Download or read book Characterization of a Plasmodium Falciparum Protein Kinase written by Sasha Roets and published by . This book was released on 2013 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Partial Characterization of Plasmodium Falciparum Protein Kinase ABCk2 PfABCk2 written by Muhammad Khalid and published by . This book was released on 2018 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are approximately 100 protein kinases in P. falciparum that are involved in phosphorylation of asexual blood stage. Hence, the phosphorylation plays an important part in the development of different stages of malarial parasites. Due to their significance in the parasite life cycle, one of the protein kinase of P. falciparum belongs to the ABC-1 family of proteins. PfABCK2 can be a therapeutic target due to its higher expression during the late schizont stage of blood stage form.
Download or read book Functional Characterization of Selected Plasmodium Falciparum Protein Kinases written by Claudia Demarta and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Genetic Investigations and Biochemical Characterization of Plasmodium Falciparum Protein Kinases written by Yi Zhao and published by . This book was released on 1993 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Discovery and Characterization of Antimalarials Targeting Plasmodium Falciparum Protein Kinases written by Alya Barq and published by . This book was released on 2019 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasmodium falciparum is the protozoan parasite that is the causative agent of malaria in humans. The World Health Organization estimates there were 219 million cases of malaria resulting in 435,000 deaths in 2017. Despite recent progress in control and treatment of the disease, malaria remains a major threat due to the emergence of resistance to all known antimalarial drugs. As a result, there is pressing need for the discovery of drugs with novel mechanisms of action to circumvent the current mechanisms of resistance.
Download or read book Studies on the Kinome of Plasmodium Falciparum and Biochemical Characterization of Atypical Protein Kinases written by Leila Equinet and published by . This book was released on 2004 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification of Plasmodium Falciparum Protein Kinase Substrates and Interacting Proteins written by Jessica C. Yap and published by . This book was released on 2012 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is a devastating disease that results in almost one million deaths annually. Most of the victims are children under the age of five in Sub-Saharan Africa. Malaria parasite strains throughout developing countries are continually building resistance to available drugs. Current therapies such as mefloquine, chloroquine, as well as artemisinin are becoming less effective, and this underscores the urgency for therapeutics directed against novel drug targets. In order to identify new drug targets, the molecular biology of the malaria parasite Plasmodium needs to be elucidated. Plasmodium exhibits a unique cell cycle in which it undergoes multiple rounds of DNA synthesis and mitosis without cytokinesis. Thus, cell cycle regulatory proteins are likely to be promising pathogen-specific drug targets. It is expected that fluctuating activity of key proteins, such as protein kinases, play an essential role in regulating the noncanonical life cycle of Plasmodium. Consequently, malarial kinases are a prime target for therapy. One way to better understand the role of malarial kinases in Plasmodium cell cycle regulation is to identify putative protein kinase substrates and interacting proteins. Two malarial kinases that have been implicated in regulating malaria parasite cell cycle stages were investigated in this study: P. falciparum CDK-like Protein Kinase 5 (PfPK5) and cAMP-Dependent Protein Kinase A (PfPKA). A transgenic P. falciparum line was created for the expression of epitope-tagged PfPK5 for pull-down analysis. Phospho-substrate antibodies were used to identify physiological substrates of both PfPK5 and PfPKA. Immunoblotting with these antibodies identified several potential substrates. Identities of the PfPKA physiological substrates were determined from the global P. falciparum phosphoproteome dataset that has recently been generated in our laboratory. Characterization of PfPKA and PfPK5 substrates, as well as the proteins they interact with, will help us to develop innovative therapies targeting binding sites.
Download or read book Functional Analysis of the Plasmodium Falciparum CGMP dependent Protein Kinase written by Christine S. Hopp and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of the Phosphatidyl inositol 3 kinase in Plasmodium Falciparum and the Effect of Selective Inhibitors of this Enzyme on the Parasite written by Nokuhle Mtombeni and published by . This book was released on 2004 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemical Characterization of Plasmodium Falciparum Heat Shock Protein 70 written by Tonderayi Sylvester Matambo and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Immunological Characterization of the Plasmodium Falciparum Circumsporozoite Protein written by Denise Louise Doolan and published by . This book was released on 1993 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of a 43 KDa Plasmodium Falciparum Protein FVP 1 Derived from Maurer s Clefts written by Stuart Jay Cohen and published by . This book was released on 1999 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Characterization of Splicing associated Kinases in the Blood Stages of the Malaria Parasite Plasmodium Falciparum written by Selina Melanie Kern and published by . This book was released on 2015 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of PFF1010c a Type IV Plasmodium Falciparum Heat Shock Protein 40 written by Hygon Mutavhatsindi and published by . This book was released on 2016 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Characterization of Four CDK like Kinases and One Calmodulin dependent Kinase of the Human Malaria Parasite Plasmodium Falciparum written by Shruti Agarwal and published by . This book was released on 2010 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of the Protein Phosphatases of Plasmodium Falciparum with Emphasis on PfPPJ and the Inhibitor Protein ARP written by Sean W. Dobson and published by . This book was released on 2001 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
