Download or read book Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites written by G. Lancini and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.

Download or read book Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites written by G. Lancini and published by . This book was released on 2014-01-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pharmaceuticals from Microbes written by Divya Arora and published by Springer. This book was released on 2019-02-12 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance. It highlights the pharmacological potential of marine microbes and endophytic fungi and their bioactive secondary metabolites. Emphasis is also given on the significance of probiotics and their specialized molecules in human health and disease as well as their role in dietary intervention for reducing the risk of non-alcoholic fatty liver disease. This work also serves as excellent reference material for researchers, students and academicians in the field of natural product chemistry, pharmacology and applied microbiology.

Download or read book The Search for Bioactive Compounds from Microorganisms written by Satoshi Omura and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.

Download or read book Biotechnology of Bioactive Compounds written by Vijai Kumar Gupta and published by John Wiley & Sons. This book was released on 2015-04-20 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.

Download or read book Bioactive Microbial Products 2 written by L. J. Nisbet and published by Academic Press. This book was released on 1983 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioactive Metabolites from Microorganisms written by M. E. Bushell and published by Elsevier Publishing Company. This book was released on 1989 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes major approaches and recent developments in the research on new bioactive metabolites of microbial origin including target-directed screening strategies, evaluation of new drugs, biosynthesis, genetic manipulation, and semisynthesis. Particular attentonis given to new microbial sources of drugs, new approaches towards directed screening, advances and future perspectives in antimicrobial, antineoplastic and phytoeffectory agents, and enzyme inhibitors as pharmacological agents. The contributions represent comprehensive surveys written by recognized scientists active in their fields of research. Together, they give an interdisciplinary view which focusses on exploitation of available microbial sources for drug development, problems of evaluation, mode of action, biosynthesis and application. The book will be of interest to scientists working in microbiology, pharmacology, pharmaceutical chemistry and pharmaceutical biotechnology.

Download or read book Biology and Biotechnology of Actinobacteria written by Joachim Wink and published by Springer. This book was released on 2017-10-19 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.

Download or read book Microbial Biotechnology written by Jayanta Kumar Patra and published by Springer. This book was released on 2018-02-14 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, is a collection of 25 chapters describing the recent advancements in the application of microbial technology in the food and pharmacology sector. The main focus of this book is application of microbes, food preservation techniques utilizing microbes, probiotics, seaweeds, algae, enzymatic abatement of urethane in fermentation of beverages, bioethanol production, pesticides, probiotic biosurfactants, drought tolerance, synthesis of application of oncolytic viruses in cancer treatment, microbe based metallic nanoparticles, agro chemicals, endophytes, metabolites, antibiotics etc. This book highlighted the significant aspects of the vast subject area of microbial biotechnology and their potential applications in food and pharmacology with various topics from eminent experts around the World. This book would serve as an excellent reference book for researchers and students in the Food Science, Food Biotechnology, Microbiology and Pharmaceutical fields.

Download or read book Volatiles and Metabolites of Microbes written by Joginder Singh Panwar and published by Academic Press. This book was released on 2021-06-22 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatiles and Metabolites of Microbes compiles the latest research and advancement in the field of volatiles, metabolites synthesized from the microbial strains such as actinomycetes, bacteria, cyanobacteria, and fungal species and their potential applications in the field of healthcare issue and sustainable agriculture. There is an urgent need to explore new and advanced biological methods for health industries and sustainable agriculture and to protect the environment from environmental pollution or contaminates, global warming, and also control the health of human beings from the side effects of various pharmaceuticals products. Focusing all these factors, Volatiles and Metabolites of Microbes explores new aspects of microorganism in terms of volatiles, enzymes, bioactive compounds synthesized from the microbes and their potential applications in the field of sustainable agriculture and health-related issues - Provides a broad aspect about volatiles, bioactive compounds, and secondary metabolites of microbes compiled in one cover - Gives the latest research and advancement in the field of volatiles, secondary metabolites, and bioactive compounds synthesized from the different microbial strains - Responds to new developments in the detection of the complex compound structures of volatiles - Offers insight to a very broad audience in Biotechnology, Applied Microbiology, Agronomy, and Pathology

Download or read book Bioactive Microbial Metabolites written by Vaibhav Mishra and published by Elsevier. This book was released on 2024-05-23 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Microbial Metabolites: Scope and Challenges not only focuses on the identification, separation and purification of bioactive metabolites, the book also provides an understanding of the metabolic pathways for bioactive metabolites production that play an important role in modern healthcare as frontline treatments for many diseases. This is a valuable reference for research students, academicians and scientists in environmental microbiology and biotechnology, and for industry personnel related to microbiology/ biotechnology. The science discussed herein plays an important role in expanding the market of antibiotics, food and agriculture but also offers eco-friendly, safer and profitable solutions to respective industries. - Focuses on the identification and structure elucidation of novel microbial metabolites - Uncovers extended functions of microbial metabolites - Provides understanding of metabolic pathways for bioactive metabolites production by using several illustrations, figures and tables so that the readers can easily grasp key concepts

Download or read book Recent Advances and Future Perspectives of Microbial Metabolites written by Surajit de Mandal and published by Elsevier. This book was released on 2022-10-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine sheds new light on various applications of microbial metabolites in the biomedical sector. The purpose of this book is to integrate the latest research advancements on the application of microbial metabolites in the medical industry into a single platform. In 10 chapters, the significance of biomedical applications and future therapeutic applications of microbial metabolites in human health are highlighted. Several chapters are dedicated to the role of microbial metabolites in precision medicine like the impact of the activities of microbial metabolites in antitumor and antidiabetic agents and immunosuppressive activities. It also provides a roadmap for drugs discovery based on antimicrobial products and the effect of microbial metabolites on humans' health and the immune system. The book finalizes with a chapter on the use of microbial metabolites in OMICS technology. Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine targets researchers from both academia and industry, professors, and graduate students from microbiology, molecular biology, biotechnology, and immunology. - Highlights various microbial metabolites and their application in the biomedical sector - Illustrates the application of microbial metabolites as potential therapeutic agents - Convenient for buyers and readers to understand the basics with advanced information of microbial metabolites

Download or read book Biotechnology of Antibiotics Second Edition written by William Strohl and published by CRC Press. This book was released on 1997-07-03 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: This incomparable Second Edition of a highly regarded reference has been entirely rewritten and enlarged to reflect the explosion of information and technologies that have emerged since the publication of the previous edition. Strikes the perfect balance between proven traditional approaches and modern methods that promise to yield new products and processes! Specifically addressing microbially derived commercially important bioactive products that are currently or soon-to-be available, Biotechnology of Antibiotics, Second Edition analyzes the use of recombinant enzymes to produce biologically active molecules, including a cholesterol-lowering agent, an anti-HIV drug for the treatment of AIDS, and b-lactam antibiotics gives insight into the biochemistry, molecular biology, and production of antibiotics used as therapeutic agents focuses on state-of-the-art techniques for the development of new antibiotics using novel approaches and strategies highlights recent advances in the genetic manipulation of antibiotic biosynthesis genes to create structures from gene combinations for new biological activities describes in detail the development and current status of newly created antibiotics and pharmacologically active natural products and much more! Written by authorities from both industry and academia and containing nearly 4000 bibliographic citations, Biotechnology of Antibiotics, Second Edition is an outstanding resource for pharmaceutical scientists, medicinal chemists and biochemists, molecular biologists and industrial microbiologists, chemical engineers, fermentation bioengineers, bioprocess technologists, and upper-level undergraduate and graduate students in these disciplines.

Download or read book Fungal Pigments written by Laurent Dufossé and published by MDPI. This book was released on 2018-03-23 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Fungal Pigments" that was published in JoF

Download or read book Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems written by Yan Sheng and published by . This book was released on 2015 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically in recent decades. On the other hand, known compounds were re-discovered again and again, possibly from related producing organisms, making natural products discovery an expensive and time-consuming endeavor. Therefore, in recent years, efforts for discovering new natural products have been redirected towards organisms from unique and untapped areas of the globe with remarkable biodiversity potential and/or extreme environment, such as deep-sea vents, caves, and other unusual ecosystems. This dissertation describes our efforts to discover new bioactive natural products from microorganisms isolated from a unique black water ecosystem in Indonesia. Indonesia is recognized as a major center in the world for biodiversity and is one of the countries with the highest level of endemic species and microorganisms that live in its various ecosystems. Among them are the "black-water" rivers, which flow in the steamy jungles of islands along the Indonesian archipelago, providing unique environments for its flora and fauna. In collaboration with scientists at the Indonesian Center for Biodiversity and Biotechnology (ICBB), we investigated bioactive secondary metabolites of microorganisms from the soil samples of a black water ecosystem on Borneo Island, Indonesia. 16S rRNA sequence analysis was used for the identification of the bacteria, and from 141 bacterial strains investigated, 77% were Streptomyces, 6% were non-Streptomyces actinomycetes, and 17% were non-actinomycete strains. About one third of the strains were screened for their bioactive secondary metabolites production. The EtOAc and n-BuOH extracts of the culture broths of the bacteria were subjected to antibacterial and antifungal assays, as well as mass spectrometry analysis. More than half of the screened Streptomyces (18 out of 24) showed activities against one or more pathogenic microorganisms, whereas only 2 out of 14 of the non-actinomycete strains showed antibacterial activities. Furthermore, chemical screening of 9 non-Streptomyces actinomycetes revealed that 3 strains, all of which are Amycolatopsis spp., produce the anticancer agents the apoptolidins. Chemical investigation of the strain Streptomyces albiflaviniger ICBB 9297 delivered four new elaiophylin-like macrolides and five known elaiophylins. The new compounds have macrocyclic skeletons distinct from those of the known elaiophylins, in which one or both of the dimeric polyketide chains contain(s) an additional pendant methyl group. However, they showed comparable antibacterial activity to elaiophylin against Staphylococcus aureus. Interestingly, those with the additional pendant methyl group on only one of the polyketide chains showed significantly increased activity against Mycobacterium smegmatis, whereas the one with two additional methyl groups and the known elaiophylin analogues showed no activity. The production of the new analogues suggests that the last acyltrasferase (AT) domain of the elaiophylin polyketide synthases has relaxed substrate specificity. Bioinfomatic analysis of the conserved active site residues within the AT domains revealed an unusual amino acid sequence of the active site motif in the AT7 domain. Investigations of the apoptolidin producer Amycolatopsis sp. ICBB 8242 led to the discovery of two succinylated apoptolidin analogues and linear apoptolidin A. The two succinylated compounds can inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A, they do not inhibit cellular respiration in H292 cells. This seemingly contradictory results may be due to an alternative biological mechanism of action or due to degradation of succinyl-apoptolidin A to apoptolidin A in the cell viability assay. This hydrolysis may not occur during the real time analysis of cellular respiration, which was performed in a relatively short experimental time. The production of succinylated apoptolidins by Amycolatopsis sp. ICBB 8242 suggests that succinylation may play a role in self-resistance and/or as an export mechanism.

Download or read book New and Future Developments in Microbial Biotechnology and Bioengineering written by Vijai G. Gupta and published by Elsevier. This book was released on 2019-06-15 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and Applications examines the areas of biotechnology and chemical engineering, covering aspects of plants, bacteria and machines, and using microbes as factories. The book is aimed at undergraduates, post-graduates and researchers studying microbial secondary metabolites, and is an invaluable reference source for biochemical engineers working in biotechnology, manipulating microbes, and developing new uses for bacteria and fungi. The applications of secondary metabolites in biotechnology, pharmaceuticals, diagnostics and medical device development are also extensively covered. The book integrates the aforementioned frontline branches into an interdisciplinary research work to satisfy those working in biotechnology, chemical engineering, alternative fuel development, diagnostics and pharmaceuticals. Chapters related to important research work on applications of microbial secondary metabolites are written by specialists in the various disciplines from the international community. Compiles the latest developments in the area of microbial secondary metabolites Authored by the top international researchers in this area Includes information related to nearly all areas of a microbial secondary metabolites system

Download or read book Poisonous Plants and Phytochemicals in Drug Discovery written by Andrew G. Mtewa and published by John Wiley & Sons. This book was released on 2020-12-22 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career