Download or read book Handbook of Cancer Chemotherapy written by Roland T. Skeel and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Seventh Edition of this pocket reference is a practical, disease-focused guide to the best current medical practice in cancer chemotherapy. In easy-to-follow outline format, the book provides complete coverage of the principles of rational chemotherapy, the chemotherapeutic and biotherapeutic agents available, the treatment of specific cancers, and selected aspects of supportive care. Emphasis is on the indications, dosage/schedule, potential toxicities, and safe administration of the drugs and their use in treating specific malignancies. This edition describes seventeen new chemotherapeutic agents, with particular attention to molecular targeted agents. Updated chapters on individual cancers and supportive care provide state-of-the-art treatment recommendations.
Download or read book Combination Therapies written by E. Garaci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances. BRMs currently are being applied clinically as both primary and adjunctive therapy to enhance the effectiveness of traditional treatments by maximizing their activities and to protect critical tissues against intolerable chemotherapeutic and radiation damage. Present constraints against the use of BRMs revolve around the nature of these substances in vivo, where many of their actions and the majority of their interactions and synergies remain to be elucidated. For example, as these molecules are thought to exert their effects locally, the systemic administration of lymphokines, cytokines and growth factors at doses adequate to produce a wanted anti-tumor effect in many instances is intolerably toxic. Efforts to overcome this formidable problem have led scientists to begin to explore the transfer of genes known to encode for these molecules into cells which otherwise inadequately elicit or produce anti-tumor or anti-infective responses.
Download or read book Combination Cancer Therapy written by Gary K. Schwartz and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert physician-scientists and clinicians review those combinations of novel target agents classic chemotherapies that hold the most promise for the future of medical oncology, and detail their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatments in cancer therapy.
Download or read book Updates on Combination Therapy for Lung Cancer written by Muhammad Abbas and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pocket Guide to Chemotherapy Protocols written by Edward Chu and published by Jones & Bartlett Learning. This book was released on 2007-07 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable quick reference for physicians, nurses, and other healthcare providers treating cancer patients! The updated Fourth Edition of the best-selling Pocket Guide to Chemotherapy Protocols is spiral bound and arranged alphabetically by cancer type for easy access, and contains combination as well as selected single-agent regimens for solid tumors and hematologic malignancies. In each case, the regimens selected are based on the published literature and are used in clinical practice in the medical oncology community. Pocket Guide to Chemotherapy Protocols, Fourth Edition, continues the success of previous editions by offering cancer care professionals complete, authoritative information in a convenient format. * Comprehensive * Authoritative * Pocket-sized * Quick access * Evidence-based * Up-to-date
Download or read book Novel Combination Therapies for the Treatment of Solid Cancers written by Khalid A. El Sayed and published by Frontiers Media SA. This book was released on 2021-12-22 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemotherapy Protocols and Infusion Sequence written by Iago Dillion Lima Cavalcanti and published by Springer Nature. This book was released on 2022-10-18 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to address the infusion sequence of the main protocols used in the treatment of varied solid cancers. Since an inadequate infusion sequence can compromise the patient's treatment, this work will provide support to professionals working in the field of oncology in assessing each chemotherapy infusion sequence. The introductory chapters present the definition, indication, and the risks and benefits of polypharmacy in cancer therapy, and discuss the importance of drug combination in cancer treatment. Chapter 2 focuses on the challenges and also the toxicity of combination therapy in cancer, while chapter 3 highlights the parameters that must be evaluated before defining the infusion sequence, such as pharmacodynamic and pharmacokinetic profiles, drugs’ stability when diluted or reconstituted, toxicological profile of each drug, among others. The remaining chapters are divided by type of cancer. The content is focused on solid tumors, dividing the chapters according to breast, gastrointestinal, genitourinary, gynecological, head and neck, lung, and neurological cancers. In each chapter the epidemiological profiles, pathophysiology, therapeutic modalities, and the main chemotherapy protocols are addressed, as well as efficacy studies and data on the infusion sequence of each mentioned protocol. This work will be a valuable resource to physicians, nurses, and pharmacists, and may help to improve health service practices.
Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Download or read book Perry s The Chemotherapy Source Book written by Michael Clinton Perry and published by Lippincott Williams & Wilkins. This book was released on 2012 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perry's The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.
Download or read book Combination Therapies 2 written by E. Garaci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd International Symposium on Combination Therapies brought together several hundred of the leading researchers, scientists and clinicians in this area to discuss new and emerging uses for biological response modifiers (BRM's) in the treatment of cancer and infectious diseases. The meeting was held during May 1-3, 1992 in Acireale, Sicily (Italy). It was hosted by Professor G. Nicoletti CU. of Catania) and organized by the Institute for Advanced Studies in Immunology and Aging (Washington, D. C. ) in collaboration with the University of Rome "Tor Vergata," the University of Catania and The George Washington University Medical Center. The synergy exhibited between BRM's and conventional therapies including bone marrow and other lymphoid cell transplants is a rapidly expanding area with significant promise for the treatment of human diseases. Advances in this area of biomedicine are leading to the rapid development of new therapeutic approaches that are being applied clinically as both primary and adjuvant therapy to enhance the effectiveness of conventional treatments. The 2nd International Symposium on Combination Therapy provided a setting for the exchange of new scientific information regarding the emerging uses for BRM's alone or in combination with conventional therapies. The 1st International Symposium on Combination Therapies was held in 1991 in Washington, D. C.
Download or read book Discovery and Delivery of Synergistic Chemotherapy Drug Combinations to Tumors written by Kathryn Militar Camacho and published by . This book was released on 2015 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy combinations for cancer treatments harbor immense therapeutic potentials which have largely been untapped. Of all diseases, clinical studies of drug combinations are the most prevalent in oncology, yet their effectiveness is disputable, as complete tumor regressions are rare. Our research has been devoted towards developing delivery vehicles for combinations of chemotherapy drugs which elicit significant tumor reduction yet limit toxicity in healthy tissue. Current administration methods assume that chemotherapy combinations at maximum tolerable doses will provide the greatest therapeutic effect -- a presumption which often leads to unprecedented side effects. Contrary to traditional administration, we have found that drug ratios rather than total cumulative doses govern combination therapeutic efficacy. In this thesis, we have developed nanoparticles to incorporate synergistic ratios of chemotherapy combinations which significantly inhibit cancer cell growth at lower doses than would be required for their single drug counterparts.
Download or read book Drug Information Handbook for Oncology written by Diedra L. Bragalone and published by Lexi-Comp. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Drug Information Handbook for Oncology is designed to meet the needs of all oncology professionals involved in prescribing, preparing, and administering therapy. This edition contains 304 drug monographs and over 375 chemotherapy regimens, cross-referenced and organized in a concise, uniform format. Valuable supporting information is included in the Appendix, Special Topics section, and the Pharmacologic. The content of the Drug Information Handbook for Oncology is presented in tabbed sections and organized like a dictionary for ease-of-use. Medications are located by generic name, with each monograph including up to 42 unique fields of information. The Chemotherapy Regimens section provides a comprehensive presentation of cancer chemotherapy regimens, listed alphabetically by regimen name (acronym). An index also lists regimens by indication. The Special Topics section covers important cancer-related issues such as pain management, bone marrow transplantation, managing infections, safe handling of hazardous drugs, and more.Updates to this Edition *18 New Drug Monographs *38 New Chemotherapy Regimens o93 New Variations within the Regimens *Special Topic Updates: oManagement of Drug Extravasations oManagement of Chemotherapy-Induced Nausea and Vomiting oHematopoietic Stem Cell Transplantation oFertility and Cancer Therapy oChronic Pain Management (Cancer) oTumor Lysis Syndrome oSafe Handling of Hazardous Drugs
Download or read book Breast Cancer written by and published by . This book was released on 1977 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-10-05 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote an immune response to cancer, researchers have developed immune checkpoint inhibitors that enable T-cells to recognize cancer cells as foreign and to prevent deactivation of an immune system response. To examine the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors, the National Cancer Policy Forum held a workshop on July 16â€"17, 2018, in Washington, DC. This workshop convened stakeholders with a broad range of expertise, including cancer researchers, clinicians, patient advocates, and representatives from industry, academia, and government. This publication summarizes the presentations and discussions from the workshop.
Download or read book Cancer Chemotherapeutic Agents written by William O. Foye and published by . This book was released on 1995 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative treatment of the discovery, development, and understanding of cancer chemotherapeutic agents. Addresses the major classes of chemotherapeutic agents, including antimetabolites, agents that react with DNA, inhibitors of transcription enzymes, topoisomerase inhibitors, DNA minor-groove binding compounds, antimotic agents, bleomycin group antitumor antibiotics, antihormones, paclitaxels, and photochemically activated agents. Provides an overview of the various classes of agents now considered important. Examines a method for determining the similarity of mechanism of the compounds in a given class.
Download or read book Tactics and Strategy in Cancer Treatment written by Georges Mathe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tactics is the art of combining the action of troops or the proper means of different arms with the object of obtaining the maximum success at combat. Strategy is the art of combining the action of aB the military forces with a view to victory. This work, wh ich publishes the communications at the Annual General Meeting of the EORTC, wh ich was held in Paris in lune 1976, was devoted to tactics and to the therapeutic strategy with a view to the recovery of cancer patients. Table of Contents v Preface . I. Tactics G. MATHE: Tactics in Cancer Treatment: Introduction 1 1. Surgery F. ECONOMIDES and M. BRULEy-RosSET: Effects of the Removal of the Regional Lymph Nodes on the Survival of Mice Bearing B16 Melanoma or EAkR Lymphosarcoma . 2 U. VERONESI: Regional Lymph Node Dissection in Melanoma of the Limbs. Stage I-A Cooperative International Trial . 8 2. Chemotherapy G. MATHE, O. HALLE-PANNENKO, and C. BOURUT: Effectiveness of Murine Leukemia Chemotherapy According to the Immune State: Reconsideration of Correlations Between Chemotherapy, Tumour Cell Killing, and Survival Time 9 A. J. S. DAVIES: C!"temotherapy of Tumours in Immuno-deprived Mice 13 P. POUILLART, G. MATHE, T. PALANGJE, J. LHERITIER, M. PmSSON, P. HUGUENIN, H. GAUTIER, P. MORIN, and R. PARROT: Treatment of Malignant Gliomas and Brain Metastases in Adults Using a Combination of Adriamycin, VM 26 and CCNU- Results of Type 11 Trial . 17 3. lmmunotherapy L. OLSSON: Immunologie and Cytokinetic Parameters of BCG-induced Growth Control of a Murine Leukemia .
Download or read book Chemotherapy written by Kurt Hellmann and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, exp~sion has been rapid, for example in cephalosporins, pen icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is rece1v1ng increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,000 papers read at the Congress we have produced Proceedings which reflect the variety and vigour of research in this important field of medicine. It was not possible to include all of the papers presented at the Congress but we have attempted to include most aspects of cur rent progress in chemotherapy.
