Download or read book Osteoarthritis written by J.-Y. Reginster and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Musculoskeletal diseases are rapidly becoming a major health concern. The incidence of osteoarthritis, the most common arthritic disorder, is increasing steadily due to the graying of the world population. This disease is responsible of human life, a time in for significant morbidity, particularly in the second half which the quality of life is of primary importance. The aim of this publication is to bring to physicians and scientists a comprehensive overview of the field, from molecules to men. The direct costs related to osteoarthritis have been increasing steadily over the years and will soon be comparable to those of other major illnesses, such as cardiovascular diseases. This, of course, does not take into account all of the other costs related to the disease which often cannot be simply calculated in dollars and cents. There has been a great deal of renewed interest in osteoarthritis in the last few decades. This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. The most recent findings and developments on the structural, bio chemical, biomechanical and molecular changes observed in clinical and ex perimental osteoarthritis are presented in this book.

Download or read book Paediatric Rheumatology written by Helen E. Foster and published by OUP Oxford. This book was released on 2012-06-14 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paediatric Rheumatology is an indispensible resource for the identification and management of specific rheumatological disorders. As well as covering common and rare rheumatological problems, there are also chapters on investigations and emergencies, designed for quick reference. The handbook includes dedicated topics on systemic diseases affecting rheumatology; the relevant clinical guidelines and information needed for a rheumatologist to successfully management a young patient; and, a coloured section for guidance on rash-related investigations. Paediatric Rheumatology is also fully endorsed by the British Society for Paediatric and Adolescent Rheumatology and the UK Paediatric Rheumatology Clinical Studies Group.

Download or read book Oxford Handbook of Rheumatology written by Alan Hakim and published by Oxford University Press, USA. This book was released on 2011-09-22 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a handbook of clinical rheumatology that provides practical guidelines to management and diagnosis. It is essential for all specialist registrars and SHO's but will also be of great relevance to general practitioners.

Download or read book Classic Papers in Rheumatology written by Paul Dieppe and published by CRC Press. This book was released on 2003-09-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: While an emphasis on the new is vital to any science, the relevance or importance of new discoveries cannot truly be appreciated without a strong sense of the framework of a discipline, and of the ideas that helped to shape it. With this in mind, the editors of this book have attempted to create a canon of texts that formed the basis of rheumatology. Experts on the diagnosis and management of the various rheumatological conditions have chosen what they consider to be the key papers in their respective domains. Every paper is carefully described and evaluated by its strengths, its weaknesses, and its contribution to the field. Papers have been chosen that define new diseases or treatments, that have changed our whole way of thinking, or that have simply stood the test of time. The editors hope that the papers profiled in this volume will stimulate debate, encourage readers to seek out the original texts, and inspire the writers of the classics of the 21st century.

Download or read book Rheumatology in Practice written by J.A. Pereira da Silva and published by Springer Science & Business Media. This book was released on 2010-01-19 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatology in Practice offers chapters which are organised and built around anatomical and regional syndromes, so reinforcing the evidence-based approach. As readers progress through the text they are given more demanding and challenging questions, encouraging them to use their diagnostic skills to identify the main syndromes and the underlying diseases responsible for the disorders in question. The text is lavishly illustrated in full colour, with detailed photos of patient examinations, complemented by radiographs and full colour line illustrations. The text also benefits from the use of summaries using coloured boxing to identify key points in diagnosis and management. Written by two of the most respected clinicians in the discipline, this book will be essential reading for rheumatologists in practice and training.

Download or read book Rheumatology and the Kidney written by Dwomoa Adu and published by OUP Oxford. This book was released on 2012-04-05 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of the many rheumatologic disorders associated with renal disease, including pathogenesis, clinical features and treatment, Rheumatology and the Kidney brings together the available information in an accessible and practical way, with a particular focus on evidence-based patient management. Part of the Oxford Clinical Nephrology Series, and featuring chapters from a team of international experts, this new edition has been completely updated since publication of the first edition in 2001 and now contains more tables and figures to make the information more accessible. Completely updated since publication of the first edition in 2001, and with more illustrations, this book brings together the available information on the many rheumatologic disorders associated with renal disease in an accessible and practical way, with a particular focus on evidence-based patient management.

Download or read book Mechanisms and Models in Rheumatoid Arthritis written by B. Henderson and published by Academic Press. This book was released on 1995-03-16 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis.Key Features:* The book is divided into five sections:* The clinical spectrum, aetiopathogenesis, the role of microbial superantigens in pathology and the present and future therapies for rheumatoid arthritis* The pathology of rheumatoid arthritis, the development and role of synovial pannus and the use of immunohistochemistry in defining synovial pathology* Cell populations involved in synovitis with chapters on synovial cells, chondrocytes, bone cells, leukocytes and leukocyte trafficking* Mediators, with coverage of: cytokines and cytokine inhibitors, growth factors, free radicals and inflammatory lipid mediators, neuropeptides and proteases* Current studies on experimental models of rheumatoid arthritis

Download or read book Immune Regulation written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.

Download or read book Practical Management of Systemic Sclerosis in Clinical Practice written by Marco Matucci-Cerinic and published by Springer Nature. This book was released on 2020-12-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical guide for managing a variety of problems encountered by the clinician in managing patients with systemic sclerosis. Chapters take a problem-orientated approach to help the reader cut through potential barriers that can arise when working with different medical specialities. Management strategies for a broad range of conditions, including pericardial and pleural effusion, sicca syndrome, calcinosis and watermelon stomach, are presented. ​Practical Management of Systemic Sclerosis in Clinical Practice describes a range of problems and clinical items encountered by a variety of medical professionals who encounter these patients. It is a valuable resource for rheumatologists, immunologists, specialist nurses and primary care professionals.

Download or read book Atlas of Rheumatoid Arthritis written by Paul Emery and published by Springer. This book was released on 2015-06-09 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Rheumatoid Arthritis is a high-quality educational initiative, written by leaders in the field of rheumatology, containing a collection of approximately 150 relevant images, with extended descriptive captions and a comprehensive bibliography. The Atlas of Rheumatoid Arthritis will provide clinicians with a visual guide to rheumatoid arthritis, focusing on assessment, diagnosis and treatment, including newer research into the signalling pathways involved in the pathogenesis of RA, before focusing on the treatment of RA. Rheumatoid arthritis (RA) is the most common and most serious of the inflammatory arthritic disorders, and it dominates clinical rheumatological practice. Effective, early treatment is vital as this can slow the course of the disease and reduce joint damage. RA is usually treated using disease-modifying anti-rheumatic drugs (DMARDs), most commonly methotrexate. The newest treatments target the disease-causing immune elements specifically and directly.

Download or read book Handbook of Juvenile Idiopathic Arthritis written by Angelo Ravelli and published by Springer. This book was released on 2015-10-19 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is an in-depth and comprehensive guide for the treatment and management of patients with juvenile idiopathic arthritis. The handbook provides an informative review of the disease looking at the epidemiology, etiology and pathogenesis, issues of diagnosis and classification, consequences and complications, general treatment aspects, as well as both non pharmacologic and pharmacologic therapy whilst considering the future outlook for patients with juvenile idiopathic arthritis. Juvenile idiopathic arthritis is the most common type of arthritis found in children and adolescents, affecting about 1 in 1,000 children. It is a chronic disease which causes inflammation, pain and swelling of the affected joints and can affect joints in any part of the body. This Handbook provides an unbiased, informative discussion of the current and emerging treatments in this field.

Download or read book Contemporary Targeted Therapies in Rheumatology written by Josef S. Smolen and published by CRC Press. This book was released on 2007-10-18 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapies of rheumatic diseases have become a reality and have completely changed patient care as well as patient expectations. Initial success with therapies aimed at blocking TNF and IL-1 has stimulated the development of additional targeted approaches focused on other cytokines as well as specific cells and pathways involved in the path

Download or read book Issues in Rheumatology Research and Practice 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Rheumatology Research and Practice: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Clinical Rheumatology. The editors have built Issues in Rheumatology Research and Practice: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clinical Rheumatology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Rheumatology Research and Practice: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Issues in Rheumatology Research and Practice 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 983 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Rheumatology Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Rheumatology Research and Practice. The editors have built Issues in Rheumatology Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Rheumatology Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Rheumatology Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book IgG4 Related Kidney Disease written by Takao Saito and published by Springer. This book was released on 2016-11-09 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Download or read book Osteoporosis Advances in Research and Treatment 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Osteoporosis in a compact format. The editors have built Osteoporosis—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Osteoporosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Osteoporosis—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.