Download or read book Cancer Biomarkers and Targets in Digestive Organs written by Nikki P. Lee and published by MDPI. This book was released on 2019-09-03 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
Download or read book Cancer Biomarkers and Targets in Digestive Organs written by Nelson Yee and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
Download or read book Essential Concepts in Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2019-11-23 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Problem Solving in Abdominal Imaging with CD ROM written by Neal C. Dalrymple, MD and published by Elsevier Health Sciences. This book was released on 2009-06-29 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elsevier's new Problem Solving in Abdominal Imaging offers you a concise, practical, and instructional approach to your most common imaging questions. It presents basic principles of problem solving to apply to imaging the abdominal and pelvic organs, gastrointestinal tract, and genitourinary tract. Inside, you'll find expert guidance on how to accurately read what you see, and how to perform critical techniques including biopsy and percutaneous drainage. User-friendly features, such as tables and boxes, tips, pitfalls, and rules of thumb, place today's best practices at your fingertips. A full-color design, including more than 700 high-quality images, highlights critical elements and compliments the text, to enhance your understanding. Best of all, a bonus CD provides you with an atlas of basic surgical procedures and survival guides for managing musculoskeletal and chest findings encountered on abdominal imaging examinations. Provides problem-solving advice to help you find abnormalities and accurately identify what you see. Presents a section devoted to clinical scenarios-organized by presenting signs or disease processes-covering those you're most likely to encounter in daily practice. Includes tips for optimization of the most common advanced imaging techniques used for the abdominal and pelvic regions-with general indications for use and special situations-to help you make the most of each modality. Offers step-by-step guidance that will help you safely approach challenging abdominal interventions, reduce complications, and improve outcomes. Features tables and boxes, tips, pitfalls, and other teaching points for easy reference. Incorporates high-quality images and a full-color design that illuminate important elements. Includes a CD containing an atlas of basic surgical procedures and survival guides for managing incidental musculoskeletal and chest findings encountered on abdominal imaging examinations.
Download or read book MicroRNAs Novel Biomarkers and Therapeutic Targets for Human Cancers written by Takahiro Ochiya and published by MDPI. This book was released on 2018-10-16 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM
Download or read book The Evolving Landscape Clinical Implications and Future Perspective of Biomarkers in Gastrointestinal Cancers written by Kenneth K. W. To and published by Frontiers Media SA. This book was released on 2022-04-11 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma written by Michael J. Murphy and published by Springer Science & Business Media. This book was released on 2011-12-02 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
Download or read book DAMP sensing pattern recognition receptors in digestive tract inflammatory responses written by Daming Zuo and published by Frontiers Media SA. This book was released on 2023-01-17 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Download or read book Genetic and proteomic biomarkers in solid tumor detection and treatment written by Jitian Li and published by Frontiers Media SA. This book was released on 2023-06-07 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Volume II Novel molecular mechanisms and innovative therapeutic approaches for age associated diseases written by Leming Sun and published by Frontiers Media SA. This book was released on 2023-01-09 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small non coding RNAs in diseases written by Xiaoyong Bao and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Download or read book Hepatobiliary Cancer written by Yuman Fong and published by PMPH USA. This book was released on 2014 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatobiliary Cancer addresses the field with contributions from talented practitioners from around the world in surgery, chemotherapy, radiation therapy, medical oncology, and integrative medicine. The text approaches these cancers by type – biliary and liver tumors – and in terms of diagnostic techniques and therapies: surgical, ablative, systemic and regional chemotherapies, biologic, and complementary. Hepatobiliary Cancer is essential reading for anyone expert in, or engaged in learning about, treating hepatobiliary cancers. Heavily illustrated with photomicrographs, photographs, drawings, and tables to support and illuminate the text, it is a concise, yet comprehensive guide to hepatobiliary cancer diagnosis and treatment.
Download or read book Biomarkers and Immunotherapy of Hepatic Biliary Pancreatic Cancers written by Yunfei Xu and published by Frontiers Media SA. This book was released on 2024-02-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatic-biliary-pancreatic cancers, mainly including hepatocellular carcinoma, cholangiocarcinoma, gallbladder cancer, are highly aggressive malignancies with few treatment options and poor prognoses. Effects of the traditional systemic treatments such as chemotherapy and radiotherapy, are quite limited to hepatic-biliary-pancreatic cancers. For the patients who suffer from hepatic-biliary-pancreatic cancer and lose the opportunity of radical surgery, few targeted drugs are available. Even for the drugs in clinical trial, potential drug targets and prognostic biomarkers for hepatic-biliary-pancreatic cancer are less studied compared to other common cancers such as lung cancer. Prognostic biomarker study is the initiation to explore new drug targets and revelation of the underlying mechanisms of tumor progression. Immunotherapy, especially PD1 or PD-L1 antagonists, has exhibited potent treatment effects on cancers. To date, many PD1 drugs are available for cancer treatment, and more than one hundred PD1 drugs are in clinical trial. However, how to screen out the sensitive patients and predict the efficacy of immunotherapy are still unsolved problems. Moreover, the predictive biomarkers and treatment guidelines of immunotherapy for hepatobiliary tumors are barely investigated.
Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
