Download or read book Cholinesterase Genes written by H. Soreq and published by . This book was released on 1990 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Cholinesterases and Anticholinesterases written by Hermona Soreq and published by Academic Press. This book was released on 2012-12-02 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.
Download or read book Cholinesterase written by Mary Whittaker and published by S. Karger AG (Switzerland). This book was released on 1986 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Function of Cholinesterases and Related Proteins written by Bhupendra P. Doctor and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth International Meeting on Cholinesterases and Related Proteins, Choli nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998. This was the first conference of the series to be held in the United States, let alone on the Pa cific Rim. Nearly 200 delegates from twenty countries-from Asia, Australia, Europe, and North and South America-heard 75 oral presentations and viewed 90 posters on current research on cholinesterases and related proteins. The meeting framework was structured to include two days of plenary sessions, followed by two days of concurrent sessions and workshops in specific areas. Communication at the concurrent sessions was facilitated by the conference settings of the Martin Johnson House, on a scenic bluff overlooking the blue Pacific Ocean, and the San Diego Supercomputer Center, which enabled projection and rotation of protein structures in three dimensions for a large audience. This book is the compilation of the presentations at the Sixth International Meeting on Cholinesterases and Related Proteins into a volume that describes recent investigations on the structure, catalytic and non-catalytic functions of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and related proteins, as well as studies on the molecular and cellular biology of these enzymes and the genes that encode them.
Download or read book Cholinesterases written by Jean Massoulié and published by . This book was released on 1991 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the proceedings of the Third International Meeting on Cholinesterases, this volume provides a wealth of new information on current cholinesterase research and explores a number of avenues for future research. Important advances resulting from new concepts and methodologies such as monoclonal antibodies and molecular genetics, are covered. Among the topics covered in its 49 full papers and 140 poster papers are polymorphism and structure, cellular biology, gene structure and expression, agents, and noncholinergic roles of cholinesterases.
Download or read book Enzymes of the Cholinesterase Family written by A.S. Balasubramanian and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.
Download or read book Cholinesterase Genes written by Zakut and published by Hart Associates. This book was released on 1990-01-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Multileveled Regulation of the Human Cholinesterase Genes and Their Protein Products written by and published by . This book was released on 1993 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ACHE and BCHE genes encoding the acetylcholine hydrolyzing enzymes acetyl- and butyrylcholinesterase (AChE, BuChE) were molecularly cloned and their chromosomal positions determined to be 7q22 and 3q26, respectively. Several point mutations were found in these two genes and their frequency determined within ethnically distinct populations of Israeli residents. Xenopus oocyte expression studies revealed the BuChE mutations variably alter sensitivity to inhibitors, including organophosphorous poisons. The promoter controlling ACHE gene expression was characterized and shown to direct the expression of human AChE in developing myotomes from transiently transgenic Xenopus laevis embryos, where the transgenic enzyme faithfully accumulated in neuromuscular junctions. Alternative splicing in ACHEmRNA transcripts was found to lead to 3 distinct enzyme forms, 2 of which are abundant in tumors. Antisense phosphorothioate oligodeoxynucleotide-targetted destruction of ACHEmRNA in mice was found to cause transient hematopoietic alterations, notably reduced erythrocyte counts. Acetylcholinesterase, Butyrylcholinesterase, DNA sequencing, Alternative splicing, Natural variants, Xenopus expression, Site-directed mutagenesis.
Download or read book Multidisciplinary Approaches to Cholinesterase Functions written by Avigdor Shafferman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multileveled Regulation of the Human Cholinesterase Genes and Their Protein Products written by Patrick A. Dreyfus and published by . This book was released on 1988 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Download or read book Two Cholinesterase Genes are Present in Amphioxus written by J. Scott McClellan and published by . This book was released on with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cholinesterases written by Anne Marie Valle and published by . This book was released on 2008 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cholinesterases are serine hydrolases that catalyze the hydrolysis of acetylcholine (ACh), the cholinergic neurotransmitter in the central and autonomic nervous systems and at neuromuscular synapses. Peripheral and central nervous system control of cardiovascular (CV) function mediated through cholinergic pathways is critical in the homeostatic maintenance of blood pressure and responsiveness to stress. The specific role for acetylcholinesterase (AChE; EC 3.1.1.7) lies in its ability to rapidly catalyze the hydrolysis of ACh. Butyrylcholinesterase (BChE; EC 3.1.1.8) catalyzes the hydrolysis of esters of choline including ACh, although it differs in its substrate and inhibitor specificities. The physiological role for BChE remains uncertain, but studies have shown a strong correlation between BChE activity and the metabolic syndrome. This dissertation investigates the role variations in cholinesterase genes play in relation to cardiovascular function and the metabolic syndrome. AChE and BChE can be found in whole blood enabling a biochemical phenotypic characterization in addition to correlation of genotype with phenotypic physiologic responses. Analysis of enzymatic activity was determined spectrophotometrically in plasma and blood cells of twin subject registries from Australia and San Diego along with a general population subject registry from San Diego. Association studies revealed significant relationships between cholinesterase activity and certain cardiovascular endpoints. For AChE, I looked at naturally occurring single nucleotide polymorphisms (SNPs) in the AChE gene in a human population in relation to catalytic properties and cardiovascular function. SNP discovery by re-sequencing of the AChE gene using genomic DNA of the general population registry and SNP genotyping was performed using genomic DNA of the San Diego twin subject registry. Nineteen SNPs have been identified: 7 SNPs in the coding region (cSNPs), 4 non-synonymous encoding for a different amino acid and 3 synonymous encoding the same amino acid; 12 are in untranslated regions (UTR) of the gene with 3 of these in a conserved region of intron 1. The non-synonymous cSNPs were inserted into a human AChE cDNA vector and transfected into human embryonic kidney (HEK) cells for protein expression. Characterization of the purified mutant enzymes encoded by the SNP polymorphisms revealed significant thermal and chemical stability differences when compared with the predominant AChE species. For BChE, I examined whether BChE activity correlated with parameters of the metabolic syndrome and cardiovascular function. Linkage analysis with data from a dizygotic twin set showed suggestive linkage at the BChE locus, and statistical analysis revealed a high correlation between BChE activity and variables associated with cardiovascular risk and the metabolic syndrome. Statistical analysis revealed a significant relationship between two BChE SNPs and BChE activity. The pattern of within-pair twin correlations by zygosity and the ACE model-fitting findings suggested the major source of variation (65%) in BChE activity was attributable to additive genetic influences. In summary the research presented here is important in defining the role of cholinesterase SNPs in disease susceptibility particularly in the realm of cardiovascular diseases and the metabolic syndrome, and individual risk associated with chemical terrorism with agents affecting cholinergic function. These enzymes, AChE and BChE, are readily accessible in blood samples however the tissues where activity most likely affects physiologic function are typically not accessible. However, my studies should reveal intrinsic differences in generalized expression parameters. Furthermore, this work underscores the importance of structure-based modeling for analytical and theoretical insights that can be ascertained based on the modeling of SNPs to a protein's crystal structure.
Download or read book Sequencing and in Vitro Expression of Two Cholinesterase Genes in Amphioxus written by Ashley Elizabeth Hawkins and published by . This book was released on with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation and Expression of Human Cholinesterase Genes written by Patrick A. Dreyfus and published by . This book was released on 1989 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Biology of Cholinesterases written by Ann Silver and published by North-Holland. This book was released on 1974 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475
