Download or read book Clinical Trials in Neurologic Practice written by José Biller and published by Butterworth-Heinemann. This book was released on 2001 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the neurologic areas where trials have become increasingly important, including stroke, epilepsy, head and spinal cord injuries, and movement disorders. By applying the clinical evidence gained from the trials to neurologic practice, clinicians will be better positioned to meet the needs of their patients. * A practical approach to assist neurologists and neurologists in training in the understanding of clinical trials for neurologic disorders * Authors have assembled a distinguished international group of contributors to critically evaluate trials that have been conducted in their areas of expertise * Ideal book for practitioners interested in evidence-based neurologic practice

Download or read book Clinical Trials in Neurology written by Felipe Fregni and published by Humana. This book was released on 2019-08-14 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides in-depth descriptions and discussion of clinical trial designs based on novel data analysis of high-quality trials for 11 different neurological conditions in order to ultimately improve the quality of care in neurology. Some of the conditions discussed in this book are stroke, traumatic brain injury, Alzheimer’s disease, epilepsy, and tumors of the central nervous system. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Clinical Trials in Neurology is a valuable guide for individuals in the research, education, and clinical practice fields, specifically in the fields of medicine, physical therapy, occupational therapy, nursing, and public health. This volume is also an important resource for clinicians aiming to improve their understanding in methodology of clinical trials.

Download or read book The Right Therapy for Neurological Disorders written by E. Beghi and published by Karger Medical and Scientific Publishers. This book was released on 2016-07-26 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists, the articles touch on important aspects of RCTs with a clear critical approach, highlighting their limitations as well as giving recommendations for their planning and conducting to address the variable genotypic and phenotypic aspects of neurological conditions. Consideration is also given to combining the clinical impact of the study results with patients’ values and the interests of pharmaceutical companies. Neurologists involved in clinical trials will certainly benefit from this book, which should become a basic text for all neurological courses dealing with evidence-based neurology.

Download or read book Clinical Trials in Neurology written by Bernard Ravina and published by Cambridge University Press. This book was released on 2012-04-12 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry.

Download or read book Neuroscience Trials of the Future written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-07 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

Download or read book Office Practice of Neurology written by Martin A. Samuels and published by . This book was released on 2003 with total page 1572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text is the perfect clinical resource, offering quick access to all of the information needed to provide out-patient neurologic care. It focuses on the common and chronic problems that require long-term management, and provides step-by-step guidance on the decision-making process. Readers will find an expanded section on multiple sclerosis as well as updated and revised information in every section, including all of the latest studies and their results. Plus, a table at the beginning of each chapter summarizes the authors' approaches to diagnosis and management. Features contributions from more than 200 authors, representing a wide spectrum of specialists in neurology and related fields. Covers the major problems that any practicing neurologist might encounter, including those that may be rare. Presents a wealth of useful clinical information with enough comprehensive coverage on the difficult, long-term, and complicated disorders. Features an expanded section on multiple sclerosis, with in-depth discussions on the clinical issues surrounding the disease. Discusses the latest molecular genetic studies, including new information on the progressive ataxias · Alzheimer's disease · Huntington's disease · mitochondrial disorders · and familial stroke and headache syndromes. Reports on the results of recent clinical studies on asymptomatic carotid atherosclerosis and symptomatic carotid endarterectomy. Includes the latest methods for treating stroke · seizures · multiple sclerosis · migraine · Parkinson's disease · amyotrophic lateral sclerosis · and Alzheimer's disease. Presents a summary table at the beginning of each chapter, highlighting the authors' approaches to various problems of diagnosis and management.

Download or read book Neurology Evidence written by Kate T. Brizzi and published by Lippincott Williams & Wilkins. This book was released on 2017-07-12 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing the vast body of literature available in neurology into one accessible, clinically relevant volume, Neurology Evidence: The Practice-Changing Studies is an invaluable resource for students, residents, and fellows, as well as neurologists at all levels of experience. Featuring the top 100 papers that have had the most significant impact on changing clinical practice, this unique title analyzes the strengths and weaknesses of both seminal and less-noticed studies. Readable commentary is provided for each study by both a senior and junior neurologist in each subspecialty.

Download or read book 50 Studies Every Neurologist Should Know written by David Y. Hwang and published by Oxford University Press. This book was released on 2016-04-13 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: 50 Studies Every Neurologist Should Know presents key studies that shape the current clinical practice of neurology. All neurologic subspecialties are covered, with a special emphasis on neurocritical care and vascular neurology. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This is the first book of its kind to present a collection of the most influential clinical trials in neurology that are detailed enough to be used on rounds, but still easily digestible. It is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

Download or read book Neuroepidemiology written by Lorene M. Nelson and published by Oxford University Press. This book was released on 2004 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fine text provides a comprehensive overview of methods for epidemiologic and clinical research on neurological disorders. The book focuses on classic principles of study design in epidemiologic research, strategies for avoiding study biases, methods for conducting clinical trials and prognostic studies, and principles of evidence-based medicine in neurology. The text gives neurologists, epidemiologists, and their students the foundation for conducting rigorous epidemiologic and clinical research on neurologic disorders.

Download or read book Clinical Trials in the Neurosciences written by Katherine M. Woodbury-Harris and published by Karger Medical and Scientific Publishers. This book was released on 2009 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed.This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.

Download or read book Evidence Based Neurology written by Bart Demaerschalk and published by John Wiley & Sons. This book was released on 2015-10-12 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: From an expert editor team drawn from the Cochrane Neurological Network, Evidence-Based Neurology provides specialists and those in training with the skills and knowledge to apply evidence-based practice in the clinical setting. fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature summarizes the most recent and important findings on treatments for neurological patients measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions now includes new non-clinical topics of interest to neurologists such as education and research

Download or read book The Clinical Science of Neurologic Rehabilitation written by Bruce H. Dobkin and published by Oxford University Press. This book was released on 2003-01-16 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of this single-authored volume integrates multiple disciplines of basic and clinical research to help clinicians further develop the best possible care for the rehabilitation of patients with neurologic diseases. From the readable descriptions of the structures and functions of pathways for movement and cognition, the reader comes to understand the potential for training induced, pharmacologic, and near-future biologic interventions to enhance recovery. Dr. Dobkin shows how functional neuroimaging serves as a marker for whether physical, cognitive, and neuromodulating therapies work and how they sculpt the plasticity of the brain. Themes, such as how the manipulation of sensory experience can serve as a formidable tool for rehabilitation, run throughout the text, built from the level of the synapse to behaviors such as grasping, walking, and thinking. From illustrating how we may one day repair the brain and spinal cord to how to retrain spared and new pathways, Dr. Dobkin draws insights from a broad swath of fundamental research to give clinicians tools they can translate into bedside practices. The book treats the medical complications and therapeutic approaches to neurologic diseases as an interconnected matrix. The management of common medical issues, impairments, and disabilities are described across diseases. Special problems posed by patients with stroke, myelopathies, brain injury, multiple sclerosis, degenerative diseases, and motor unit disorders receive individual comment. Short-term and delayed pulse interventions for patients, along with clinical trials, are dissected and put into perspective. The First Edition of this book was titled Neurologic Rehabilitation. The title has been changed to reflect Dr. Dobkin's sense that fundamental research now drives the field of neurologic rehabilitation even more than it could in 1996 when the First Edition was published. The Second Edition features entirely new chapters on functional neuroimaging of recovery; neurostimulators and neuroprosteses; integration into the book of many new clinical and neuroscientific observations relevant to the clinician; and extensive updating and expansion of all chapters. Readers, whether clinicians serving the rehabilitation team, or students or researchers in neuroscience, neurology, physical medicine, allied health, or bioengineering, will acquire new insights and tools for creative pursuits that aim to lessen the disabilities of patients.

Download or read book Clinical Trials in Neurology written by Roberto J. Guiloff and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.

Download or read book Neurology Evidence written by Kate T. Brizzi and published by LWW. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing the vast body of literature available in neurology into one accessible, clinically relevant volume, Neurology Evidence: The Practice-Changing Studies is an invaluable resource for students, residents, and fellows, as well as neurologists at all levels of experience. Featuring the top 100 papers that have had the most significant impact on changing clinical practice, this unique title analyzes the strengths and weaknesses of both seminal and less-noticed studies. Readable commentary is provided for each study by both a senior and junior neurologist in each subspecialty. Features: Focuses on those studies that have had the greatest impact on how neurologists care for patients today, explaining the relevance of the information, engaging readers through questions and answers, and offering commentary on future directions. Analyzes the insights gained from both positive and negative trials, with the overall goal of improving clinical outcomes for patients suffering from neurological disease. Provides interpretation by residents and fellows with a particular interest in each clinical topic, as well as the input of accomplished senior neurologists. Includes multiple studies on ischemic stroke, cerebral hemorrhage, traumatic brain injury, neurologic intensive care, neuroinfectious diseases, neuro-oncology, neuromuscular diseases, movement disorders, multiple sclerosis, autoimmune neurology, epilepsy, headache and pain, cognitive neurology, and pediatric neurology. Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time -- providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click

Download or read book Principles and Practice of Clinical Research written by John I. Gallin and published by Elsevier. This book was released on 2011-04-28 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers. *Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government

Download or read book Neurological Therapeutics written by John Noseworthy and published by CRC Press. This book was released on 2003-04-03 with total page 2864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological Therapeutics is a two-volume reference text that covers all aspects of pharmaceutical and interventional therapy for neurological diseases and disorders. Whereas many texts have superficially covered treatments, this book examines which therapies are currently available, how effective they are, and what results one can expect. All the contributors are well-known in their subspecialties and the 268 chapters are based on personal experience. John Noseworthy has selected the world's leading neurologists as section editors, and they in turn have chosen leaders from all the neurological subspecialties. Given the comprehensive coverage within the 14 sections, neurologists will readily consult this book for both rare and common diseases and disorders, whether their patients are elderly, middle-aged or adolescent. Martin Dunitz has collaborated closely with the Mayo Clinic Publications Department to produce this magnificent work that will be read by neurologists, psychiatrists, geriatricians and pediatricians.

Download or read book Neurological Disorders in Clinical Practice written by Şerefnur Öztürk and published by Springer. This book was released on 2015-11-05 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book promotes the importance of a carefully obtained patient history when making a neurological diagnosis and explains the effects of disease symptoms on the patient’s daily life. Communication between doctor and patient through active listening, observation and problem solving skills will be improved. Based on real patients suffering from the most common neurological disorders, these fictional case histories provide an understanding of initial symptoms and disease progress from the point of view of the patients and their relatives. Neurological Disorders in Clinical Practice: Case Histories for Medical Students and Residents is aimed at medical students, neurology residents, family practitioners, and those interested in medical teaching and training.