Download or read book Biomarkers of Cardiometabolic Risk Inflammation and Disease written by Filipe Palavra and published by Springer. This book was released on 2015-04-11 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Risk, Inflammation and Disease is aimed at doctors specializing in internal medicine, neurology, cardiology, rheumatology, nephrology or endocrinology and will also be of interest to GPs, trainee doctors and clinical and basic researchers working on cardiovascular and autoimmune disorders.
Download or read book Biomarkers in Cardiovascular Diseases written by Dimitris Tousoulis and published by CRC Press. This book was released on 2013-07-29 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The establishment of precise and reliable biomarker tests for the early stages of cardiovascular disease is of great importance and can be the cornerstone in the prevention of future cardiovascular disease (CVD). Furthermore, some biomarkers may provide important information concerning the pathogenesis of CVD or appear to be useful in risk stratification, in CVD diagnosis, or in monitoring therapy; many others may be risk factors themselves, representing therefore potential targets of therapy. The ideal biomarker should have the following characteristics: highly sensitive, specific, reliable, accessible, standardized, dependable, cost effective, and easily interpretable by clinicians. The present book focuses on the presentation and evaluation of the most promising classical and novel biochemical markers used in CVD (coronary artery disease, hypertension, heart failure, hyperlipidemia, peripheral arterial disease). The underlying pathophysiological characteristics of each biomarker, as well as potential clinical implications in daily practice are reviewed in this book.
Download or read book Biomarkers in Cardiovascular Disease written by Vijay Nambi and published by Elsevier Health Sciences. This book was released on 2018-11-27 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. - Covers lab standards and statistical interpretation of biomarkers with a clinical focus. - Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. - Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. - Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Download or read book 25 hydroxyvitamin D and Biomarkers of Cardiometabolic Disease written by Bibiana Garcia Bailo and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular biomarkers of cardiometabolic disease written by Mirjana Macvanin and published by Frontiers Media SA. This book was released on 2024-08-22 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiometabolic disease (CMD) represents the major cause of mortality, accounting for one-third of all global deaths, 75% of which occur in middle- and low-income countries. CMD encompasses a broad spectrum of conditions characterized by limited prediction, based mainly on classical risk factors due to a lack of accurate molecular CMD predictors. Thus, there is an urgent need for improved diagnostics solutions to support early intervention and improve outcomes. Early detection and adequate intervention are crucial to prevent CMD-associated complications, encouraging the quest for appropriate biomarkers with diverse applications ranging from risk assessment and screening to diagnosis and prognosis. Different circulating biomarkers for quantifying the CMD risk have been reported in the literature, such as C-reactive protein (CRP), leptin, and adiponectin. In addition, accumulating evidence in the literature points to the emergence of novel CMD biomarkers, such as cytokines, various metabolites, apelin, microRNAs, inflammasome molecules, and cardiac fibrosis markers. However, large meta-analyses have not sufficiently investigated and confirmed their biological roles in CMD diagnosis, prognosis, and/or potential reduction.
Download or read book Cardiac Biomarkers in Clinical Practice written by James L. Januzzi and published by Jones & Bartlett Learning. This book was released on 2011 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Biomarkers in Clinical Practice was just honored with 4 Stars from Doody's Book Review! Cardiac Biomarkers in Clinical Practice presents a case based approach to biomarkers in heart diseases including heart failure, ischemic heart disease, and outpatient. Divided into six sections, this book provides physicians and other health care providers with a clear understanding of the role of biomarkers in clinical cardiovascular medicine.
Download or read book Nutrigenomics Inflammation and Biomarkers of Cardiovascular Disease written by Benedicte Fontaine-Bisson and published by . This book was released on 2008 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic inflammation is a common feature of obesity, type 2 diabetes and cardiovascular disease. Nuclear factor kappa B (NF-kappaB) is a transcription factor that plays a central role in inflammation by regulating the expression of a number of important genes, such as the major pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha. Both NF-kappaB and TNF-alpha have been implicated in the pathogenesis of insulin resistance and the development of a pro-atherogenic lipid profile. Their production can be modulated by dietary polyunsaturated fatty acids (PUFAs), from both the n-3 and n-6 series, as well as by genetic variations that alter transcriptional activity. The objective of this thesis was to determine whether common variations in major genes regulating inflammation (NF-kappaB and TNF-alpha) modify the association between dietary PUFAs intake and biomarkers of cardiovascular disease in two different populations. In summary, the NF-kappaB -49Ins/Del ATTG and TNF-alpha -238G>A and -308 G>A polymorphisms modify the association between dietary PUFAs intake and plasma HDL-cholesterol in two different populations. Taken together, these findings suggest that inflammation may mediate the effect of dietary PUFAs on the reverse cholesterol transport and impact the risk of cardiovascular disease. The first population involved overweight or obese men and women (n=109) aged 42--75 years with type 2 diabetes. The second population involved mostly lean and healthy men and women (n=595) aged 20--29 years. Subjects were genotyped for the NF-kappaB -49Ins/Del ATTG and for the TNF-alpha -238G>A and -308G>A polymorphisms. Dietary intake was assessed using either a 3-day food record or a food frequency questionnaire. Among individuals with type 2 diabetes, the association between dietary PUFAs intake and plasma HDL-cholesterol concentrations was modified by variations in both the NF-kappaB and TNF-alpha genes. The association between PUFAs intake and HDL-cholesterol was either positive, inverse or null, depending on the particular NF-kappaB and TNF-alpha genotype. In the population of young adults, genetic variations in both the NF-kappaB and TNF-alpha genes also modified the association between dietary PUFAs intake and plasma HDL-cholesterol. NF-kappaB and TNF-alpha genotypes did not modify the association between other dietary fatty acids and other plasma lipids in either population.
Download or read book Role of Biomarkers in Medicine written by Mu Wang and published by BoD – Books on Demand. This book was released on 2016-08-17 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.
Download or read book Cardiovascular and Metabolic Disease written by Philip Peplow and published by Royal Society of Chemistry. This book was released on 2015-05-22 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular disease, and diabetes in turn, following an introduction to the molecular links between them. The final chapter provides perspectives on future directions of the field. Chapters are contributed by leaders in the field from academia and industry and cover biomarkers, risk factors, gene-environment interactions, therapies and the various types of animal models that have been used to study each disease. Case studies describing the implementation of animal models in drug development further enhance the book’s usefulness as a comprehensive guide to this important therapeutic area. Providing a full picture of the various types of animal models that have been used to study obesity, hypertension, and insulin resistance with recent case studies, this book provides a valuable resource for medicinal chemists and clinicians working in these disease areas.
Download or read book Clinical Management Pathogenesis and Biomarkers of Cardiovascular Disease Associated with Systemic Autoimmune Disorders written by Carlos Pérez-Sánchez and published by Frontiers Media SA. This book was released on 2022-12-27 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Risk Factors Related Vascular Injury and New Molecular Biomarkers written by Yuli Huang and published by Frontiers Media SA. This book was released on 2022-10-21 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Biomarkers written by Alan S Maisel and published by JP Medical Ltd. This book was released on 2012 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Biomarkers describes the most recent developments in the field of biomarkers, providing best practice and current guidelines. It also discusses how these guidelines may alter in the future. With contributions from internationally-based clinicians and scientists, this book includes almost 100 detailed images and illustrations. Topics covered include: Markers of Cardiac Arrest, Markers of Cardiac Ischemia, Natriuretic Peptides for Heart Failure, Biomarkers in Cardio Renal Disease and Future Developments.
Download or read book Frailty and Cardiovascular Diseases written by Nicola Veronese and published by Springer Nature. This book was released on 2020-01-01 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.
Download or read book Biomarkers in Heart Disease written by James de Lemos and published by John Wiley & Sons. This book was released on 2009-01-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Heart Disease is the first title in the AHAClinical Series and is aimed at meeting the needs of clinicians,providing cardiologists, internists, emergency physicians,laboratorians, and other healthcare providers with a clearunderstanding of the role of biomarkers in contemporarycardiovascular medicine. The book covers both the strengths and pitfalls of currentlyavailable markers, and provides information on the most promisingbiomarkers that are likely to impact practice in the next fewyears. It is divided into four parts, organized around clinicalscenarios rather than individual biomarkers. This book will help the practicing physician decide whichbiomarkers to measure, when to measure them, how to interpret theresults and how to make decisions based on the test result.
Download or read book Integrin Activation on Circulating Inflammatory Monocytes written by Greg Allen Foster and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary artery disease (CAD) results in the narrowing of the small blood vessels that supply oxygen to the heart and is the major cause of morbidity and mortality in the U.S. Since CAD is largely asymptomatic, clinicians rely on biomarkers in the blood (e.g., low- and high-density lipoprotein cholesterol, C-reactive protein, and triglyceride levels) to determine cardiovascular risk and to guide therapy for an individual patient. However, these conventional biomarkers lack in specificity to inform on vascular health, as they fail to identify >20% of subjects at risk for future complications resulting from coronary blockage. Atherosclerosis underlying CAD is dependent on the recruitment of circulating monocytes to inflamed endothelium expressing vascular cell adhesion molecule-1 (VCAM-1). Therefore, the objectives of this work were: 1) develop unique assays to assess the functional phenotype of circulating monocytes during inflammation associated with atherogenesis, 2) characterize the relationship between activated monocytes and cardiovascular risk, and 3) elucidate the mechanism through which activated blood monocytes recruit to inflamed endothelium. To address the objectives of this dissertation, we fabricated a microfluidic based lab-on-a-chip to quantify the adhesion efficiency of monocytes sheared in whole blood on VCAM-1. The lab-chip device, combined with fluorescent antibody labeling against CD14 and CD16, allowed us to characterize the recruitment efficiency of monocyte subsets, in particular the inflammatory CD14++CD16+ (Mon2). We found that Mon2 adhered with 7-fold higher efficiency than other subsets and capture was dependent on integrins CD11c/CD18 and very late antigen-4 (VLA-4). To characterize the relationship between capture of inflammatory Mon2 and cardiovascular risk, we studied a range of subjects that included otherwise healthy individuals with elevated serum triglyceride levels to patients presenting with acute myocardial infarction resulting from coronary disease. We found that Mon2 from hypertriglyceridemic subjects exhibited increased CD11c expression and capture on VCAM-1 compared to subjects with normal serum triglyceride levels. CD11c expression and capture efficiency was further elevated in patients with known CAD suggesting a hierarchal relationship between activation of Mon2 and cardiovascular disease risk. Upregulation of CD11c in blood was attributable to Mon2 uptake of triglyceride rich lipoproteins and subsequent signaling via a phospholipase C (PLC)-dependent mechanism to increase CD11c expression, VLA-4 function, and integrin co-clustering within focal adhesive sites on VCAM-1. Using a unique antibody that allosterically binds CD11c and induces a high affinity conformation, we found that outside-in activation of CD11c on the membrane directly activated VLA-4 adhesion via phospho-spleen tyrosine kinase (pSyk) and paxillin within focal adhesion complexes. In summary, this work reveals that CD11c is an inducible integrin on inflammatory Mon2, whose expression correlates with monocyte inflammatory state in subjects at risk for atherogenesis and in patients with CAD. Therefore CD11c on Mon2 is a biomarker of cardiovascular risk and a potential target for drug therapy to ameliorate the recruitment of inflammatory monocytes during atherogenesis.
Download or read book Epicardial Adipose Tissue written by Gianluca Iacobellis and published by Springer Nature. This book was released on 2020-03-25 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.
Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
