Download or read book Cerebral Amyloid Angiopathy in Alzheimer s Disease and Related Disorders written by M.M. Verbeek and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).
Download or read book Alzheimer s Disease and Related Disorders written by Serge Gauthier and published by CRC Press. This book was released on 2005-09-22 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: A progress report on the cutting-edge research into Alzheimer‘s Disease and other forms of dementia, this important volume has particular emphasis on topics that are applicable to clinical practice.In this latest instalment, Serge Gauthier, Philip Scheltens and Jeffrey Cummings cover some of the emerging therapies for Alzheimer‘s Disease, including
Download or read book Cerebral Small Vessel Disease and Cerebral Amyloid Angiopathy written by Raffaella Valenti and published by Firenze University Press. This book was released on 2018 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Amyloid beta clearance in Alzheimer s disease written by Robert Marr and published by Frontiers Media SA. This book was released on 2015-03-24 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
Download or read book Cerebral Microbleeds written by David J. Werring and published by Cambridge University Press. This book was released on 2011-05-26 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.
Download or read book Cerebral Arterial Diseases Advances in Research and Treatment 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral Arterial Diseases—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cerebral Arterial Diseases in a concise format. The editors have built Cerebral Arterial Diseases—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cerebral Arterial Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cerebral Arterial Diseases—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Cerebrovascular Pathology in Alzheimer s Disease written by Jack C. De La Torre and published by . This book was released on 1997 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do changes in the cerebrovascular system precede or follow clinical onset of Alzheimer's Disease? In this book a distinguished group of contributors addressES this question and explores the extent to which the pathological changes found in the brains of persons with Alzheimer's disease are related to cerebral blood flow, perfusion, and blood-brain barrier dysfunction. Other topics include the role of stroke, heart disease, diabetes, menopause, and blood pressure on the evolution of Alzheimer's disease; genetic factors affecting the cerebrovasculature; brain metabolic and chronic cerebral hypoperfusion; and the influence of the cerebromicrovasculature on neuronal function--all issues of critical importance in orienting research lines that may provide new answers to the Alzheimer puzzle.
Download or read book Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases written by Neville Vassallo and published by Springer. This book was released on 2015-06-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed ‘amyloid’. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer’s disease-related dementia and Parkinson’s disease, as well as other less prevalent conditions like Huntington’s disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents. This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders. Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others. The topic of this book is relevant to a wide audience, from academia and university students in the biological and chemical sciences, to physicians and allied health professionals, as well as people working in the nutraceutical industry.
Download or read book Alzheimer s Disease and Related Conditions written by G. E. W. Wolstenholme and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Download or read book Molecular Pathology of Alzheimer s Disease written by Rudy Castellani and published by Biota Publishing. This book was released on 2013-10-01 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Download or read book Alzheimer s Disease and Related Disorders written by and published by . This book was released on 1989 with total page 1368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxford Textbook of Cognitive Neurology and Dementia written by Masud Husain and published by Oxford University Press. This book was released on 2018-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. It is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.
Download or read book Alzheimer s Disease Epidemiology Neuropathology Neurochemistry and Clinics written by Konrad Maurer and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Alzheimer's Disease - Epidemiology, Neuropathology, Neurochemistry, and Clinics is derived from an International Symposium on the occasion of the 125th Anniversary of the Birth of Alois Alzheimer (14.6.1864-19.12.1915). Over the past decade, as the elderly have become the fastest-growing segment of the population in industrialized countries, Alzheimer's disease has emerged as one of the major mental health problems. The contributors to this book represent internationally recognized authorities in the field of dementia and present new information about epidemiology, neuropathology, neurochemistry, and clinics in Alzheimer's disease. This book is a rich and valuable up-to-date resource for psychiatrists, neurologists, scientists working in the fields of neuropathology, neurochemistry and molecular genetics, behavioral scientists, family physicians and all who share an interest in understanding and treating the older individual with Alzheimer's disease/dementia.
Download or read book Cerebral Arterial Diseases Advances in Research and Treatment 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral Arterial Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cerebral Arterial Diseases in a concise format. The editors have built Cerebral Arterial Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cerebral Arterial Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cerebral Arterial Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Uncommon Causes of Stroke written by Julien Bogousslavsky and published by Cambridge University Press. This book was released on 2001-05-24 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.
Download or read book Alzheimer s Disease A Century of Scientific and Clinical Research written by G. Perry and published by IOS Press. This book was released on 2006-06-26 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.
Download or read book Alzheimer s Disease From Basic Research to Clinical Applications written by Hermann J. Gertz and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.
