Download or read book Chromosome Structural Analysis written by Wendy Bickmore and published by OUP Oxford. This book was released on 1999-05-20 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: The DNA of eukaryotes is packaged into chromosomes - each chromosome consisting of a very long molecule of DNA and various proteins (e.g. histones), and the number of chromosomes being characteristic for the species concerned. Chromosome analysis can provide a great deal of information for many aspects of cellular genetics such as DNA replication, protein:DNA interactions and genetic manipulation. The book is structured in a methodical fashion - the introductory chapters are centred around analysis of chromatin with chapters on the mapping of protein:DNA interactions in vivo using ligation-mediated PCR and the mapping of chromatin-associated proteins by formaldehyde cross-linking. The next chapters concentrate on the study of whole chromosome structure, including: fission yeast chromosome analysis using FISH and CHIP, isolation of vertebrate metaphase chromosomes and their analysis by FISH, the study of vertebrate chromosome progression through mitosis, and the analysis of mammalian interphase chromosomes by immunofluorescence and FISH. There then follow chapters on FISH in whole-mount tissues and the analysis of the sub-structure of mammalian nuclei in vitro. The final two chapters deal with the experimental manipulation of chromosome structure, including: chromosome assembly in vitro using Xenopus egg extracts and chromosome fragmentation in vertebrate cell lines. This comprehensive and informative laboratory manual includes a diverse range of experimental models for the analysis of chromosomes - such as vertebrates, Drosophila, yeast and Xenopus. Fully illustrated, it focuses on modern techniques and approaches to the study of chromosome structure and will be invaluable to researchers and academic staff in genetics, biomedical science and molecular biology.
Download or read book Chromosome Organization Structural Analyses and Theoretical Implications written by and published by . This book was released on 1975 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Chromosome Atlas written by Claudia Behrend and published by Springer. This book was released on 2017-07-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.
Download or read book Chromosome Structure and Function written by Andreas Houben and published by Springer My Copy UK. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the function and structure of chromosomes and their interrelationship has grown in recent years. The chapters in this issue describe the advances that have been made possible by combining microscope techniques with sophisticated biochemical and genetic approaches to unlock the secrets of chromosomes. The authors look at many aspects of chromosome biology, such as protein, DNA and RNA composition of chromosomes, defined chromosome structures, unusual chromosome structures and specialized chromosomes and microscope tools for chromosome analysis. 'Chromosome Structure and Function' will be an invaluable resource for undergraduate and postgraduate students in fields such as plant and animal sciences, genetics, and molecular biology. In fact, any student, teacher or researcher interested in chromosome biology will find this special issue indispensable.
Download or read book Chromosome Structure and Function written by Rudi Appels and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Historical Perspective on the Study of Chromosome Structure and Function R. Appels Division of Plant Industry CSIRO P.O. Box 1600 A.C.T. AUSTRALIA "Modern physical science gives us no model to explain the re duplication of the gene-string in each cell generation, or to ex plain the production of effective quantities of specific enzymes or other agents by specific genes. The precise pairing and inter change of segments by homologous gene-strings at meiosis also suggest novel physical properties of this form of matter". Stadler (1954) The very strong influence of reductionism in the history of understanding chromosome structure and function is evident in the above quotation from Stadler's 1954 paper, "The gene". Earlyob servations on the constancy of the cytological appearance of chromo somes and their regular behaviour in cell division led to specula tion on their biological importance. As genetics became more refined in the early decades of the 20th century the genes-on-a string model of chromosomes developed and greater emphasis was placed on the further dissection of these structures. As a result, in the 1980's the reductionist approach is reaching a crest as extensive regions of the genetic material are being sequenced.
Download or read book Chromosome Structure and Aberrations written by Tariq Ahmad Bhat and published by Springer. This book was released on 2017-02-08 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of various chapters contributed by a group of leading researchers from different countries and covering up to date information based on published reports and personal experience of authors in the field of cytogenetics. Beginning with the introduction of chromosome, the subsequent chapters on organization of genetic material, karyotype evolution, structural and numerical variations in chromosomes, B-chromosomes and chromosomal aberrations provide an in-depth knowledge and easy understanding of the subject matter. A special feature of the book is the inclusion of a series of chapters on various types of chromosomal aberrations and their impact on breeding behaviour and crop improvement. The possible mechanism, their consequences and role in genetic analysis has been emphasized in these chapters. A few chapters have also been dedicated on various techniques routinely used in the laboratory by students and researchers. Each chapter ends with an extensive bibliography so that the students and researchers may find it relevant to consult more literature on the subject than a book of this size can offer. The book is intended to fulfill the needs of undergraduate and post graduate students of botany, zoology and agriculture besides, teachers and researchers engaged in the field of genetics, cytogenetics, and molecular genetics. In general the readers will find each chapter of the book informative and easy to understand.
Download or read book Some Aspects of Chromosome Structure and Function written by R.C. Sobti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was at the end of the 19th century that a Swiss biologist, Karl Nageli first proposed the existence of hereditary organelles that carried information from parent to offspring. Ensuing decades experienced vigorous studies that led to the development of discovery that chromosomes are indeed the carriers of genetic information. Subsequent studies, especially by Morgan and Bridges, established unequivocally the chromosome theory of inheritance. Today, the structure of chromosome is well established. At the physical level, eukaryotic chromosomes are composed of a single, linear, double helix of DNA. The elementary helical structure involves nucleosomes, comprised of histones around which the DNA is wrapped. A hierarchy of higher order of chromosomal architecture may possibly be responsible for the regulation of gene helical structures expression. The localized condensations of DNA constitute chromomeres. Uncoiled structures sometimes extending from chromomeres, which form loops, is the result of discontinuities in the regular coiling of the DNA in the chromosome.
Download or read book Structural Analysis of DNA Sequences written by Armin Schmitt and published by . This book was released on 1995 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional and Structural Analysis of a Dispensable Chromosome in Nectria Haematococca written by Jürg Enkerli and published by . This book was released on 1997 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Wheat Genetics From Genome to Field written by Yasunari Ogihara and published by Springer. This book was released on 2015-09-15 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings is a collection of 46 selected papers that were presented at the 12th International Wheat Genetics Symposium (IWGS). Since the launch of the wheat genome sequencing project in 2005, the arrival of draft genome sequences has marked a new era in wheat genetics and genomics, catalyzing rapid advancement in the field. This book provides a comprehensive review of the forefront of wheat research, across various important topics such as germplasm and genetic diversity, cytogenetics and allopolyploid evolution, genome sequencing, structural and functional genomics, gene function and molecular biology, biotic stress, abiotic stress, grain quality, and classical and molecular breeding. Following an introduction, 9 parts of the book are dedicated to each of these topics. A final, 11th part entitled “Toward Sustainable Wheat Production” contains 7 excellent papers that were presented in the 12th IWGS Special Session supported by the OECD. With rapid population growth and radical climate changes, the world faces a global food crisis and is in need of another Green Revolution to boost yields of wheat and other widely grown staple crops. Although this book focuses on wheat, many of the newly developed techniques and results presented here can be applied to other plant species with large and complex genomes. As such, this volume is highly recommended for all students and researchers in wheat sciences and related plant sciences and for those who are interested in stable food production and food security.
Download or read book Plant Chromosomes written by Archarna Sharma and published by Routledge. This book was released on 2019-06-18 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past two decades have brought with them remarkable progress in plant chromosomal research. The chromosome structure has been clarified in great detail, enabling identification of gene sequences at the microscopic level, which has aided the analysis of biodiversity. Knowledge of chromosome structure has played a crucial role in the improvement of crop species and has far-reaching implications. The manipulation and engineering of chromosomes involves a panoply of novel methods, combining conventional and modern techniques of biotechnology. A working knowledge of such techniques is essential for today's students and researchers, and the plant system, because of totipotency, requires special treatment. This treatise covers all the latest methods involved in the study of evolution, biodiversity, chromosome manipulation and engineering.
Download or read book Eukaryotic Chromosomes written by R. C. Sobti and published by . This book was released on 1991 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular and Functional Analysis of Chromosome Structure written by Octavian Henegariu and published by . This book was released on 2008 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chromosome Structural Variants Epidemiology Identification and Contribution to Human Diseases written by Zirui Dong and published by Frontiers Media SA. This book was released on 2022-10-19 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Function of Eukaryotic Chromosomes written by Wolfgang Hennig and published by Springer. This book was released on 1987 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of various aspects of chromosome research, written by leading experts of the respective fields, combining classic and recent molecular biological results. The variety and comprehensiveness make it a handbook of chromosome research for all scientists, teachers and graduate students interested in this field. Dieses Buch faßt die unterschiedlichen Aspekte der Chromosomenforschung in Beiträgen von führenden Wissenschaftlern zusammen, wobei die klassischen Erkenntnisse mit neuesten Forschungsdaten zu einem umfassenden Überblick über das Gebiet kombiniert werden.
Download or read book The Principles of Clinical Cytogenetics written by Steven L. Gersen and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1989, one of us (SLG), along with his mentor, Dorothy Warb- ton, attended the Tenth International Workshop on Human Gene Mapping. The me- ing was held at Yale University in celebration of the first such event, which also took place there. This meeting was not open to the general public; one had to have contributed to mapping a gene to be permitted to attend. The posters, of course, were therefore all related to gene mapping, and many were covered with pretty, colorful pictures of a novel, fluorescent application of an old technology, in situ hybridization. Walking through the room, Dorothy remarked that, because of this new FISH technique, ch- mosomes, which had become yesterday’s news, were once again “back in style. ” Approximately three years later, a commercial genetics company launched a FISH assay for prenatal ploidy detection. A substantial number of cytogeneticists across the country reacted with a combination of outrage and panic. Many were concerned that physicians would be quick to adopt this newfangled upstart test and put us all on the unemployment line. They did not at the time realize what Dorothy instinctively already knew—that FISH would not spell the doom of the cytogenetics laboratory, but it would, rather, take it to new heights.
