finison and published by Penguin. This book was released on 2021-01-26 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meet Doug, an ordinary kid who doesn't like hugs, in this fun and exuberant story which aims to spark discussions about bodily autonomy and consent--from author Carrie Finison and the #1 New York Times bestselling illustrator of The World Needs More Purple People, Daniel Wiseman. Doug doesn't like hugs. He thinks hugs are too squeezy, too squashy, too squooshy, too smooshy. He doesn't like hello hugs or goodbye hugs, game-winning home run hugs or dropped ice cream cone hugs, and he definitely doesn't like birthday hugs. He'd much rather give a high five--or a low five, a side five, a double five, or a spinny five. Yup, some people love hugs; other people don't. So how can you tell if someone likes hugs or not? There's only one way to find out: Ask! Because everybody gets to decide for themselves whether they want a hug or not.

Download or read book HIV written by Frederic Bushman and published by Cold Spring Harbor Perspective. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic biology of the HIV virus provides a model for a more general understanding of retroviruses, and the worldwide epidemic of AIDS makes research into the disease process and potential therapies among the most critical in biomedical science. This book explores work on the molecular biology of HIV, host-virus interactions, host immune responses, HIV transmission, and more.

Download or read book Glia written by Ben Barres and published by Cold Spring Harbor Perspective. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The majority of cells in the nervous system are glia. Long thought of as passive bystanders, glial cells are increasingly being appreciated for their active roles in nourishing, supporting, and protecting the neuronal cells that relay electrical signals through the nervous system. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the development of the major classes of glial cells-astrocytes, oligodendrocytes, Schwann cells, and microglia-and their roles in normal physiology and disease. The contributors describe how glia help establish and refine synaptic connections, maintain the metabolic and ionic milieu of nerve cells, myelinate axons, modulate nerve signal propagation, and contribute to the blood-brain barrier. The biological characteristics of glial cells in vertebrate and invertebrate model systems, including those of Drosophila, Caenorhabditis elegans, and zebrafish, are also covered. The authors also discuss the roles of glia in repair and regeneration, as well as in cancer and neurodegenerative diseases (e.g., Alzheimer's). This volume is therefore a valuable reference for all neurobiologists and biomedical scientists wishing to understand these diverse and dynamic cells.

Download or read book Epigenetics written by C. David Allis and published by CSHL Press. This book was released on 2007 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Download or read book Aging written by Stuart Jay Olshansky and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--