Download or read book Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials written by Meinhard Kieser and published by Springer Nature. This book was released on 2020-11-19 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided. The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable for beginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.

Download or read book Resonance Self Shielding Calculation Methods in Nuclear Reactors written by Liangzhi Cao and published by Woodhead Publishing. This book was released on 2022-10-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resonance Self-Shielding Calculation Methods in Nuclear Reactors presents the latest progress in resonance self-shielding methods for both deterministic and Mote Carlo methods, including key advances over the last decade such as high-fidelity resonance treatment, resonance interference effect and multi-group equivalence. As the demand for high-fidelity resonance self-shielding treatment is increasing due to the rapid development of advanced nuclear reactor concepts and progression in high performance computational technologies, this practical book guides students and professionals in nuclear engineering and technology through various methods with proven high precision and efficiency. - Presents a collection of resonance self-shielding methods, as well as numerical methods and numerical results - Includes new topics in resonance self-shielding treatment - Provides source codes of key calculations presented

Download or read book Carbon Emission Calculation Methods for Highway Tunnel Construction written by Chun Guo and published by Springer Nature. This book was released on 2021-09-01 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the research background and significance of carbon emissions in the tunnel industry and systematically reviewed the research progresses of carbon emission researches for tunnels, LCA (life cycle assessment) research framework, and uncertainty research progress. The authors propose a novel modular carbon emission calculation method for highway tunnel construction and expounds on the modular LCA system boundary theory of tunnel construction. This method does not require abundant knowledge of LCA modeling, which is convenient for general engineering and technical personnel to calculate the carbon emission level of tunnel construction. The calculation formulas for input and carbon emissions of each module are provided. It also analyzes the parameter uncertainty, model uncertainty, and scenario uncertainty of the carbon emissions from tunnel construction by the Monte Carlo method. Further, this book proposes the fitting model of carbon emissions of unit engineering quantity in tunnel construction, which benefits to simplify the calculation of carbon emissions.This book is mainly aimed at engineering and technical personnel in the construction industry, especially tunnel and underground engineering, including tunnel design engineers; tunnel construction engineers, experts, and scholars; tunnel owners; management departments.

Download or read book The DV X Molecular Orbital Calculation Method written by Tomohiko Ishii and published by Springer. This book was released on 2014-11-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multi-author contributed volume contains chapters featuring the development of the DV-Xα method and its application to a variety of problems in Materials Science and Spectroscopy written by leaders of the respective fields. The volume contains a Foreword written by the Chairs of Japanese and Korea DV-X alpha Societies. This book is aimed at individuals working in Quantum Chemistry.

Download or read book Standard Calculation Methods for Structural Fire Protection written by American Society of Civil Engineers and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard ASCE/SEI/SFPE 29-05 provides the most current and proven methods for calculating the fire resistance of selected structural members and barrier assemblies.

Download or read book Calculation Procedure for Sand Transport by Wind on Natural Beaches written by Abdel-Latif Kadib and published by . This book was released on 1964 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Computer Methods Part A written by and published by Academic Press. This book was released on 2009-03-10 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data. These better analyses have enhanced the conclusions that can be drawn from biomedical data, and they have changed the way that experiments are designed and performed. This volume, along with previous and forthcoming 'Computer Methods' volumes for the Methods in Enzymology serial, aims to inform biomedical researchers about recent applications of modern data analysis and simulation methods as applied to biomedical research.

Download or read book Settlement Calculation on High Rise Buildings written by Xiangfu Chen and published by Springer Science & Business Media. This book was released on 2011-12-21 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Settlement Calculation on High-Rise Buildings: Theory and Application" discusses, for the first time, the latest developments in settlement calculation theory and case studies including analysis and research results for more than thirty high-rise buildings with a height of 100m-420m. Rigorously reviewed, this book provides a number of useful methods and a unique practical perspective on settlement calculation of high-rise buildings. It covers soft soil constitutive model and computation parameters, the theory of soil stress and strain, and new methods of settlement calculation in super long pile and space-varying rigidity group piles, box(raft), pile-box(raft), diaphragm wall-pile-box(raft) and rock foundation on high-rise buildings. This book is a useful design and construction resource for scientists and engineers, as well as for professionals in structural mechanics and geotechnical engineering. Professor Xiangfu Chen is chairman of the Academic Commission of China State Construction Engineering Corporation (CSCEC), chief engineer of China Construction Beijing Design and Research Institute, and a Doctoral Tutor at Tongji University Shanghai.

Download or read book An Investigation of Two Variations of the Gas Generator Method to Calculate the Thrust of the Afterburning Turbofan Engines Installed in an F 111A Airplane written by Frank W. Burcham and published by . This book was released on 1971 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Food Engineering Practice written by Kenneth J. Valentas and published by CRC Press. This book was released on 1997-07-23 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food engineering has become increasingly important in the food industry over the years, as food engineers play a key role in developing new food products and improved manufacturing processes. While other textbooks have covered some aspects of this emerging field, this is the first applications-oriented handbook to cover food engineering processes and manufacturing techniques. A major portion of Handbook of Food Engineering Practice is devoted to defining and explaining essential food operations such as pumping systems, food preservation, and sterilization, as well as freezing and drying. Membranes and evaporator systems and packaging materials and their properties are examined as well. The handbook provides information on how to design accelerated storage studies and determine the temperature tolerance of foods, both of which are important in predicting shelf life. The book also examines the importance of physical and rheological properties of foods, with a special look at the rheology of dough and the design of processing systems for the manufacture of dough. The final third of the book provides useful supporting material that applies to all of the previously discussed unit operations, including cost/profit analysis methods, simulation procedures, sanitary guidelines, and process controller design. The book also includes a survey of food chemistry, a critical area of science for food engineers.

Download or read book Passive Solar Calculation Methods written by CCB/Cumali Associates and published by . This book was released on 1979 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Heterogeneous Reactor Calculation Methods written by Carl N. Klahr and published by . This book was released on 1961 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pedestrian and Evacuation Dynamics 2008 written by Wolfram W. F. Klingsch and published by Springer Science & Business Media. This book was released on 2010-03-11 with total page 807 pages. Available in PDF, EPUB and Kindle. Book excerpt: The international conference on "Pedestrian and Evacuation Dynamics", held on February 27-29, 2008 at Wuppertal University in Germany, was the fourth in this series after successful meetings in Duisburg (2001), Greenwich (2003) and Vienna (2005). The conference was aimed at improving the scientific exchange between scientists, experts and practitioners of various fields of pedestrian and evacuation dynamics and featured: the analysis of evacuation processes and pedestrian motion, modeling of pedestrian dynamics in various situations, experiments on pedestrian dynamics, human behavior research, regulatory action. All these topics are included in this book to give a broad and state-of-the-art overview of pedestrian and evacuation dynamics.

Download or read book Daylighting Performance and Design written by Gregg D. Ander and published by John Wiley & Sons. This book was released on 2003-05-30 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Daylighting is the process of incorporating natural lighting into the design of buildings. The new edition of this concise resource makes theory, calculations, and execution crystal clear with straight-to-the-solution examples and uncluttered language. In a practical, applied approach, this book covers daylighting strategies, materials, and methods of construction, including significant advances in lighting and daylighting technology.

Download or read book Issues in Mathematics Teaching written by Peter Gates and published by Psychology Press. This book was released on 2001 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing a range of issues relating to the teaching of mathematics, this text builds on knowledge already gained on ITT and PGCE courses and encourages teachers to consider and reflect on the issues that affect their teaching skills.

Download or read book Asset Accounting Configuration in SAP ERP written by Andrew Okungbowa and published by Apress. This book was released on 2015-12-31 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, noted expert Andrew Okungbowa explains SAP Asset Accounting (FI-AA) in SAP-ERP, including its associated business benefits, and guides you through the considerable complexities of SAP-ERP configuration. Using FI-AA for fixed asset management enables you to manage assets in multinational companies across a broad range of industries and produce reports to meet various needs in line with legal requirements. Configuring SAP-ERP can be a daunting exercise, however, and there are few resources that address these issues. Asset Accounting Configuration in SAP ERP fills that resource gap by covering the major aspects of SAP FI-AA for anyone with SAP experience and the basic accounting knowledge and bookkeeping skills necessary to apply configuration. It provides configuration explanations in the simplest forms possible and provides step-by-step guidance with illustrations and practical examples. What You'll Learn “li>In-depth coverage of FI-AA syllabus How to configure FI-AA accounting in SAP How to integrate FI-AA accounting with other SAP modules How to explain the functionalities of SAP FI-AA Knowledge gained from real-world practical examples and case studies Who This Book Is For The key target audience for this book includes SAP consultants, developers, accountants, support organizations and beginners. It is also a resourceful learning manual for universities and institutions whose curricula covers SAP-ERP Asset Accounting.

Download or read book The Finite Element Method written by Bofang Zhu and published by John Wiley & Sons. This book was released on 2018-03-12 with total page 873 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the Finite Element Method (FEM), this book provides the fundamentals together with a wide range of applications in civil, mechanical and aeronautical engineering. It addresses both the theoretical and numerical implementation aspects of the FEM, providing examples in several important topics such as solid mechanics, fluid mechanics and heat transfer, appealing to a wide range of engineering disciplines. Written by a renowned author and academician with the Chinese Academy of Engineering, The Finite Element Method would appeal to researchers looking to understand how the fundamentals of the FEM can be applied in other disciplines. Researchers and graduate students studying hydraulic, mechanical and civil engineering will find it a practical reference text.