Download or read book Chromatographic Methods in Clinical Chemistry and Toxicology written by Roger Bertholf and published by John Wiley & Sons. This book was released on 2007-01-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.
Download or read book Advances in Chromatographic Techniques for Therapeutic Drug Monitoring written by Amitava Dasgupta and published by CRC Press. This book was released on 2009-10-06 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for imp
Download or read book Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography written by Steven H.Y. Wong and published by Routledge. This book was released on 2017-09-19 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.
Download or read book Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry written by Donald M. Wieland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1906, Michael T. Sweet first developed the chromatographic method by using an adsorbant to separate pigments. Since that time, the technological advances in TLC and HPLC have brought about new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is especially dependent on the chromat ographic technique because of the relatively small amount of material in most radiopharmaceuticals-often so small that the usual physical methods of analytical chemistry cannot be used. As a result, this collection of papers represents the key to successful radiopharmaceutical development by setting the standard for the pres of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics Associate Director The Squibb Institute for Medical Research New Brunswick, New Jersey Preface The chapters herein are updated and expanded versions of presentations that the authors made at a symposium held on June 4, 1984 in Los Angeles, California under the sponsorship of the Radiopharmaceutical Science Council of the Society of Nuclear Medicine. All manuscripts were refereed. The intent of the symposium organizers was to enlist participants who work on a day-to-day basis with the analytical and chromatographic techniques to be discussed at the symposium. We feel confident that this distillation of hands-on experience will be of value to graduate students as well as experienced researchers in radio pharmaceutical chemistry and related fields which use radiotracer methodology.
Download or read book Liquid Chromatography written by G. Baird and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical chemistry is the discipline within laboratory medicine concerned with measuring the concentrations of analytes in blood, body fluids, and tissues. Liquid chromatography is already commonly used in the clinical chemistry laboratory for measuring the concentrations of small molecules, such as drugs and hormones, using a variety of solid phases for separation and numerous detection modalities, most important mass spectrometry. Additional liquid chromatographic methods are now being developed for measuring the concentrations of proteins in blood and tissues, taking advantage of the rapid development of novel mass-spectrometry instruments and methodologies.
Download or read book GC MS in Clinical Chemistry written by Petra Gerhards and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book enables the reader to gain a rapid understanding of GC/MS analysis through a basic knowledge of the fundamental principles, linking these with simple and practical applications in the field of industrial medicine and analysis of drugs. Additional information from other specialist fields is also provided with the aim of helping the analyst to understand their relevance to the interpretation of results. The book describes efficient methods of sample preparation and quality assurance and provides information on epidemiology and pharmacology, without which drug screening is impossible. This comprehensive overview is mainly written for the practical analyst in the clinical laboratory but it is equally suited for teaching purposes.
Download or read book Drug Monitoring and Clinical Chemistry written by Georg Hempel and published by Elsevier. This book was released on 2004-05-15 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field
Download or read book Chromatographic Techniques in the Forensic Analysis of Designer Drugs written by Teresa Kowalska and published by CRC Press. This book was released on 2018-01-31 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.
Download or read book Analytical Methods in Human Toxicology written by A.S. Curry and published by Springer. This book was released on 2017-01-10 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HPLC Methods on Drug Analysis written by Mantu K Ghosh and published by . This book was released on 1992-02-21 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microextraction Techniques in Analytical Toxicology written by Rajeev Jain and published by CRC Press. This book was released on 2021-12-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microextraction Techniques in Analytical Toxicology provides the information readers need to include about cutting-edge sample preparation techniques into their everyday analytical practice, including comprehensive information about principles and state-of-the-art microextraction sample preparation techniques for the analysis of drugs and poisons in biological specimens, especially in forensic and clinical settings. This book also focuses on theoretical discussions of solid-based and liquid-based microextraction techniques, their method development, validation, and applications. A detailed compilation of analytical protocols based on published microextraction procedures to aid in method development, synthesis, and the application of green solvents (ionic liquids and deep eutectic solvents) and new sorbents, such as molecularly imprinted polymers, and their application in microextraction techniques are also covered. Features: Provides a systematic review of microextraction techniques applied in analytical toxicology A comprehensive guide for the practical implementation of microextraction techniques in forensic, clinical, and analytical laboratories Contains figures and tables for easy understanding and quick adaptation of the parameters of microextraction techniques Fundamentals, development, and applications of microextraction techniques as a sample preparation procedure are discussed in detail Extremely useful for the researchers and academicians engaged in analytical method development using microextraction techniques This book appeals to a wide readership of forensic, clinical, and analytical toxicologists, as well as academicians and researchers. Written by eminent scientists and leading experts on sample preparation techniques, this book serves as a desk reference for routine laboratory analysis and as an indispensable teaching tool in the classroom for graduate and Ph.D. students.
Download or read book High Pressure Liquid Chromatography in Clinical Chemistry written by Peter Frederick Dixon and published by . This book was released on 1976 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Practical Gas Chromatography written by Katja Dettmer-Wilde and published by Springer. This book was released on 2014-11-05 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas chromatography continues to be one of the most widely used analytical techniques, since its applications today expand into fields such as biomarker research or metabolomics. This new practical textbook enables the reader to make full use of gas chromatography. Essential fundamentals and their implications for the practical work at the instrument are provided, as well as details on the instrumentation such as inlet systems, columns and detectors. Specialized techniques from all aspects of GC are introduced ranging from sample preparation, solvent-free injection techniques, and pyrolysis GC, to separation including fast GC and comprehensive GCxGC and finally detection, such as GC-MS and element-specific detection. Various fields of application such as enantiomer, food, flavor and fragrance analysis, physicochemical measurements, forensic toxicology, and clinical analysis are discussed as well as cutting-edge application in metabolomics is covered.
Download or read book Chromatography written by Toma J. Quintin and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatography is the collective term for a set of laboratory techniques for the separation of mixtures. It involves passing a mixture dissolved in a "mobile phase" through a stationary phase, which separates the analyte to be measured from other molecules in the mixture and allows it to be isolated. Chromatography may be preparative or analytical. The purpose of preparative chromatography is to separate the components of a mixture for further use (and is thus a form of purification). Analytical chromatography is done normally with smaller amounts of material and is for measuring the relative proportions of analytes in a mixture. This new and important book gathers the latest research from around the globe in the study of chomatography and herein highlights such topics as: analysis of veterinary drugs using chromatographic techniques, liquid chromatography for the determination of mycotoxins in foods, chromatography in the research of phenolic secondary metabolites, and others.
Download or read book Gas Chromatography written by Percy Henrichon and published by . This book was released on 2020-02-14 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Gas Chromatography: History, Methods and Applications focuses on the main applications of gas chromatography in clinical and forensic toxicology, mainly in the determination of drugs of abuse including the new psychoactive substances in several types of biological matrices. The authors go on to investigated the analysis of gaseous or volatile substances using sensor gas chromatography equipped with a semiconductor gas sensor detector. The simplicity, ease of handling, and high sensitivity of this method allow results to be obtained rapidly, which may provide valuable information for forensic diagnosis. This compilation addresses the way in which food adulteration practices are potentially harmful to human health and so food safety and authenticity constitute an important issue in food chemistry. The chemical composition of foodstuffs is an excellent indicator of quality, origin, authenticity and/or adulteration. The concluding study aims to determine the organic compounds of vinasse through gas chromatography-mass spectrometry GC-MS. Vinasse is a byproduct of ethanol and poses long-term risk to public health because of its persistent and toxic nature"--
Download or read book High performance Liquid Chromatography written by Ivan Lucero and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this collection, the authors discuss the way in which it is possible to detect the low concentrations at which toxic compounds and metabolites are present in specimens due to the huge development of chromatographic techniques. Chromatography is an analytical procedure used for the separation of compounds/drugs and its most commonly used types are based on either high performance liquid chromatography or gas chromatography, both coupled to mass spectrometry. As such, the advances in liquid chromatography coupled to different detectors, particularly mass spectrometry, giving examples of its applications in the areas of clinical and forensic toxicology. The authors present the importance of using high-performance liquid chromatography in analytical chemistry, as well as the positive aspects related to the use of chemometric approaches for the optimization of processes during the development of analytical methods. Case studies about real applications of chemometric tools focusing on the analysis of water samples polluted with a mixture of polycyclic aromatic hydrocarbons are presented. Next, sample preparation is considered as a difficult part of any analytical procedure in which the chemical compounds are present at low concentrations in complex matrices. Graphene based materials have been more and more popular in the procedure of sample preparation. Graphene is a material that has good physical-chemical properties, high fracture stretch, ultra-high specific surface area with nanosheets morphology and good mechanical and thermal stability. In the concluding study, the authors present a simple, economic and environmental friendly modification of stationary phase by self-assembly positive charged photosensitive diazoresin. The preparation and modification process of the chromatographic stationary phases is discussed. Additionally, the separation performance of chromatographic stationary phase is also discussed.
Download or read book HPLC Methods on Drug Analysis written by Mantu Kumar Ghosh and published by Springer. This book was released on 1992 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPLC methods are among the most important methods of drug analysis. Ghosh describes more than 1000 HPLC methods published in the literature for 650 commonly used drugs. The concise presentation is intended as an immediate guide and enables a quick selection of methods to be made in laboratory. The book will be a great help to scientists, researchers, engineers and technicians involved in the analysis of drugs or their metabolites in pharmaceutical preparations or biological materials. HPLC methods are among the most important methods of drug analysis. Ghosh describes more than 1000 published HPLC methods for 650 commonly used drugs, including some drug components and metabolites. The concise presentation is intended as an immediate guide and enables a quick selection of methods to be made in the laboratory.
