Download or read book Biopharmaceutics and Drug Interactions written by Donald Elton Cadwallader and published by Raven Press (ID). This book was released on 1983 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction 1; 2. The complex system 8; 3. Biological half-life, elimination rate constant, and volume of distribution 14; 4. Bioavailability, blood levels, and urinary excretion data 21; 5. Anatomy and physiology of the gastrointestinal tract 34; 6. Mechanism of drug absorption 39; 7. Dissolution and drug absorption 51; 8. Effect of drug product design and manufacture on drug availability 67; 9. Bioavailability testing and drug product selection 87; 10. Terminology associated with drug interactions 107; 11. Drug interactions in the gastrointestinal tract 110; 12. Drug interactions during transport 118; 13. Drug interactions associated with metabolism 123; 14. Drug interactions at the receptor site 134; 15. Drug interactions associated with renal excretion 140; 16. Reading and resource material 148.
Download or read book Biopharmaceutics and Drug Interactions written by Donald E. Cadwallader and published by . This book was released on 1974 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Drug Interactions for Therapeutic Biologics written by Honghui Zhou and published by John Wiley & Sons. This book was released on 2013-05-10 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.
Download or read book Drug Interactions written by Ivan H. Stockley and published by . This book was released on 1996 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a source book of adverse drug reactions covering their clinical importance, mechanisms and management. This fourth edition has been revised from an extensive database. Major interaction mechanisms are followed by alphabetically-arranged material covering all the drug groups. As with prior editions, there is a series of monographs with a consistent plan devised to offer quick and easy reading. Both British and American drug names have been used throughout the book and bibliogrpahies are provided for those who wish to use the book as a reference source.
Download or read book Drug Drug Interactions in Pharmaceutical Development written by Binghe Wang and published by John Wiley & Sons. This book was released on 2008-03-05 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.
Download or read book Drug Drug Interactions Scientific and Regulatory Perspectives written by and published by Academic Press. This book was released on 1997-11-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug drug interactions, the prediction of drug drug interaction potential of new drugs, and the avoidance of clinically significant drug drug interaction in patients. Provides useful references on the science of drug-drug interactions Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint Contains original data from academic and industrial laboratories Presents an overview of regulatory agency positions
Download or read book Nutrient Drug Interactions written by Kelly Anne Meckling and published by CRC Press. This book was released on 2006-06-23 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current research has given us a more complete understanding of how the chemicals in foods and herbs interact with natural and synthetic drugs. In some cases a single food or supplement can profoundly increase or decrease the toxicity and/or efficacy of a single drug. Although it is standard practice to examine the effects of food consumption on the
Download or read book Drug Drug Interactions written by A. David Rodrigues and published by CRC Press. This book was released on 2001-10-19 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents comprehensive coverage of the preclinical, clinical, toxicological, regulatory, and marketing perspectives of metabolism-based drug-drug interactions-relating pharmacokinetic concepts to Michaelis-Menten kinetics. The book provides helpful examples, representative enzyme systems, and computer-aided modeling to clarify key concepts. It offers nearly 200 useful tables, equations, drawings, and photographs, and contributions by world-renowned experts in the field. They discuss kinetics-based in vitro-in vivo correlations, methods for the development of a metabolic drug interaction (MDI) database, and more.
Download or read book Evaluations of Drug Interactions written by American Pharmaceutical Association and published by American Pharmaceutical Association. This book was released on 1976 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enzyme and Transporter Based Drug Drug Interactions written by K. Sandy Pang and published by Springer Science & Business Media. This book was released on 2009-12-17 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.
Download or read book Pocket Guide to Evaluations of Drug Interactions written by Frederic J. Zucchero and published by American Pharmaceutical Association. This book was released on 1999 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: A condensed version of Evaluations of Drug Interactions, designed to facilitate quick access to the information most frequently needed by busy health practitioners. It contains 952 drug interaction monographs organized by drug class. Most monographs contain eight concise pieces of information and the volume is indexed by generic names.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Biopharmaceutics and Drug Interactions written by Cadwallader DE. and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Trials of Drugs and Biopharmaceuticals written by Chi-Jen Lee and published by CRC Press. This book was released on 2005-09-19 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmaceutical industry is on the verge of an exciting and challenging century. Advances in pharmaceutical sciences have dramatically changed the processes of discovery and development of new therapeutic drugs and, in turn, resulted in an extraordinary increase in the potential prophylactic and therapeutic interventions. In this atmosphere, an
Download or read book Managing Clinically Important Drug Interactions written by Philip D. Hansten and published by Facts and Comparisons. This book was released on 2005 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handy book provides brief descriptions of clinically important drug interactions selected from the authoritative looseleaf reference, Drug Interactions Analysis and Management. Only level 1 and 2 interactions and those level 3 interactions most likely to affect patient outcomes are included. The information is compiled from up-to-date biomedical studies and case reports and presented in a quick-reference format. For each interaction, the authors provide a clinical significance rating and information on risk factors, similar drugs that might also interact, and patient management. The book is indexed by generic drug names, with selected trade names cross-referenced to generic equivalents.
Download or read book Stockley s Drug Interactions written by Claire L. Preston and published by . This book was released on 2016 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stockley's Drug Interactions is still the most indispensible and authoritative international source of drug interaction information. Based upon the many thousands of published clinical papers and reports, it provides a series of detailed, yet concise, monographs designed for quick and easy reference.
Download or read book Handbook of Food Drug Interactions written by Beverly McCabe-Sellers and published by CRC Press. This book was released on 2003-04-29 with total page 937 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from the fields of pharmacy, dietetics, and medicine, Handbook of Food-Drug Interactions serves as an interdisciplinary guide to the prevention and correction of negative food-drug interactions. Rather than simply list potential food-drug interactions, this book provides explanations and gives specific recommendations based on th