Download or read book Cellular Domains written by Ivan R. Nabi and published by John Wiley & Sons. This book was released on 2011-07-12 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular domains play vital roles in a wide range of cellular functions. Defining cellular domains and understanding the molecular basis of their formation is essential to the study of cell functionality. This authoritative reference provides the most comprehensive analysis available on cellular domains, with emphasis on the definition and molecular composition of the domain as well as the functional implications of domain organization.
Download or read book The Cytoskeleton and Cellular Compartmentation Cilia as Specialized Cellular Domains written by Helena Soares and published by Frontiers Media SA. This book was released on 2021-12-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Helicases from All Domains of Life written by Renu Tuteja and published by Academic Press. This book was released on 2018-10-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases are ubiquitous enzymes found throughout evolution. Research in the helicase field has been going on for a long time now but in recent past with the completion of so many genomes, these enzymes have been discovered in a number of organisms. But the available literature is scattered. The huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make difficult for the interested scholar to grasp a comprehensive view of the field. Helicases from all Domains of Life is the first book to compile information about helicases from many different organisms in one place. Knowledge of the functions and features of helicases across the different kingdoms of life are a valuable source of novel ideas and information The book begins with a chapter on the evolutionary history of helicases followed by three "overview" chapters: one for bacteria/archaea (which are not mentioned), one for plants/algae and one for human helicases The overview chapters are followed by specific chapters on selected helicases of great importance from a biological/applicative point of view
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Function Spaces and Wavelets on Domains written by Hans Triebel and published by European Mathematical Society. This book was released on 2008 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wavelets have emerged as an important tool in analyzing functions containing discontinuities and sharp spikes. They were developed independently in the fields of mathematics, quantum physics, electrical engineering, and seismic geology. Interchanges between these fields during the last ten years have led to many new wavelet applications such as image compression, turbulence, human vision, radar, earthquake prediction, and pure mathematics applications such as solving partial differential equations. This book develops a theory of wavelet bases and wavelet frames for function spaces on various types of domains. Starting with the usual spaces on Euclidean spaces and their periodic counterparts, the exposition moves on to so-called thick domains (including Lipschitz domains and snowflake domains). Specifically, wavelet expansions and extensions to corresponding spaces on Euclidean $n$-spaces are developed. Finally, spaces on smooth and cellular domains and related manifolds are treated. Although the presentation relies on the recent theory of function spaces, basic notation and classical results are repeated in order to make the text self-contained. This book is addressed to two types of readers: researchers in the theory of function spaces who are interested in wavelets as new effective building blocks for functions and scientists who wish to use wavelet bases in classical function spaces for various applications. Adapted to the second type of reader, the preface contains a guide on where to find basic definitions and key assertions.
Download or read book Viscoelasticity From Individual Cell Behavior to Collective Tissue Remodeling written by Ivana Dusan Pajic-Lijakovic and published by Frontiers Media SA. This book was released on 2021-11-25 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Textbook of Structural Biology written by Anders Liljas and published by World Scientific. This book was released on 2009 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. It covers various aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution - the comparative structural biology.
Download or read book Cellular Molecular Mechanisms in Epigenetic Evolutionary Biology written by John Torday and published by Springer Nature. This book was released on 2020-02-13 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been no mechanistic explanation for evolutionary change consistent with phylogeny in the 150 years since the publication of ‘Origins’. As a result, progress in the field of evolutionary biology has stagnated, relying on descriptive observations and genetic associations rather testable scientific measures. This book illuminates the need for a larger evolutionary-based platform for biology. Like physics and chemistry, biology needs a central theory in order to frame the questions that arise, the way hypotheses are tested, and how to interpret the data in the context of a continuum.The reduction of biology to its self-referential, self-organized properties provides the opportunity to recognize the continuum from the Singularity/Big Bang to Consciousness based on cell-cell communication for homeostasis.
Download or read book Fundamentals of Microbiology written by Jeffrey C. Pommerville and published by Jones & Bartlett Publishers. This book was released on 2014 with total page 1023 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every new copy of the print book includes access code to Student Companion Website!The Tenth Edition of Jeffrey Pommerville's best-selling, award-winning classic text Fundamentals of Microbiology provides nursing and allied health students with a firm foundation in microbiology. Updated to reflect the Curriculum Guidelines for Undergraduate Microbiology as recommended by the American Society of Microbiology, the fully revised tenth edition includes all-new pedagogical features and the most current research data. This edition incorporates updates on infectious disease and the human microbiome, a revised discussion of the immune system, and an expanded Learning Design Concept feature that challenges students to develop critical-thinking skills.Accesible enough for introductory students and comprehensive enough for more advanced learners, Fundamentals of Microbiology encourages students to synthesize information, think deeply, and develop a broad toolset for analysis and research. Real-life examples, actual published experiments, and engaging figures and tables ensure student success. The texts's design allows students to self-evaluate and build a solid platform of investigative skills. Enjoyable, lively, and challenging, Fundamentals of Microbiology is an essential text for students in the health sciences.New to the fully revised and updated Tenth Edition:-New Investigating the Microbial World feature in each chapter encourages students to participate in the scientific investigation process and challenges them to apply the process of science and quantitative reasoning through related actual experiments.-All-new or updated discussions of the human microbiome, infectious diseases, the immune system, and evolution-Redesigned and updated figures and tables increase clarity and student understanding-Includes new and revised critical thinking exercises included in the end-of-chapter material-Incorporates updated and new MicroFocus and MicroInquiry boxes, and Textbook Cases-The Companion Website includes a wealth of study aids and learning tools, including new interactive animations**Companion Website access is not included with ebook offerings.
Download or read book Cell Biology E Book written by Thomas D. Pollard and published by Elsevier Health Sciences. This book was released on 2022-12-13 with total page 947 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding. - Clear, readable explanations provide a concise story about how cells function at the molecular level. - An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology. - Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases. - Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation. - Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.
Download or read book Recent Advances in T Cell Biology New Ligands New Functions and New Translational Perspectives written by Dieter Kabelitz and published by Frontiers Media SA. This book was released on 2016-02-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional α/β T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and >95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells. Dieter Kabelitz & Julie Déchanet-Merville
Download or read book Handbook of Systems Biology written by Marian Walhout and published by Academic Press. This book was released on 2012-12-31 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers
Download or read book Astrocytes in Patho Physiology of the Nervous System written by Vladimir Parpura and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.
Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases
Download or read book Formal Methods for Computational Systems Biology written by Marco Bernardo and published by Springer Science & Business Media. This book was released on 2008-05-20 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a set of 14 papers accompanying the lectures of leading researchers given at the 8th edition of the International School on Formal Methods for the Design of Computer, Communication and Software Systems, SFM 2008, held in Bertinoro, Italy in June 2008. SFM 2008 was devoted to formal techniques for computational systems biology and covered several aspects of the field, including computational models, calculi and logics for biological systems, and verification and simulation methods. The first part of this volume comprises nine papers based on regular lectures, the second part of this volume comprises five papers based on talks given by people involved in the Italian BISCA research project on Bio-Inspired Systems and Calculi with Applications.
Download or read book Water Worlds in the Solar System written by Antony Joseph and published by Elsevier. This book was released on 2022-11-25 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water Worlds in the Solar System: In Search of Habitable Environments and Life is a comprehensive reference on the formation, availability, habitability potential, and astrobiological implications of water in the Solar System. The book provides understanding of the importance of water on Earth to elucidate potential water and biosignature sources on other bodies in the Solar System. It covers processes involved in the formation of Earth and its Moon, genesis of water on those bodies, events on early Earth, and other processes that are applicable to celestial bodies in the Solar System, directly correlating data available on water on other bodies to over 15 Earth analogue sites. This book forms a comprehensive overview on water in the Solar System, from formation to biosignature and habitability considerations. It is ideal for academics, researchers and students working in the field of planetary science, extraterrestrial water research and habitability potential. - Presents a comprehensive reference on water in the Solar System, developing readers' understanding of the importance and occurrence of water on Earth and beyond, all from an oceanographer's perspective - Contrasts terrestrial analogues in relation to their roles in understanding and exploring ocean worlds and habitability - Includes numerous figures, illustrations, tables and videos to help readers better understand concepts covered
Download or read book Kelley and Firestein s Textbook of Rheumatology written by Gary S. Firestein and published by Elsevier Health Sciences. This book was released on 2016-06-21 with total page 2561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consult the definitive resource in rheumatology for an in-depth understanding of scientific advances as they apply to clinical practice. Masterfully edited by Drs. Gary S. Firestein, Ralph C. Budd, Sherine E. Gabriel, Iain B. McInnes, and James R. O'Dell, and authored by internationally renowned scientists and clinicians in the field, Kelley and Firestein’s Textbook of Rheumatology, 10th Edition, delivers the knowledge you need for accurate diagnoses and effective patient care. From basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes, this state-of-the-art reference provides a global, authoritative perspective on the manifestations, diagnosis and treatment of rheumatic diseases. An ideal balance of the basic science you need to know and how to apply that information to clinical practice. An integrated chapter format allows you to review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance for the full range of rheumatologic diseases and syndromes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. New content on the latest diagnostic perspectives and approaches to therapy, including five brand-new chapters: Metabolic Regulation of Immunity, Principles of Signaling, Research Methods in the Rheumatic Diseases, Novel Intracellular Targeting Agents, and IgG4-Related Diseases. New and expanded chapter topics on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. More schematic diagrams clearly summarize information and facilitate understanding.
