Download or read book Cellular Mechanisms during Normal and Abnormal Craniofacial Development written by Poongodi Geetha-Loganathan and published by Frontiers Media SA. This book was released on 2022-03-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Craniofacial Development written by Peter Thorogood and published by . This book was released on 1988 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Craniofacial Development Growth and Evolution written by Murray Clyde Meikle and published by . This book was released on 2002 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Over the past twenty years craniofacial biology has been revolutionized by major developments in our understanding of the cellular, molecular and genetic mechanisms underlying embryonic development. Many of these advances have been based on animal models, most notably the fruitfly Drosophila, the chick and the mouse. Since these developmental processes have been highly conserved during evolution, this information is relevant not only to understanding normal human development but also to understanding how genetic mutations produce particular malformations or inherited diseases. This book incorporates these discoveries into traditional morphological description of craniofacial development, and in a form accessible to clinicians with an interest in the head and neck." --book cover.
Download or read book The Effects of Genetic and Environmental Perturbations on Craniofacial Development written by Rachel Segal Greenberg and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Formation of craniofacial structures is a delicate developmental process that is disrupted in many disease states. These disease states can occur due to genetic anomalies within a developing embryo or environmental irregularities in utero during gestation. Frequently, craniofacial developmental disorders are caused by defects in a particular population of transient, migratory stem cells called neural crest cells. In my Dissertation research, I have endeavored to elucidate the molecular and cellular mechanisms underlying specific genetic disorders and exposure to specific teratogens, with a focus on the fascinating cell type that is the neural crest cell (NCC). To this end, I have studied craniofacial disorder Floating-Harbor Syndrome (FHS), which is caused by heterozygous truncating mutations in SRCAP, a gene encoding a chromatin remodeler that mediates incorporation of histone variant H2A.Z. I demonstrated that FHS-associated mutations result in loss of SRCAP nuclear localization, alter neural crest gene programs in human in vitro models and Xenopus laevis embryos, and cause craniofacial defects. These defects are mediated by one of two H2A.Z subtypes, H2A.Z.2, whose knockdown mimics and whose overexpression rescues the FHS phenotype. Selective rescue by H2A.Z.2 is conferred by one of the three amino acid differences that evolved between the H2A.Z subtypes, S38/T38. I further showed that H2A.Z.2 preferentially occupies AT-rich enhancers, while H2A.Z.1 broadly binds regulatory regions, with the highest enrichment at promoters. Genes associated with H2A.Z.2-enriched enhancers are sensitized to heterozygous SRCAP truncations. Altogether, these results illuminate the mechanism underlying a human syndrome and uncover selective functions of H2A.Z subtypes during development. In addition, I have studied how Zika virus (ZIKV) infection during pregnancy, which is linked to microcephaly, can affect neural crest cell in vitro. In addition to giving rise to most cranial bones, NCCs exert paracrine effects on the developing brain. I reported that NCCs are productively infected by ZIKV, but not by the related dengue virus. These ZIKV-infected NCCs undergo limited apoptosis but secrete cytokines that promote death and drive aberrant differentiation of neural progenitor cultures. Addition of two such cytokines, LIF or VEGF, at levels comparable to those secreted by ZIKV-infected NCCs is sufficient to recapitulate premature neuronal differentiation and apoptotic death of neural progenitors. My results suggest that NCC infection by ZIKV may contribute to associated embryopathies through signaling crosstalk between developing face and brain structures.
Download or read book Dento Oro Craniofacial Anomalies and Genetics written by Agnes Bloch-Zupan and published by Elsevier. This book was released on 2012-03-21 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format
Download or read book Craniofacial Malformations written by Michel Stricker and published by . This book was released on 1990 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers craniofacial malformations and growth, and their treatment, surgery and classification. Written for practising plastic surgeons and maxillofacial surgeons, it should also be of interest to oral and ENT surgeons and orthodontists.
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Craniofacial Growth and Development Novel Insights written by Erika Kuchler and published by Frontiers Media SA. This book was released on 2021-10-13 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Therapy In Oral and Maxillofacial Surgery written by Shahrokh C. Bagheri and published by Elsevier Health Sciences. This book was released on 2011-09-19 with total page 1133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by expert surgeons and educators, Current Therapy in Oral and Maxillofacial Surgery covers the latest treatment strategies, surgical techniques, and potential complications in OMS. Emphasizing an evidence-based approach, it covers all 12 subspecialties of OMS, addressing topics from surgical principles to oral surgery, anesthesia, cranio-maxillofacial trauma surgery, head and neck surgery, maxillofacial reconstructive surgery, orthognathic surgery, pediatric craniofacial surgery including cleft lip and palate, temporomandibular joint disorders, facial plastic surgery including rhinoplasty and facelifts, obstructive sleep apnea, and oral and maxillofacial infections. At the end of each chapter, Pearls and Pitfalls summarize the authors' insight, recommendations, and experience on that topic. Editor Dr. Shahrokh Bagheri is a noted professor, researcher, and speaker on OMS, and he leads an expert author team including Dr. R. Bryan Bell and Dr. Husain Ali Khan to help you master and apply the latest advances in OMS. More than 1,200 full-color photos and 200 color line drawings illustrate concepts and provide visual guidance in clinical areas. Comprehensive sections and chapters represent essential topics, the newest advances, and controversial topics. Clinical coverage brings together the latest knowledge in OMS in a concise, easy-to-apply way. Resident-specific coverage describes the wide array of subspecialties and treatments available in the armamentarium of the modern OMS. A focus on complications ensures that you are knowledgeable in this important part of any therapy or surgical discipline. Expert contributors include the "best of the best," featuring leading, well-established, and respected surgeons and educators writing on their areas of specialty and providing current treatment strategies.
Download or read book Neural Crest Cells written by Paul Trainor and published by Academic Press. This book was released on 2013-11-23 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects. BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association Provides timely, comprehensive synthesis of the current knowledge of neural crest cells Covers the evolution and development of neural crest cells Includes content on applications for tissue engineering, repair and regeneration
Download or read book Clinical Neuroembryology written by Hans J. ten Donkelaar and published by Springer Science & Business Media. This book was released on 2006-09-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in developmental neurobiology and advances in (neuro) genetics have been spectacular. The high resolution of modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS). This book provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders. It provides a unique combination of data from human embryology, animal research and developmental neuropathology, and there are more than 400 figures in over a hundred separate illustrations.
Download or read book Biological Mechanisms of Tooth Movement written by Vinod Krishnan and published by John Wiley & Sons. This book was released on 2021-05-24 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Download or read book Referral Guidelines for Funding Components of PHS written by and published by . This book was released on 1998 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Referral Guidelines for Funding Components of PHS written by Center for Scientific Review (National Institutes of Health) and published by . This book was released on 1998 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mayo Clinic Medical Neurosciences written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2017-11-06 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders
Download or read book MicroRNA Profiling written by Sweta Rani and published by Springer Nature. This book was released on 2022-11-28 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides updated and comprehensive methods on miRNA biogenesis and their role in the development and progression of various human diseases. Chapters detail miRNA biogenesis, isolating RNA, extracellular vesicles (EVs), circulating miRNAs, analyzing miRNA and miRDeep-P2, protocols for total RNA isolation from cells, cell-derived products, isolation and characterization of exosomes, serum, plasma specimens, and software tools. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, MicroRNA Profiling: Methods and Protocols, Second Edition aims to provide comprehensive and accessible methods to undergraduate, graduate, and established scientist.
Download or read book Oral Diseases written by Torello M. Lotti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brilliant collection of colour pictures, augmented by appropriate discussion, describing both common and unusual afflictions. Sections on clinical manifestations, histologic findings, differential diagnosis, and treatment, complemented by significant references, have been written by selected authorities in the field. Dermatologists, dentists, and even primary care physicians will find this an indispensable volume in their practices.
