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Book Characterization of the Role of Herpes Simplex Virus Protein VP16 in Viral Gene Expression Through Interactions with the Virion Host Shutoff Protein  VHS  and HCF 1  microform

Download or read book Characterization of the Role of Herpes Simplex Virus Protein VP16 in Viral Gene Expression Through Interactions with the Virion Host Shutoff Protein VHS and HCF 1 microform written by Jozo Knez and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2003 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes Simplex Virus 1 (HSV1) VP16 transcriptionally activates viral immediate-early (IE) genes, through the formation of a multi-protein structure termed the VP16-induced complex (VIC). VIC is comprised of cellular transcription factors Oct-1 and HCF-1. In addition, VP16 is a pre-formed, structural protein that has a critical role in virion assembly. At least one aspect of its role at late times post-infection includes the downregulation of the virion host shutoff protein (vhs); which functions to indiscriminately degrade mRNA.

Book Herpesvirus Transcription and Its Regulation

Download or read book Herpesvirus Transcription and Its Regulation written by Edward K. Wagner and published by CRC Press. This book was released on 1991-01-03 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The herpesviruses are arguably the most successful animal viruses, and nearly 100 distinct examples have been described. Currently, a number of active research groups throughout the world are making important contributions concerning the precise molecular nature of herpesvirus transcripts, the proteins they encode, and the viral and host factors responsible for the control of their expression. Herpesvirus Transcription and Its Regulation describes current programs in a number of leading laboratories and emphasizes the research regarding herpes simplex virus type 1, due primarily to its importance in herpesvirus research. However, several other well-characterized herpesviruses are also described. New research areas covered include molecular analyses of herpesvirus regulatory functions and herpes simplex virus latent phase gene expression. This volume is a timely guide for established research workers and advanced students currently engaged in research on animal virology, viral pathogenesis, and virus-host interactions.

Book Functional Analysis of the Herpes Simplex Virus Type 1 Immediate early Protein ICPO

Download or read book Functional Analysis of the Herpes Simplex Virus Type 1 Immediate early Protein ICPO written by Erik Kristian Lium and published by . This book was released on 1997 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Human Herpesviruses

    Book Details:
  • Author : Ann Arvin
  • Publisher : Cambridge University Press
  • Release : 2007-08-16
  • ISBN : 1139461648
  • Pages : 1325 pages

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Book Viral Vectors for Gene Therapy

Download or read book Viral Vectors for Gene Therapy written by Curtis A. Machida and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Vectors for Gene Therapy: Methods and Protocols consists of 30 ch- ters detailing the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Chapter cont- butions provide perspective in the use of viral vectors for applications in the brain and in the central nervous system. Viral Vectors for Gene Therapy: Methods and Protocols contains step-by-step methods for successful rep- cation of experimental procedures, and should prove useful for both experienced investigators and newcomers in the field, including those beginning graduate study or undergoing postdoctoral training. The “Notes” section contained in each chapter provides valuable troublesho- ing guides to help develop working protocols for your laboratory. With Viral Vectors for Gene Therapy: Methods and Protocols, it has been my intent to develop a comprehensive collection of modern molecular methods for the construction, development, and use of viral vectors for gene transfer and gene therapy. I would like to thank the many chapter authors for their contributions. They are all experts in various aspects of viral vectors, and I appreciate their efforts and hard work in developing comprehensive chapters. As editor, it has been a privilege to preview the development of Viral Vectors for Gene Therapy: Methods and Protocols, and to acquire insight into the various methodological approaches from the many different contri- tors.

Book Characterization of a Novel Plasmid based Herpes Simplex Virus Vector System

Download or read book Characterization of a Novel Plasmid based Herpes Simplex Virus Vector System written by Robert Troy Ramos and published by . This book was released on 1990 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Viral Vectors for Treating Diseases of the Nervous System

Download or read book Viral Vectors for Treating Diseases of the Nervous System written by David S. Latchman and published by Gulf Professional Publishing. This book was released on 2003 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Pathogenicity of Human Herpesviruses due to Specific Pathogenicity Genes

Download or read book Pathogenicity of Human Herpesviruses due to Specific Pathogenicity Genes written by Yechiel Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Six members of the Herpesviridae family are human pathogens, including herpes and 2 (HSV-I and 2), Epstein-Barr virus (EBV), varicella zoster simplex virus I virus (VZV), human cytomegalovirus (HCMV), and human herpesvirus 6 (HHV 6). Each of these viruses is capable of causing distinct diseases of varying severity in children, young adults, and the aged. The diseases range from infection of epithelial tissue to the infection of internal organs and white blood cells. A common feature of the six pathogenic human herpesviruses is their ability to latently infect different cell types in which the viral DNA is not integrated and is unable to express its pathogenicity. Reactivation of the herpesviruses is a result of cellular processes which reactivate viral genes, leading to virus progeny and to signs of infection. Due to their ability to become latent after initial infection, once the pathogenic herpesviruses infect children they are maintained throughout life, having the potential of cause various diseases upon reactivation.

Book Biomedical Index to PHS supported Research  pt  A  Subject access A H

Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Protein Expression in Animal Cells

Download or read book Protein Expression in Animal Cells written by and published by Academic Press. This book was released on 1994-10-18 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critically acclaimed for more than 25 years, the Methods in Cell Biology series provides an indispensable tool for the researcher. Each volume is carefully edited by experts to contain state-of-the-art reviews and step-by-step protocols. Techniques are described completely so that methods are made accessible to users. - Describes both well-established and novel recombinant vector systems for expression of proteins - Presents methods for efficient delivery of recombinant genes into differentiated cells, tissues, and whole animals - Covers high-level and inducible systems, plus assays for protein expression - Provides beginning and advanced investigators and students with the information they need to choose the optimal viral or plasmid system for their protein - Practical, benchtop-style presentation works in lab and in the classroom

Book Cell Biology of Herpes Viruses

Download or read book Cell Biology of Herpes Viruses written by Klaus Osterrieder and published by Springer. This book was released on 2017-05-20 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered.