Download or read book Characterization of Factors Affecting the Virion Host Shutoff Function of Herpes Simplex Virus written by David Alan Shivak and published by . This book was released on 1998 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of the Role of Herpes Simplex Virus Protein VP16 in Viral Gene Expression Through Interactions with the Virion Host Shutoff Protein VHS and HCF 1 microform written by Jozo Knez and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2003 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes Simplex Virus 1 (HSV1) VP16 transcriptionally activates viral immediate-early (IE) genes, through the formation of a multi-protein structure termed the VP16-induced complex (VIC). VIC is comprised of cellular transcription factors Oct-1 and HCF-1. In addition, VP16 is a pre-formed, structural protein that has a critical role in virion assembly. At least one aspect of its role at late times post-infection includes the downregulation of the virion host shutoff protein (vhs); which functions to indiscriminately degrade mRNA.
Download or read book Characterization of the Herpes Simplex Virus Type 1 Virion Host Shutoff Protein written by Bradley M. Karr and published by . This book was released on 1994 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies of the Virion Host Shutoff Function of Herpes Simplex Virus written by Annette Schmidt Pak and published by . This book was released on 1992 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Characterization and Packaging of the Herpes Simplex Type 1 Virion Host Shutoff Protein written by Mary Patterson and published by . This book was released on 1997 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies of MRNA Degradation Mediated by the Virion Host Shutoff Function of Herpes Simplex Virus Type 1 written by Charles R. Krikorian and published by . This book was released on 1992 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Control of Viral MRNA Stability by the Virion Host Shutoff Function of Herpes Simplex Virus written by Asha A. Oroskar and published by . This book was released on 1989 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Beyond Host Shut off written by Christopher Cotter and published by . This book was released on 2011 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Herpes Simplex Virus Virion Host Shutoff Protein is Targeted to MRNA Cleavage Sites Through Interactions with Components of the Host Translational Apparatus written by Lora Ann Shiflett and published by . This book was released on 2010 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The virion host shutoff protein (Vhs) is a herpes simplex virus (HSV) protein involved in early shutoff of the host cell. It is a component of the infecting virion, located in the tegument region, that works by rapidly degrading both viral and cellular messenger RNA (mRNA). in vivo and within infected cells, Vhs is selective for degrading messenger RNA opposed to non-messenger RNA. This dissertation sought to examine Vhs cleavage of an mRNA that utilizes the cap-dependent scanning mechanism for translation initiation and to see if cleavage was connected to early events of translation initiation. mRNA encoding HSV-1 thymidine kinase (pBK2) was used for the majority of the experiments, and studies were designed to map the cut sites produced by Vhs in a rabbit reticulocyte lysate (RRL) system. Additional experiments investigated whether Vhs was selective for degrading certain types of mRNAs over others, particularly IRES-containing mRNAs. Studies revealed that Vhs specifically cleaves pBK2 mRNA within the first 300 bases from the 5' cap, and these cut sites are close to and slightly upstream from the first three AUG codons of the sequence. The proximity of the cutting to the AUG codons led to speculations that early events of translation initiation might be involved in Vhs degradation of mRNA. This was found to be true, where data revealed that blocking early stages such as (1) recruitment of translation initiation factors to the 5' cap and/or (2) ATP hydrolysis RNA helicase activity important for unwinding RNA secondary structure and the scanning process hinder Vhs cleavage. However, blocking later stages of translation initiation only had a modest effect on RNase activity. Results also found that a 5' cap analog inhibits Vhs site-specific cleavage of mRNA at regions near the 5' cap. Interestingly, a cap appears to be required for Vhs production of specific cleavage sites within the first 300 bases of the transcript. Work went on to study whether there was a difference between Vhs cleavage of circularized RNA that normally experiences cap-dependent scanning and circularized RNA that initiates translation in a cap-independent manner. Results indicated that Vhs requires a free 5' end for specific cleavage of mRNA that undergoes cap-dependent scanning. However, Vhs does not require a free 5' end to specifically cleave a circular RNA that utilizes cap-independent methods for translation initiation. Mutational work, with pBK2 mutants which contained mutations in or surrounding the AUG codon, further supported a mechanism for Vhs cleavage that involved Vhs association with the scanning complex to reach some of its preferred cut sites. Mutating the first AUG to a non-AUG inhibited Vhs specific cleavage of pBK2 mRNA at a region just upstream from the AUG codon. Additionally, mutating bases surrounding the AUG codon to put it in an optimal context enhanced cleavage at regions near the start codon. Inserting a stable hairpin near the 5' cap to block scanning also reduced Vhs cleavage at prominent sites within the first 300 bases of the transcript. To conclude, this work provides several indications that Vhs associates with components of the translational apparatus to access at least some of its cut sites.
Download or read book Genetic Characterization of a Delayed Host Shutoff Temperature Sensitive Mutant of Herpes Simplex Virus Type I written by Edward Francis.* Arko and published by . This book was released on 1989 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Study of the Herpes Simplex Virus Virion Host Shutoff Protein s Endoribonuclease Activity written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Herpesvirus Latency written by Benedikt B. Kaufer and published by Frontiers Media SA. This book was released on 2020-09-14 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book MRNA Decapitation Induced by the Herpes Simplex Virus Virion Host Shutoff Protein written by Christopher William Hayes and published by . This book was released on 1996 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Virion associated Immediate Early Protein ICP4 of Herpes Simplex Virus Type 1 written by Tong-yuan Yang and published by . This book was released on 1996 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Interaction of Herpes Simplex Virus1 HSV 1 Virion Host Shutoff VHS with Heat Shock Protein 70 HSP70 written by Ronen Elfassy and published by . This book was released on 2012 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Characterization of Stable Attachment Receptors for Herpes Simplex Virus written by Aleida Pérez and published by . This book was released on 1997 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
