Download or read book Can Variation in Subgroups Average Treatment Effects Explain Treatment Effect Heterogeneity written by Marianne P. Bitler and published by . This book was released on 2014 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this paper, we assess whether welfare reform affects earnings only through mean impacts that are constant within but vary across subgroups. This is important because researchers interested in treatment effect heterogeneity typically restrict their attention to estimating mean impacts that are only allowed to vary across subgroups. Using a novel approach to simulating treatment group earnings under the constant mean-impacts within subgroup model, we find that this model does a poor job of capturing the treatment effect heterogeneity for Connecticut's Jobs First welfare reform experiment using quantile treatment effects. Notably, ignoring within-group heterogeneity would lead one to miss evidence that the Jobs First experiment's effects are consistent with central predictions of basic labor supply theory.

Download or read book Can Variation in Subgroups Average Treatment Effects Explain Treatment Effect Heterogeneity written by Marianne P. Bitler and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this paper, we assess whether welfare reform affects earnings only through mean impacts that are constant within but vary across subgroups. This is important because researchers interested in treatment effect heterogeneity typically restrict their attention to estimating mean impacts that are only allowed to vary across subgroups. Using a novel approach to simulating treatment group earnings under the constant mean-impacts within subgroup model, we find that this model does a poor job of capturing the treatment effect heterogeneity for Connecticut's Jobs First welfare reform experiment using quantile treatment effects. Notably, ignoring within-group heterogeneity would lead one to miss evidence that the Jobs First experiment's effects are consistent with central predictions of basic labor supply theory.

Download or read book Can Variation in Subgroups s Average Treatment Effects Explain Treatment Effect Heterogeneity written by Marianne P. Bitler and published by . This book was released on 2014 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Download or read book Doing Meta Analysis with R written by Mathias Harrer and published by CRC Press. This book was released on 2021-09-15 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including calculation and pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced but highly relevant topics such as network meta-analysis, multi-three-level meta-analyses, Bayesian meta-analysis approaches and SEM meta-analysis are also covered. A companion R package, dmetar, is introduced at the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide. The programming and statistical background covered in the book are kept at a non-expert level, making the book widely accessible. Features • Contains two introductory chapters on how to set up an R environment and do basic imports/manipulations of meta-analysis data, including exercises • Describes statistical concepts clearly and concisely before applying them in R • Includes step-by-step guidance through the coding required to perform meta-analyses, and a companion R package for the book

Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Download or read book Individual Treatment Effect Heterogeneity in Multiple Time Points Trials written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In biomedical studies, the treatment main effect is often expressed in terms of an "average difference." A treatment that appears superior based on the average effect may not be superior for all subjects in a population if there is substantial "subject-treatment interaction." A parameter quantifying subject-treatment interaction is inestimable in two sample completely randomized designs. Crossover designs have been suggested as a way to estimate the variability in individual treatment effects since an "individual treatment effect" can be measured. However, variability in these observed individual effects may include variability due to the treatment plus inherent variability of a response over time. We use the "Neyman - Rubin Model of Causal Inference" (Neyman, 1923; Rubin, 1974) for analyses. This dissertation consists of two parts: The quantitative and qualitative response analyses. The quantitative part focuses on disentangling the variability due to treatment effects from variability due to time effects using suitable crossover designs. Next, we propose a variable that defines the variance of a true individual treatment effect in a two crossover designs and show that they are not directly estimable but the mean effect is estimable. Furthermore, we show the variance of individual treatment effects is biased under both designs. The bias depends on time effects. Under certain design considerations, linear combinations of time effects can be estimated, making it possible to separate the variability due to time from that due to treatment. The qualitative section involves a binary response and is centered on estimating the average treatment effect and bounding a probability of a negative effect, a parameter which relates to the individual treatment effect variability. Using a stated joint probability distribution of potential outcomes, we express the probability of the observed outcomes under a two treatment, two periods crossover design. Maximum likelihood estimates of these probabilities are found using an iterative numerical method. From these, we propose bounds for an inestimable probability of negative effect. Tighter bounds are obtained with information from subjects that receive the same treatments over the two periods. Finally, we simulate an example of observed count data to illustrate estimation of the bounds.

Download or read book Estimation of Average Treatment Effects Using Panel Data when Treatment Effect Heterogeneity Depends on Unobserved Fixed Effects written by Shosei Sakaguchi and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper proposes a new panel data approach to identify and estimate the time-varying average treatment effect (ATE). The approach allows for treatment effect heterogeneity that depends on unobserved fixed effects. In the presence of this type of heterogeneity, existing panel data approaches identify the ATE for limited subpopulations only. In contrast, the proposed approach identifies and estimates the ATE for the entire population. The approach relies on the linear fixed effects specification of potential outcome equations and uses exogenous variables that are correlated with the fixed effects. I apply the approach to study the impact of a mother's smoking during pregnancy on her child's birth weight.

Download or read book Evaluating the Performance of Continuous Analysis of Symmetrically Predicted Endogenous Subgroups written by Anthony J. Gambino and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing and measuring treatment effect heterogeneity is essential to improving our understanding of the experimental "black box" and our expectations for how interventions' impacts may vary across diverse settings and contexts. However, this becomes difficult to accomplish when researchers are interested in how an intermediate variable (one measured after random assignment, such as a fidelity of implementation measure) may have been related to variation in the average treatment effect. An additional complexity commonly present in these scenarios is that the intermediate variable may have only been measured in one experimental group. Analysis of symmetrically predicted endogenous subgroups (ASPES) is an understudied statistical method that can allow researchers to assess how intermediate variables in their randomized experiments may have been related to heterogeneity in their average treatment effect. Two benefits of this method are that it can accommodate discrete or continuous intermediate variables, and it is designed to be applied in studies where the intermediate variable was only measured in one experimental group. ASPES has been studied in the setting of a discrete intermediate variable, but its performance in the setting of a continuous one has not received similar attention. Thus far, insufficient research has been done on the bias mechanisms present in the continuous ASPES estimator or its general performance across reasonable conditions researchers could expect to experience in practice. This dissertation research was an attempt to help fill these gaps in the literature and pave the way for future research on continuous ASPES. A Monte Carlo simulation study was conducted to evaluate the performance of continuous ASPES across several settings, including ones where the relationship between the intermediate variable and the average treatment effect was nonlinear, and ones where other intermediate variables related to the causal process were omitted. The simulation results showed promise for its application in large samples.

Download or read book Nonparametric Tests for Treatment Effect Heterogeneity written by and published by . This book was released on 2006 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: A large part of the recent literature on program evaluation has focused on estimation of the average effect of the treatment under assumptions of unconfoundedness or ignorability following the seminal work by Rubin (1974) and Rosenbaum and Rubin (1983). In many cases however, researchers are interested in the effects of programs beyond estimates of the overall average or the average for the subpopulation of treated individuals. It may be of substantive interest to investigate whether there is any subpopulation for which a program or treatment has a nonzero average effect, or whether there is heterogeneity in the effect of the treatment. The hypothesis that the average effect of the treatment is zero for all subpopulations is also important for researchers interested in assessing assumptions concerning the selection mechanism. In this paper we develop two nonparametric tests. The first test is for the null hypothesis that the treatment has a zero average effect for any subpopulation defined by covariates. The second test is for the null hypothesis that the average effect conditional on the covariates is identical for all subpopulations, in other words, that there is no heterogeneity in average treatment effects by covariates. Sacrificing some generality by focusing on these two specific null hypotheses we derive tests that are straightforward to implement

Download or read book The Handbook of Historical Economics written by Alberto Bisin and published by Elsevier. This book was released on 2021-04-27 with total page 1002 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Historical Economics guides students and researchers through a quantitative economic history that uses fully up-to-date econometric methods. The book's coverage of statistics applied to the social sciences makes it invaluable to a broad readership. As new sources and applications of data in every economic field are enabling economists to ask and answer new fundamental questions, this book presents an up-to-date reference on the topics at hand. Provides an historical outline of the two cliometric revolutions, highlighting the similarities and the differences between the two Surveys the issues and principal results of the "second cliometric revolution" Explores innovations in formulating hypotheses and statistical testing, relating them to wider trends in data-driven, empirical economics

Download or read book Comparative Effectiveness Review Methods written by U. S. Department of Health and Human Services and published by Createspace Independent Pub. This book was released on 2013-05-17 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Agency for Healthcare Research and Quality (AHRQ) commissioned the RTI International–University of North Carolina at Chapel Hill (RTI-UNC) Evidence-based Practice Center (EPC) to explore how systematic review groups have dealt with clinical heterogeneity and to seek out best practices for addressing clinical heterogeneity in systematic reviews (SRs) and comparative effectiveness reviews (CERs). Such best practices, to the extent they exist, may enable AHRQ's EPCs to address critiques from patients, clinicians, policymakers, and other proponents of health care about the extent to which “average” estimates of the benefits and harms of health care interventions apply to individual patients or to small groups of patients sharing similar characteristics. Such users of reviews often assert that EPC reviews typically focus on broad populations and, as a result, often lack information relevant to patient subgroups that are of particular concern to them. More important, even when EPCs evaluate literature on homogeneous groups, there may be varying individual treatment for no apparent reason, indicating that average treatment effect does not point to the best treatment for any given individual. Thus, the health care community is looking for better ways to develop information that may foster better medical care at a “personal” or “individual” level. To address our charge for this methods project, the EPC set out to answer six key questions (KQ). Key questions for methods report on clinical heterogeneity include: 1. What is clinical heterogeneity? a. How has it been defined by various groups? b. How is it distinct from statistical heterogeneity? c. How does it fit with other issues that have been addressed by the AHRQ Methods Manual for CERs? 2. How have systematic reviews dealt with clinical heterogeneity in the key questions? a. What questions have been asked? b. How have they pre-identified population subgroups with common clinical characteristics that modify their intervention-outcome association? c. What are best practices in key questions and how these subgroups have been identified? 3. How have systematic reviews dealt with clinical heterogeneity in the review process? a. What do guidance documents of various systematic review groups recommend? b. How have EPCs handled clinical heterogeneity in their reviews? c. What are best practices in searching for and interpreting results for particular subgroups with common clinical characteristics that may modify their intervention-outcome association? 4. What are critiques in how systematic reviews handle clinical heterogeneity? a. What are critiques from specific reviews (peer and public) on how EPCs handled clinical heterogeneity? b. What general critiques (in the literature) have been made against how systematic reviews handle clinical heterogeneity? 5. What evidence is there to support how to best address clinical heterogeneity in a systematic review? 6. What questions should an EPC work group on clinical heterogeneity address? Heterogeneity (of any type) in EPC reviews is important because its appearance suggests that included studies differed on one or more dimensions such as patient demographics, study designs, coexisting conditions, or other factors. EPCs then need to clarify for clinical and other audiences, collectively referred to as stakeholders, what are the potential causes of the heterogeneity in their results. This will allow the stakeholders to understand whether and to what degree they can apply this information to their own patients or constituents. Of greatest importance for this project was clinical heterogeneity, which we define as the variation in study population characteristics, coexisting conditions, cointerventions, and outcomes evaluated across studies included in an SR or CER that may influence or modify the magnitude of the intervention measure of effect (e.g., odds ratio, risk ratio, risk difference).

Download or read book Treatment Heterogeneity and Potential Outcomes in Linear Mixed Effects Models written by Troy E. Richardson and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies commonly focus on estimating a mean treatment effect in a population. However, in some applications the variability of treatment effects across individual units may help to characterize the overall effect of a treatment across the population. Consider a set of treatments, {T, C}, where T denotes some treatment that might be applied to an experimental unit and C denotes a control. For each of N experimental units, the duplet {gamma[subscript]Ti, gamma[subscript]Ci}, i=1,2 ..., N, represents the potential response of the i[superscript]th experimental unit if treatment were applied and the response of the experimental unit if control were applied, respectively. The causal effect of T compared to C is the difference between the two potential responses, gamma[subscript]Ti- gamma[subscript]Ci. Much work has been done to elucidate the statistical properties of a causal effect, given a set of particular assumptions. Gadbury and others have reported on this for some simple designs and primarily focused on finite population randomization based inference. When designs become more complicated, the randomization based approach becomes increasingly difficult. Since linear mixed effects models are particularly useful for modeling data from complex designs, their role in modeling treatment heterogeneity is investigated. It is shown that an individual treatment effect can be conceptualized as a linear combination of fixed treatment effects and random effects. The random effects are assumed to have variance components specified in a mixed effects "potential outcomes" model when both potential outcomes, gamma[subscript]T, gamma[subscript]C, are variables in the model. The variance of the individual causal effect is used to quantify treatment heterogeneity. Post treatment assignment, however, only one of the two potential outcomes is observable for a unit. It is then shown that the variance component for treatment heterogeneity becomes non-estimable in an analysis of observed data. Furthermore, estimable variance components in the observed data model are demonstrated to arise from linear combinations of the non-estimable variance components in the potential outcomes model. Mixed effects models are considered in context of a particular design in an effort to illuminate the loss of information incurred when moving from a potential outcomes framework to an observed data analysis.

Download or read book Evaluating the impacts of the FAO s Cash Programme in Mali written by Dao, T.H., Daidone, S., Kangasniemi, M. and published by Food & Agriculture Org.. This book was released on 2021-05-27 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents findings from a study of the economic and food security impacts of the FAO project "Productive safety nets as a tool to reinforce the resilience in the Sahel" (hereinafter referred to as the project/programme Cash+) that took place from April 2015 to February 2017. The project aimed to strengthen the resilience of households vulnerable to shocks and heavily affected by food insecurity and was carried out in two countries: Mali and Mauritania. Unconditional in-cash and in-kind transfers were distributed to the most vulnerable households, which also benefited from other training and technical activities which aimed to strengthen their productive capacity. This report focuses on Mali, where the FAO Cash+ project targeted 36 villages in the Nioro Cercle (“Cercle de Nioro du Sahel”) of Kayes region. Two sets of intervention of equal financial value have been provided to the beneficiaries: i) one called "Cash Only" consisting primarily of a cash transfer and ii) another called "Cash+" associating a cash transfer with distribution of goats, training on good practices of livestock breeding and raising awareness of children's nutrition. The main objective of this report is evaluating the impacts of the FAO’s Cash+ programme in Mali and investigating eventual heterogenous effects of the two types of treatment. Using data collected nine months after the project ended, we analyse its lasting impacts across various livelihood aspects, namely food security, dietary diversity, hygiene practices, food and non-food expenditures, livestock production, non-farm activities, aspirations and expectations.

Download or read book Examining the Foundations of Methods That Assess Treatment Effect Heterogeneity Across Intermediate Outcomes written by Avi Feller and published by . This book was released on 2015 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this study is to better understand how methods for estimating treatment effects of latent groups operate. In particular, the authors identify where violations of assumptions can lead to biased estimates, and explore how covariates can be critical in the estimation process. For each set of approaches, the authors first review the assumptions necessary for identification and discuss practical issues that arise in estimation; second, they then examine how covariates allow for improved estimation, and determine the conditions necessary for using covariates to identify causal effects in latent groups; and third, they then compare the different methods using simulation studies built from datasets constructed by imputing missing class membership and potential outcomes from real-world studies. This allows for examining the performance of the different techniques under a variety of plausible circumstances. Analyzed is data from the Job Search Intervention Study (JOBS II), a randomized evaluation of an intervention for unemployed workers consisting of a series of training sessions and also the Head Start Impact Study, a large-scale randomized evaluation of the Head Start program in which children randomized to treatment were offered a seat in a classroom in a Head Start program. The authors conclude that, in practice, randomized trials should attempt to collect such covariates by, for example, having expert assessment of likelihood of compliance collected at baseline and that for identification, many methods require assumptions that are quite strong.

Download or read book Assessing Treatment Effect Heterogeneity written by Konstantinos Papangelou and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Statistical Methods for Studying Heterogeneous Treatment Effects with Instrumental Variables written by Michael William Johnson and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing interest in estimating heterogeneous treatment effects in randomized and observational studies. However, most of the work relies on the assumption of ignorability, or no unmeasured confounding on the treatment effect. While instrumental variables (IV) are a popular technique to control for unmeasured confounding, there has been little research conducted to study heterogeneous treatment effects with the use of an IV. This dissertation introduces methods using an IV to discover novel subgroups, estimate their heterogeneous treatment effects, and identify individualized treatment rules (ITR) when ignorability is expected to be violated. In Chapter 2, we present a two-part algorithm to estimate heterogeneous treatment effects and detect novel subgroups using an IV with matching. The first part uses interpretable machine learning techniques, such as classification and regression trees, to discover potential effect modifiers. The second part uses closed testing to test for statistical significance of each effect modifier while strongly controlling the familywise error rate. We apply this method on the Oregon Health Insurance Experiment, estimating the effect of Medicaid on the number of days an individual's health does not impede their usual activities by using a randomized lottery as an instrument. In Chapter 3, we generalize methods to identify ITR using a binary IV to using multiple, discrete valued instruments, or equivalently, multilevel instruments. Several new problems arise when generalizing to multilevel instruments, requiring novel solutions. In particular, multilevel IV give rise to many latent subgroups that may experience heterogeneous treatment effects. Additionally, it may be unclear how to combine and compare the different levels of the IV to estimate treatment heterogeneity. We provide methods that use a prediction of the latent subgroup to identify optimal ITR, and methods to dynamically combine levels of the multilevel IV to estimate the heterogeneous treatment effects, effectively individualizing estimation of an ITR. Further, we provide and discuss necessary and sufficient conditions to identify an optimal ITR using a multilevel IV. We apply our methods to identify an ITR for two competing treatments, carotid endarterectomy and carotid artery stenting, on preventing stroke or death within 30 days of their index procedure.