Download or read book Chasing Pain The Search for a Neurobiological Mechanism written by Kenneth L. Casey and published by Oxford University Press. This book was released on 2019-02-22 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.

Download or read book Chasing Pain The Search for a Neurobiological Mechanism of Pain written by Kenneth L. Casey and published by Oxford University Press. This book was released on 2019-02-22 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.

Download or read book The Right to Pain Relief and Other Deep Roots of the Opioid Epidemic written by Mark Sullivan and published by Oxford University Press. This book was released on 2023-01-24 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pain has always been a problem for Western Society, but not the same kind of problem. Until about 1500, pain was primarily understood as a religious problem. Pain and suffering challenged the truth of religious belief and the legitimacy of the Church: How could a just, merciful, and all-powerful God allow so much pain and suffering in the world? As our society became more secular over the next 300 years, pain came to be understood primarily as a social problem. This modernizing society aimed to create the best environment for human flourishing: How might human society be designed and regulated to reduce the pain and suffering of everyone to the minimum possible? At least since 1900, we have separated pain as a medical problem from the remainder of human suffering. We have aimed to reduce this problem to a minimum through medical treatment. This quest has led us to our opioid epidemic. To fully comprehend the limitations of this medical interpretation, we must appreciate how the medical explanation of pain grew out of earlier religious and social interpretations of pain"--

Download or read book Feeling Pain and Being in Pain second edition written by Nikola Grahek and published by MIT Press. This book was released on 2011-12-16 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the two most radical dissociation syndromes of the human pain experience—pain without painfulness and painfulness without pain—and what they reveal about the complex nature of pain and its sensory, cognitive, and behavioral components. In Feeling Pain and Being in Pain, Nikola Grahek examines two of the most radical dissociation syndromes to be found in human pain experience: pain without painfulness and painfulness without pain. Grahek shows that these two syndromes—the complete dissociation of the sensory dimension of pain from its affective, cognitive, and behavioral components, and its opposite, the dissociation of pain's affective components from its sensory-discriminative components (inconceivable to most of us but documented by ample clinical evidence)—have much to teach us about the true nature and structure of human pain experience. Grahek explains the crucial distinction between feeling pain and being in pain, defending it on both conceptual and empirical grounds. He argues that the two dissociative syndromes reveal the complexity of the human pain experience: its major components, the role they play in overall pain experience, the way they work together, and the basic neural structures and mechanisms that subserve them. Feeling Pain and Being in Pain does not offer another philosophical theory of pain that conclusively supports or definitively refutes either subjectivist or objectivist assumptions in the philosophy of mind. Instead, Grahek calls for a less doctrinaire and more balanced approach to the study of mind–brain phenomena.

Download or read book Encyclopedia of the Neurological Sciences written by and published by Academic Press. This book was released on 2014-04-29 with total page 4744 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Download or read book Introduction to Neuroimaging Analysis written by Mark Jenkinson and published by Oxford University Press. This book was released on 2018 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This accessible primer gives an introduction to the wide array of MRI-based neuroimaging methods that are used in research. It provides an overview of the fundamentals of what different MRI modalities measure, what artifacts commonly occur, the essentials of the analysis, and common 'pipelines'.

Download or read book Dopamine Nation written by Dr. Anna Lembke and published by Penguin. This book was released on 2023-01-03 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: INSTANT NEW YORK TIMES and LOS ANGELES TIMES BESTSELLER “Brilliant . . . riveting, scary, cogent, and cleverly argued.”—Beth Macy, author of Dopesick, as heard on Fresh Air This book is about pleasure. It’s also about pain. Most important, it’s about how to find the delicate balance between the two, and why now more than ever finding balance is essential. We’re living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting . . . The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we’ve all become vulnerable to compulsive overconsumption. In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain . . . and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.

Download or read book Refractory Migraine written by Elliot A. Schulman, FACP, MD and published by Oxford University Press. This book was released on 2010-08-05 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have book for any health professional who treats patients with headache disorders, Refractory Migraine is written by international experts from the world's top headache centers. It describes how they approach the treatment of migraine patients who continue to suffer despite appropriate medical treatment. First, it highlights current ideas about the definition and characterization of refractory migraine, and reviews underlying causes and contributing factors. Then, individual chapters cover every important aspect of migraine treatment with the focus entirely on refractory forms of the disorder. Its many features include detailed algorithms for outpatient and inpatient withdrawal from overused medications, innovative drug therapy and nonpharmacological treatments, a list of questions to ask before deciding to try hormonal therapies, and detailed descriptions of how to recognize and interact with patients who have challenging personality disorders or concomitant psychiatric problems. We're confident you'll often turn to this book for advice about challenges in migraine management. When you do, the bulleted lists and boxes that highlight and condense the main messages of each chapter put the information you need at your fingertips. If you treat patients with migraine, you will recognize many of the challenging situations and topics covered in this book - and you will be encouraged by the innovative and resourceful therapeutic strategies suggested by seasoned headache doctors with a wealth of clinical experience. Readable, comprehensive and up to date, this book gives you access to ingenious treatment approaches developed and refined in specialty headache clinics that regularly - and successfully - treat patients with refractory headache problems. When you meet the next migraine patient who says "I've tried it all, and nothing works", you will know where to go for practical advice about what to do next.

Download or read book Transcutaneous Electrical Nerve Stimulation TENS written by Mark I. Johnson and published by OUP Oxford. This book was released on 2014-03-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcutaneous electrical nerve stimulation (TENS) is a technique that delivers mild electrical currents across the intact surface of the skin to reduce pain. TENS is used by practitioners throughout the world to manage painful conditions and TENS equipment can be purchased by the general public so that they can self-administer treatment. There are thousands of experimental and clinical research studies published on TENS and related techniques yet there is uncertainty about the best way to administer TENS in clinical practice. This is because currents used during TENS can be administered in a variety of ways and the findings of research studies have been inconclusive. This book provides guidance on how best to use TENS based on an evaluation of current research evidence. The book covers what TENS is, how it works, and safe and appropriate clinical techniques for many conditions including chronic low back pain, osteoarthritis and cancer pain. It also offers solutions to the problems faced by researchers when trying to design clinical trials on TENS. Accessibility written, Transcutaneous Electrical Nerve Stimulation (TENS) provides a comprehensive coverage of research issues and findings about TENS and will be essential reading for healthcare professionals, practitioners and students.

Download or read book William Richard Gowers 1845 1915 written by Ann Scott and published by Oxford University Press. This book was released on 2012-08-23 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sir William Richard Gowers was one of the pre-eminent clinical neurologists of the nineteenth century. Co-authored by one of Dr Gowers' descendents and two leading neurologists, this book is the definitive reference work on the life of one of the founding fathers of neurology.

Download or read book Neuroeconomics written by Paul W. Glimcher and published by Academic Press. This book was released on 2013-08-13 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since it first published, Neuroeconomics: Decision Making and the Brain has become the standard reference and textbook in the burgeoning field of neuroeconomics. The second edition, a nearly complete revision of this landmark book, will set a new standard. This new edition features five sections designed to serve as both classroom-friendly introductions to each of the major subareas in neuroeconomics, and as advanced synopses of all that has been accomplished in the last two decades in this rapidly expanding academic discipline. The first of these sections provides useful introductions to the disciplines of microeconomics, the psychology of judgment and decision, computational neuroscience, and anthropology for scholars and students seeking interdisciplinary breadth. The second section provides an overview of how human and animal preferences are represented in the mammalian nervous systems. Chapters on risk, time preferences, social preferences, emotion, pharmacology, and common neural currencies—each written by leading experts—lay out the foundations of neuroeconomic thought. The third section contains both overview and in-depth chapters on the fundamentals of reinforcement learning, value learning, and value representation. The fourth section, "The Neural Mechanisms for Choice, integrates what is known about the decision-making architecture into state-of-the-art models of how we make choices. The final section embeds these mechanisms in a larger social context, showing how these mechanisms function during social decision-making in both humans and animals. The book provides a historically rich exposition in each of its chapters and emphasizes both the accomplishments and the controversies in the field. A clear explanatory style and a single expository voice characterize all chapters, making core issues in economics, psychology, and neuroscience accessible to scholars from all disciplines. The volume is essential reading for anyone interested in neuroeconomics in particular or decision making in general. - Editors and contributing authors are among the acknowledged experts and founders in the field, making this the authoritative reference for neuroeconomics - Suitable as an advanced undergraduate or graduate textbook as well as a thorough reference for active researchers - Introductory chapters on economics, psychology, neuroscience, and anthropology provide students and scholars from any discipline with the keys to understanding this interdisciplinary field - Detailed chapters on subjects that include reinforcement learning, risk, inter-temporal choice, drift-diffusion models, game theory, and prospect theory make this an invaluable reference - Published in association with the Society for Neuroeconomics—www.neuroeconomics.org - Full-color presentation throughout with numerous carefully selected illustrations to highlight key concepts

Download or read book Affective Neuroscience written by Jaak Panksepp and published by Oxford University Press. This book was released on 2004-09-30 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have argued that emotions, especially animal emotions, are illusory concepts outside the realm of scientific inquiry. However, with advances in neurobiology and neuroscience, researchers are demonstrating that this position is wrong as they move closer to a lasting understanding of the biology and psychology of emotion. In Affective Neuroscience, Jaak Panksepp provides the most up-to-date information about the brain-operating systems that organize the fundamental emotional tendencies of all mammals. Presenting complex material in a readable manner, the book offers a comprehensive summary of the fundamental neural sources of human and animal feelings, as well as a conceptual framework for studying emotional systems of the brain. Panksepp approaches emotions from the perspective of basic emotion theory but does not fail to address the complex issues raised by constructionist approaches. These issues include relations to human consciousness and the psychiatric implications of this knowledge. The book includes chapters on sleep and arousal, pleasure and fear systems, the sources of rage and anger, and the neural control of sexuality, as well as the more subtle emotions related to maternal care, social loss, and playfulness. Representing a synthetic integration of vast amounts of neurobehavioral knowledge, including relevant neuroanatomy, neurophysiology, and neurochemistry, this book will be one of the most important contributions to understanding the biology of emotions since Darwins The Expression of the Emotions in Man and Animals

Download or read book Pain written by Margo McCaffery and published by . This book was released on 1999 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain: Clinical Manual advocates an interdiciplinary approach to the care of patients with often under-treated pain. This book makes the application to scientific knowledge to the development of practical tools and guidelines for the care of patients in all clinical settings and all age groups. * Provides ready-to-use forms and recommendations for pain care committees to assist health care facilities to prepare for JCAHO inspections. * Includes two FREE pocket-size, laminated cards: equianalgesic charts to assist clinicians with dose calculations when changing routes of administration or analgesics, and dosing guides to commonly used adjuvants and nonopioids. * Includes FREE access to Mosby's PAIN WEBSITE. * The most clinically useful book ever published on pain, written by authorities who helped establish the pain management movement. * Includes 11 new chapters and five expanded and updated chapters to provide the most accurate, up-to-date, and comprehensive pain management information. * Includes icons to alert the reader to important, need-to-know information, such as pediatric content, patient examples, and reproducible material. * Features over 200 boxes and tables to help quickly locate key information and apply complex concepts at the bedside. * Presents a unique, multidisciplinary perspective. * Provides ready-to-use, practical, proven, and reproducible tools, pain assessment and documentation forms, and guides to analgesic use. * Contains patient information handouts on analgesics and nondrug methods of pain relief to educate the patient/family/caregiver about the patient's specific pain management. * Includes reproducible key policies, procedures, and protocols to assist the clinician in implementing patient focused interdisciplinary pain management. * Presents pharmacology content in four chapters - the three analgesic groups and an overview of how to combine them - to provide a readily understandable reference and practical resource. * Includes quick guides with illustrations of selected pain problems, such as pain related to sickle cell disease, peripheral neuropathy, and fibromyalgia. * Contains pain rating scales in over 20 languages to enhance patient/clinician communication in culturally diverse populations.

Download or read book Ultrasound Guided Regional Anesthesia written by Stuart A. Grant and published by Oxford University Press. This book was released on 2016 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed, stepwise approach to performing ultrasound guided regional anesthesia, identifying pearls and pitfalls to ensure success. Basic principles are covered, followed by techniques for upper extremity, lower extremity, and chest, trunk and spine nerve blocks. Each nerve block is comprehensively explained, divided up by introduction, anatomy, clinical applications, technique, alternate techniques, complications, and pearls.

Download or read book The Comatose Patient written by Eelco F.M. Wijdicks and published by Oxford University Press. This book was released on 2014-04-28 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Comatose Patient, Second Edition, is a critical historical overview of the concepts of consciousness and unconsciousness, covering all aspects of coma within 100 detailed case vignettes. This comprehensive text includes principles of neurologic examination of comatose patients as well as instruction of the FOUR Score coma scale, and also discusses landmark legal cases and ethical problems. As the Chair of Division of Critical Care Neurology at Mayo Clinic, Dr. Wijdicks uses his extensive knowledge to discuss a new practical multistep approach to the diagnosis of the comatose patient. Additionally, this edition includes extensive coverage of the interpretation of neuroimaging and its role in daily practice and decision making, as well as management in the emergency room and ICU. Dr. Wijdicks details long-term supportive care and an appropriate approach to communication with family members about end-of-life decision making. In addition, video clips on neurologic examination and neurologic manifestations seen in comatose patients can be found here: http://oxfordmedicine.com/comatosepatient2e. All video recordings from the first edition have been reformatted and remastered for optimal use, and several more video clips of patients have also been included.

Download or read book Anaesthesia for the Elderly Patient written by Chris Dodds and published by Oxford University Press. This book was released on 2017-01-21 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Anaesthesia for the Elderly Patient offers a fully up-to-date, comprehensive introduction to the major clinical issues facing anaesthetists working with elderly patients.

Download or read book ANOVA written by Ellen R. Girden and published by SAGE. This book was released on 1992 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on situations in which analysis of variance (ANOVA) involving the repeated measurement of separate groups of individuals is needed, Girden reveals the advantages, disadvantages, and counterbalancing issues of repeated measures situations. Using additive and nonadditive models to guide the analysis in each chapter, the book covers such topics as the rationale for partitioning the sum of squares, detailed analyses to facilitate the interpretation of computer printouts, the rationale for the F ratios in terms of expected means squares, validity assumptions for sphericity or circularity and approximate tests to perform when sphericity is not met.