Download or read book Calcium Study to Alzheimer s Therapeutics written by Seung Hyun Yoo and published by Cambridge Scholars Publishing. This book was released on 2024-04-26 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be informative and challenging for scientists, enlightening and stimulating for intellectuals and serious students, and highly beneficial and interesting for Alzheimer’s workers and the public. The first half is a historical account of recent scientific discoveries on calcium (Ca2+) storage and control organelles in cells, explaining the major role of secretory granules in the cytoplasm and the newly identified nucleoplasmic Ca2+ store vesicles in the nucleus. The second half not only presents unprecedented and highly relevant information on the pathogenic process of Alzheimer’s disease and current research, but also introduces Alzheimer’s therapeutics, which is ready to proceed to clinical trials. In light of this, it contains valuable information which will greatly benefit Alzheimer’s workers, patients, the families, and anybody interested in Alzheimer’s disease.

Download or read book Calcium Signalling in Alzheimer s Disease written by Mounia Chami and published by MDPI. This book was released on 2021-04-22 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) is the most well-known neurodegenerative disorder, causing dementia. In recent decades, several studies have reported calcium dysregulation in AD occurring through the intervention of several calcium receptors and channels, and affecting different cellular compartments, such as mitochondria, the endoplasmic reticulum, lysosomes, and microdomains within the plasma membrane. Calcium signalling dysregulation is now considered a common proximal cause of dysfunctional neurons and glial supporting cells. This book gathers the newest results and advances in calcium signaling deregulation mechanisms in AD, how they are linked to other players involved in AD, and the potential therapies targeting calcium alterations to treat AD.

Download or read book Examinations Into the Calcium Hypothesis of Alzheimer s Disease written by Dustin J. Shilling and published by . This book was released on 2013 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) is devastating to the patient, their family and friends, and represents a significant fiscal burden to our society. Currently available therapeutics provide only mild symptomatic relief and do not alter the course of the disease. Developing the next generation of disease modifying therapies requires an understanding of the early cellular changes responsible for AD. A hindrance to progress is the fact that most patients develop AD sporadically. However, mutations in the presenilin (PS) homologs cause dominantly inherited, early-onset AD. These mutations provide an important tool for understanding the cellular changes that cause AD. One consequence of PS mutations is exaggerated intracellular Ca2+ ([Ca2+]i) signaling. However, the mechanisms underlying this phenomenon remain controversial and its role in AD pathogenesis is unknown. Presented here are data indicating that exaggerated [Ca2+]i signaling is dependent upon the inositol 1,4,5-trisphosphate receptor (InsP3R) and contributes to AD pathogenesis in vivo. We began our studies by testing multiple proposed mechanisms for exaggerated [Ca2+]i signaling. To do this we employed multiple Ca2+ imaging protocols and Ca2+ indicators to directly measure ER Ca2+ dynamics in several cell systems. We found that decreasing InsP3R protein level rescues exaggerated [Ca2+]i signaling in primary cortical neurons and hippocampal slices from mutant PS1 expressing mice. We then determined the contribution of exaggerated [Ca2+]i signaling to AD pathogenesis. Using a combination of genetic, biochemical, electrophysiological and behavioral techniques, we found that rescue of exaggerated [Ca2+]i signaling dramatically attenuates mild cognitive impairment and AD phenotypes in AD mouse models. Reduction of InsP3R1 protein level in PS1M146V-KIN mice rescued enhanced hippocampal ryanodine receptor protein level, enhanced hippocampal synaptic potentiation, and constitutive activation of the CaMKIV-CREB transcriptional pathway. In 3xTg mice, reduced InsP3R1 protein level attenuated Abeta and phospho-tau accumulation and hippocampal electrophysiology and memory impairments. Together, these results reveal that mutant PS-associated exaggerated [Ca2+]i signaling is InsP3R1-dependent, a proximal event, and contributes to the development of AD in vivo. These findings advance our understanding of the pathological role of exaggerated [Ca2+]i signaling in AD and identify several novel targets for the development of disease modifying therapeutics.

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Download or read book Capacitative Calcium Entry written by James W. Putney and published by Springer. This book was released on 1997-06-15 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alzheimer s Disease Drug Development written by Jeffrey Cummings and published by Cambridge University Press. This book was released on 2022-03-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Download or read book Current State of Alzheimer s Disease Research and Therapeutics written by and published by Academic Press. This book was released on 2012-07-24 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology explores the Current State of Alzheimer's Disease Research and Therapeutics. Chapters cover such topics as the The role heat shock proteins play in the Alzheimer's Theater, Gamma-Secretase as a Target for Alzheimer's Disease, and Identification of protein kinase C for the treatment of dementias. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. - Explores the current state of Alzheimer's disease research and therapeutics - Chapters cover a variety of topics such as the role heat shock proteins play in the Alzheimer's theater, gamma-secretase as a target for Alzheimer's disease, and identification of protein kinase C for the treatment of dementias - With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Download or read book Ion Channels Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Ion Channels. The editors have built Ion Channels—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ion Channels in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ion Channels—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Mental Disorders Advances in Research and Treatment 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mental Disorders. The editors have built Mental Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mental Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Mental Disorders: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Basic Clinical and Therapeutic Aspects of Alzheimer s and Parkinson s Diseases written by Toshiharu Nagatsu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 797 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume work contains the full text of the oral and poster presentations and the general discussion at the round table discussion of the Second International Conference on Alzheimer's and Parkinson's Diseases: Basic and Therapeutic Strategies, held at the Kyoto Park Hotel in Kyoto, Japan, on November 6-10, 1989. The First Conference was held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. The record of this First Conference was published by Plenum Press in 1986 as Volume 29 in Advances in Behavioral Biology, under the title "Alzheimer's and Parkinson's Diseases: Strategies for Research and Development." We are happy that the comprehensive texts of the oral and poster presentations of the Second Conference could again be published within the framework of this series. Since the First Conference in 1985, rapid progress has been made in both basic and 'therapeutic aspects of these diseases. About 700 scientists from allover the world participated in the Second Conference, and 300 papers were presented in oral and poster sessions. Many people and organizations have helped to organize this multi disciplinary international conference and hence have contributed to the scientific quality of these two volumes. We thank the members of the organizing committee, the organizations that provided financial support, and the contributing scientists for their enthusiastic participation. These two volumes follow the same publishing philosophy as the volume derived from the First Conference. They span a broad spectrum of topics and bridge preclinical and clinical concepts related to these diseases.

Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alzheimer s Disease written by Khalid Iqbal and published by John Wiley & Sons. This book was released on 2003-01-24 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Download or read book Advances in Dementia Research and Treatment 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Dementia Research and Treatment: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Dementia Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Dementia Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Pharmacological Mechanisms in Alzheimer s Therapeutics written by A. Claudio Cuello and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for effective therapy to treat Alzheimer’s disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.

Download or read book Deciphering Drug Targets for Alzheimer s Disease written by Dileep Kumar and published by Springer Nature. This book was released on 2023-10-02 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.

Download or read book Epilepsy and Alzheimer s disease shared pathology clinical presentations and targets for treatment written by Beth Leeman-Markowski and published by Frontiers Media SA. This book was released on 2024-09-30 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging data suggest a link between Alzheimer’s disease (AD) and epilepsy. AD and other dementias pose increased risk for seizures, with seizure incidence in AD up to ten times greater than in age-matched controls. Mouse models of AD also demonstrate seizures and abnormal spikes or sharp wave discharges (“interictal epileptiform discharges” [IEDs]) on electroencephalography (EEG). Seizures and IEDs may underlie fluctuating cognitive abilities in AD, with the impact of antiseizure medication (ASM) requiring further investigation. Many epilepsy patients have memory and other cognitive deficits, due to multiple factors. Most adult-onset epilepsy occurs in people =60 years of age, and epilepsy patients are at increased risk of developing dementia. Hyperphosphorylated tau and amyloid deposits were found in resected temporal lobe tissue of epilepsy patients, similar to AD, and increased total and phosphorylated tau levels in the cerebrospinal fluid may predict the onset of AD and other dementias. The mechanisms underlying the associations between AD, epilepsy, tau deposition, and beta amyloid plaques, and their relationships to clinical features, are unknown. Some epilepsy patients develop dementia, and some AD patients develop seizures, while others do not. Analyses of resected tissue in epilepsy patients also suggest variable amyloid and tau deposition across patients and studies. Who is at risk? What does shared pathology indicate regarding disease development, progression, and treatment? Better understanding of the associations between epilepsy and dementia with respect to epidemiology, pathophysiology, genetics, clinical presentations, and treatment approaches based on animal models and human studies is needed to optimize patient care. Insight into the relationship between epilepsy and AD requires various approaches, including tissue analysis, imaging, genetic techniques, cognitive testing, and electroencephalography in animals and humans. We welcome manuscripts that span these approaches, including original research articles, brief research articles, clinical trials, case reports, reviews, systematic reviews, mini-reviews, methods articles, hypothesis and theory articles, perspectives, and opinions. Themes may include: • Diagnosis (e.g., seizure or interictal discharge detection in dementia patients, distinguishing comorbid dementia from epilepsy-related cognitive dysfunction) • Epidemiology (e.g., incidence and prevalence of comorbid AD and epilepsy, occurrence of epilepsy in other dementias, seizure types, age or stage of onset) • Genetic risk factors • Pathophysiology underlying seizure generation in AD and cognitive decline in epilepsy • Treatment approaches (e.g., effects of ASMs on cognitive decline, impact of disease modifying AD treatments on seizures, neurostimulation) • What can be learned from other disorders in which cognitive deficits and seizures are common (i.e., traumatic brain injury)

Download or read book Starving into Remission Alzheimer s Parkinson s and Multiple Sclerosis Nutritional Integrative Therapies written by James C. Tibbetts and published by Lulu.com. This book was released on 2016-11-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's, Parkinson's, and MS can be brought into permanent remission on a Living Foods nutritional therapy approach. As a nutritional lifestyle these diseases can be stopped and kept at a distance once they are put into remission through this Live-food nutrition therapy. This book presents real people, some cured and some not, it is about clinical experience, journal studies, testimonials and advanced nutritional understandings. This work is about five years of research. It involves a major lifestyle change moving into a Live-Food or raw vegan diet, and doing juice fasting, smoothies, and juicing. Having a positive spiritual approach and exercise routine is also helpful. The case studies and testimonials are part of the evidence that these neuro-degenerative diseases can be put into complete remission.