Download or read book Carry s Trials written by Charles Thynne and published by BoD – Books on Demand. This book was released on 2023-10-14 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reprint of the original, first published in 1875.
Download or read book Carry s Trials and Other Tales written by and published by . This book was released on 2020-04-16 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cross over Trials in Clinical Research written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2003-07-25 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.
Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by . This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.
Download or read book Reports of Patent Design and Trade Mark Cases written by and published by . This book was released on 1985 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Crossover Designs written by Kung-Jong Lui and published by John Wiley & Sons. This book was released on 2016-09-26 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. Each chapter is self-contained, allowing the book to be used a reference resource. Uses real-life examples to illustrate the practical use of test procedures and estimators Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.
Download or read book An Introduction to Stochastic Modeling written by Mark Pinsky and published by Academic Press. This book was released on 2011 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serving as the foundation for a one-semester course in stochastic processes for students familiar with elementary probability theory and calculus, Introduction to Stochastic Modeling, Fourth Edition, bridges the gap between basic probability and an intermediate level course in stochastic processes. The objectives of the text are to introduce students to the standard concepts and methods of stochastic modeling, to illustrate the rich diversity of applications of stochastic processes in the applied sciences, and to provide exercises in the application of simple stochastic analysis to realistic problems. New to this edition: Realistic applications from a variety of disciplines integrated throughout the text, including more biological applications Plentiful, completely updated problems Completely updated and reorganized end-of-chapter exercise sets, 250 exercises with answers New chapters of stochastic differential equations and Brownian motion and related processes Additional sections on Martingale and Poisson process Realistic applications from a variety of disciplines integrated throughout the text Extensive end of chapter exercises sets, 250 with answers Chapter 1-9 of the new edition are identical to the previous edition New! Chapter 10 - Random Evolutions New! Chapter 11- Characteristic functions and Their Applications
Download or read book Sharing Clinical Trial Data written by Institute of Medicine and published by National Academies Press. This book was released on 2015-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Download or read book Statistical Design Monitoring and Analysis of Clinical Trials written by Weichung Joe Shih and published by CRC Press. This book was released on 2021-10-25 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors’ courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book’s balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.
Download or read book Acts of the Parliament of the Dominion of Canada written by Canada and published by . This book was released on 1919 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Migration in Fishes written by James D. McCleave and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last major synthesis of our knowledge of fish migration and the underlying transport and guidance phenomena, both physical and biological, was "Fish Migration" published 16 years ago by F.R. Harden Jones (1968). That synthesis was based largely upon what could be gleaned by classical fishery-biology techni.ques, such as tagging and recapture studies, commercial fishing statistics, and netting and trapping studies. Despite the fact that Harden Jones also provided, with a good deal of thought and speculation, a theoretical basis for studying the various aspects of fish migration and migratory orientation, progress in this field has been, with a few excepti.ons, piecemeal and more disjointed than might have been expected. Thus we welcomed the approach from the NATO Marine Sciences Programme Panel and the encouragement from F.R. Harden Jones to develop a proprosal for, and ultimately to organize, a NATO Advanced Research Institute (ARI) on mechanisms of fish migration. Substantial progress had been made with descriptive, analytical and predictive approaches to fish migration since the appearance of "Fish ~ligration." Both because of the progress and the often conflicting results of research, we felt that the time was again right and the effort justified to synthesize and to critically assess our knowledge. Our ultimate aim was to identify the gains and shortcomings and to develop testable hypotheses for the next decade or two.
Download or read book Angel s Revenge written by Ronald S. Parsons and published by iUniverse. This book was released on 2000-11-13 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of two men and a woman whose lives become entwined in one common interest the ‘Red Fox’ mystery. Their track in search of an answer takes them across the lush vegetation of the Dohfar Valley over the Gara Mountains with its trees of frankincense and myrrh to the Oman Desert border to the colorful Hadhramaut valley to the arid desert wastelands of eastern Yemen. They reap the benefits by torture, get caught in an ambush, stare death in the face and experience a lucky escape in the Hadhramaut valley. The love hates and cares of two men and woman and an explosion of anger that leads to the death by lethal injection of a notorious killer.
Download or read book Lees Loss Prevention in the Process Industries written by Frank Lees and published by Butterworth-Heinemann. This book was released on 2012-11-05 with total page 3685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Safety in the process industries is critical for those who work with chemicals and hazardous substances or processes. The field of loss prevention is, and continues to be, of supreme importance to countless companies, municipalities and governments around the world, and Lees’ is a detailed reference to defending against hazards. Recognized as the standard work for chemical and process engineering safety professionals, it provides the most complete collection of information on the theory, practice, design elements, equipment, regulations and laws covering the field of process safety. An entire library of alternative books (and cross-referencing systems) would be needed to replace or improve upon it, but everything of importance to safety professionals, engineers and managers can be found in this all-encompassing three volume reference instead. The process safety encyclopedia, trusted worldwide for over 30 years Now available in print and online, to aid searchability and portability Over 3,600 print pages cover the full scope of process safety and loss prevention, compiling theory, practice, standards, legislation, case studies and lessons learned in one resource as opposed to multiple sources
Download or read book The Philippines written by and published by . This book was released on 1990 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Sensory Working Memory written by Pierre Jolicoeur and published by Elsevier. This book was released on 2016-06-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Sensory Working Memory: Attention and Performance XXV provides an update on research surrounding the memory processes that are crucial for many facets of cognitive processing and experience, with new coverage of emerging areas of study, including a new understanding of working memory for features of stimuli devoid of verbal, phonological, or long-term memory content, such as memory for simple visual features (e.g., texture or color), simple auditory features (e.g., pitch), or simple tactile features (e.g., vibration frequency), now called sensory memory to distinguish from verbal memory. This contemporary focus on sensory memory is just beginning, and this collection of original contributions provides a foundational reference for the study mechanisms of sensory memory. Students, scholars, and researchers studying memory mechanisms and processes in cognitive neuroscience, cognitive science, neuroscience, and psychology will find this book of great value to their work. Introduces the study of sensory mechanisms of working memory as distinct from verbal memory Covers visual memory, auditory memory, and tactile memory Includes translational content as the breakdown of working memory is often associated with a disease, disorder, or trauma to the brain
Download or read book Biometrics written by and published by . This book was released on 1996 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Graph Colouring and the Probabilistic Method written by Michael Molloy and published by Springer Science & Business Media. This book was released on 2002 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, many major advances have been made in the field of graph colouring via the probabilistic method. This monograph provides an accessible and unified treatment of these results, using tools such as the Lovasz Local Lemma and Talagrand's concentration inequality. The topics covered include: Kahn's proofs that the Goldberg-Seymour and List Colouring Conjectures hold asymptotically; a proof that for some absolute constant C, every graph of maximum degree Delta has a Delta+C total colouring; Johansson's proof that a triangle free graph has a O(Delta over log Delta) colouring; algorithmic variants of the Local Lemma which permit the efficient construction of many optimal and near-optimal colourings. This begins with a gentle introduction to the probabilistic method and will be useful to researchers and graduate students in graph theory, discrete mathematics, theoretical computer science and probability.
