Download or read book Cell Biological Aspects of Disease written by W.Th. Daems and published by Springer. This book was released on 2011-10-09 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: W. TH. DAEMS This volume contains the papers presented at a Boerhaave Course for Post graduate Education on The cell-biological aspects of disease: the plasma membrane and lysosomes. One of the purposes of this introduction is to explain the reasons for this choice of subject. The first question which might be asked - why a postgraduate course on the cell biological aspects of disease was considered neccessary - is not difficult to answer: the impact of the basic sciences on medicine is im measurably strong, and among these sciences cell biology has contributed immensely to the advances made in medicine during recent decades. It has provided clues leading to general insights into etiology and pathogenesis as well as to the development of diagnostic tools and a basis for therapeutic methods. These insights derived mainly from the still-increasing body of knowledge about the architecture of cells. Initially, this knowledge arose from the notion that cells are either simply bags full of enzymes or complex sponge like structures in which all organelles are permanently interconnected (Fig. 1). Later, this notion was replaced by a highly schematized picture of the cell as an essentially two-compartment structure (Fig. 2) in which cell organelles are discrete units separated from each other by membranes, enabling each organelle to maintain an internal microenvironment with optimal conditions for its specific metabolic pro cesses.
Download or read book Cell Biological Aspects of Disease the Plasma membrane and Lysosomes written by and published by . This book was released on 1979 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lysosomes written by Frederick R. Maxfield and published by John Wiley & Sons. This book was released on 2016-06-27 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development
Download or read book Pathobiology of Cell Membranes written by Benjamin F. Trump and published by Academic Press. This book was released on 2013-10-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathobiology of Cell Membranes, Volume I, represents the first in a multivolume treatise designed for pathologists and cell biologists interested in the role of membrane alterations in disease processes. The treatise will emphasize concepts related to membrane alterations in cell injury as well as methods for elucidating such changes. The book begins with a discussion of the general conceptual aspects of cell injury and some details about the role of membrane alterations in the pathogenesis of both lethal and sublethal cellular reactions. This is followed by separate chapters on applications of circular dichroism to the study of membranes; a cell injury mechanism involving membrane components at the molecular level; and fundamental aspects of cell volume regulation and the modification of this regulation by primary or secondary damage of the cell membrane. Subsequent chapters deal with comparative roles of lysosomal and other membrane damage in cell injury; the role of membrane movements and various types of lysosome formation; toxic effects on mitochondrial membranes; and the concept of a biological membrane in health and disease at the tissue level.
Download or read book Lysosomes and Lysosomal Diseases written by and published by Academic Press. This book was released on 2015-02-04 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Cell Biology looks at methods for lysosomes and lysosomal diseases. Chapters focus upon practical experimental protocols to guide researchers through the analysis of multiple aspects of lysosome biology and function. In addition, it details protocols relevant to clinical monitoring of patients with lysosomal diseases. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come. Covers sections on model systems and functional studies, imaging-based approaches and emerging studies Chapters are written by experts in the field Cutting-edge material
Download or read book Lysosomes written by Pooja Dhiman and published by BoD – Books on Demand. This book was released on 2017-08-30 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers current advances in disorders associated with lysosomal function along with techniques to study its function. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on lysosomal diseases and opens new possible research paths.
Download or read book Lysosomes written by Paul Saftig and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.
Download or read book Plasma Membrane Repair written by and published by Academic Press. This book was released on 2019-10-12 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysosomes and Membrane Function, Volume 84 in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting interesting chapters on a variety of topics, including Parasite invasion and PMR, Actin dynamics and myosin contractility during plasma membrane repair: Does one ring really heal them all?, The role of intercellular signaling in cell membrane repair, Role of lipids in plasma membrane repair, Lysosomes and plasma membrane repair, Alveolar epithelial cell membrane integrity: a venerable target in the lung, Conservative evolution of natural versus artificial PEG-induced mechanisms of PMR in eukaryotes, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Updated release includes the latest information on lysosomes and membrane function
Download or read book Molecules Cells and Disease written by J.L. VanLancker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: In tracing their origin and their fate, the beginning and the end of their environment, humans have often been guided by curiosity. Such concern has helped man to discover, among other things, the structure of the universe from star to atom and the evolution of life from unicellular organism to human being. The study of disease is unique. Although it may have been in spired by the curiosity of a few, it has always been the concern of all, because preventing or curing disease has meant survival not only of individuals, but of entire nations, not only of humans, but of fellow living creatures. If greed, force, religion, and language have been major causes of wars, diseases, more than arms, have often decided the outcome of battles and thereby have woven the pattern of history. For millennia, a large fraction of the human race believed that disease expressed the wrath of God(s) against individuals or societies. Therefore, only priests or priestesses, kings, and queens were endowed with the power of healing. In the West, Hippocrates is credited for exorcising this concept of disease and for objectively describing and cataloguing them. The contributions of Greek physicians to Western medicine made possible more accurate diagnoses and prognoses.
Download or read book Ion and Molecule Transport in Lysosomes written by Bruno Gasnier and published by CRC Press. This book was released on 2020-06-09 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research
Download or read book Biology of the Lysosome written by John B. Lloyd and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 27 provides a comprehensive review of current knowledge of lysosome function in mammalian cells. The book's unique contribution is its series of chapters that offers unparalleled treatment of the metabolic activities of lysosomes.
Download or read book Biomembranes written by J. M. Tager and published by Springer. This book was released on 1988 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane research holds a central position in cell and molecular biology. In recent years it has become clear that the study of membranes at the molecular level is of great importance not only to decipher all cellular processes but also to understand the alterations leading to abnormal cells (including cancer cells) and/or to understand the action of various drugs. This book covers the multidisciplinary approach of research in this area and the permanent need for information regarding recent advances. It will serve both workers studying basic aspects of membrane structure and function as well as medically oriented scientists. The selection of topics illustrating interconnections between basic and applied membrane biology will cross-fertilize research in both groups.
Download or read book Endosomes and Lysosomes A Dynamic Relationship written by B. Storrie and published by . This book was released on 1993-06 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intent in initiating this volume was to bring together a series of essays which would define our present understanding of the endosome and lysosome and their interrelationship. The editors deliberately encouraged the contributors to be speculative; to strive to put order to the "real" world of incomplete and sometimes conflicting data. Seeing science from the laboratory bench can often be like viewing an impressionistic painting from up close; a series of paint dabs with no apparent order. The contributors to this volume were asked to step back and leave the reader with a sense of the whole as well as the detail. To the extent that this has happened, the credit should go to the individual authors. Our understanding of endosomes and lysosomes has undergone a molecular revolution over the last decade. Hence, we now know much about the molecular features required for internalization of an endocytic receptor, or the function of mannose 6-phosphate receptors in the transport of lysosomal enzymes. We can trace and follow the flow of molecules. In this volume current molecular knowledge concerning the function and relationship of endosomes and lysosomes is presented. Because of this vast increase in knowledge of molecules, we have realized that endosomes in particular are very ephemeral organelles. In fact, endosomes may well not be discrete entities but rather continuously changing and evolving in their molecular composition. The dynamic nature of the relationship between endosomes and lysosomes is the unifying focus of the genetic, biochemical, microscopic, and molecular biological approaches described in the chapters which follow.
Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Download or read book Organelle Contact Sites written by Mitsuo Tagaya and published by Springer. This book was released on 2017-08-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
Download or read book Pharmaceuticals in Marine and Coastal Environments written by Juan Carlos Duran-Alvarez and published by Elsevier. This book was released on 2021-06-23 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceuticals in Marine and Coastal Environments: Occurrence, Effects, and Challenges in a Changing World is divided into three sections that address a) coastal areas as the main entrance of pharmaceuticals into the ocean, b) the occurrence and distribution of pharmaceuticals in the environmental compartments of the ocean media, and c) the effects that such pollutants may cause to the exposed marine organisms. With its comprehensive discussions, the book provides a wide depiction of the current state-of-the-art on these topics in an effort to open new sources of investigation and find suitable solutions. Includes maps edited by the Water Information Network System of the International Hydrological Program (IHP-WINS) Provides a compilation of information regarding the occurrence and distribution of pharmaceuticals in the marine environment which will help establish new and more efficient monitoring programs and new research lines Depicts the most important results of environmental risk assessments that can be used as a first step for further toxicological studies
