Download or read book The Professional Guinea Pig written by Roberto Abadie and published by Duke University Press Books. This book was released on 2010-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.

Download or read book Collective Memory and Dutch East Indiehb written by DOOLAN and published by Heritage and Memory Studies. This book was released on 2021-09-27 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the afterlife of decolonization in the collective memory of the Netherlands. It offers a new perspective on the cultural history of representing the decolonization of the Dutch East Indies, and maps out how a contested collective memory was shaped. Taking a transdisciplinary approach and applying several theoretical frames from literary studies, sociology, cultural anthropology and film theory, the author reveals how mediated memories contributed to a process of what he calls "unremembering." He analyses in detail a broad variety of sources, including novels, films, documentaries, radio interviews, memoires and historical studies, to reveal how five decades of representing and remembering decolonization fed into an unremembering by which some key notions were silenced or ignored. The author concludes that historians, or the historical guild, bear much responsibility for the unremembering of decolonization in Dutch collective memory.

Download or read book A Reader s Guide to Contemporary Literary Theory written by Raman Selden and published by . This book was released on 1989 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unsurpassed as a text for upper-division and beginning graduate students, Raman Selden's classic text is the liveliest, most readable and most reliable guide to contemporary literary theory. Includes applications of theory, cross-referenced to Selden's companion volume, Practicing Theory and Reading Literature.

Download or read book The CA3 Region of the Hippocampus How is it What is it for How does it do it written by Enrico Cherubini and published by Frontiers Media SA. This book was released on 2015-08-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.

Download or read book When the World Breaks Open written by Seema Reza and published by Red Hen Press. This book was released on 2016-03-08 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A poet’s story of healing herself, working with wounded veterans, and learning that silence does not equal strength, written “with self-lacerating honesty” (Kirkus Reviews). In this poignant and unabashed self-examination, Seema Reza uncovers the lessons she learned through motherhood and a dysfunctional and abusive marriage, and how she used her discoveries to make a meaningful difference in the world. This lyrical, non-linear narrative memoir traces Reza’s journey from repressed suburban housewife to coordinator of a unique creative-expression military hospital program. Through observing her own experiences from the darkest moments of her life and investigating societal attitudes towards loss, love, motherhood, and community, Reza exposes her triumphs, weaknesses, fears, and regrets, and undermines the idea that strength requires silence. “Lyrical . . . powerful . . . It is her self-reflection which empowers this memoir; her responsibility to take action for herself and not to languish as she was.” —Entropy Literature Review

Download or read book No Medium written by Craig Dworkin and published by MIT Press. This book was released on 2013-02-15 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Close readings of ostensibly “blank” works—from unprinted pages to silent music—that point to a new understanding of media. In No Medium, Craig Dworkin looks at works that are blank, erased, clear, or silent, writing critically and substantively about works for which there would seem to be not only nothing to see but nothing to say. Examined closely, these ostensibly contentless works of art, literature, and music point to a new understanding of media and the limits of the artistic object. Dworkin considers works predicated on blank sheets of paper, from a fictional collection of poems in Jean Cocteau's Orphée to the actual publication of a ream of typing paper as a book of poetry; he compares Robert Rauschenberg's Erased De Kooning Drawing to the artist Nick Thurston's erased copy of Maurice Blanchot's The Space of Literature (in which only Thurston's marginalia were visible); and he scrutinizes the sexual politics of photographic representation and the implications of obscured or obliterated subjects of photographs. Reexamining the famous case of John Cage's 4'33”, Dworkin links Cage's composition to Rauschenberg's White Paintings, Ken Friedman's Zen for Record (and Nam June Paik's Zen for Film), and other works, offering also a “guide to further listening” that surveys more than 100 scores and recordings of “silent” music. Dworkin argues that we should understand media not as blank, base things but as social events, and that there is no medium, understood in isolation, but only and always a plurality of media: interpretive activities taking place in socially inscribed space.

Download or read book A Constellation of Half Lives written by Seema Reza and published by SCB Distributors. This book was released on 2019-04-22 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Constellation of Half-Lives is a collection of poems that attempt to reconcile the crisis of living on a collapsing planet with the unreasonable joy of loving and the pleasure of being alive. With careful precision and an exquisite eye for detail, poet Seema Reza examines what it means to be a mother, a daughter, and an American in a time of war. Through second-person poems she questions whether the beauty of this world outweighs its fragility and risk.

Download or read book Leadership as Practice written by Joseph Raelin and published by Routledge. This book was released on 2016-01-29 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops a new paradigm in the field of leadership studies, referred to as the "leadership-as-practice" (L-A-P) movement. Its essence is its conception of leadership as occurring as a practice rather than residing in the traits or behaviours of particular individuals. A practice is a coordinative effort among participants who choose through their own rules to achieve a distinctive outcome. It also tends to encompass routines as well as problem-solving or coping skills, often tacit, that are shared by a community. Accordingly, leadership-as-practice is less about what one person thinks or does and more about what people may accomplish together. It is thus concerned with how leadership emerges and unfolds through day-to-day experience. The social and material contingencies impacting the leadership constellation – the people who are effecting leadership at any given time – do not reside outside of leadership but are very much embedded within it. To find leadership, then, we must look to the practice within which it is occurring. The leadership-as-practice approach resonates with a number of closely related traditions, such as collective, shared, distributed, and relational leadership, that converge on leadership processes. These approaches share a line of inquiry that acknowledges leadership as a social phenomenon. The new focus opens up a plethora of research opportunities encouraging the study of social processes beyond influence, such as intersubjective agency, shared sense-making, dialogue, and co-construction of responsibilities.

Download or read book The Cambridge Introduction to Satire written by Jonathan Greenberg and published by Cambridge University Press. This book was released on 2019 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview for both beginning and advanced students of satiric forms from ancient poetry to contemporary digital media.

Download or read book Superintendent s Report written by Watertown (N.Y.) Board of education and published by . This book was released on 1916 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Privilege and Property written by Ronan Deazley and published by Open Book Publishers. This book was released on 2010 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can and can't be copied is a matter of law, but also of aesthetics, culture, and economics. The act of copying, and the creation and transaction of rights relating to it, evokes fundamental notions of communication and censorship, of authorship and ownership - of privilege and property. This volume conceives a new history of copyright law that has its roots in a wide range of norms and practices. The essays reach back to the very material world of craftsmanship and mechanical inventions of Renaissance Italy where, in 1469, the German master printer Johannes of Speyer obtained a five-year exclusive privilege to print in Venice and its dominions. Along the intellectual journey that follows, we encounter John Milton who, in his 1644 Areopagitica speech 'For the Liberty of Unlicensed Printing', accuses the English parliament of having been deceived by the 'fraud of some old patentees and monopolizers in the trade of bookselling' (i.e. the London Stationers' Company). Later revisionary essays investigate the regulation of the printing press in the North American colonies as a provincial and somewhat crude version of European precedents, and how, in the revolutionary France of 1789, the subtle balance that the royal decrees had established between the interests of the author, the bookseller, and the public, was shattered by the abolition of the privilege system. Contributions also address the specific evolution of rights associated with the visual and performing arts. These essays provide essential reading for anybody interested in copyright, intellectual history and current public policy choices in intellectual property. The volume is a companion to the digital archive Primary Sources on Copyright (1450-1900), funded by the UK Arts and Humanities Research Council (AHRC): www.copyrighthistory.org.

Download or read book Instrument Flying Training written by and published by . This book was released on 1942 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Contemporary Authors Cumulative Index 03 written by and published by Gale Cengage. This book was released on 2006-02 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Glutamate Receptors written by Robert W. Gereau and published by Springer Science & Business Media. This book was released on 2008-02-23 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student. It condenses two previous landmark volumes into one easily accessible volume, and covers the extraordinary research and significant developments in the decade since the previous books were published. This includes the central role glutamate receptors play in neurotransmission.

Download or read book Weather and Climate Services in Europe and Central Asia written by and published by World Bank Publications. This book was released on 2008-01-01 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Weather and Climate Services in Europe and Central Asia is part of the World Bank Working Paper series. These papers are published to communicate the results of the Bank's ongoing research and to stimulate public discussion. Worldwide, the accuracy and value of weather and climate services are rising, bringing great economic benefits. However, many national hydrometeorological services in Europe and Central Asia are in decline. As a result, these potential gains are often missed. Much more could be done to mitigate weather disasters, support the productivity of smallholding and commercial agriculture, conserve energy, and promote safe aviation and transport by road and rail. Although capacity deficiencies are serious, they could be remedied significantly by relatively modest-but sustained-investments. Chapter 1 describes the worldwide growth in weather forecasting skill, presents principal issues and questions in Europe and Central Asia (ECA), and sets out the study's organization. Chapter 2 assesses the needs of the key sectoral clients of the national hydrometeorological services in the region. Chapter 3 addresses ECA's natural weather and climate issues: vulnerability to transboundary weather events, extreme weather, variable weather, and projected climate change. Chapter 4 presents the forecasting workflow, and then presents key regional and national capacity gaps. Chapter 5 discusses ways to estimate the economic benefit of existing and upgraded forecasting capacity. This study is part of an ongoing Regional Working Paper Series sponsored by the Chief Economist's Office in the Europe and Central Asia Region of the World Bank.

Download or read book Recent Advances In Retinal Degeneration written by Robert E. Anderson and published by Springer Science & Business Media. This book was released on 2007-12-03 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The product of perhaps the most important research meeting in the field, this essential text outlines all the latest research in retinal degeneration. Culled from the proceedings of the International Symposium on the subject, the topics in this volume explore the etiology, cellular mechanisms, epidemiology, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. A must-read for researchers in the field.

Download or read book The Translator As Communicator written by Basil Hatim and published by Routledge. This book was released on 2005-08-19 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.