Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Download or read book Italian Mathematics Between the Two World Wars written by Angelo Guerraggio and published by Springer Science & Business Media. This book was released on 2006-01-20 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes Italian mathematics in the period between the two World Wars. It analyzes the development by focusing on both the interior and the external influences. Italian mathematics in that period was shaped by a colorful array of strong personalities who concentrated their efforts on a select number of fields and won international recognition and respect in an incredibly short time. Consequently, Italy was considered a third mathematical power after France and Germany.

Download or read book Anger written by Thich Nhat Hanh and published by Penguin. This book was released on 2001-09-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: "[Thich Nhat Hanh] shows us the connection between personal, inner peace and peace on earth." –His Holiness The Dalai Lama Nominated by Martin Luther King, Jr. for a Nobel Peace Prize, Thich Nhat Hanh is one of today’s leading sources of wisdom, peace, compassion and comfort. It was under the bodhi tree in India twenty-five centuries ago that Buddha achieved the insight that three states of mind were the source of all our unhappiness: wrong knowing, obsessive desire, and anger. All are difficult, but in one instant of anger—one of the most powerful emotions—lives can be ruined, and health and spiritual development can be destroyed. With exquisite simplicity, Buddhist monk and Vietnam refugee Thich Nhat Hanh gives tools and advice for transforming relationships, focusing energy, and rejuvenating those parts of ourselves that have been laid waste by anger. His extraordinary wisdom can transform your life and the lives of the people you love, and in the words of Thich Nhat Hanh, can give each reader the power "to change everything."

Download or read book War Against All Puerto Ricans written by Nelson A Denis and published by Bold Type Books. This book was released on 2015-04-07 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The powerful, untold story of the 1950 revolution in Puerto Rico and the long history of U.S. intervention on the island, that the New York Times says "could not be more timely." In 1950, after over fifty years of military occupation and colonial rule, the Nationalist Party of Puerto Rico staged an unsuccessful armed insurrection against the United States. Violence swept through the island: assassins were sent to kill President Harry Truman, gunfights roared in eight towns, police stations and post offices were burned down. In order to suppress this uprising, the US Army deployed thousands of troops and bombarded two towns, marking the first time in history that the US government bombed its own citizens. Nelson A. Denis tells this powerful story through the controversial life of Pedro Albizu Campos, who served as the president of the Nationalist Party. A lawyer, chemical engineer, and the first Puerto Rican to graduate from Harvard Law School, Albizu Campos was imprisoned for twenty-five years and died under mysterious circumstances. By tracing his life and death, Denis shows how the journey of Albizu Campos is part of a larger story of Puerto Rico and US colonialism. Through oral histories, personal interviews, eyewitness accounts, congressional testimony, and recently declassified FBI files, War Against All Puerto Ricans tells the story of a forgotten revolution and its context in Puerto Rico's history, from the US invasion in 1898 to the modern-day struggle for self-determination. Denis provides an unflinching account of the gunfights, prison riots, political intrigue, FBI and CIA covert activity, and mass hysteria that accompanied this tumultuous period in Puerto Rican history.

Download or read book Our America written by Smithsonian American Art Museum and published by Giles. This book was released on 2014 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores how one group of Latin American artists express their relationship to American art, history and culture.

Download or read book The Fundamental Principles of Old and New World Civilizations written by Zelia Nuttall and published by . This book was released on 1901 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Castellinaria and Other Sicilian Diversions written by Henry Festing Jones and published by . This book was released on 1911 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Minor Histories written by Mike Kelley and published by MIT Press. This book was released on 2004-02-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of writings by Los Angeles artist Mike Kelley, focusing on his own work. What John C. Welchman calls the "blazing network of focused conflations" from which Mike Kelley's styles are generated is on display in all its diversity in this second volume of the artist's writings. The first volume, Foul Perfection, contained thematic essays and writings about other artists; this collection concentrates on Kelley's own work, ranging from texts in "voices" that grew out of scripts for performance pieces to expository critical and autobiographical writings.Minor Histories organizes Kelley's writings into five sections. "Statements" consists of twenty pieces produced between 1984 and 2002 (most of which were written to accompany exhibitions), including "Ajax," which draws on Homer, Colgate- Palmolive, and Longinus to present its eponymous hero; "Some Aesthetic High Points," an exercise in autobiography that counters the standard artist bio included in catalogs and press releases; and a sequence of "creative writings" that use mass cultural tropes in concert with high art mannerisms—approximating in prose the visual styles that characterize Kelley's artwork. "Video Statements and Proposals" are introductions to videos made by Kelley and other artists, including Paul McCarthy and Bob Flanagan and Sheree Rose. "Image-Texts" offers writings that accompany or are part of artworks and installations. This section includes "A Stopgap Measure," Kelley's zestful millennial essay in social satire, and "Meet John Doe," a collage of appropriated texts. "Architecture" features an discussion of Kelley's Educational Complex (1995) and an interview in which he reflects on the role of architecture in his work. Finally, "Ufology" considers the aesthetics and sexuality of space as manifested by UFO sightings and abduction scenarios.

Download or read book Our Blessed Hope written by Baruch Korman and published by . This book was released on 2019-07-31 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do you know what Our Blessed Hope is? Most believers in the Messiah do not. This term is found in Titus 2:13 and is the Biblical name for the Rapture. What most people know about the Rapture is what they have heard other people say. Isn't it time for you to read the relevant Scriptures for yourself? In this short and easy to read booklet, Baruch Korman discusses the primary passages that deal with the Rapture and demonstrates what the Word of G-d truly states about this wonderful promise from Yeshua (Jesus). There are important questions which demand answers; for example, "Is the last seven years of tribulation all G-d's wrath? What is the Abomination of Desolations and why is this event mentioned in regard to the end? To what end is Yeshua referring when He states that the Gospel of the Kingdom must be proclaimed throughout the world then the end will come? Paul speaks about the Day of Messiah (Christ). Is this the same thing as the Day of the L-ord? These questions and more will be addressed in an understandable manner that will leave the reader with a Biblical comprehension of the Rapture.

Download or read book Latin American Art and Music written by Judith Page Horton and published by . This book was released on 1989 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays, curriculum units, and study guides on Latin American art and musical traditions is designed to help interested teachers take a comprehensive approach to teaching these subjects. The introduction features the essay, "Media Resources Available on Latin American Culture: A Survey of Art, Architecture, and Music Articles Appearing in Americas" (K. Murray). Section 1, The Visual Arts of Latin America, has the following articles: "The Latin American Box: Environmental Aesthetics in the Classroom" (R. Robkin); "Mascaras y Danzas de Mexico y Guatemala" (J. Winzinger); "The Five Creations and Four Destructions of the Aztec World" (C. Simmons; R. Gaytan); "Art Forms of Quetzalcoatl: A Teaching Guide for Spanish, History, and Art Classes" (A. P. Crick); "The Art and Architecture of Mesoamerica: An Overview" (J. Quirarte); "Interpreting the Aztec Calendar" (L. Hall); "Mexican Muralism: Its Social-Educative Roles in Latin America and the United States" (S. Goldman); "Mexico: An Artist's History" (K. Jones); "A Historical Survey of Chicano Murals in the Southwest" (A. Rodriguez); and "El Dia de los Muertos" (C. Hickman). Section 2, The Musical Heritage of Latin America, has an introduction: "The Study of Latin American Folk Music and the Classroom" (G. Behague) and the following articles: "Value Clarification of the Chicano Culture through Music and Dance" (R. R. de Guerrero); "'La Bamba': Reflections of Many People" (J. Taylor); "The Latin American Art Music Tradition: Some Criteria for Selection of Teaching Materials" (M. Kuss); "Mariachi Guide" (B. San Miguel); "'El Tamborito': The Panamanian Musical Heritage" (N. Samuda); "A Journey through the History of Music in Latin America" (J. Orrego-Salas); "A Multicultural Tapestry for Young People" (V. Gachen); and "A Survey of Mexican Popular Music" (A. Krohn). A list of Education Service Centers in Texas is in the appendix. (DB)

Download or read book Printing the Revolution written by Claudia E. Zapata and published by Princeton University Press. This book was released on 2020-12 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Printing and collecting the revolution : the rise and impact of Chicano graphics, 1965 to now / E. Carmen Ramos -- Aesthetics of the message : Chicana/o posters, 1965-1987 / Terezita Romo -- War at home : conceptual iconoclasm in American printmaking / Tatiana Reinoza -- Chicanx graphics in the digital age / Claudia E. Zapata.

Download or read book The Sounds of Korean written by Jiyoung Shin and published by Cambridge University Press. This book was released on 2012-11-01 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to the sounds of Korean is designed for English-speaking students with no prior knowledge of the language and includes online sound files, which demonstrate the sounds and pronunciation described. It will be an invaluable resource for students of Korean wanting to understand the basis of the current state of Korean phonetics and phonology, as well as for those studying Korean linguistics. • Provides a complete and authoritative description and explanation of the current state of Korean phonetics and phonology • Gives clear comparisons with English and provides practical advice on pronunciation • Provides a wealth of authentic Korean examples • Each chapter contains exercises and Did you know? sections to help students put their knowledge into practice.

Download or read book Wild Guide Portugal written by Edwina Pitcher and published by . This book was released on 2017-03-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Stars of Galileo Galilei and the Universal Knowledge of Athanasius Kircher written by Roberto Buonanno and published by Springer. This book was released on 2016-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this fascinating book, the author traces the careers, ideas, discoveries, and inventions of two renowned scientists, Athanasius Kircher and Galileo Galilei, one a Jesuit, the other a sincere man of faith whose relations with the Jesuits deteriorated badly. The Author documents Kircher’s often intuitive work in many areas, including translating the hieroglyphs, developing sundials, and inventing the magic lantern, and explains how Kircher was a forerunner of Darwin in suggesting that animal species evolve. Galileo’s work on scales, telescopes, and sun spots is mapped and discussed, and care is taken to place his discoveries within their cultural environment. While Galileo is without doubt the “winner” in the comparison with Kircher, the latter achieved extraordinary insights by unconventional means. For all Galileo’s fine work, the author believes that scientists do need to regain the power of dreaming, vindicating Kirchner’s view.

Download or read book A Chorus Line written by Edward Kleban, James Kirkwood, Michael Bennett, Nicholas Dante, Marvin Hamlisch, Frank Rich, Samuel G. Freedman and published by Hal Leonard Corporation. This book was released on 2000-05-01 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Applause Books). It is hard to believe that over 25 years have passed since A Chorus Line first electrified a New York audience. The memories of the show's birth in 1975, not to mention those of its 15-year-life and poignant death, remain incandescent and not just because nothing so exciting has happened to the American musical since. For a generation of theater people and theatergoers, A Chorus Line was and is the touchstone that defines the glittering promise, more often realized in lengend than in reality, of the Broadway way. This impressive book contains the complete book and lyrics of one of the longest running shows in Broadway history with a preface by Samuel Freedman, an introduction by Frank Rich and lots of photos from the stage production.

Download or read book The Native Races of the Pacific States of North America Wild tribes 1874 written by Hubert Howe Bancroft and published by . This book was released on 1874 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive anthropological, ethnographic, linguistic, archaeological, and historical work on the Indians of the North, Central, and South Americas and, in North America, as far east as the Mississippi Valley.

Download or read book The Glass Highway written by Loren D. Estleman and published by Open Road Media. This book was released on 2011-06-28 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: DIVA newscaster’s son disappears, and Amos Walker dives into the depths of Detroit to rescue the boy/divDIV/divDIVOn screen, Sandy Broderick is everything a newscaster is supposed to be. He has a deep voice, a ten-thousand-watt smile, and the God-given ability to banter with weathermen until his ears fall off. But when the cameras turn off, he has a private problem: His twenty-year old son, Bud, has disappeared. Amos Walker is going to find him./divDIV /divDIVThe boy and his junkie girlfriend are both gone, and Broderick is terrified—not for his son, but for his career. The station is about to do an exposé on drugs in Detroit, and the newscaster doesn’t want his boy’s addict girlfriend to get in the way of his Pulitzer. This new client may be sleazy, but Walker handles scum for a living, and it’s time to go to work./divDIV /divDIVThis ebook features an illustrated biography of Loren D. Estleman including rare photos from the author’s personal collection./div