Download or read book 100 Years of Human Chorionic Gonadotropin written by Laurence A. Cole and published by Elsevier. This book was released on 2020-02-07 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: 100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world’s leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. Provides updated information on a complex and changing subject in five sections Reviews historical perspectives and developments over the last 100 years Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. Includes chapters on the development and use of hCG vaccines Includes a section on hCG and in subunits in cancer

Download or read book Human Chorionic Gonadotropin hCG written by Laurence A. Cole and published by Elsevier. This book was released on 2010-09-21 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. It provides comprehensive information on hCG from basic science to clinical medicine Written by specialists in the field

Download or read book Human Chorionic Gonadotropin hCG written by Laurence A. Cole and published by Elsevier. This book was released on 2014-12-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus.

Download or read book Chorionic Gonadotropin written by Sheldon J. Segal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.

Download or read book Biology of Trophoblast written by Y. W. Loke and published by Elsevier Publishing Company. This book was released on 1983 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Gonadotropins written by Laurence A. Cole and published by Elsevier. This book was released on 2022-07-27 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Gonadotropins is a must-have reference for basic science researchers looking to maximize their knowledge in this specific field of study. Luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin are essential for reproduction and outlined in detail in this work, covering topics ranging from antibodies and immunoassays, to commercial products and standards, genetics, and receptors and intermediaries for gonadotropins. Dr. Laurence Cole has been recognized for his outstanding research throughout his illustrious career. He has received awards from the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. This detailed resource compiles all the recent research together into one volume, with one consistent voice. Covers the evolution, structure, synthesis, and functions of gonadotropins in meticulous detail Includes sections on Degradation, Antibodies and Immunoassays, Commercial Products and Standards, and Receptors and Intermediaries Details a section on Reproduction and Cancer, covering gestational trophoblastic diseases, ovarian cystic disorders, and hCG and cancer

Download or read book Knobil and Neill s Physiology of Reproduction written by Ernst Knobil and published by Gulf Professional Publishing. This book was released on 2006 with total page 1780 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 3rd edition, the first new one in ten years, includes coverage of molecular levels of detail arising from the last decade's explosion of information at this level of organismic organization. There are 5 new Associate Editors and about 2/3 of the chapters have new authors. Chapters prepared by return authors are extensively revised. Several new chapters have been added on the topic of pregnancy, reflecting the vigorous investigation of this topic during the last decade.The information covered includes both human and experimental animals; basic principels are sought, and information at the organismic and molecular levels are presented. *The leading comprehensive work on the physiology of reproduction*Edited and authored by the world's leading scientists in the field*Is a synthesis of the molecular, cellular, and organismic levels of organization*Bibliogrpahics of chapters are extensive and cover all the relevant literature

Download or read book Plant Growth Substances 1970 written by D. J. Carr and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the 6th International Conference on Plant Growth Substances, held in Carleton University, Ottawa in 1968, it was decided that the 7th should be held in Czecho slovakia, following an invitation by Dr. Kutacek. Historical events intervened and in 1969 another venue was sought. An offer from the Academy of Science in Canberra was accepted by the steering committee. This left rather less time than is desirable to organize an international meeting of this nature and it was with surprise and great relief that the Organizing Committee in Canberra welcomed the arrival of 183 delegates, including a relatively large overseas contingent, to the meeting in December, 1970. The aim of these Conferences is, of course, to provide a forum for discussion of new work and recent trends, both in the lecture sessions and in conversation. Although many of those who initiated these meetings (e.g. Skoog, Went, Blackman, Bennet-Clark) were absent from the Canberra conference - some have retired -it was good to see present so many of the new generation of research workers in this field.

Download or read book Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research written by National Research Council and published by National Academies Press. This book was released on 2007-03-22 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is widely understood that stem cell treatments have the potential to revolutionize medicine. Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells. For this research to move forward, however, will require a steady supply of stem cells, particularly human embryonic stem cells. Those stem cells are collected from developing human embryos created from eggs-or oocytes-harvested from the ovaries of female donors. Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort. The oocyte donation process is not without risk, however. Donors are given doses of hormones to trigger the production of more eggs than would normally be produced, and this hormone treatment can have various side effects. Once the eggs have matured in the ovary, they must be retrieved via a surgical procedure that is typically performed under anesthesia, and both the surgery and the anesthesia carry their own risks. Furthermore, given the very personal nature of egg donation, the experience may carry psychological risks for some women as well. With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006. This report is a summary and synthesis of that workshop.

Download or read book Equine Reproductive Procedures written by John Dascanio and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Equine Reproductive Procedures is a user-friendly guide to reproductive management, diagnostic techniques, and therapeutic techniques on stallions, mares, and foals. Offering detailed descriptions of 161 procedures ranging from common to highly specialized, the book gives step-by-step instructions with interpretative information, as well as useful equipment lists and references for further reading. Presented in a highly portable spiral-bound format, Equine Reproductive Procedures is a practical resource for daily use in equine practice. Divided into sections on the non-pregnant mare, the pregnant mare, the postpartum mare, the stallion, and the newborn foal, the book is well-illustrated throughout with clinical photographs demonstrating procedures. Equine Reproductive Procedures provides practical guidance for performing basic and advanced techniques associated with the medical management of horses.

Download or read book Pituitary Function and Immunity written by Istvan Berczi and published by CRC Press. This book was released on 1986-02-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The influence of hormones secreted or regulated by the pituitary gland on the immune system is examined in detail, including dis-cussions of adrenocorticotropic hormone, glucocorticoids, cate-cholamines, growth hormone, insulin, prolactin, gonadotropins, sex steroid hormones, and thyroid hormones. The relative importance of various hormones in immunoregulation is considered, and evi-dence for interaction between the immune and neurohormonal sys-tems is presented The possible effects of hormonal immunomodu-lation in reproduction, infections and parasitic disease, autoimmu-nity, and cancer are examined. This comprehensive reference serves both basic and clinical researchers and practitioners in im-munology, microbiology, endocrinology, reproduction biology, neurology, oncology, psychology, medicine, and veterinary medicine.

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Download or read book Managing Gonadotropin Deficiency written by and published by . This book was released on 1986 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bovine Reproduction written by Richard M. Hopper and published by John Wiley & Sons. This book was released on 2014-08-18 with total page 2735 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bovine Reproduction is a comprehensive, current reference providing information on all aspects of reproduction in the bull and cow. Offering fundamental knowledge on evaluating and restoring fertility in the bovine patient, the book also places information in the context of herd health where appropriate for a truly global view of bovine theriogenology. Printed in full color throughout, the book includes 83 chapters and more than 550 images, making it the most exhaustive reference available on this topic. Each section covers anatomy and physiology, breeding management, and reproductive surgery, as well as obstetrics and pregnancy wastage in the cow. Bovine Reproduction is a welcome resource for bovine practitioners, theriogenologists, and animal scientists, as well as veterinary students and residents with an interest in the cow.

Download or read book Drug Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Download or read book Part 1 MRCOG Revision Notes and Sample SBAs written by Neelanjana Mukhopadhaya and published by Cambridge University Press. This book was released on 2020-12-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise yet comprehensive guide is focused on the curriculum and current exam style of the MRCOG Part 1 examination. It integrates clinical knowledge with basic science, providing readers with a deeper understanding of pathophysiology of medical disorders in obstetrics and gynaecology. The lead editor is a member of the Part 1 Examination Committee and her insights are skilfully woven into the book's revision notes, sample Single Best Answer (SBA) question and answer explanations, and tips on exam technique. The book encourages a structured thought process to develop, making it easier for clinicians to make differential diagnoses and conduct relevant investigations and treatment plans. The focus on basic sciences also endows readers with the ability to develop research ideas and evaluate findings. Featuring easy-to-read text, highlighted key points, illustrations, and plenty of practice papers, this succinct guide is essential preparation reading for trainee obstetricians and gynaecologists taking the challenging Part 1 MRCOG exam.

Download or read book A Textbook of Clinical Embryology written by Eliezer Girsh and published by Cambridge University Press. This book was released on 2021-05-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personnel working in assisted reproductive technology often lack the opportunities for dedicated training in the specialized techniques and technologies required for the procedures. As such, success in the form of live birth rates can range from over 50% to less than 10% per treatment cycle. This comprehensive introductory textbook is an essential resource for trainee embryologists, medical students and nurses. The recent revolutions in biotechnology and molecular biology involved in delivering assisted reproductive services are thoroughly discussed. Basic knowledge such as the development and physiology of both male and female reproductive systems is covered, with practical aspects of IVF including gamete and embryo manipulation, cryopreservation and genetic testing explained in detail. A full description of the optimal structure and management of the IVF laboratory is given, helping ensure procedures are safe and effective. Extensive and highly detailed colour illustrations bring the content to life and aids readers in their understanding.