Download or read book Chemotherapy for Trypanosomiasis written by A. S. Peregrine and published by ILRI (aka ILCA and ILRAD). This book was released on 1990-01-01 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress in Human African Trypanosomiasis Sleeping Sickness written by Michel Dumas and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.
Download or read book The Trypanosomiases written by Ian Maudlin and published by CABI. This book was released on 2004-07-09 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art reference book includes comprehensive coverage of the biology and control of African, Asian and South American trypanosomiasis ("sleeping sickness") in man and animals. It describes recent research developments in the biology and molecular biology of trypanosomes (the protozoan parasite) and their vectors, and methods in diagnosis and control, such as trapping tsetse fly vectors. Different sections of the book are devoted to biology of trypanosomes, vector biology, epidemiology and diagnosis, pathogenesis, disease impact, chemotherapy and disease control, and vector control. The book contains contributions from leading experts from Europe, North and South America, and Africa.
Download or read book Trypanosomiasis and Leishmaniasis written by Geoff Hide and published by . This book was released on 1997 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trypanosomiasis and Leishmaniasis are related diseases caused by single celled organisms (protozoa) transmitted by insects. Between them, these diseases are responsible for much suffering among humans and livestock and so a greater understanding of their biology is a vital part of the campaign to control them. Modern molecular techniques available for use in understanding the control of these diseases are becoming more sophisticated and are increasingly becoming universally applicable to a wide variety of diseases. This book brings together the research approaches that are used interchangeably to understand both Trypanosomiasis and Leishmaniasis. Examples of such fruitful integration can be seen in a number of research areas: genome mapping, molecular and population genetic approaches to epidemiology, studies on polyamine metabolism and possible targets for rational drug design, studies on cellular signalling as a route to understanding host-parasite interactions and studies on chemotherapy and drug resistance. There are also chapters that consider those features that are unique to either Trypanosomiasis or Leishmaniasis. Thus a broad overview of the biology of each disease from the molecular level right up to the whole animal is provided. Contributors come from the leading research groups working on these diseases and include clinicians, laboratory based researchers and social scientists. The book provides an up-to-date summary of the advances in the understanding of these diseases that have come about through the use of modern technologies. By presenting an integration of research into both Trypanosomiasis and Leishmaniasis this book provides an innovative contribution to the literature in this area. It is important reading for all parasitologists, pharmacologists, epidemiologists and clinicians working with these organisms. It is also a useful resource for veterinarians, public health workers, policy makers and social scientists concerned with Trypanosomiasis or Leishmaniasis.
Download or read book American Trypanosomiasis written by Jenny Telleria and published by Elsevier. This book was released on 2010-09-03 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: - The host: human and mammalian reservoirs - The insect vectors: domestic and sylvatic vectors - The causative parasite: Trypanosoma cruzi - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts
Download or read book The African Trypanosomiases written by William Herbert Potts and published by . This book was released on 1970 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Chemotherapy written by Robert J. Schnitzer and published by . This book was released on 1967 with total page 1042 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Emerging and Re emerging Infections written by Sunit Kumar Singh and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 2365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.
Download or read book Diseases of Cattle in the Tropics written by Miodrag Ristic and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the future increase in livestock production is expected to occur in the tropical and subtropical regions of the world. Cattle are the most numerous of the ruminant species in the tropics and provide the largest quantity of animal food products. More than one-third of the world's cattle are found in the tropics. Disease is the major factor which prohibits full utilization of these regions for cattle production. Various infectious and transmissible viral, rick ettsial, bacterial, and particularly protozoan and helminthic diseases, are widespread in the tropics and exert a heavy toll on the existing cattle industry there. This uncontrolled disease situation also discourages investment in cattle industries by private and government sectors. In Africa alone, it is estimated that 125 million head of cattle could be accommodated in the tropical rainbelt if the disease and other animal husbandry factors could be resolved. The potential of efficient cattle production under more favorable conditions prompted various international agencies to establish a multi million dollar International Laboratory for Research in Animal Diseases (ILRAD) in Nairobi, Kenya, Africa. In South America, principal sites for raising cattle are shifting to the savannah lands because the more fertile soils are being used for crop produc tion, however, in the savannahs also, disease remains the most powerful deterrent in implementing the cattle industry.
Download or read book Proteins and Proteomics of Leishmania and Trypanosoma written by André L.S. Santos and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
Download or read book Different Aspects on Chemotherapy of Trypanosomatids written by Leonor Leon and published by . This book was released on 2017 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the knowledge that there are several pieces of information concerning the chemotherapy of trypanosomatids, it is important to put together the different aspects of this subject. This book is an updated version of several areas such as molecular biology, biochemistry, immune response to the studied compounds, pharmacology, etc. The chapters were written by experts in those different specialties. It reinforces the necessity to look to those trypanosomatids associated with severe diseases, such as Chagas disease, leishmaniases and African trypanosomiasis, which constitute a public health problem in poor countries where basic sanitary conditions are non-existent. This book intends to show the importance of specific methodologies to save time and money during the drug development process. Each step should be carefully planned from the selection of test compounds, the choice of a molecular target within parasites, the definition of a lead compound and the adequacy of the animal models. It is also important to focus on the activity of compounds, synthetic or from natural sources, in different species and life stages of the parasites, besides the way these compounds are metabolized in these laboratory conditions. In conclusion, this book will bring you information that could stimulate the development of better treatments for these highly neglected diseases.
Download or read book Experimental Chemotherapy written by R. J. Schnitzer and published by Elsevier. This book was released on 2013-10-22 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Chemotherapy, Volume I, attempts to condense the existing knowledge in the broad field of experimental chemotherapy in a comprehensive form. The arrangement of the subject matter follows a plan by which the not always avoidable repetitive description is reduced to a minimum. In most of the protozoan and metazoan infections it appeared advantageous to discuss the different series of active compounds according to the specific diseases and their causative agents. In other cases, owing to the wide range of activity of certain antibacterials, the material is arranged according to the groups of compounds. This first volume deals with infections caused by parasites, both protozoan and metazoan; it also contains general chapters on history of chemotherapy, toxicology, statistics, and drug resistance. It is hoped that the treatise will be useful to experimental workers engaged in the search for new chemotherapeutic remedies and in the study of their mechanism of action; to all who are involved in the teaching of pharmacology and therapeutics; and to physicians and veterinarians interested in the experimental basis of the drugs they are using.
Download or read book Biochemistry and Molecular Biology of Parasites written by Joseph Marr and published by Elsevier. This book was released on 1995-09-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of parasitic organisms at the molecular level has yielded fascinating new insights of great medical, social, and economical importance, and has pointed the way for the treatment and prevention of the diseases they cause. Biochemistry and Molecular Biology of Parasites presents an up-to-date account of this modern scientific discipline in a manner that allows and encourages the reader to place the biochemistry and molecular biology of these organisms in their biological context. The chapters are cross-referenced and grouped in an arrangement that provides a fully integrated whole, and permits the reader to create a composite of the biochemical function of these organisms.Individual chapter includes those devoted to metabolism, in both aerobic and anaerobic protozoa; antioxidant mechanisms; parasite surfaces; organelles; invasion mechanisms; and chemotherapy. The helminths are discussed not only from the point of view of their cellular biochemistry and metabolism, but also with respect to both their integrated functions such as neurochemistry, structure and functions of surfaces, and reproduction. Written by expert investigators, this book will be of interest to all experienced researchers, graduate students, and to the newcomer eager to become familiar with the biochemistry and molecular biology of parasites.
Download or read book Encyclopedic Reference of Parasitology written by Heinz Mehlhorn and published by Springer Science & Business Media. This book was released on 2001-05-21 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides a comprehensive review of the facts and trends in veterinarian and human parasitology. Several internationally renowned specialists have been added to the authors of the first edition, and the whole is now organised in an encyclopedic arrangement of comprehensive keywords, thus speeding up the search for information.
Download or read book One Health 2nd Edition written by Jakob Zinsstag and published by CABI. This book was released on 2020-09-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: One Health, the concept of combined veterinary and human health, has now expanded beyond emerging infectious diseases and zoonoses to incorporate a wider suite of health issues. Retaining its interdisciplinary focus which combines theory with practice, this new edition illustrates the contribution of One Health collaborations to real-world issues such as sanitation, economics, food security and vaccination programmes. It includes more non-infectious disease issues and climate change discussion alongside revised case studies and expanded methodology chapters to draw out implications for practice. Promoting an action-based, solutions-oriented approach, One Health: The Theory and Practice of Integrated Health Approaches highlights the lessons learned for both human and animal health professionals and students.
Download or read book Chemotherapy of Parasitic Diseases written by W.C. Campbell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done.
Download or read book Antimicrobial compounds from natural sources written by Mirian A. F. Hayashi and published by Frontiers E-books. This book was released on 2014-08-29 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature is a generous source of compounds with the potential to treat diseases, including infectious diseases, which is of utmost importance for modern medicine as antimicrobial resistances increase. Known sources of natural compounds with valuable antimicrobial activity include medicinal plants, and marine and terrestrial organisms such as fungi and bacteria. Nevertheless, there is still a vast fauna and flora that, once systematically explored, could provide additional antimicrobial leads and drugs. Investigators are welcome to contribute original research and/or review articles in this area, specifically with studies exploiting the mechanism of action and the structure-activity aspects of natural compounds with antimicrobial activity that provide insights into potential ways to overcome antimicrobial resistance.
