Download or read book Bone Cell Biomechanics Mechanobiology and Bone Diseases written by Airong Qian and published by Elsevier. This book was released on 2023-08-28 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful in understanding the role of mechanobiology in bone health and bone diseases, as well for investigating novel strategies for diagnosis and therapy of bone diseases. Cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast and chondrocyte. Cone diseases covered are osteoporosis, scoliosis and osteoarthritis. This comprehensive reference is written for researchers, scientists, clinicians and students. Presents a comprehensive introduction of current knowledge and recent advances of bone cell biomechanics Introduces new technologies for bone cell research Discusses the bone cell mechanotransduction, mechanism and bone diseases

Download or read book Skeletal Aging and Osteoporosis written by Matthew J. Silva and published by Springer Science & Business Media. This book was released on 2012-08-30 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this book is on mechanical aspects of skeletal fragility related to aging and osteoporosis. Topics include: Age-related changes in trabecular structure and strength; age-related changes in cortical material properties; age-related changes in whole-bone structure; predicting bone strength and fracture risk using image-based methods and finite element analysis; animal models of osteoporosis and aging; age-related changes in skeletal mechano responsiveness; exercise and physical interventions for osteoporosis.

Download or read book Multiscale Mechanobiology of Bone Remodeling and Adaptation written by Peter Pivonka and published by Springer. This book was released on 2017-06-20 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Download or read book Bone Remodeling Process written by Rabeb Ben Kahla and published by Academic Press. This book was released on 2021-08-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Remodeling Process: Mechanics, Biology, and Numerical Modeling provides a literature review. The first part of the book discusses bones in a normal physiological condition, bringing together the involved actors and factors reported over the past two decades, and the second discusses pathological conditions, highlighting the attack vectors of each bone disease. The third part is devoted to the mathematical descriptions of bone remodeling, formulated to develop models able to provide information that is not amenable to direct measurement, while the last part focuses on models using the finite element method in investigating bone biomechanics.This book creates an overall image of the complex communication network established between the diverse remodeling actors, based on overwhelming control evidence revealed over recent years, as well as visualizes the remodeling defects and possible treatments in each case. It also regroups the models allowing readers to analyze and assess bone mechanical and biological properties. This book details the cellular mechanisms allowing the bone to adapt its microarchitecture to the requirements of the human body, which is the main issue in bone biology and presents the evolution of mathematical modeling used in a bone computer simulation. Each chapter covers a core topic in bone biomechanics Provides a multidisciplinary view that effectively links orthopaedics, cellular biology, mechanics, and computer simulation Draws an overall image about bone biology and cell interactions, for identifying cell populations that are crucial for the remodeling process

Download or read book Bone Mechanics written by Stephen C. Cowin and published by CRC Press. This book was released on 1989 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This informative volume summarizes what is known about bone mechanics. It describes the methods used to acquire that knowledge and suggests the nature of future research on this topic. This easy-to-read book keeps mathematical notation simple and minimal and presents data in summary form. Bone Mechanics is concerned with the mechanical behavior and functional stress adaptation of whole bones as structural elements, the mechanical behavior and functional adaptation of bone tissue as material, and the physiological significance of the mechanical properties of bone and the biological response of bone to applied stress. Orthopaedic surgeons, dentists, anatomists, biologists, biomedical engineers and physiologists are among those who will find this volume to be of interest.

Download or read book Skeletal Function and Form written by Dennis R. Carter and published by Cambridge University Press. This book was released on 2007-08-25 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. In the bones, cartilage, tendons, ligaments, and muscles of all vertebrates there is a graceful and efficient physical order. This book is about how function determines form. It addresses the role of mechanical factors in the development, adaptation, maintenance, ageing and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for understanding, and will appeal to a wide audience of bioengineers, zoologists, anthropologists, palaeontologists and orthopaedists.

Download or read book Skeletal Tissue Mechanics written by R. Bruce Martin and published by Springer. This book was released on 2015-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter

Download or read book Mechanobiology in Health and Disease written by Stefaan Verbruggen and published by Academic Press. This book was released on 2018-08-09 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Download or read book Mechanobiology written by Glen L. Niebur and published by Elsevier. This book was released on 2019-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli Provides a review of diseases with known or purported mechanobiological underpinnings Includes the role of mechanobiology in tissue engineering and regenerative medicine Covers experimental methods to capture mechanobiological phenomena

Download or read book Bone Research in Biomechanics written by G. Lowet and published by IOS Press. This book was released on 1997 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the structure of bone, and its consequences for the mechanical behaviour of the bone structure. The first part of this book focuses on the development of models to predict the adaptation of bone due to changes on the mechanical loading situation (such as provoked by an implant). But far more important than the computer power presently available, the incorporation of knowledge on the biological processes have led to new kinds of models. Next to the development of models itself, the issue of model validation though comparison with clinical data is a main issue addressed in the papers of this symposium. The second part, dealing with the relationship between bone architecture and competence of bone, focuses on the morphology of trabecular bone structure. This work is mainly carried out in the context of research on osteoporosis, and look for the relation between bone structure and fracture risk. The last part is devoted to ultrasound research in bone biomechanics. Several methods have been described for the in vitro and in vivo measurement of ultrasound velocity and attenuation, both on cortical and on trabecular bone. The reader will not only discover the state-of-the-art when reading though this book. This book can give a taste of the fascinating perspectives the research in bone biomechanics still have to offer, even after more than 100 years.

Download or read book Mechanical Loading of Bones and Joints written by Hideaki E. Takahashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bones and joints are always under mechanical loading a key concept in understanding bone metabolism. Among the most common diseases of bones and joints in the elderly are osteoporosis and joint osteoarthritis. Dynamic changes in mechanical loading give rise to problems resulting in stenosis of the spinal column at the cervical, thoracic, and lumbar levels. Mechanical loading also accelerates joint destruction caused by inflammation from such conditions as chronic rheumatoid arthritis. An understanding of mechanical loading is essential therefore to clinicians, basic researchers, and engineers working with bones and joints. Providing up-to-date research and clinical findings, the contents of this volume are from the papers, symposia, and special lectures presented at the 12th Annual Meeting of the Orthopaedic Research Meeting of the Japanese Orthopaedic Association in Niigata, in October 1997.

Download or read book The Computational Mechanics of Bone Tissue written by Jorge Belinha and published by Springer Nature. This book was released on 2020-02-11 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.

Download or read book Cellular and Biomolecular Mechanics and Mechanobiology written by Amit Gefen and published by Springer Science & Business Media. This book was released on 2010-12-02 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Download or read book Biomechanics of Hard Tissues written by Andreas Öchsner and published by John Wiley & Sons. This book was released on 2011-08-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph assembles expert knowledge on the latest biomechanical modeling and testing of hard tissues, coupled with a concise introduction to the structural and physical properties of bone and cartilage. A strong focus lies on the current advances in understanding bone structure and function from a materials science perspective, providing practical knowledge on how to model, simulate and predict the mechanical behavior of bone. The book presents directly applicable methods for designing and testing the performance of artificial bones and joint replacements, while addressing innovative and safe approaches to stimulated bone regeneration essential for clinical researchers.

Download or read book Mechanobiology Handbook Second Edition written by Jiro Nagatomi and published by CRC Press. This book was released on 2018-12-07 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.

Download or read book Bone Remodeling and Mechanomics written by Madge Martin and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our skeleton, an essential structure for the human body, has multiple functions, among which are the regulation of metabolism and the protection of organs. We focus here on bone remodeling, a process by which the structure and chemical composition of bone evolve over time. The biochemical and structural changes of bone tissue are orchestrated by bone cells, able to synthesize bone matrix (osteoblasts), resorb mineralized bone (osteoclasts), and to regulate biochemical signaling pathways according to their mechanical environment (osteocytes). In this context, we are particularly interested in mechanomics, which is the description of the action of mechanics on biological tissues.We first study the mechanics of bone remodeling at the cellular level, where signaling pathways are essential. We therefore introduce a fine mathematical representation of bone remodeling by a system of differential equations describing the interactions between bone cells of osteoclastic and osteoblastic lineages, as well as the regulation of the biochemical environment by osteocytes. This model reproduces the bone loss in the contexts of micro-gravity during space flight and postmenopausal osteoporosis (PMO). The development of a pharmacokinetic-pharmacodynamic model coupled with biochemical dynamics makes it possible to link the dosage of an anabolic treatment of PMO (romosozumab) and the gain of bone mass, which would be beneficial for the design of a treatment specific to the patient.We also propose a macroscopic description of bone remodeling based on a generalized continuum mechanics model. First, this representation is introduced in the context of rotary remodeling of the bone microstructure. Indeed, bone is a material with a micro-architecture, composed of a mineralized collagen matrix and a fluid phase which hosts active bone cells. First, we propose an analytical identification of stable equilibrium states of rotary remodeling. This theory is then used in a 2D finite element study applied to the human femoral head. Finally, we enrich this theoretical framework by linking macroscopic mechanics to mechanobiology: the kinematics of bone remodeling is described through the evolution of macroscopic deformation, microstructural rotation, mineral fraction, porous fraction and cells concentrations. This description encompassing chemistry, biology and mechanics provides a structure for the study of interactions between these three fields in the context of remodeling. The promising results of our preliminary simulations enable an interpretation of remodeling on a small scale that can be compared with clinical data.Finally, we present in this thesis a first clinical application of our multi-scale theory with the study of bone remodeling in patients with idiopathic scoliosis of the adolescent (AIS), pathology of unknown origin characterized by a three-dimensional deviation of the spine. The analysis of the first vertebral body samples from AIS patients taken intraoperatively suggests a dependence of the properties of the material on the abnormal loading conditions due to the pathology. These observations motivate the prospect of a comparison of these results with simulations based on our mechanistic theory.In summary, we present in this thesis several bone remodeling modeling approaches, resulting in the development of a novel unifying theory whose purpose is to better understand and address the mechanisms of bone pathologies, which ultimately aim at the development of patient-specific therapeutic solutions.

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t