Download or read book Cell and Molecular Biology of Endometrial Carcinoma written by H. Kuramoto and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting the latest work in the cell and molecular biology of endometrial carcinoma, this volume is a valuable resource for gynecologists, pathologists, and molecular biologists.
Download or read book Molecular Genetics of Endometrial Carcinoma written by Lora Hedrick Ellenson and published by Springer. This book was released on 2016-12-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Download or read book Precision Molecular Pathology of Uterine Cancer written by Michael T. Deavers and published by Springer. This book was released on 2017-10-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Download or read book Molecular Biology of Endometrial Carcinoma written by Ivana Marková and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Endometrial Carcinoma.
Download or read book Cell and Molecular Biology of the Uterus written by W. Leavitt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume were presented at the Symposium on Cell Biology of the Uterus held December 12, 1986, on the NIH campus, Bethesda, MD. This was the first of a series of meetings that will be held in con junction with the annual meeting of the American Society for Cell Biology. The uterus is now recognized as an extremely complex organ whose nor mal function is orchestrated by a delicate procession of cellular and molecular events that investigators are beginning to unravel for the first time. Powerful new analytical methods and the tools of molecular biology are now providing exciting breakthroughs in our basic understanding of uterine structure and function. Thus, the program of this meeting was or ganized to cover recent developments in uterine cell biology including the mechanism of hormone action, control of gene expression by nuclear acceptor sites and nuclear receptors, role of growth factors, endometrial cell kine tics during the menstrual cycle, regulation of specific protein synthesis and secretion, decidual cell function, and the role of early pregnancy pro teins. The material presented in this volume is concerned not only with how hormones and growth factors prepare the endometrium for implantation of the blastocyst, but it also details the recent characterization and identification of specific marker proteins secreted in response to hormone action and early pregnancy.
Download or read book Molecular Research of Endometrial Pathophysiology written by Paola Viganò and published by MDPI. This book was released on 2019-10-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]
Download or read book Endometrial Cancer From Biological to Clinical Approaches written by Massimo Nabissi and published by Frontiers Media SA. This book was released on 2019-09-26 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: In developed countries, cancer of the endometrium (EC) is the most common cancer of the female reproductive organs, affecting mainly postmenopausal women. The highest incidence of EC is in Northern America and Europe, but its incidence is growing around the world. Several factors influence the risk of developing EC, including: impaired hormone levels, obesity, physical activity, family history, and having been diagnosed with breast or ovarian cancer in the past. For EC, a standard screening test does not exist. It is often diagnosed at stage I/II due to frequent vaginal bleeding, while invasive EC (stage III/IV) is mainly diagnosed in its advanced stage. Despite the different clinical improvements when EC is progressed to the advanced/metastatic stage, the patients still have poor prognoses and unsatisfactory outcomes with conventional chemotherapy. The need for precision drugs is underscored by the limited number of options these patients have. So, the introduction of new techniques and the discovery of new biological characteristics, such as identification of transcriptome, proteome and metabolomics profiles, and new potential diagnostic/prognostic biomarkers are fundamental to improve our knowledges on EC. The scope of this Research Topic is to welcome articles and reviews from clinicians and scientists around the world in order to give an updated vision of the recent clinical insights, technical advances, and cellular and molecular targets related to endometrial cancer. Dedicated to Mr. Dario Conti, which supported endometrial cancer research.
Download or read book Biology of Female Cancers written by Simon P. Langdon and published by CRC Press. This book was released on 1997-03-18 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Female Cancers explores what can be learned about female cancers by summarizing what is known about the mechanisms of growth regulation and genetic features associated with common forms of female cancers, including malignancies of the breast, ovary, uterus, cervix, vulva, and gestational trophoblastic disease. The book describes the etiology, incidence, pathology, staging, and treatment of each type of cancer. The risk of developing particular tumor types and how their growth may be influenced by hormones, growth factors, and cytokines is also discussed. For oncologists, gynecologists and obstetricians, cell biologists, and everyone interested in learning more about female cancers, the Biology of Female Cancers offers a comprehensive, unique approach.
Download or read book Molecular Diagnosis and Targeting for Gynecologic Malignancy written by Seiji Isonishi and published by Springer Nature. This book was released on 2021-03-05 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.
Download or read book Molecular Biology and Prevention of Endometrial Cancer written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To increase our understanding of the molecular aberrations associated with endometrial carcinogenesis and the biologic mechanisms underlying the protective effect of oral contraceptive therapy. Methods: 1) Oligonucleotide microarray analysis was performed on a panel of endometrial cancers. 2) A subset of adenocarcinoma cases from the International DES Registry was analyzed for MSI and the poor quality of the DNA from many of these cases prohibited an adequate analysis of the entire set. The cases are currently being evaluated for PTEN expression. 3) We are in the process of analyzing the endometrium from cymologous macaques that were exposed to long term progestins as part of the three year randomized controlled trial. 4) A clinical trial comparing progestin versus placebo is underway that will facilitate investigation of the effects of progestin exposure on the endometrial lining Results: 1) Different histological types of endometrial cancer have unique genomic expression patterns. 2) Endometrioid endometrial cancers with microsatellite instability have a genomic expression pattern that is different from those microsatellite stability.
Download or read book Introduction to the Cellular and Molecular Biology of Cancer written by Leonard Maurice Franks and published by Oxford University Press, USA. This book was released on 1991 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the most out of HP′s eagerly anticipated webOS device! HP′s revolutionary new portable device - the TouchPad - boasts features that put it in a class of its own. Veteran For Dummies author Andy Rathbone brings his talent for taking complex material and presenting it in a way that makes it easy to understand as he helps you become familiar-and savvy-with this exciting new device. Packed with insider information, this straightforward-and-entertaining guide shows you how to set up your TouchPad, use the multitouch screens, and get comfortable with the new webOS. You'll discover how to browse the Internet; e-mail contacts; download apps, music, movies, photos, and ebooks; troubleshoot; and become part of the social networking world. Plus, timesaving tips and tricks put you well on your way to getting the most out of your HP TouchPad. Covers the basics of the TouchPad including downloading apps, using it as an e-reader, copying files, e-mailing, browsing the web, and more Draws from the author′s insider information to offer invaluable tips on troubleshooting, handling security, and getting the most out of your device Discusses how to get used to the multitouch screen mindset; using the new webOS; social networking; downloading apps, books, and magazines; and importing music, movies, and photos Start using your HP TouchPad ASAP with this handy guide!
Download or read book Uterine Cancer written by Franco Muggia and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications. The Editors first met in May 2003 at a stimulating Italian symposium on endometrial cancer (organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni, with participation of the deans of Italian Gynecologic Oncology, Ugo Bianchi and Constantino Mangioni) that took place at Bergamo and Caravaggio. The impressive gains in biology and clinical trials were further discussed by the two editors and others that are co-authors in this venture on this side of the Atlantic at a 2004 Educational Session at the American Society of Clinical Oncology (ASCO). The pace of progress in various aspects of management of uterine cancer was no- worthy, not only was tumor biology fueling novel hypotheses such as questioning the mesenchymal origin of carcinosarcomas, but knowledge of molecular pathways was beginning to be applied as prognostic and as predictive factors portending benefit from systemic therapies. Surgical staging and sensitive imaging provided the underpinning for refining our treatment algorithms. Finally, a role for che- therapy had finally become established, principally through phase III studies c- paring chemotherapy to radiation in mostly locally advanced stages III and IV that had undergone resection.
Download or read book Molecular Biology of Cancer written by Fiona Macdonald and published by Taylor & Francis. This book was released on 2004-06-02 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.
Download or read book Molecular and Cellular Changes in the Cancer Cell written by and published by Academic Press. This book was released on 2016-11-16 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Changes in the Cancer Cell,the latest volume in the Progress in Molecular Biology and Translational Science series, includes a comprehensive summary of the evidence accumulated thus far on the molecular and cellular regulation of the various adaptations taking place in response to exercise. This volume examines some of the latest advances, highlighting some of the most important molecular and cellular alterations and environmental influences that collectively cause a normal cell to become cancerous. Special emphasis is given to changes that take place at the molecular and cellular level. Comprehensive and up-to-date survey of current knowledge on the cancer cell Includes the latest advances and the most important molecular and cellular alterations and environmental influences collectively causing cells to become cancerous Written by leading experts in the field
Download or read book Regulation of Vascular Endothelial Growth Factor in Endometrial Cancer Cells by Food Compounds written by James Dann and published by . This book was released on 2008 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
