Download or read book The Road to Discovery written by Jan Anthony Witkowski and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Road to Discovery: A Short History of Cold Spring Harbor Laboratory was published in 2015 to mark the 125th anniversary of Cold Spring Harbor Laboratory. At Cold Spring Harbor, in a bucolic setting on the north shore of New York's Long Island, two interdependent research centers in biology were founded as Charles Darwin's insights into heredity and evolution shook the world of science. Fifty years later, those centers would emerge as a single institution that would cradle another revolution, the new science of molecular biology, and advance to world renown in research and professional education. It is a remarkable story, with a path of progress that was neither simple nor assured. The Road to Discovery traces half a century of changes in name, leadership, governance, and financial fortune. And scientific missteps, most notoriously in eugenics, were triumphed by innovative work in genetics, human metabolism, and cancer. From the 1940s through the 1960s, the Laboratory was home to fundamental discoveries about the nature of genetic material and a cauldron of critical assessment of ideas about genes by sharp-tongued summer visitors. James D. Watson, a junior member of that group, would go on to deduce the structure of DNA with Francis Crick in 1953 and help create the new field of molecular genetics before returning to Cold Spring Harbor as Director 15 years later. As the book shows, his "Bold Plan" would inspire, cajole, and goad into existence an era of expansion, new research directions, and initiatives in conferences, courses, publishing, and education that redefined the scope of the Laboratory. Under Bruce Stillman's leadership, that scope has grown still more, making the Laboratory unique among research institutions worldwide--envied, imitated, but not reproduced. The book's author is the science historian Jan Witkowski. His knowledge of the subject is wide and his affection for it deep. He brings to his task insights that only a decades-long career as a staff member can provide. For over a century, the Laboratory has been influenced by exceptional personalities, outstanding achievements, and dramatic events. The Road to Discovery captures that history in a lively narrative illuminated by vignettes on the importance of individual scientists and their discoveries. Abundantly documented with material from the Laboratory's archives, it is an accessible book that will appeal to anyone interested in the development of biomedical science and biotechnology through the 20th century to the present day.

Download or read book Don t Hug Doug written by Carrie Finison and published by Penguin. This book was released on 2021-01-26 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meet Doug, an ordinary kid who doesn't like hugs, in this fun and exuberant story which aims to spark discussions about bodily autonomy and consent--from author Carrie Finison and the #1 New York Times bestselling illustrator of The World Needs More Purple People, Daniel Wiseman. Doug doesn't like hugs. He thinks hugs are too squeezy, too squashy, too squooshy, too smooshy. He doesn't like hello hugs or goodbye hugs, game-winning home run hugs or dropped ice cream cone hugs, and he definitely doesn't like birthday hugs. He'd much rather give a high five--or a low five, a side five, a double five, or a spinny five. Yup, some people love hugs; other people don't. So how can you tell if someone likes hugs or not? There's only one way to find out: Ask! Because everybody gets to decide for themselves whether they want a hug or not.

Download or read book Around Cold Spring written by Trudie A. Grace and published by Arcadia Publishing. This book was released on 2011 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The historic village of Cold Spring lies on the east bank of the Hudson River in the heart of the scenic Hudson Highlands, about 50 miles north of New York City. Around Cold Spring features images of Cold Spring, the neighboring hamlet of Garrison, and the village of Nelsonville. Many of the photographs date from the late 19th and early 20th centuries and depict street scenes, patriotic celebrations, and historic and architecturally significant buildings like mansions, churches, and schools. Photographs, postcards, and other visual materials further illuminate the story of Cold Spring and its surrounding area.

Download or read book Cold Springs written by Rick Riordan and published by Bantam. This book was released on 2004-03-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the #1 New York Times bestselling author of the Percy Jackson and the Olympians series The Edgar, Shamus, and Anthony award-winning Rick Riordan delivers a spellbinding novel of a man on an edge so extreme that his fall will destroy not only him—but all that he holds dear. Cold Springs Chadwick’s life was balanced on a knife’s edge—his career, his marriage, his relationship with his dangerously troubled daughter. And then one autumn night, the worst possible thing happened…. Now, a decade later, Chadwick’s heart is on the mend. Working for an old military buddy, he saves kids for a living, escorting troubled teens to a Texas wilderness school that specializes in the toughest brand of love. Until he gets a phone call that threatens to shatter his new life. Mallory Zedman is taking the same terrible path Chadwick’s own daughter once took. Defiant and out of control, Mallory is determined to destroy herself and anyone who tries to stop her. No sooner does Chadwick snatch her off the streets than he discovers she is wanted for questioning in a brutal murder—a slaying that seems directly linked to Chadwick’s past.To save Mallory, tough love will not be enough. Chadwick must find the truth behind the murder—and in doing so revisit the infidelities, shattered promises, and violent passions that cracked his world apart. And he must jeopardize the one thing he still has left to lose—a slim hope of redemption.

Download or read book Coldspring written by Cheri Mancuso and published by . This book was released on 2010-01-01 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Katie the Catsitter written by Colleen AF Venable and published by Random House Graphic. This book was released on 2021-01-05 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOMINATED FOR MULTIPLE STATE AWARDS! Calling all Raina Telgemeier fans! Introducing an irresistible new middle-grade graphic novel series about growing up, friendship, heroes, and cats (lots of cats!)--perfect for fans of Guts, Awkward and Real Friends (not to mention anyone who loves cats!) “Readers will revel in the heroic antics.” --The New York Times Katie is dreading the boring summer ahead while her best friends are all away at camp--something that's way out of Katie and her mom's budget, UNLESS Katie can figure out a way to earn the money for camp herself. But when Katie gets a job catsitting for her mysterious upstairs neighbor, life get interesting. First, Madeline has 217 cats (!) and they're not exactly . . . normal cats. Also, why is Madeline always out EXACTLY when the city's most notorious villain commits crimes?! Is it possible that Katie's upstairs neighbor is really a super villain? Can Katie wrangle a whole lot of wayward cats, save a best friendship (why is Beth barely writing back? And who's this boy she keeps talking about?!), AND crack the biggest story in the city's history? Some heroes have capes . . . Katie has cats! Don't miss the next Katie the Catsitters—Katie the Catsitter 2: Best Friends for Never and Katie the Catsitter 3: Secrets and Sidekicks! A Florida Sunshine State Reader Award nominee A South Carolina Book Award nominee A Connecticut Nutmeg Book Award nominee A Vermont Golden Dome Book Award nominee A Maine Student Book Award nominee A North Carolina Children's Book Award nominee An Indiana Young Hoosier Book Award nominee An Illinois Bluestem Readers’ Choice nominee And more!

Download or read book Cold Spring Harbor written by Richard Yates and published by Random House. This book was released on 2010-12-23 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evan Shepard is a young man with a chequered past when he first meets the Drakes, after his car breaks down outside their house. Behind him, he has a troubled adolescence, a failed marriage and a little daughter, but his meeting with the quiet and beautiful Rachel heralds a new start. However, after their swift marriage, things don't work out quite as planned and the stresses of living with Rachel's family, in their shared house in Cold Spring Harbor, begin to take their toll on the new couple.

Download or read book The Gathering written by Dan Poblocki and published by Scholastic Incorporated. This book was released on 2016-08-30 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some houses are more than just haunted... they're hungry. Dash, Dylan, Poppy, Marcus, and Azumi don't know this at first. They each think they've been summoned to Shadow House for innocent reasons. But there's nothing innocent about Shadow House. Something within its walls is wickedly wrong. Nothing -- and nobody -- can be trusted. Hallways move. Doors vanish. Ghosts appear. Children disappear. And the way out? That's disappeared, too... Enter Shadow House... if you dare. Don't just read about Shadow House -- explore its haunted depths with the free app!

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Download or read book The Nematode Caenorhabditis Elegans written by William Barry Wood and published by . This book was released on 1988 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dracula written by Hamilton Deane and published by Samuel French, Inc.. This book was released on 1960 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drama Hamilton Deane and John L. Balderston, from Bram Stoker's novel Characters: 6 male, 2 female 3 Interior Scenes An enormously successful revival of this classic opened on Broadway in 1977 fifty years after the original production. This is one of the great mystery thrillers and is generally considered among the best of its kind. Lucy Seward, whose father is the doctor in charge of an English sanitorium, has been attacked by some mysterious illness. Dr. Van Helsing,

Download or read book Retroviruses written by John M. Coffin and published by CSHL Press. This book was released on 1997 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.

Download or read book Phage Display written by Carlos F. Barbas and published by CSHL Press. This book was released on 2001 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.

Download or read book Telomeres written by Titia De Lange and published by . This book was released on 2006 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Download or read book The P53 Protein written by Guillermina Lozano and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.

Download or read book Bioelectronic Medicine written by Valentin A. Pavlov and published by Perspectives Cshl. This book was released on 2019 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cold Spring Harbor perspectives in medicine."

Download or read book C Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR