Download or read book CCN Proteins written by Bernard V. Perbal and published by Imperial College Press. This book was released on 2005 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: - First such book in the CCN field - Chapters are written by the most prominent specialists in the field
Download or read book CCN proteins in health and disease written by Annick Perbal and published by Springer Science & Business Media. This book was released on 2010-04-26 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information. The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions. In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes. Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.
Download or read book CCN Proteins written by Masaharu Takigawa and published by Springer Nature. This book was released on 2022-11-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with updated methodologies and practical tips to overcome obstacles associated with experimentation pertaining to chemistry, biology, physiology, pathology, medical and dental sciences, and pharmacology of CCN proteins. The chapters in this book cover topics such as CCN4 immunofluorescence for tissue microarray; utilizing public molecular biological databases for CCN family research; the effects of CCN4 on pancreatic beta cell proliferation; gene expression analysis of CCNs; novel cell biological assays for measuring bone remodeling activities of CCN proteins; and the function of CCN2 in tubular epithelium cells with a focus on renal fibrogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, CCN Proteins: Methods and Protocols, Second Edition is a valuable resource for experienced CCN researchers looking for new approaches and novice researchers just starting out in the field of CCN research.
Download or read book CCN proteins in health and disease written by Annick Perbal and published by Springer. This book was released on 2010-10-24 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information. The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions. In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes. Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.
Download or read book CCN Intercellular Signaling Proteins Advances in Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CCN Intercellular Signaling Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book CCN Intercellular Signaling Proteins Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about CCN Intercellular Signaling Proteins in a concise format. The editors have built CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CCN Intercellular Signaling Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CCN Intercellular Signaling Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book CCN Intercellular Signaling Proteins Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about CCN Intercellular Signaling Proteins in a concise format. The editors have built CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about CCN Intercellular Signaling Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of CCN Intercellular Signaling Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Vitamins and Hormones written by and published by Elsevier. This book was released on 2005-03-18 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. * First published in 1943, Vitamins and Hormones is AP's longest running serial * Each volume contains cutting edge reviews by leading contributors
Download or read book Neuroplasticity and Extracellular Proteolysis written by Jerzy W. Mozrzymas and published by Frontiers Media SA. This book was released on 2016-05-18 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroplasticity refers to the ability of the Central Nervous System (CNS) to alter its structure and function in response to a variety of physiological and pathological processes such as development, cognition, injury or neurological diseases. Since more than four decades, studies on synaptic plasticity in the context of memory and learning attracted a remarkable interest. Soon after first seminal works on synaptic plasticity were published, research in this field was extended by studies on non-synaptic as wells as structural plasticity towards a goal to understand cellular and molecular determinants of cognition. Over the past two decades, yet two additional crucial players in neuroplastic phenomena started to be intensely investigated – glial cells and the extracellular matrix (ECM). Growing awareness that glial cells, especially astrocytes, are important regulators of synaptic functions gave rise to a novel concept of a tri-partite synapse. Also, over the last two decades, a growing body of evidence has accumulated that the extracellular matrix (ECM) in the brain is strongly involved in regulation of neurons, in particular, in synaptic plasticity. Thus, a concept of tetra-partite synapse was put forward by some neuroscientists. The cross-talk between neuron-glia-ECM system involves enzymatic degradation of proteins or peptides and amino acids occurring in each of these brain constituents by means of a variety of proteases. Importantly, it has been realized that proteases such as serine proteases and matrix metalloproteinases, not only accompany “robust” phenomena such as cell division, or development or neurodegnerative conditions but may play a very subtle signaling functions, particularly important in memory acquisition. Indeed, the repertoire of substrates for these enzymes covers a wide variety of proteins known to play important role in the neuroplastic phenomena (e.g. BDNF, TNF-a, ephrin systems, various cell adhesion molecules, etc.). In result, the role of metalloproteinases and such serine proteases as tissue plasminogen activator (tPA), neuropsin or neurotrypsin in synaptic plasticity as well as in learning and memory has been particularly well demonstrated. It needs to be emphasized, however, that in spite of a remarkable progress in this field, several basic questions regarding molecular and cellular mechanisms remain unanswered. Potential involvement of so many important players (various proteases and their substrates in neurons, glia and in ECM) points to an enormous potential for plasticity phenomena but makes also studies into underlying mechanisms particularly difficult. In the proposed Research Topic we provide both review of the current state of the art and present some original reports on specific aspects of the role of proteolysis in neuroplasticity phenomena. The present ebook starts with extensive reviews describing involvement of proteolysis not only in synaptic plasticity but also in regulating endogenous excitability and structural changes at the network, cellular and subcellular levels. Cross-talk between neuroplasticity and proteolysis is also emphasized in the context of development and in relation to various pathologies. Whereas in the first part of the present ebook, the major focus is on metalloproteinases, the successive articles address the role of neuropsin and thrombin. The Research Topic is concluded with a series of articles describing the components of extracellular matrix and adhesion proteins and their elaboration by mechanisms dependent directly or indirectly on proteolysis. We do hope that the present ebook will further stimulate the interest in the fascinating investigations into neuroplasticity-proteolysis cross-talk.
Download or read book Impact of the CCN proteins CYR61 CCN1 and WISP3 CCN6 on Mesenchymal Stem Cells and Endothelial Progenitor Cells written by Rita Schenk and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel cancer related biomarkers written by Viktor Magdolen and published by Walter de Gruyter. This book was released on 2012-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.
Download or read book New Trends in Cancer for the 21st Century written by Antonio Llombart-Bosch and published by Springer Science & Business Media. This book was released on 2006-09-28 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view.
Download or read book Molecular Mechanisms of Skin Aging and Age Related Diseases written by Taihao Quan and published by CRC Press. This book was released on 2016-04-21 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes
Download or read book Composition and Function of the Extracellular Matrix in the Human Body written by Francesco Travascio and published by BoD – Books on Demand. This book was released on 2016-06-15 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.
Download or read book Extracellular Matrix and Egg Coats written by and published by Academic Press. This book was released on 2018-05-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Matrix and Egg Coats, Volume 130, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on The Human Egg’s Zona Pellucida, the Structure of Zona Pellucida Module Proteins, The Fish Egg’s Zona Pellucidam The Chicken Egg’s Zona Pellucidam The Marsupial Egg’s Zona Pellucida, the Evolution of Zona Pellucida Proteins, The Mouse Egg’s Zona Pellucida, Aspects of ECM, ECM and Morphogenesis, Collagen fibril assembly and function, The Ear's Tectorial Membrane, ECM and Cell Fate, and the Aspects of ECM. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on the Extracellular Matrix in Development
Download or read book Cells Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 4017 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells—Advances in Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cells. The editors have built Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Interface Oral Health Science 2009 written by Takashi Sasano and published by Springer Science & Business Media. This book was released on 2010-04-03 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 2002, the Tohoku University Graduate School of Dentistry has proposed “Interface Oral Health Science” as a major theme for next-generation dental research. That theme is based on the following new concept: healthy oral fu- tion is maintained by biological and biomechanical harmony among three s- tems: (1) oral tissues (host); (2) parasitic microorganisms of the oral cavity (parasites); and (3) biomaterials. The concept implies that oral diseases such as dental caries, periodontal disease, and temporomandibular disorders should be interpreted as “interface disorders” that result from disruption of the intact int- face among these systems. The uniqueness of this concept rests on the fact that it not only encompasses the field of dentistry and dental medicine, but also expands the common ground shared with other fields, including medicine, ag- culture, material science, engineering, and pharmacology. We aim to promote advances in dental research and to activate collaboration with related fields by putting interface oral health science into practice. On this basis, we have already organized the 1st and 2nd International Symposiums for Interface Oral Health Science, which included inspiring special lectures, symposiums, poster pres- tations, and other discussions. The contents of the two symposiums were p- lished as monographs entitled Interface Oral Health Science in 2005 and 2007. The 3rd International Symposium was held in January 2009 as part of this project.