Download or read book Bone Morphogenetic Protein And Collagen An Advances In Tissue Banking Specialist Publication written by Glyn O Phillips and published by World Scientific. This book was released on 2004-01-16 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are bone morphogenetic proteins (BMPs) and how can they be used in orthopaedic practice? Ever since Urist proposed in 1976 that protein factors from cortical bone appeared to modulate bone healing in animals, there has been a search for these mysterious osteoinductive components. Now that their structure has been elucidated, they have been purified and cloned, and are now available for the improvement of bone healing.The best source of BMPs is demineralised bone. This bone allograft is used to achieve greater osteoinductive capacity. But are the actions of procurement, processing, demineralisation and sterilisation harmful to the BMPs? Unless the BMPs can be assayed, neither their clinical nor their scientific effectiveness can be appraised. All these aspects are logically and scientifically described in this volume. In addition, there is a review of the biochemistry of one of the two main components of bone, namely collagen. This subject is itself a confusing but rapidly growing field. This comprehensive review describes the procedures for building up bone in vivo and in vitro.Bone Morphogenetic Protein and Collagen answers most of the questions of orthopaedic surgeons and tissue bankers on how BMPs can be produced and used to their maximum effectiveness.

Download or read book Bone Morphogenetic Proteins Regeneration of Bone and Beyond written by Slobodan Vukicevic and published by Springer. This book was released on 2012-11-28 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica cy of BMPs in almost all crucial developmental events as well as during regenera tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.

Download or read book Bone Morphogenetic Proteins From Local to Systemic Therapeutics written by Slobodan Vukicevic and published by Springer Science & Business Media. This book was released on 2008-08-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration.

Download or read book Bone Morphogenetic Proteins written by Slobodan Vukicevic and published by Springer. This book was released on 2012-11-28 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions. This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

Download or read book Bone Morphogenetic Proteins Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Morphogenetic Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bone Morphogenetic Proteins. The editors have built Bone Morphogenetic Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Bone Morphogenetic Proteins Advances in Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Morphogenetic Protein 6 in a concise format. The editors have built Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Protein 6 in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Bone Morphogenetic Proteins Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Morphogenetic Proteins in a concise format. The editors have built Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Bone Morphogenetic Proteins Systems Biology Regulators written by Slobodan Vukicevic and published by Springer. This book was released on 2017-03-14 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

Download or read book The Bone Morphogenetic Protein Type II Receptor is Induced by Type I Collagen in Endothelial Cells and Up regulated in an in Vivo Angiogenesis Model written by Carlo Regazzoni and published by . This book was released on 1999 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of Bone Morphogenetic Protein 7 on Mechanically Adaptive Bone Modeling written by Aaron Jacob Cheline and published by . This book was released on 2000 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Bone Morphogenetic Protein Type II Receptor is Induced by Type I Collagen in Endothelial Cells and Up regulated in an in Vivo Angiogenesis Model written by Carlo Regazzoni (Naturwissenschaftler.) and published by . This book was released on 1999 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bone Morphogenetic Protein written by Thomas Ratko and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Bone morphogenetic proteins (BMP) are key factors necessary for bone regeneration and healing. Recombinant DNA techniques have been used to produce BMP2 and BMP7 as alternatives to autograft bone to enhance healing of bony defects and fractures in patients where autograft bone harvest is unfeasible or contraindicated. Currently, two rhBMPs and four associated carrier/delivery systems (one of which has been voluntarily withdrawn from the U.S. market) have received approval as devices from the U.S. Food and Drug Administration (FDA). The InFUSE(r) system (Medtronic Sofamor Danek, Inc.) consists of rhBMP2 on an absorbable collagen sponge carrier. OP-1(r) (Stryker Biotech) consists of rhBMP7 and bovine collagen, which is reconstituted with saline to form a paste. The addition of carboxymethylcellulose forms putty. METHODS: This assessment is based on an electronic search of the literature as follows: 1. MEDLINE(r) (January 1, 1998, through July 28, 2009)2. EMBASE(r) (January 1, 1998, through July 28, 2009)3. Cochrane Controlled Trials Register (no date restriction) The searches were updated in February 2010. The interventions of interest for all Key Questions (see table, following) are the use of either of the two commercially available BMP products in the U.S. Interventions were considered to be delivered on-label when administered according to the indication specified in the FDA-approved marketing label. All other uses and applications of BMP products were considered off-label. Studies were selected to address 10 Key Questions identified for this technology assessment. In general, we abstracted data from full-length randomized, controlled trials (RCTs) and nonrandomized, comparative trials that utilized BMP therapy in patients with a bony defect that required intervention and reported at least one outcome of interest. The quality of included studies was assessed using the general approach to grading evidence developed by the U.S. Preventive Services Task Force (USPSTF). The strength of the overall body of evidence was assessed using a framework developed by AHRQ for the EPC Methods Guide, based on a system developed by the GRADE Working Group. RESULTS: The electronic literature search yielded 1,992 records. Among those, 1,738 were excluded at initial title and abstract review and 254 were retrieved for full text examination. Forty-one articles describing results of comparative studies were abstracted.

Download or read book Advances in Skeletal Reconstruction Using Bone Morphogenetic Proteins written by T. Sam Lindholm and published by World Scientific. This book was released on 2002 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bone morphogenetic protein (BMP) is a special growth factor for the induction of new bone formation. Today, the extract of the BMP originating from bone tissue as well as genetically modified BMPs, particularly BMP-2 and -7, can be used. Though the BMP as an implant is as yet an unregistered drug or medical tool in Europe and the US, specialists are confident that it will obtain final government approval based on the results of clinical tests conducted on more than 3000 patients. This important book focuses mainly on the clinical BMP treatment of patients -- namely in orthopaedic cases (fractures, bone transplants, non-unions and pseudoarthroses), maxillofacial surgery (sinus lift before dental implantation), dental surgery (filling out of cavities) and spinal surgery (using a BMP implant instead of the patient's own bone).

Download or read book Composite Grafts of Collagen hydroxylapatite and Bovine Bone Morphogenetic Protein in Rat Calvarial Defects written by Steven Forrest Kolb and published by . This book was released on 1987 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Bone Morphogenetic Protein 2 and Parathyroid Hormone related Peptide on Collagen XI During Skeletal Development written by Neda Shefa and published by . This book was released on 2015 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Long bones develop via endochondral ossification, a process in which cartilage precedes bone. During endochondral ossification prechondrogenic cells undergo proliferation and apoptose as cells of the periosteum differentiate into bone. The process of endochondral ossification is regulated by a group of endocrine as well as paracrine molecules that includes bone morphogenetic protein-2 (BMP-2) and parathyroid hormone-related peptide (PTHrP). Collagens are extracellular matrix molecules that are present in a spatiotemporal manner during endochondral ossification. Collagen XI alpha 1 (Col11a1) is a minor fibrillar collagen that is alternatively spliced during development and can result in up to eight different spliceforms. During endochondral ossification Col11a1 spliceforms have a distinct expression profile in the growing long bone. The significance of the different spliceforms has not been characterized. Here, I studied the effects of BMP-2 and PTHrP on the expression of Col11a1 in pre-chondrogenic mouse ATDC5 and pluripotent mouse C2C12 cells. I also investigated the role of different Col11a1 spliceforms in BMP-2-mediated C2C12 osteoblast differentiation. My results suggest a role for BMP-2 in regulating Col11a1 splicing and expression that includes the induction of exons 6A, 7, and 8. Further I show that while PTHrP alone did not affect Col11a1 expression, when combined with BMP-2, PTHrP was able to diminish BMP-2-induced Col11a1 expression. In addition, Col11a1 NTD[p6b-7] reduced BMP-2 activity in C2C12 cells while Col11a1 NTD[p7] did not have any significant effects. Col11a1 NTD[p6b-7] also reduced the expression of alkaline phosphatase and collagen 1 alpha 1 and increased the expression of Runx2 and osteocalcin while NTD[p7-8] induced the expression of osteocalcin, Runx2, and collagen alpha 1. When Col11a1 was knocked down, the expression of BMP-2-induced markers alkaline phosphatase, Runx2, osteocalcin, and collagen 1 alpha 1 were reduced at 24h post induction with BMP-2 suggesting a role for collagen XI alpha 1 during early osteoblast differentiation. In ATDC5 cells, I determined a role for PTHrP in the induction of collagen XI alpha 1 exons 6A, 7, and 8 during early chondrocyte differentiation and exon 6B during late chondrocyte differentiation. Overall the results of this project show a novel role for collagen XI alpha 1 in BMP-2-mediated osteoblast differentiation and also suggest a role for PTHrP in regulating collagen XI alpha splicing and expression during ATDC5 chondrocyte differentiation."--Boise State University ScholarWorks.

Download or read book Mimicking the Extracellular Matrix written by Gregory H. Hudalla and published by Royal Society of Chemistry. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Download or read book Porcine Collagen as a Delivery System for Bone Morphogenetic Proteins written by Brian Rothman and published by . This book was released on 2010 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aims to determine the biochemical and histological parameter of bone formed heterotopically in the rodent bioassay osteoinduction model, of enzymatically and chemically treated xenogeneic insoluble collagenous bone matrix (ICBM) loaded with porcine BMP complex, purified according to a proprietary high yield purification procedure.