Download or read book Characterizing Atrial Fibrillation Substrate by Electrogram and Restitution Analysis written by Mark Nothstein and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterizing Atrial Fibrillation Substrate Via Molecular and Electrical Fingerprint written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by irregular rhythm and rapid heart beats. Although fibrosis has been traditionally considered a key factor in AF development, the current research challenges this notion. The findings suggest that lone fibrosis is not the sole culprit in AF trigger and persistence, indicating the involvement of additional and parallel pathophysiological mechanisms. Proteostasis, the maintenance of protein homeostasis, plays a significant role in AF pathogenesis. The present study sheds light to the importance of HSPs as chaperones that maintain proteostasis in atrial cardiomyocyte, and consequently its proper function. It was shown that levels of HSPs, including HSP70, cvHSP, HSP60, and HSP27, can serve as potential indicators of AF stage, recurrence after therapy, and post-operative AF onset. Assessing electrical remodeling through high-resolution epicardial mapping is a promising approach for identifying features of electropathology, and ultimately bio-electrical markers in AF. This methodology provides valuable insights into the correlation between molecular findings and electrophysiological features. By characterizing the molecular mechanisms underlying electrical alterations, clinicians acquire a deeper understanding of AF and tailor treatment strategies accordingly. Furthermore, cytoskeletal proteins, such as desmin, lamin A/C, titin, seem to have an important role driving AF. Genetic variants in these proteins can lead to contractile and electrophysiological atrial abnormalities in cardiomyocytes, associated with AF. In summary, these articles collectively contribute to our understanding of AF by exploring AF substrate under molecular and electrical perspectives.
Download or read book A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation A Translational Study to Guide Ablation Therapy written by Sánchez Arciniegas, Jorge Patricio and published by KIT Scientific Publishing. This book was released on 2022-05-30 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Download or read book The Characterisation of Risk Factors Substrate and Management Strategies for Atrial Fibrillation written by Geetanjali Rangnekar and published by . This book was released on 2015 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The rising global incidence and prevalence of atrial fibrillation (AF) imposes significant burden on health care systems. Recently, several novel risk factors for AF have been identified. However, there remains a need to understand the differential impact of more established predisposing factors for incident AF. Further, there is insufficient knowledge surrounding the atrial changes that occur at the advent of AF and how this arrhythmia is managed on presentation to health care facilities. This thesis seeks to improve our understanding of the risk factors associated with this arrhythmia; to characterise any detrimental changes that occur upon its onset and to identify the AF patients that are most likely to significantly burden the hospital system. To this effect, the focus of each of the chapters is presented forthwith. Chapter 2 focuses on the independent risk factors for incident non-valvular AF via a systematic literature review and meta-analysis. Chapters 3 and 4 characterise the entity of newly diagnosed AF. Chapters 5 and 6 focus on the burden that AF confers upon the hospital system by way of hospital admissions and readmissions."--Abstract.
Download or read book Multimodal Characterization of the Atrial Substrate written by Laura Anna Unger and published by . This book was released on 2022* with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Mapping written by Mohammad Shenasa and published by John Wiley & Sons. This book was released on 2019-04-04 with total page 1304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The expanded guide to cardiac mapping The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth. Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions' comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find: Full coverage of all aspects of cardiac mapping, and imaging Explorations of mapping in experimental models of arrhythmias Examples of new catheter-based techniques Access to a companion website featuring additional content and illustrative video clips Cardiac Mapping is an indispensable resource for scientists, clinical electrophysiologists, cardiologists, and all physicians who care for patients with cardiac arrhythmias.
Download or read book Cardiac Electrophysiology From Cell to Bedside E Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2017-05-13 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Download or read book Cardiac Arrhythmias written by Ambrose S. Kibos and published by Springer Science & Business Media. This book was released on 2013-12-13 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.
Download or read book Artificial Intelligence in Heart Modelling written by Rafael Sebastian and published by Frontiers Media SA. This book was released on 2022-05-11 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book J Wave Syndromes written by Charles Antzelevitch and published by Springer. This book was released on 2016-06-27 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.
Download or read book Cardiac Arrhythmia written by Philip J. Podrid and published by Lippincott Williams & Wilkins. This book was released on 2001 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of this clinically oriented textbook about cardiac arrhythmia management continues to be a must-have volume for practicing cardiologists and internists, who require up-to-date information for the daily management of their patients. The material, prepared by recognized experts in the field, presents an in-depth look at diagnostic and treatment protocols in a readable, well-organized format. Unique chapters regarding pregnancy, athletes, and genetics also are included. A Brandon-Hill recommended title.
Download or read book Cardiac Electrophysiology from Cell to Bedside written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2013-10-25 with total page 1395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald's Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.
Download or read book Zipes and Jalife s Cardiac Electrophysiology From Cell to Bedside written by Jose Jalife and published by Elsevier Health Sciences. This book was released on 2021-12-16 with total page 1709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new standalone chapters that are organized into discrete topics for improved access. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association.
Download or read book Exploring Mechanisms of Cardiac Rhythm Disturbances Using Novel Computational Methods Prediction Classification and Therapy written by Xin Li and published by Frontiers Media SA. This book was released on 2023-03-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Management of Cardiac Arrhythmias written by Gan-Xin Yan and published by Springer Nature. This book was released on 2020-07-27 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: A significantly expanded third edition, this book provides a comprehensive and concise overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. Additionally, the book emphasizes decision-making strategies in approaching each individual patient and the application of technical innovations in specific clinical situations. Organized into eight parts, beginning chapters introduce the concepts and principles of cardiac electrophysiology, unique rhythms, and ECG waves/signs. These chapters are designed to integrate emerging knowledge in basic science and clinical medicine. Subsequent chapters focus on the diagnosis of a variety of cardiac arrhythmias using non-invasive methodology. Throughout the book, chapters continue to analyze pharmacological and other approaches to therapy of specific arrhythmias, including supraventricular tachycardias, atrial fibrillation and flutter, ventricular arrhythmias, and bradyarrhythmias. Finally, the book closes with coverage on inherited cardiac arrhythmia syndromes including the long, short QT, and J-wave syndromes, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. The third edition of Management of Cardiac Arrhythmias, is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac surgery, vascular surgery, cardiac electrophysiology, and cardiac radiology.
Download or read book Monophasic Action Potentials written by Michael R. Franz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades monophasic action potential (MAP) recording has matured into a technique that provides a link between basic and clinical electrophysiology. International experts present exciting data on MAP recording techniques, the mechanism and interpretation of MAPs, and novel aspects of repolarization-related arrhythmias.
Download or read book Cardiac Repolarization written by Nabil El-Sherif and published by Springer Nature. This book was released on 2019-08-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.
