Download or read book Cholinergic Ligand Interactions written by D. J. Triggle and published by Academic Press. This book was released on 2014-06-28 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease. The volume contains nine chapters and begins with a study on possible conformational changes in acetylcholinesterase. This is followed by separate chapters on the subunits of acetylcholinesterase; in vitro studies with the cholinergic receptor of the eel electroplax; identification and isolation of acetylcholine receptors; assay and properties of essential (junctional) cholinesterases of the rat diaphragm; and structural variations in cholinergic ligands. Subsequent chapters deal with ligand interactions at the muscarinic receptors and changes in cholinesterases isozymes during normal and dystrophic muscle development.

Download or read book Cholinergic Ligand Interactions with Acetylcholine Receptor Proteins and Solvent Interactions with N N Dialkylnicotinamides written by John William Bean and published by . This book was released on 1987 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic Ligand Interactions Proceedings of a Symposium Held May 25 26 1970 at the State University of New York written by buffalo Symposium on cholinergic ligand interactions and published by . This book was released on 1971 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic Ligand Interactions with Acetylcholine Receptor Proteins Isloated from D r o s o p h i l a M e l a n o g a s t e r and T o r p e d o C a l i f o r n i c a written by John William Bean and published by . This book was released on 1984 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic Ligand Interactions Edited by D J Triggle J F Moran and E A Barnard written by Eric A. Barnard and published by . This book was released on 1971 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book CHOLINERGIC LIGAND INTERACTIONS PROCEEDINGS OF A SYMPOSIUM written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic Ligand Interactions written by D. J. Triggle and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic ligand interactions Proceedings of a Symposium Cholinergic Ligand Interactions held May 25 26 1970 at the State Univ of New York at Buffalo written by David J. Triggle and published by . This book was released on 1971 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Interaction of Multiple Types of Cholinergic Ligands with a Nicotinic Acetylcholine Receptor written by Hideki Kawai and published by . This book was released on 1998 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of a Nicotinic Acetylcholine Receptor and Its Interaction with Cholinergic Ligands written by Sue-Jan Tine and published by . This book was released on 1995 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic Mechanisms From Molecular Biology to Clinical Significance written by J. Klein and published by Elsevier. This book was released on 1996-12-18 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in this volume, are due to recent methodological breakthroughs. These discoveries throw new light on many areas of cholinergic mechanisms.

Download or read book Interactions of Local Anesthetics and Cholinergic Ligands with Membrane bound Acetylcholine Receptor from Torpedo Californica written by Steven Gerard Blanchard and published by . This book was released on 1980 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nicotinic Acetylcholine Receptors written by Jean-Pierre Changeux and published by ODILE JACOB PUBLISHING CORP. This book was released on 2005-09-08 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.

Download or read book Nicotinic Acetylcholine Receptors and Their Interactions with Allosteric Ligands written by Joseph Newcombe and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neurochemistry of Cholinergic Receptors written by Eduardo D. P. De Robertis and published by . This book was released on 1974 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Nicotinic Acetylcholine Receptor written by Francisco J. Barrantes and published by Springer. This book was released on 1998-08-19 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Different techniques from various disciplines have made possible the analysis of the structure and the multiplicity of functions performed by ligand- and voltage-gated ion channels and receptors. This book covers one of the fastest growing fields in the molecular neurosciences - that of the ligand-gated ion channels (LGIC). Future trends, which are analyzed in each chapter, encompass the likely strategies for decoding structure-function relationships of the receptor molecule, the establishment of the differences in ionic selectivity and the mechanisms of permeability through the pore, and the possible use of genetic kindredness between actylcholine receptors of different species for the diagnosis of new genetic diseases.

Download or read book Animal Models of Cognitive Impairment written by Edward D Levin and published by CRC Press. This book was released on 2019-08-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.