Download or read book Chromatin Regulation and Dynamics written by Anita Göndör and published by Academic Press. This book was released on 2016-10-25 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Download or read book Chromatin written by Ralf Blossey and published by CRC Press. This book was released on 2017-08-04 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.
Download or read book Chromatin written by Ralf Blossey and published by CRC Press. This book was released on 2017-08-04 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.
Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Download or read book Chromatin and Disease written by Tapas K. Kundu and published by Springer Science & Business Media. This book was released on 2007-05-04 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.
Download or read book Epigenetic Gene Expression and Regulation written by Suming Huang and published by Academic Press. This book was released on 2015-10-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. - Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science
Download or read book Plant Chromatin Dynamics written by Célia Baroux and published by . This book was released on 2018 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chromatin Structure and Dynamics written by J. Zlatanova and published by Gulf Professional Publishing. This book was released on 2004 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.
Download or read book Nuclear Architecture and Dynamics written by Christophe Lavelle and published by Academic Press. This book was released on 2017-10-27 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. - Highlights the link between the (bio)chemistry and the (bio)physics of chromatin - Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin - Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds
Download or read book Characterization of Chromatin Dynamics During DNA Repair and Transcriptional Regulation written by Beth Ann Tamburini and published by . This book was released on 2006 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epigenetic Contributions in Autoimmune Disease written by Esteban Ballestar and published by Springer. This book was released on 2011-08-23 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.
Download or read book Chromatin Stability and Dynamics Targeting and Recruitment of Chromatin Modifiers written by Sara Farrona and published by Frontiers Media SA. This book was released on 2021-07-27 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chromatin Regulation in Cell Fate Decisions written by José Luis Sardina and published by Frontiers Media SA. This book was released on 2021-10-20 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Regulation of Chromatin Dynamics by Histone Chaperones and Variants written by Rachel Miriam Zunder and published by . This book was released on 2011 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: In all eukaryotic organisms, DNA is packaged into chromatin, which controls gene expression and genomic stability. The chromatin landscape is dynamic and responds to environmental signals to direct different cellular programs. Chromatin architecture is regulated by a network of structural and enzymatic proteins that interact with histones to alter nucleosome composition. In my dissertation, I examined 1) the interaction between histone chaperones and newly synthesized histones during nucleosome assembly and 2) the interplay between canonical histone isotypes, histone variants, and histone modifications. My work established how the unusual domain architecture of a newly discovered histone chaperone, Rtt106, provides specificity for acetylated histone cargo. Additionally, I discovered several new histone modifications and examined the relationship between the histone variant H2A.Z and two canonical histone H2B isotypes (Htb1 and Htb2). My dissertation establishes a framework for understanding the additional levels of genomic regulation achieved by histone chaperones, variants, isotypes, and modifications. In chapter 2, I examine the structural basis for the specificity of the histone chaperone Rtt106 for H3 molecules modified by an acetylation at lysine 56 (H3K56ac). The X ray crystal structure, determined by our collaborators Andy Antczak and James Berger, revealed that Rtt106 contains a double pleckstrin homology (PH) motif. A targeted mutational screen identified two regions on Rtt106 that, when mutated individually, each disrupted Rtt106-H3 binding. One region was a basic surface on the N-terminal PH domain and the other was a loop within the C-terminal PH domain. Although binding experiments did not directly identify an H3K56ac binding pocket on Rtt106, a comparative analysis with the chromatin remodeling protein Pob3 implicated the C-terminal loop as the source of H3K56ac-specificity in the Rtt106-H3 interaction. This work establishes new domain architecture for acetyl-lysine recognition and expands our understanding of how chaperone-histone binding is regulated. Armed with Rtt106 mutants that reduced H3 binding activity, in chapter 3 I examine the role of Rtt106-mediated nucleosome assembly during replication, transcription, and silencing. Although Rtt106 mutant proteins localized to origins of replication and silent chromatin, without the ability to bind H3, these mutants could not deliver H3K56ac into chromatin. Reduced H3K56ac occupancy was detrimental to replication whereas excess unincorporated H3K56ac was antagonistic to silencing. In contrast, H3K56ac binding was required to recruit Rtt106 to histone gene promoters. Without recruitment of Rtt106 to these loci, we observed defects in H3K56ac incorporation and histone gene repression. Our work demonstrates that Rtt106-H3 binding is necessary for all known branches Rtt106-mediated nucleosome assembly, however these different branches rely on distinct genomic localization cues to target Rtt106 to chromatin. To analyze the relationships between canonical histones, modifications, and variants, in chapter 4 I explore the unique functions of two histone H2B isotypes, Htb1 and Htb2. In collaboration with the Freitas lab at the Ohio State University, we discovered three new modifications on H2B, one of which was isotype-specific. Although the dimeric association of H2A.Z with H2B did not reveal an isotype-specific interaction, the interplay between canonical histone isotypes and variants remains an intriguing paradigm for chromatin regulation. In collaboration with the Giaever lab at the University of Toronto, we used chemical genomic profiling to define unique functions associated with the Htb1 and Htb2 isotypes. However, all chemical sensitivities identified resulted from changes in histone expression rather than Htb1 and Htb2 protein activity. Although we are still searching for a functional distinction between the two H2B isotypes, mass spectrometry analyses coupled with chemical-genomic profiling represents a promising strategy for discovering these relationships and defining their functional impact.
Download or read book Chromatin Signaling and Neurological Disorders written by and published by Academic Press. This book was released on 2019-05-24 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. - Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more - Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics - Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders
Download or read book Chromatin Dynamics and the Regulation of beta globin Gene Expression written by Marcus Govert Johannes Maria Wijgerde and published by . This book was released on 1998 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Dynamics written by K. Nagata and published by Springer Science & Business Media. This book was released on 2007-12-03 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
