Download or read book Characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases written by Chengjin Gao and published by Frontiers Media SA. This book was released on 2024-03-19 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and γδ T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases.
Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.
Download or read book Early Rheumatoid Arthritis written by Paul Emery and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.
Download or read book Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2017-11-09 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase
Download or read book Idiotypes in Medicine Autoimmunity Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
Download or read book Newman and Carranza s Clinical Periodontology and Implantology E Book written by Michael G. Newman and published by Elsevier Health Sciences. This book was released on 2023-04-28 with total page 1877 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody’s Core Titles® 2024 in Dentistry** Learn and master a range of clinical techniques and achieve therapeutic goals with Newman and Carranza’s Clinical Periodontology and Implantology, 14th Edition! Unmatched for its comprehensive approach, this resource provides detailed, up-to-date information on the etiology and pathogenesis of periodontal disease. Basic and advanced evidence-based information on the various treatment modalities employed in periodontics and implantology is presented in an easy-to-read format, with callout boxes throughout the text highlighting the clinical relevance of foundational basic science information. Full-color photos and radiographic images depict periodontal conditions and procedures, and the Atlas of Periodontal Pathology is one of the most comprehensive ever compiled in a periodontal textbook. Written by a team of leading experts led by Michael G. Newman, this text not only demonstrates how to perform periodontal procedures but explains the evidence supporting each treatment and provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook version included with print purchase also includes Periopixel 3D color illustrations, a periodontal classification calculator and interactive learning tool, review questions, case studies, videos, 3D animations, and more! This edition features new chapters on Precision Medicine, Pocket Reduction Therapy, Periodontal Referral, and Digital Implant Workflows, as well as an updated glossary of terms linked to the eBook. It also features first-of-its-kind content on the effects of COVID-19 on treatment from key opinion leaders in this area. Case studies reflect the new format of the Integrated National Board Dental Exam (INBDE). Full-color photos, illustrations, radiographs, animations, simulations, and videos demonstrate how to perform periodontal and implant procedures. Current information on clinical techniques in periodontology and the latest advances in basic science. Evidence-based treatment planning provides knowledge on how to achieve the best possible outcomes of periodontal therapy and implant treatment. Extensive color atlas of periodontal pathology Internationally known experts contribute chapters on their areas of specialty. An eBook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud.
Download or read book Stress Challenges and Immunity in Space written by Alexander Choukèr and published by Springer Nature. This book was released on 2019-11-27 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Inflammasomes Clinical and Therapeutic Implications written by Mario D. Cordero and published by Springer. This book was released on 2018-09-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.
Download or read book Biological Microarrays written by Ali Khademhosseini and published by Humana Press. This book was released on 2010-10-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments in microarray technology have changed the landscape of biology and biomedical research, and they have revolutionized RNA and DNA research. In Biological Microarrays: Methods and Protocols, expert researchers explore exciting new developments in the field, providing a comprehensive approach to biological microarrays that conveys not only the state-of-the-art fundamentals, but also includes applications of the most innovative methods. Chapters address both the application of biological microarrays, including DNA/RNA, apatmer, proteins, tissues, oligonucleotides, carbohydrates, biomaterials, cells, bacteria, and virus microarrays, and also explore the different techniques used for generating microarray platforms. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and revolutionary, Biological Microarrays: Methods and Protocols serves as a primary source for academics, practitioners, and professionals in related fields, including biologists, biotechnologists, biochemists, analytical chemists, and biomedical, physical, and microsystems engineers, to name a few, appealing to all of those interested in the present and future state of biological microarray research.
Download or read book Pathophysiology E Book written by Kathryn L. McCance and published by Elsevier Health Sciences. This book was released on 2018-01-10 with total page 1720 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content. Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes. Additional What’s New boxes highlight the most current research and clinical development. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. Chapter summary reviews provide concise synopses of the main points of each chapter. NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns. NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits. NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts. NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Download or read book Indoor Allergens written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.
Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Download or read book Molecular Mechanisms in Stress and Trauma Related Disorders written by Anthony S. Zannas and published by Frontiers Media SA. This book was released on 2020-04-20 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
