Download or read book Characterization of Expression of the Herpes Simplex Virus Type 1 ICP22 and Us1 5 Proteins written by John Jason Bowman and published by . This book was released on 2008 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using this system and newly generated C-terminal specific ICP22 Abs, we show that Us1.5 expression is independent of full length ICP22. In addition, we demonstrate that the reported Us1.5 start sites, M147 and M171 are incorrect and that Us1.5 initiates translation at M90 of the ICP22 ORF. Mutation of M90 to alanine resulted in loss of Us1.5 expression but had no effect on expression of the full length protein. We introduced the M90A mutation into the viral genome and, as observed in transfected cells, Us1.5 expression was greatly reduced in M90A-infected cells. Although Us1.5 expression was greatly reduced, the M90A mutant replicated efficiently in restrictive Rab-9 cells and levels of the late gene gC accumulated to WT levels. Collectively, this dissertation describes multiple systems to transiently express ICP22. Using this system we mapped the true start site of the Us1.5 protein and raised questions to the origin of Us1.5 protein expression.

Download or read book Identification and Characterization of Cis acting Elements Upstream of Herpes Simplex Virus Type 1 GC TATA Box written by Chin-Cheng Huang and published by . This book was released on 1998 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of the Chromatin Structure of the Herpes Simplex Virus Type 1 HSV 1 ICP22 Promoter in an Episomal Vector written by Shao-Chung Hsia and published by . This book was released on 1999 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Herpes Simplex Virus 1 DNA Packaging written by Ying Fan and published by . This book was released on 1997 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Aberrant Phosphorylation of RNA Polymerase II During Herpes Simplex Type I Infection written by Kathryn Aileen Fraser and published by . This book was released on 2007 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Expression and Characterization of Four Herpes Simplex Virus Type 1 Gene Products Required for the Replication of Viral DNA written by Janice Mackenzie Paterson and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of the Role of Herpes Simplex Virus Protein VP16 in Viral Gene Expression Through Interactions with the Virion Host Shutoff Protein VHS and HCF 1 microform written by Jozo Knez and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2003 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes Simplex Virus 1 (HSV1) VP16 transcriptionally activates viral immediate-early (IE) genes, through the formation of a multi-protein structure termed the VP16-induced complex (VIC). VIC is comprised of cellular transcription factors Oct-1 and HCF-1. In addition, VP16 is a pre-formed, structural protein that has a critical role in virion assembly. At least one aspect of its role at late times post-infection includes the downregulation of the virion host shutoff protein (vhs); which functions to indiscriminately degrade mRNA.

Download or read book Characterization of the Herpes Simplex Virus Type 1 Virion Host Shutoff Protein written by Bradley M. Karr and published by . This book was released on 1994 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanism of Expression and Functional Analysis of Herpes Simplex Virus Type 1 Proteins OBPC 1 and OBPC 2 written by Malen Amanda Link and published by . This book was released on 2007 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes simplex virus type 1 (HSV-1) DNA replication is thought to progress through two distinct stages, I and II. Stage I is origin- and OBP-dependent. Stage II is origin- and OBP-independent. The events that control the switch from stage I to stage II replication are not known. However, it is likely that the switch from stage I to stage II replication involves the loss of OBP activity or OBP itself from viral origins.

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 906 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diseases of Poultry written by and published by John Wiley & Sons. This book was released on 2019-11-19 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most complete and definitive reference to all aspects of poultry diseases, Diseases of Poultry, Fourteenth Edition has been fully revised and updated to offer a comprehensive survey of current knowledge. Updates the definitive reference of poultry health and disease Provides more clinically relevant information on management of specific diseases, contributed by clinical poultry veterinarians Offers information on disease control in organic and antibiotic-free production Presents more concise, streamlined chapters for ease of use Incorporates advances in the field, from new diagnostic tools and information to changes brought about by the increasing globalization and the re-emergence of zoonotic pathogens

Download or read book Fields Virology DNA Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2021-05-17 with total page 2429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.

Download or read book Latency Strategies of Herpesviruses written by Janos Minarovits and published by Springer Science & Business Media. This book was released on 2006-12-13 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of the latency strategies developed during the estimated 200,000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Unconventional Animal Models in Infectious Disease Research written by Gheyath Khaled Nasrallah and published by Frontiers Media SA. This book was released on 2021-12-30 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Discovering Genomics Proteomics and Bioinformatics written by A. Malcolm Campbell and published by Benjamin-Cummings Publishing Company. This book was released on 2007 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovering Genomics is the first genomics text that combines web activities and case studies with a problem-solving approach to teach upper-level undergraduates and first-year graduate students the fundamentals of genomic analysis. More of a workbook than a traditional text, Discovering Genomics, Second Edition allows students to work with real genomic data in solving problems and provides the user with an active learning experience. The companion website at www.aw-bc.com/geneticsplace is regularly updated to keep up with changes to online databases. The Second Edition has been thoroughly revised and updated to incorporate the latest scientific findings on popular topics such as disease-causing organisms and genetic defects. Case study chapters have been placed throughout the book to tie real-life scenarios into the concepts that follow. Two of the book's key pedagogical features, Discovery Questions and Math Minutes, have also been updated and expanded. The interactive companion website has been reprogrammed with JMOL, the latest 3-D software used to view DNA structures.