Download or read book Carbohydrate based Drug Discovery written by Chi-Huey Wong and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Download or read book Carbohydrates in Drug Discovery and Development written by Vinod K. Tiwari and published by Elsevier. This book was released on 2020-07-31 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades.This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. - Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development - Highlights the use of functionalized carbohydrates as synthons for the construction of various systems - Covers recent developments in the synthesis of various glycohybrid molecules and vaccines - Highlights the significance of heparin mimetics as tools for the modulation of biology - Provides an impact of glycan microarrays and carbohydrate– protein interaction

Download or read book Carbohydrate based Drug Discovery 2 Volume Set written by Chi-Huey Wong and published by John Wiley & Sons. This book was released on 2003-10-17 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Download or read book Carbohydrates in Drug Design and Discovery written by Jesús Jímenez-Barbero and published by Royal Society of Chemistry. This book was released on 2015-04-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.

Download or read book Carbohydrates as Drugs written by Peter H. Seeberger and published by Springer. This book was released on 2014-11-14 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Download or read book Carbohydrate Based Drugs Discovery written by Jian Yin and published by . This book was released on 2024-03-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates play an essential role in the organism and have many bioactivities. Carbohydrate-based drug discovery is an up-and-coming area of research in medicinal chemistry. Bioactive carbohydrates open up a new source for drug development. More than 170 carbohydrate-based drugs have been successfully approved as anticoagulants, antitumor agents, antidiabetic agents, antibiotics, antiviral agents, and vaccines. However, most carbohydrates have low druggability. As such, new methods and strategies to improve carbohydrates' druggability are in high demand. This Special Issue aimed to serve as an open forum where researchers can share their experiences and findings on carbohydrate-based drugs, with a focus on the discovery and development of new carbohydrate-based therapeutic agents. Contributions to this issue, in the form of both original research and review articles, cover the separation, identification, synthesis, and pharmacology of bioactive carbohydrates, including monosaccharides, oligosaccharides, polysaccharides, glycopeptides, glycoproteins, glycomimetics, and others.

Download or read book Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics written by Laura Cipolla and published by World Scientific. This book was released on 2015-07-23 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.

Download or read book Carbohydrate Based Therapeutics written by Roberto Adamo and published by John Wiley & Sons. This book was released on 2023-12-04 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate-Based Therapeutics Comprehensive resource summarizing opportunities and latest progress in design methodologies for carbohydrate-based therapeutics through a disease-oriented approach Carbohydrate-Based Therapeutics covers current progress and explores new frontiers in carbohydrate-based therapeutic applications, utilizing a unique approach by providing a detailed background of diseases coupled with subsequent carbohydrate-based therapies. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and a broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure– activity relationship, and impact on health and diseases. The text also discusses newer topics like nanoparticles, material science, and tissue generation. Carbohydrate-Based Therapeutics includes information on: Antimicrobial carbohydrate-based therapies, covering antibacterial and antiviral vaccines, antifungal therapies, anti-influenza therapeutics, and antiadhesive carbohydrates and glycomimetics Anti-cancer carbohydrate-based therapies, covering cancer vaccines and immunotherapy, and carbohydrate tools in cancer biology Carbohydrate-based therapies in metabolic, neuronal, and immune disorders, covering carbohydrate-based therapeutics for lysosomal disorders and neurodegenerative diseases New frontiers in carbohydrate-based therapies, covering carbohydrates for tissue engineering, antiangiogenic and regenerative medicine Providing comprehensive coverage of foundational knowledge on the subject in a unique and highly accessible format while also exploring the state of the art in the field’s applications, Carbohydrate-Based Therapeutics is an essential resource for medicinal, pharmaceutical, and organic chemists, chemists in industry, biochemists, and biotechnologists.

Download or read book Carbohydrate Drug Design written by Anatoliĭ Alekseevich Klesov and published by . This book was released on 2006 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is becoming more obvious in recent years that carbohydrates present a new dimension in drug design for targeting specific diseases. Carbohydrates birthed a whole new vocabulary into chemistry, biochemistry and related disciplines -- a new language in the form of distinct characters and images providing professional chemists not in the area of carbohydrates to become familiar and knowledgeable on the topic. Carbohydrate Drug Design provides the indispensable understanding of the mutual challenge between carbohydrate-based drugs and the deadly diseases which they target. Carbohydrate Drug Design discusses pre-clinical studies and clinical trials of carbohydrate-based drugs, drug delivery and pain managements, biocompatibility, clearance and metabolic pathways of carbohydrate drugs, and actual medical devices employing carbohydrates. The invasion of cancer cells, protein-glycan interactions and their inhibitors, new carbohydrate-based therapeutics, crystal structure of antibodies with unusually high affinity for carbohydrates, and a number of other features of carbohydrate drugs are also comprehensively covered. Galactomannans and hyaluronans, as well as thio-, imino- and carba-sugars are particularly considered in respect to their structural and functional impacts.

Download or read book Carbohydrates 2018 written by Amélia Pilar Rauter and published by MDPI. This book was released on 2020-03-25 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Download or read book Carbohydrate Recognition written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Download or read book Carbohydrate Based Vaccines and Immunotherapies written by Zhongwu Guo and published by John Wiley & Sons. This book was released on 2009-06-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.

Download or read book Carbohydrate Mimics written by Yves Chapleur and published by Wiley-VCH. This book was released on 1998-09-10 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Mimics Concepts and Methods Edited by Yves Chapleur Apart from the various functions of carbohydrates in natural processes they are important building blocks for drugs, especially antibiotics. In addition, carbohydrates are considered as important structures in the immunological recognition process of the antigen-antibody reaction. The modification of the structure and thereby the chemistry of substrates is a common procedure in nature. This naturally occurring process is reflected in the concept of molecular mimicry, which has become a useful approach in drug discovery. The search for carbohydrate analogues that exhibit better binding activity, biological activity, and stability began with the synthesis of azasugars. A lot of structural modifications around the anomeric center of carbohydrates has been achieved over the last decade, and these are summarized in terms of the different chemical and biological aspects of carbohydrate mimics in one part of this book. In addition to the well established fields of C-glycosides, azasugars and carbasugars the other part of the book focusses on outstanding achievements in carbohydrate mimic research. Everybody who is active in carbohydrate research or is interested in moving into this exciting field will benefit from this up-to-date source of informations. The leading experts in this field describe their scientific approaches to real interdisciplinary puzzles. This book should be an inspiration to scientists in organic, medicinal chemistry, biochemistry, and biology.

Download or read book Carbohydrate based Synthetic Methodology and Polymer Development written by Vishwanath Venkatesh Gaitonde and published by . This book was released on 2015 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates are some of the most abundant organic molecules on earth. They are ubiquitous compounds, most commonly known for providing energy for working and are biologically stockpiled as glycogen. Modern Era advancement in disciplines of glycomics, glycobiology, and bio-renewable studies has played a pivotal role in generating robust interest in the study of carbohydrate chemistry. The advances in the field have progressed to cover an expansive range of scientific areas. For example, there is strong interest in i) developing synthetic methodology, ii) understanding reactivity, iii) performing structural studies, iv) exploring enzyme catalysis, v) biological and medical applications, as well as exploiting their use in food and polymer industries. From a biological perspective it is recognized that carbohydrates play a fundamental role in cell recognition, cell-cell interaction, cell differentiation, cell growth, survival of living cells and organisms. Synthetically, a variety of natural products and antibiotics contains carbohydrate moieties, providing a vast platform for glyco-based synthesis. In addition, biochemical inquiries over last few decades have established the association of carbohydrates with various disease conditions and identified glycan(s) as untapped tools in drug discovery. Development of the carbohydrate-based drug discovery can be categorized by one of the following approaches. i) producing native glycans with desired biological activity, ii) structural modification via glycomimetic approaches, iii) generating a glyco-scaffold for achieving carbohydrate diversity, and iv) developing glyco-fused therapeutics. The scope of work covered in this dissertation covers several carbohydrate-related areas. First, we desired to i) develop a series of ß-glycosyl amide linkages demonstrating the use of ß-glycosyl-2,4-dinitrobenzenesulfonamides as key intermediates in the chemoselective formation of these motifs, ii) produce glycosyl fluoride moieties to study their potential inhibitory activity against Mycobacterium tuberculosis (Mtb) GlgE, iii) generate oligosaccharides to study their interaction with the glucan binding site of Mtb GlgE, and iv) demonstrate the utilization of furfural (degradation product of pentose sugars from hemicellulose, bio-resource) to access a bisfuran monomer, in order to generate furan based polymeric materials. Glycosyl amide linkages are key motifs found in glycosyl amino acids, N-linked glycopeptides besides several natural products. Some of the popular strategies to access these linkages include Lansbury aspartylation involving direct coupling of glycosylamine with activated aspartic acid on protected amino acid. Alternatively, a route to access ß-glycosyl amide linkage is via Staudinger reduction-acylation or traceless Staudinger ligation of ß-glycosyl azide. This method ends up producing a mixture of a/ß glycosyl amides. 2,4-Dinitrobenzenesulfonyl chloride (dNBS-Cl) has been used to protect the primary amines producing the 2,4-dinitrobenzenesulfonamides (dNBS-NH2, dNBS). dNBS can be used to produce secondary amines and diamines as noted by Fukuyama et al. dNBS were later explored for producing amides, thioamides, ureas, and thioureas, and only very recently this strategy has been taken as a possible chemoselective approach to form peptide linkage and neoglycoconjugates. To further this chemistry in our chemoselective studies producing the ß-glycosyl amides, we explored the scope of this methodology by reacting a series of ß-dNBS glycosides with thioacetic acid. The N-glycosyl-2,4-dinitrobenzenesulfonamides were accessed via benzoyl-protected ß-glycosyl azides. The azides were i) reduced with Adams' catalyst to the corresponding amines, ii) the glycosylamines were sulfonated with 2,4-dinitrobenzenesulfonyl chloride to form N-glycosyl-2,4-dinitrobenzenesulfonamides in moderate yields, and iii) the ß-glycosyl amides were then prepared in 67 - 81 % yields by treatment of the sulfonamides with thioacetic acid and cesium carbonate. The conversion of the glycosylsulfonamide to the glycosyl amide proceeded with high stereoselectivity. A second project area involved new approaches to preapare oligosaccharide. Mtb is the causative agent of tuberculosis (TB), which is one of the leading cause of death due to an infectious disease. Designing susbtrates, inhibitors and biochemical probes to understand and overcome this disease condition is of significant interest. Mtb GlgE an a-1,4-glucan: phosphate maltosyltransferase is a genetically validated tuberculosis target. Underlining this target, we designed glycosyl fluoride derivatives, as biochemical probes to determine the active-site residues and better understand the Mtb GlgE catalytic mechanism. 5-fluoro-L-idosyl fluoride, an epimer of 5-fluoro-D-glucosyl fluoride has been synthesized over 5-steps. Starting with D-glucose a key step was photobromination at the C-5 using NBS and AIBN followed by substituting the bromide with fluoride using AgF. Mtb GlgE transfers the maltosyl units on to the elongating the a-1,4-glucan polymer. As a concurrent project we sought to access the oligosaccharide units mimicking the a-glucan polymer in the Mtb GlgE. The oligosaccharides are envisioned to be useful for probing the a-glucan binding site. During the oligosaccharide synthesis, we propose a stereoselective glycosylation strategy was pursued applying a preactivation methodology. Starting with D-maltose, the building blocks for the a-1,4-glucan oligosaccharide were accessed via a divergent synthetic route by creating the donor (4',6'-O-benzylidene-ß-maltosyl thioglycoside) and the acceptor (4'-OH-ß-maltosyl thioglycoside) substrates. During synthesis the donor is first accessed, which was further regioselectively reduced at the 4',6'-O-benzylidene to create 4'-OH (non-reducing end), generating the acceptor substrate. Glycosylation between the donor and acceptor substrate is then envisioned to proceed using a [2+2] preactivated method to build the tetrasachharide unit. This tetrasaccharide on regioselective reduction at the 4',6'-O-benzylidene creates the 4'-OH (non-reducing end), which then acts as a template to produce [4+2] hexasaccharide and/or [4+4] octasaccharide, and so on to access a-1,4-glucan oligosaccharide units of desired length. In a final area of research, carbohydrates were explored as feedstocks for polymer synthesis Starch is commonly understood as a first generation biorenewable feedstock and lignocellulose as second generation biorenewable. Lignocellulose consists of cellulose (40 -- 45 %), hemicellulose (24 -- 40 %), and lignin (18 -- 25 %). Hemicellulose consists chiefly of the pentose sugar xylose and arabinose. The degradation of these pentose sugars yields furfural. The latter is considered to be a leading candidate for bio-renewable building blocks and as a platform chemical for its application in diverse commercial sectors. In the same direction there is a substantial interest and progress in the utilization of this bio-based feedstock to fulfill the growing demands in the sector of fuel, chemical, pharmaceutical and polymer industries. As a part of our preliminary investigation, starting with commercial furfural, we have designed a four steps synthetic route to access a bisfuran diol (BFD) as a monomer feedstock to generate polymeric materials. Starting with commercial furfural i) reaction with 1,2-ethanedithiol in recyclable glycerol produced the 1,3-dithiane protected furfural in 93 % yield after distillation, ii) treatment with acetone and 50% aqueous sulfuric acid produced a dimerized Friedel Crafts product in 58% yield, iii) deprotection of the 1,3-dithiane was accomplished using selenium dioxide along with acetic acid to generate dialdehyde in 90% yield, and iv) the penultimate dialdehyde was reduced to afford the final diol, the BFD in 96 % yield. BFD was crystallized in the monoclinic space group and X-ray studies were undertaken to understand the molecular arrangement in space, hydrogen bonding and packing of the molecule. These set of data were compared with Bisphenol A (BPA, a known endocrine disruptor), and its known derivatives to predict the potential estrogenic or anti-estrogenic activities in BFD. Further, BFD was employed in polymerization studies to successfully generate bisfuran polyester (BFPE-1), a low-molecular weight novel polyester material of amorphous nature.

Download or read book Carbohydrate Chemistry Biology and Medical Applications written by Hari G. Garg and published by Elsevier. This book was released on 2011-09-06 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research. - Explains how carbohydrates are important to life - Details the chemistry, biology and medical aspects of carbohydrates - Interdisciplinary and international team of authors

Download or read book Synthetic Strategies in Carbohydrate Chemistry written by Vinod Kumar Tiwari and published by Elsevier. This book was released on 2023-11-01 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.