Download or read book Cell Polarity 2 written by Klaus Ebnet and published by Springer. This book was released on 2015-02-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or several aspects of cell polarity are impaired, and in which a loss of cell polarity possibly contributes to disease (e.g. epithelial-to-mesenchymal transition in cancer, role of polarity proteins in cancer). Both volumes are intended for professors, group leaders and researchers in cell biology as well as for medical professionals working in anatomy, cell biology, physiology, pathology and tumor biology.
Download or read book Cell Polarity in Development and Disease written by Douglas W Houston and published by Academic Press. This book was released on 2017-11-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and development Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer Includes historical context of cell polarity research for potential future breakthroughs
Download or read book Cell Polarity 1 written by Klaus Ebnet and published by Springer. This book was released on 2015-03-04 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.
Download or read book Cell Polarity and Cancer written by Andrew D. Chalmers and published by . This book was released on 2012 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The majority of cells exhibit some form of polarization by having an asymmetric distribution of macromolecules within them. Epithelial cells, for example, have distinct apical and basolateral plasma membrane domains which are separated by specialized cell - cell junctions. This asymmetry is essential for cellular function
Download or read book Cell Polarity in Development and Disease written by and published by Elsevier. This book was released on 2023-04-28 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cell polarity in the protist-to-animal transition, Polarized actin networks in development: Case studies from Drosophila, Protein clustering and cell polarization, Polarity in the Drosophila female germline, Context Matters: Mechanisms governing epithelial polarization in C. elegans, Epithelial polarity in the fly: Principles and diversity, Polarizing epithelial expulsion and expulsion driven by mispolarization, The Role of Apical-Basal Polarization in the Mammalian First Cell Fate Decision, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Updated release includes the latest information on Cell Polarity in Development and Disease
Download or read book Cell Polarity written by J.R. Bartles and published by Elsevier. This book was released on 1998-08-25 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of "cell polarity". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems.
Download or read book Cell Extracellular Matrix Interactions in Cancer written by Roy Zent and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.
Download or read book Establishing and Maintaining Cell Polarity written by Benjamin Lin and published by Frontiers Media SA. This book was released on 2021-12-22 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of PKC in Cell Polarity Mitosis and Cancer written by Rebecca Louise Gresham and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Apical basal Polarity as a Tumor Suppressive Mechanism written by Rachel Catterall and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The majority of human cancers originate in epithelial tissue. Normal epithelial tissue is highly organized and maintains apical-basal polarity to establish different signaling compartments at the cellular membrane and polarity within the cell, including in the cortex and distribution of organelles. This organization is often lost in cancers, leading to disrupted control of cell processes including proliferation, apoptosis, adhesion, and motility. In this project, I first sought to understand polarity status of invasive carcinomas, using breast cancer as a model. To investigate the cell polarity statuses of invasive breast cancers, we performed multiplex imaging of polarity markers on tissue samples from patients with a spectrum of grades, stages, and molecular subtypes. Apical-basal cell polarity was lost in 100% of cells in all cases studied, indicating that loss of epithelial polarity is a universal feature of invasive breast cancer. I then analyzed genomic events from the TCGA dataset for an 18-gene set of core polarity genes. Our data indicate that apical and basal polarity proteins are more often amplified than deleted and that genomic events likely contribute to pervasive disruption of epithelial polarity observed in invasive breast cancer. Having established a disrupted apical domain as a feature of breast carcinoma, we next explored apical-basal polarity as a tumor suppressive mechanism. To do this, we induced apical-basal polarization in human adenocarcinoma CaCo-2 cells expressing oncogenic KRASG12V by overexpressing CD13, a protein involved in early apical membrane specialization. CD13 expression was sufficient to re-establish apical-basal polarity and revert KRASG12V-expressing spheroids from a solid, malignant phenotype to a single layer of cells surrounding a hollow lumen. We demonstrate that following induction of polarization, the lumen is cleared through JNK-mediated apoptosis. RNA-seq data indicates that re-polarization induced by CD13 overexpression alters a subset of pathways regulated by KRASG12V, including apoptosis-related genes. These findings reveal unexpected epithelial plasticity maintained in malignant cells. Overall, this thesis provides data supporting apical-basal polarity is a tumor suppressive feature of epithelial cells that must be suppressed during tumorigenesis"--
Download or read book Electric Cell Substrate Impedance Sensing and Cancer Metastasis written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2012-09-14 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology, cancer biology, and other areas of chemistry, medicinal chemistry, life and medical science. Written by experts in the area of cell impedance sensing, including the Nobel Laureate Dr Ivar Giaever, this books covers the background of electric cell-substrate impedance sensing, their applications in cell based investigations, particularly in the area of cancer biology. This book is the first on this technology platform and will be a highly useful reference for molecular and cell biologists, cancer biologists, chemists and biochemists, clinical researchers who work in the areas of cell biology, molecular biology, toxicology, pharmaceutical industry, life science and medical research.
Download or read book Cancer Between Glycolysis and Physical Constraint written by Laurent Schwartz and published by Springer Science & Business Media. This book was released on 2004-03-22 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable effort has gone into the research of common cancers - lung, bowel, ovarian, cervical, and prostate cancer. In recent years, however, there has been a lack of breakthroughs in therapeutic advances. By challenging many established beliefs, Cancer explores these issues by offering new perspectives on the study of cancer and exploring the areas of mathematics, physics and chemistry in cancer research. This book is for cancer specialists, clinicians, and researchers interested in an innovative view in cancer research.
Download or read book Investigating the Role of Spatial Presentation of Physical and Chemical Cues in Regulating Normal and Cancer Cell Polarity written by Robert John Natividad and published by . This book was released on 2016 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the body, different cell types are required to move in order to perform their normal physiological functions. Immune cells constantly patrol the body in search of infections. Epidermal cells remain stationary until required to move to heal a nearby wound. Cells in hair follicles or intestinal crypts continuously migrate outward to replace routine losses. These processes all require cells to move at a specific rate and in a given direction appropriate to their task and environment. Sometimes, the cellular programming that dictates these movements malfunctions, leading to disease. Preventing these diseases or enhancing these functions requires a fundamental understanding of cell migration. Placing cells in flat, plastic dishes and analyzing their movement, has led to a great many discoveries about the mechanics of how cells move. However, the same lack of environmental features that enables studies of unbiased cell movement, makes it challenging to study how cells migrate in response to external mobilizing signals. On the other extreme, watching cells move in an intact organism, such as axon growth in C. elegans or border cell migration in Drosophila, runs the risk of having too many external signals to account for. To address this gap, we have developed an experimental platform that enables select soluble cues to be presented to cells in a controllable fashion, such as a gradient. The substrate of the platform is modified to present patterns of physical cues at well-defined orientations to the soluble cue. This system allows the application of multiple, physiologically relevant cues to cells while minimizing external influences and maintaining the accessibility and ease of measurement common to traditional cell culture dishes. This platform was applied to the study of cell polarity and motility in normal and cancerous cells by combining gradients of chemotactic factors and patterns of adhesive extracellular ligands. We find that even in this minimalist system, unexpected factors bias the polarity of stationary cells on micropatterns, mobile cells fail to respond to linear chemotactic gradients and Nucleus-Golgi polarity is not a universal characteristic of individually migrating cells. However, Nucleus-Golgi polarity can be induced by adding select features of the cancer environment back into the system. These findings highlight the utility of having the ability to add or subtract individual components from a well-defined multicomponent system.
Download or read book The Possible Role of Cell Polarity for Cancer Disease U2013 the Implication of Cancer Regression by Human Body Axes Interaction written by Pang Chu (Chung) and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction / Background: The human body anatomical axes (HBAAs) interaction shows an anti-inflammatory effect (Ou MC decrescendo phenomenon, OuDP, Am J Emerg Med. 2012) which indicates a normalization of dysfunctional cells and has shown to induce tumor regression (TJOG, 2017; Cancer arch, 2019).Methodology: OuDP treatment is performed by putting the contralateral hand over the lesion along human body anatomical axis of left-right, dorsoventral or vertical axis by the patient.Results: Ten patients with cancer diseases including gynecological cancers as uterine leiomyosarcoma (1/10), endometrial cancer (2/10), ovarian cancer (1/10) and breast cancer (1/10) showed initial cancer suppression or regression. However, long term follow up showed tumor regrowth in endometrial cancer (2/10) and the ovarian cancer.Conclusion: The signaling system of embryonic axes has shown to impart polarization of individual cells in Drosophila. Normal cell polarity is essential for normal cell function. The effect of OuDP is rapid, which indicates a direct mending effect on cell function (ICST, 2015). Normalizing the tumor cells and microenvironment function may make tumor cells conform to the regulations with apoptosis, metastasis suppression, preventing uninhibited proliferation, minimizing angiogenesis and supervision by host immunological systems. Long term follow up of advanced cancer diseases treated with OuDP showed tumor regrowth after initial regression, which may be due to poor accessibility, insufficient therapeutic efficacy or escape phenomenon. However, OuDP may be availed for an active prevention for cancer.
Download or read book Impact of the Cell Polarity Protein Scribble on Liver Cancer Formation and Progression written by Shan Wan and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Mechanics and Tumor Development written by Ronald L. Huston and published by . This book was released on 2020 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
