Download or read book Chemotherapy of Parasitic Diseases written by W.C. Campbell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done.

Download or read book Parasitic Diseases written by John M. Mansfield and published by . This book was released on 1980 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Parasitic Diseases written by John M. Mansfield and published by . This book was released on 1981 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Parasites Fungi and Viruses written by J. D. Williams and published by Springer. This book was released on 2012-09-13 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is receiving increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,000 papers read at the Congress we have produced Proceedings which reflect the variety and vigour of research in this important field of medicine. It was not possible to include all of the papers presented at the Congress but we have attempted to include most aspects of cur rent progress in chemotherapy.

Download or read book Chemotherapy of Tropical Parasitic Infections written by T. K. Chatterjee and published by PHI Learning Pvt. Ltd.. This book was released on 2004-08 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Chemotherapy of Human Parasitic Disease written by Václav Bozdech and published by . This book was released on 1992 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Control of Human Parasitic Diseases written by and published by Elsevier. This book was released on 2007-03-23 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Control of parasitic infections of humans has progressed rapidly over the last three decades. Such advances have resulted from focal disease control efforts based on historically effective interventions to new approaches to control following intensive research and pilot programs. Control of Human Parasitic Diseases focuses on the present state of control of the significant human parasitic infectious diseases. Includes the impact of recent research findings on control strategy Discusses the health policy implications of these findings and the importance of evaluation and monitoring Highlights the lessons learned and the interactions between control programs and health systems

Download or read book Preventive Chemotherapy in Human Helminthiasis written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual focuses on how and when a set of low-cost or free drugs should be used in developing countries to control a set of diseases caused by worm infections. Preventive chemotherapy in this context means using drugs that are effective against a broad range of worm infections to simultaneously treat the four most common diseases caused by worms: river blindness (onchocerciasis), elephantiasis (lymphatic filariasis), schistosomiasis, and soil-transmitted helminthiasis. Significant opportunities also exist to integrate these efforts with the prevention and control of diseases such as trachoma. The new approach provides a critical first step in combining treatment regimens for diseases which, although different in themselves, require common resources and delivery strategies for control or elimination.

Download or read book Parasites Fungi and Viruses written by J. D. Williams and published by Springer. This book was released on 1976-03-01 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is receiving increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,000 papers read at the Congress we have produced Proceedings which reflect the variety and vigour of research in this important field of medicine. It was not possible to include all of the papers presented at the Congress but we have attempted to include most aspects of cur rent progress in chemotherapy.

Download or read book Handbook of Drugs for Tropical Parasitic Infections written by Urban Hellgren and published by CRC Press. This book was released on 2003-05-20 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical parasitic infections were introduced more than 30 years ago. Most of these drugs are toxic and have complicated dosage regimens, but, because of the low economic incentive, pharmaceutical companies have shown little interest in developing new drugs to control diseases prevalent in developing countries.; However, there has been notable progress in research into parasitic diseases and a number of important drugs have been introduced for some diseases since the 1970s. Moreover, recent data on the pharmacokinetics and field evaluations of these drugs have revealed that their effectiveness can be improved and their safety increased.; This handbook is designed to provide information about the pharmacological properties and therapeutic uses of the major drugs currently employed to combat the human parasitic infections encountered in the tropics. Each of the 38 drugs covered in the book are presented under the following headings: chemical structure, physical properties, pharmacology and mechanism of action, pharmacokinetics, clinical trials, pregnancy and lactation, side effects, contraindications and precautions, dosage, preparations, and references.

Download or read book Chemotherapeutic Targets in Parasites written by Tag E. Mansour and published by . This book was released on 2002 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. Emphasized throughout is the design of more selective and less toxic drugs than in the past.

Download or read book Chemotherapy and the Immune System written by L. H. Chappell and published by Cambridge University Press. This book was released on 1992 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This specially commissioned text covers a range of topics relating to chemotherapy and the immune system.

Download or read book Approaches to Design and Synthesis of Antiparasitic Drugs written by N. Anand and published by Elsevier. This book was released on 1997-07-10 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Download or read book Development of Chemotherapeutic Agents for Parasitic Diseases written by Maurice Marois and published by North-Holland. This book was released on 1975 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemotherapeutic Targets in Parasites written by Tag E. Mansour and published by Cambridge University Press. This book was released on 2002-11-04 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets. There are sections discussing helminths; including metabolic, neuromuscular, microtubular and tegumental targets. The design of more selective and less toxic drugs is emphasized throughout.

Download or read book Drug Development for Parasite induced Diarrheal Diseases written by Anjan Debnath and published by Frontiers Media SA. This book was released on 2017-08-25 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease. In Asia, Africa, and Latin America, about 500,000 new giardiasis cases are reported each year. Cryptosporidium accounts for 20% and 9% of diarrheal episodes in children in developing and developed countries, respectively. Infection with Cryptosporidium can be chronic and especially debilitating in immunosuppressed individuals and malnourished children. A recent study to measure disease burden, based on disability-adjusted life years (DALYs), found that cryptosporidiosis and amebiasis produce about 10.6 million DALYs. This exceeds the DALYs of any helminth infection currently being targeted by the World Health Organization for preventive chemotherapy. Because of its link with poverty, Giardia and Cryptosporidium were included in the WHO Neglected Diseases Initiative in 2004. E. histolytica, G. lamblia, and C. parvum have been listed by the National Institutes of Health (NIH) as category B priority biodefense pathogens due to low infectious dose and potential for dissemination through compromised food and water supplies in the United States. Despite the prevalence of amebiasis, giardiasis, and cryptosporidiosis there are no vaccines or prophylactic drugs. The first-line drugs for invasive amebiasis and giardiasis chemotherapy are nitroimidazoles, with the prototype, metronidazole, being the most common drug used worldwide. Metronidazole has been shown to be both mutagenic in a microbiological system and carcinogenic to rodents, and frequently causes gastrointestinal side effects. In spite of the efficacy of nitroimidazole drugs, treatment failures in giardiasis occur in up to 20% of cases. Clinical resistance of G. lamblia to metronidazole is proven and cross resistance is a concern with all commonly used antigiardial drugs. Nitazoxanide, the only FDA-approved drug for the treatment of cryptosporidiosis, is effective in the treatment of immunocompetent patients and partially effective for immunosuppressed patients. Therefore, it is critical to search for more effective drugs to treat amebiasis, giardiasis, and cryptosporidiosis. This Research Topic for Frontiers in Microbiology will explore the recent progress in drug development for parasitic diarrheal diseases. This includes an understanding of drug resistance mechanisms. We would also welcome submissions on the drug development for other diarrheal parasites. We hope that this research topic will include a comprehensive survey of various attempts by the parasitology research community to create effective drugs for these diseases.

Download or read book Trace Metals and Infectious Diseases written by Jerome O. Nriagu and published by MIT Press. This book was released on 2024-06-11 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang