Download or read book Advanced Tactical Engagement Simulation Concepts ATESC written by and published by . This book was released on 1999 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Trainers for force on force training exercises at the Army's maneuver combat training centers and at home station are often distracted from coaching and mentoring responsibilities by the need to perform exercise control and feedback (OAF) functions. The fielding of new weapons and reconnaissance, surveillance, and target acquisition (RSTA) systems as part of force modernization will overwhelm trainers with new requirements unless improved concepts for tactical engagement simulation (TES) and instrumentation systems (IS) are implemented. This study produced an online database that was used to assess the benefits of implementing various new TES and IS concepts, or combinations of concepts, in terms of the number of OAF functions automated, the extent to which each function disrupts trainer coaching and mentoring activities, the number of gaps in training feedback addressed, and the number of systems to which each function or feedback gap applies. The TES and IS concepts we evaluated were designed to address the additional goal of avoiding the stove-pipe nature of past systems. The online database can be used to extent%mine the benefits of additional TES and IS concepts. The study sponsor is using the results to define requirements for future TES systems and IS for live training at CTCs and home stations."--DTIC.
Download or read book Soil Survey of various Counties Etc written by and published by . This book was released on 1963 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boots on the Ground written by Johanu Botha and published by University of Toronto Press. This book was released on 2022-03-31 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last century, the scale of Canada’s domestic disaster response system has grown significantly due to the country’s increased capacity for emergency management and the rise in natural hazards. However, there has been no systematic assessment of how effectively this multilevel system, which includes all levels of government and the military, has been integrated, and how efficient this system actually is at responding to high-level disasters. Using in-depth archival analysis and interviews with senior military and civilian officials on the inside, Boots on the Ground provides a detailed examination of Canada’s disaster response system. Including policy recommendations focused on the expansion of emergency management networks, the maintenance of Canada’s decentralized emergency management system, and disaster response resources for First Nations communities, Boots on the Ground aims to highlight opportunities to improve Canada’s urgent disaster response. Boots on the Ground offers helpful lessons for students, policy makers, emergency management practitioners, and military officers, ensuring that readers gain concrete insights into the strategic and efficient implementation of disaster response initiatives.
Download or read book Hearings written by United States. Congress. House. Committee on Appropriations and published by . This book was released on 1942 with total page 1652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Soil Survey Washabaugh County South Dakota written by Robert E. Radeke and published by . This book was released on 1969 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Models of Argument written by P. Baroni and published by IOS Press. This book was released on 2010 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents papers from the Third Conference on Computational Models of Argument, held in September 2010 in Desanzano del Garda, Italy. Providing a view of this important research field, this book is of interest to those involved in the use and development of artificial intelligence systems.
Download or read book Handbook of Nucleobase Complexes written by James R. Lusty and published by CRC Press. This book was released on 2017-11-22 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes methods of preparation, characterization, toxicity, and therapeutic indices of transition metal complexes of the naturally occurring heterocyclic nucleobases and their derivatives. Modes of coordination are listed together with the relevant spectral data and major methods of investigation. Where appropriate, the spectrum of the sample is included in the pertinent section on spectroscopy. Data on the uncomplexed bases, such as solubility, pK, accepted structure(s) in the solid state and solutions, and the natural occurrence of the base are also included. Volume II of this work provides the spectroscopic data to accompany Volume I. Volume II is divided into two sections: Section 1 summarizes the data and Section 2 is comprised of figures. In Section 1, the complexes are arranged according to the method of study. In Section 2, figures are listed by base type and follow the sequence of Volume I, mainly complexes of the pyrimidine bases, nucleosides and nucleotides, and then purine bases, nucleosides, and nucleotides.
Download or read book Hearings written by United States. Congress. Joint Committee ... and published by . This book was released on 1942 with total page 1826 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hearings written by United States. Congress. House and published by . This book was released on 1942 with total page 2558 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Soil Survey Shannon County South Dakota written by Robert E. Radeke and published by . This book was released on 1971 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Biomarkers for Predicting Response to Cancer Immunotherapy written by Jinghua Pan and published by Frontiers Media SA. This book was released on 2023-07-11 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.
Download or read book Tumor Microenvironment and Metabolic Reprogramming in Cancer written by Wei Chong and published by Frontiers Media SA. This book was released on 2024-10-18 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic reprogramming is the hallmark of malignant tumors. Both metabolic phenotype and metabolic dependence are changed during the development of cancer from precancerous tissue to local invasion to metastasis. Cancer cells autonomously alter their flux through various metabolic pathways in order to meet the increased bioenergetic and biosynthetic demand as well as mitigate oxidative stress required for cancer cell proliferation and survival. The change of the tumor microenvironment (TME) is a key factor driving tumor metabolic reprogramming. The tumor microenvironment denotes the non-cancerous cells and components presented in the tumor, including molecules produced and released by them. The constant interactions between tumor cells and the tumor microenvironment play decisive roles in tumor initiation, progression, metastasis, and response to therapies. More and more evidence has pointed out that the change in the tumor microenvironment is a key factor driving tumor metabolic reprogramming. However, the specific relationship between tumor metabolic reprogramming and tumor microenvironment remains unclear. Indeed, emerging evidence indicates that cancer cells are able to suppress the anti-tumor immune response by competing for and depleting essential nutrients or otherwise reducing the metabolic fitness of tumor-infiltrating immune cells. The actual process of how metabolic reprogramming and cancer immune response affect each other has not been understood.
Download or read book Orange Coast Magazine written by and published by . This book was released on 1989-10 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orange Coast Magazine is the oldest continuously published lifestyle magazine in the region, bringing together Orange County¹s most affluent coastal communities through smart, fun, and timely editorial content, as well as compelling photographs and design. Each issue features an award-winning blend of celebrity and newsmaker profiles, service journalism, and authoritative articles on dining, fashion, home design, and travel. As Orange County¹s only paid subscription lifestyle magazine with circulation figures guaranteed by the Audit Bureau of Circulation, Orange Coast is the definitive guidebook into the county¹s luxe lifestyle.
Download or read book Dictionary Catalog of the Research Libraries of the New York Public Library 1911 1971 written by New York Public Library. Research Libraries and published by . This book was released on 1979 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Genetics and Emerging Therapies for Epithelial Ovarian Cancer Basic Research and Clinical Perspectives written by Stergios Boussios and published by Frontiers Media SA. This book was released on 2023-11-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial ovarian cancer (EOC) is the most lethal gynecological disorder due to a lack of effective early detection strategies. Worldwide, approximately 230,000 women are diagnosed annually, whereas 150,000 die. It represents the seventh most commonly diagnosed cancer among women in the world with 5-year survival rate of 46%. More than one-fifth of EOC have been related to hereditary conditions. Considerable efforts have been made to implement screening of the general population to diagnose EOC early; nevertheless, this has been ineffective and there is no approved strategy. Nowadays, new approaches for early diagnosis and prevention based on molecular genomics are in development. Whole genome sequencing has established the potency of the somatic genome, characterised with diverse DNA repair deficiencies that can be used to stratify EOCs into distinct biological groups with predictive signatures of resistance or relapse. The incorporation of next-generation sequencing (NGS) into clinical practice remains challenging for two reasons. Firstly, the EOC risk is not clear for some of the included genes and secondly, the variant of uncertain significance rates increase as more genes are analyzed. Finally, beyond germline pathogenic variants, somatic mutations may also affect therapeutic choices, and as such upfront tumor sequencing may be equally important to NGS, particularly as we continue to challenge treatment paradigms in the first‐line management of EOC.
Download or read book Chronology of Canadian military aviation written by H. A. Halliday and published by University of Ottawa Press. This book was released on 1975-01-01 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: A chronological listing of significant events in the evolution of Canadian military aviation from 1883 to 1974, including the significance of individual achievements of the many men and women who contributed to its development.
Download or read book National War Agencies Appropriation Bill for 1945 written by United States. Congress. House. Appropriations and published by . This book was released on 1944 with total page 1870 pages. Available in PDF, EPUB and Kindle. Book excerpt:
