Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Download or read book Sittig s Handbook of Toxic and Hazardous Chemicals and Carcinogens written by Richard P. Pohanish and published by William Andrew. This book was released on 2008-01-10 with total page 2888 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than a quarter century, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens has proven to be among the most reliable, easy-to-use and essential reference works on hazardous materials. Sittig's 5th Edition remains the lone comprehensive work providing a vast array of critical information on the 2,100 most heavily used, transported, and regulated chemical substances of both occupational and environmental concern.Information is the most vital resource anyone can have when dealing with potential hazardous substance accidents or acts of terror. Sittig's provides extensive data for each of the 2,100 chemicals in a uniform format, enabling fast and accurate decisions in any situation. The chemicals are presented alphabetically and classified as a carcinogen, hazardous substance, hazardous waste, or toxic pollutant. This new edition contains extensively expanded information in all 28 fields for each chemical (see table of contents) and has been updated to keep pace with world events. Chemicals classified as WMD have been included in the new edition as has more information frequently queried by first responders and frontline industrial safety personnel. *Includes and references European chemical identifiers and regulations.*The only single source reference that provides such in-depth information for each chemical.*The two volume set is designed for fast and accurate decision making in any situation.
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Carcinogens written by Marcel Castegnaro and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The chemical laboratory is actually not a dangerous place to work in, but it demands a reasonable prudence on the part of the experimenters and instructers, to keep it a safe place. Emphasis must be positive, indicating the proper, correct and safe procedure to be followed in all laboratory operations or when confron ted with an emergency situation. Too heavy stress upon the horrors associated with laboratory accidents or graphic descriptions of gory injuries or nasty fires should be avoided. Frightened, timid students are more likely to have accidents than the confident laboratory man who works with due regard to safety. " This statement, written by 1. R. Young (1) in 1971, in The Journal of Chemical Education, applies not only to students working in the chemical laboratory but can be extended to all scientists and technicians working with hazardous products, and in particular with chemical carcinogens. The hazards of handling toxic or dangerous chem icals have been well documented. Besides safety notices and articles in the scientific literature, a large number of books have been dedicated to this subject, among which can be cited Safety and Accident Prevention in Chemical Operations (2), Handbook of Laboratory Safety (3), Hazards in the Chemical Laboratory (4), 1 Handbook of Reactive Chemical Hazards (5), Safety in Working with Chemicals (6) and Prudent Practices for Handling Hazardous Chemicals in Laboratories (7).
Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Download or read book Some Industrial Chemicals written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication represents the views and expert opinion of an IARC Working Group which met in Lyon, 15-22 February 2000.
Download or read book NIH Guidelines for the Laboratory Use of Chemical Carcinogens written by National Institutes of Health (U.S.) and published by . This book was released on 1981 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Review of Human Carcinogens written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Carcinogenesis written by Claudio Nicolini and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it.
Download or read book Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 1999 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine
Download or read book Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis written by Miriam Christine Poirier and published by World Scientific. This book was released on 2018-09-28 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.
Download or read book Toxicological Carcinogenesis written by David B. Clayson and published by CRC Press. This book was released on 2000-09-28 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do we know if a chemical is carcinogenic? How accurate and relevant to humans are the current assays? With the increasing influx of chemicals in our food and environment, these questions become more critical everyday. Written by an expert with more than fifty years experience in this field, Toxicological Carcinogenesis gives you a balanced and authoritative treatment of the issues. The book provides a summary of the present knowledge of chemicals that induce cancer. The author avoids the overuse of technical jargon and explains scientific concepts clearly and succinctly. He has included an appendix containing bibliographic references, making the text easier to read and keeping the information available as a reference. He covers: How carcinogens are detected in humans using epidemiology, bioassays, and alternative approaches Agents leading to human cancer such as exposure due to occupation, cigarette smoking, and diet and nutrition Carcinogenesis mechanisms The use of legislation to control exposures to noxious agents. Toxicological Carcinogenesis fills a gap in the current literature by providing just enough background information to give a complete general overview of the subject. It explores the emerging debates that related to the potential chemical causes of cancer. In addition to the comprehensive coverage the book provides, it explains the potential problems caused by possible misinformation about chemical carcinogenesis.
Download or read book Potential Carcinogenic Hazards from Drugs written by R. Truhaut and published by Springer. This book was released on 2012-04-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Carcinogens written by Charles E. Searle and published by . This book was released on 1976 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer causing agents are now known to exist throughout the environment-in polluted air and tobacco smoke, in various plants and foods, and in many chemicals that are used in industry and laboratories. With the incidence of cancer apparently on the rise, there has been an even greater push to find the causes of this ancient disease. The increased worldwide research effort has produced a vast amount of data and new information which must be collated and interpreted. This monograph contains comprehensive accounts of the latest theories of cancer chemistry and biology and of the major hazards identified so far.
