Download or read book C C Bond Activation written by Guangbin Dong and published by Springer. This book was released on 2014-09-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students

Download or read book C H Bond Activation and Catalytic Functionalization I written by Pierre H. Dixneuf and published by Springer. This book was released on 2015-12-18 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal.

Download or read book Special Topic Methods Involving C C Bond Activation and Cleavage written by Erick M. Carreira and published by . This book was released on 2015 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Carbon carbon Bond Formation written by Robert L. Augustine and published by CRC Press. This book was released on 1979-04-01 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Activation and Functionalization of C H Bonds written by Karen I. Goldberg and published by ACS Symposium. This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Activation and Functionalization of C-H Bonds explores recent developments in the reaction chemistry of solution-phase transition-metal based systems with simple hydrocarbons and with more complex organic molecules. More than 20 internationally leading research groups contributed to this volume, and their chapters cover such topics as fundamental theoretical and mechanistic studies of C-H bond activation by metal complexes, catalytic systems for alkane functionalization, and new applications in synthetic organic chemistry. An introductory chapter offers an overview of stoichiometric and catalytic reactions of C-H bonds with transition metal complexes. The C-H bond is the most widespread linkage in organic chemistry, present in virtually every organic molecule. Unfortunately, C-H bonds are famously resistant to selective chemical transformations. The development of methods for their selective transformations has enormous potential value in fields ranging from the chemistry of fuels (for example, the conversion of methane to methanol) to the synthesis of the most complex organic molecules.

Download or read book C C Bond Activation by Organometallic Compounds written by Chul Ho Jun and published by . This book was released on 1987 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Catalysis of Organic Reactions written by Robert L. Augustine and published by CRC Press. This book was released on 2020-09-10 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete updating of important developments in the study of catalysis as it applies to organic synthesis — with applications in major industrial processes. It covers a broad variety of catalytic processes — both homogeneous and heterogeneous.

Download or read book C H Activation for Asymmetric Synthesis written by Françoise Colobert and published by John Wiley & Sons. This book was released on 2019-11-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.

Download or read book Cleavage of Carbon Carbon Single Bonds by Transition Metals written by Masahiro Murakami and published by John Wiley & Sons. This book was released on 2015-09-21 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by leading experts and pioneers in the field, this is the first up-to-date book on this hot topic. The authors provide synthetic chemists with different methods to activate carbon-carbon sigma bonds in organic molecules promoted by transition metal complexes. They explain the basic principles and strategies for carbon-carbon bond cleavage and highlight recently developed synthetic protocols based on this methodology. In so doing, they cover cleavage of C-C bonds in strained molecules, reactions involving elimination of carbon dioxide and ketones, reactions via retroallylation, and cleavage of C-C bonds of ketones and nitriles. The result is an excellent information source for researchers in academia and industry working in the field of synthetic organic chemistry, while equally serving as supplementary reading for advanced courses in organometallic chemistry and catalysis.

Download or read book Amide Bond Activation written by Michal Szostak and published by MDPI. This book was released on 2019-07-12 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.

Download or read book Green Techniques for Organic Synthesis and Medicinal Chemistry written by Wei Zhang and published by John Wiley & Sons. This book was released on 2018-01-18 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Download or read book C O Bond Activation and C C Bond Formation Paths in Catalytic CO Hydrogenation written by Brett Loveless and published by . This book was released on 2012 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental mechanistic details regarding C-O bond activation and C-C bond formation remain unknown in catalytic CO hydrogenation to heavy hydrocarbons (Fischer-Tropsch synthesis, FTS). This study combines infrared spectroscopic and density functional theory methods (DFT) to first identify relevant surface CO coverages during FTS; reaction energy profiles are then calculated using DFT to determine the most facile path for C-O bond activation on Ru cluster surfaces. Kinetic responses of CO conversion rates and product selectivities to changes in H2 and CO pressures are measured in a packed-bed reactor at differential conversions on supported Ru catalysts to develop kinetic rate equations for FTS and corresponding sets of elementary reaction steps consistent with such equations. The effects of Ru cluster size on CO turnover rates, CO adsorption equilibrium constants, and CO conversion activation energies are also investigated to identify the Ru coordination environment in which C-O bonds are activated during FTS. C-C bond formation paths are then probed by measuring the effects of H2 and CO pressures on chain termination parameters, which provide a direct comparison between chain termination and chain propagation rates for all hydrocarbon products. DFT simulations of chain termination and chain propagation reactions as a function of carbon number are also performed to elucidate relevant C-C bond formation paths and to explain the apparent difficulty in forming the initial C-C bond during FTS. Calculated CO adsorption energies decrease with increasing CO coverage on flat extended Ru(0001) surfaces and on 201-atom Ru cluster surfaces(Ru201) due to repulsive intermolecular CO-CO interactions; such repulsive interactions are alleviated on convex Ru201 cluster surfaces, which can also accommodate CO coverages above a stoichiometric monolayer by forming geminal di-carbonyl species (also identified by infrared spectroscopy of CO adsorbed on Ru/SiO2 catalysts) at under-coordinated corner and edge Ru atoms. DFT-derived activation barriers for H-assisted CO activation paths on Ru atoms in high-coordination environments are much smaller than such barriers for direct CO bond cleavage, suggesting that CO species can be activated via H-assistance on low-index surfaces. Direct CO activation barriers on under-coordinated corner and step-edge sites are larger than those on high-coordination sites because of unfavorable interactions between di-carbonyl species and vicinal C-O activation transition states. DFT results also show that C-O bond activation during FTS is irreversible, and any direct CO dissociation path, as a result, is inconsistent with the reported effects of H2 and COpressures on FTS rates. Kinetic responses of CO conversion turnover rates and oxygen rejection selectivities (in the form of H2O/CO2 formation rate ratios) are consistent with CO activation occurring predominantly via H-assisted paths on Ru catalysts, irrespective of Ru cluster size. CO adsorption equilibrium constants and CO conversion activation energies, measured during FTS reactions, are the same for both small and large Ru clusters, suggesting that CO activation occurs in similar environments on both particle sizes. Turnover rates are smaller on small (~ 1 nm) Ru clusters than rates on large (~ 7 nm) Ru clusters when rates are normalized by the total number of exposed Ru atoms. Such differences in turnover rates become much smaller, however, when rates are normalized by the number of exposed Ru atoms in low-index (111) planes; CO activation reactions, as a result, likely occur on Ru atoms in high-coordination environments on both small and large Ru clusters. Increases in H2 pressures increases CH4 selectivities and decreases C5+ selectivities because chain termination is proportional to the concentration of surface hydrogen atoms (H*); chain growth reactions are favored at high CO pressures where termination is suppressed. Chain termination parameters for C1 species (to CH4) are much larger than such parameters for C2+ species; these parameters depend exponentially on the difference in chain termination and chain propagation barriers for each carbon number. DFT-derived activation barriers for termination reactions (via hydrogenation of surface alkyl species) are small and independent of chain length because such reactions are exothermic and proceed via early transition states; chain propagation reactions (via alkyl migration to vicinal CO* species), however, proceed through late transition states where surface-alkyl bonds are broken completely. Surface methyl (CH3*) species are bound to surfaces much more strongly than ethyl (C2H5*) and propyl (C3H7*) species; C1 propagation barriers, as a result, are much larger than such barriers for C2+ hydrocarbons, a result that is consistent with measured chain termination parameters on supported Ru catalysts. A steady-state treatment of reactive intermediates shows that CO conversion rate equations must include terms for CO consumption via CO activation as well as for consumption via chain growth with CO* monomers. This study unites experiment and theory to investigate fundamental C-O bond activation and C-C bond formation reactions on relevant catalyst surfaces during FTS. Kinetic and selectivity measurements remain vital in the understanding of elementary steps involved in bond making and bond breaking events in FTS reactions; theoretical tools can be used to investigate elementary reactions under conditions inaccessible to experimental techniques. Theoretical investigations of FTS reactions must be performed on cluster surfaces at high CO* coverages that prevail during relevant conditions because CO* coverages affect thermodynamic and kinetic parameters included in apparent activation energies. High CO* coverages also weaken Ru-CO bonds, consistent with quasi-equilibrated CO adsorption-desorption processes during FTS. This study is an important example of how theoretical calculations performed on relevant surfaces at relevant coverages are an invaluable compliment to experimental studies of metal-catalyzed chemical reactions.

Download or read book Organometallic Chemistry in Industry written by Thomas J. Colacot and published by John Wiley & Sons. This book was released on 2020-05-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Download or read book Stereoselective Organocatalysis written by Ramon Rios Torres and published by John Wiley & Sons. This book was released on 2013-04-29 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sets forth an important group of environmentally friendly organic reactions With contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (C–C), carbon-nitrogen (C–N), and carbon-halogen (C–X) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the standards of green chemistry. Stereoselective Organocatalysis begins with an historical overview and a review of activation modes in asymmetric organocatalysis. The next group of chapters is organized by bond type, making it easy to find bonds according to their applications. The first of these chapters takes a detailed look at the many routes to C–C bond formation. Next, the book covers: Organocatalytic C–N bond formation C–O bond formation C–X bond formation C–S, C–Se, and C–B bond formation Enantioselective organocatalytic reductions Cascade reactions forming both C–C bonds and C–heteroatom bonds The final chapter is devoted to the use of organocatalysis for the synthesis of natural products. All the chapters in the book are extensively referenced, serving as a gateway to the growing body of original research reports and reviews in the field. Based on the most recent findings and practices in organic synthesis, Stereoselective Organocatalysis equips synthetic chemists with a group of organocatalytic reactions that will help them design green reactions and overcome many challenges in organic synthesis.

Download or read book Computational Modeling of Homogeneous Catalysis written by Feliu Maseras and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent results on a wide array of catalytic processes are collected in this volume. The book illustrates the importance of computational modelling in homogeneous catalysis by providing up-to-date reviews of its application to a variety of reactions of industrial interest.

Download or read book Activation of Unreactive Bonds and Organic Synthesis written by Shinji Murai and published by Springer. This book was released on 2003-07-01 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years a large repetoire of methods for the activation of unreactive organic functionalities and for their use in organic synthesis has been developed. In this volume, areas ranging from the activation of C-H bonds to the chemical transformation of dinitrogen are authoritatively discussed by leading experts in the field. To activate means to be able to cleave otherwise inert chemical bonds. The cleavage and formation of chemical bonds is fundamental to organic synthesis; these new activation methodologies make hitherto infeasible reactions extremely easy and create new opportunities for innovative organic transformations, for both industry and academia. This is the first book that provides a thorough and timely coverage of both inorganic and organic synthetic aspects of bond activation, thus giving a broad overview of the field and allowing both inorganic and organic chemists ready access to the methodologies involved.

Download or read book C H and C X Bond Functionalization written by Xavi Ribas and published by Royal Society of Chemistry. This book was released on 2013 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron û an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation. Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry.