Download or read book Biology Computing and the History of Molecular Sequencing written by M. García-Sancho and published by Springer. This book was released on 2012-05-11 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.
Download or read book Biology Computing and the History of Molecular Sequencing written by M. García-Sancho and published by Palgrave Macmillan. This book was released on 2012-05-11 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.
Download or read book Welcome to the Genome written by Robert DeSalle and published by John Wiley & Sons. This book was released on 2020-01-27 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popular introduction to the genomic revolution for non-scientists—the revised and updated new edition Welcome to the Genome is an accessible, up-to-date introduction to genomics—the interdisciplinary field of biology focused on the structure, function, evolution, mapping, and editing of an organism's complete set of DNA. Written for non-experts, this user-friendly book explains how genomes are sequenced and explores the discoveries and challenges of this revolutionary technology. Genomics is a mixture of many fields, including not only biology, engineering, computer science, and mathematics, but also social sciences and humanities. This unique guide addresses both the science of genomics and the ethical, moral, and social questions that rise from the technology. There have been many exciting developments in genomics since this book's first publication. Accordingly, the second edition of Welcome to the Genome offers substantial new and updated content to reflect recent major advances in genome-level sequencing and analysis, and demonstrates the vast increase in biological knowledge over the past decade. New sections cover next-generation technologies such as Illumina and PacBio sequencing, while expanded chapters discuss controversial ethical and philosophical issues raised by genomic technology, such as direct-to-consumer genetic testing. An essential resource for understanding the still-evolving genomic revolution, this book: Introduces non-scientists to basic molecular principles and illustrates how they are shaping the genomic revolution in medicine, biology, and conservation biology Explores a wide range of topics within the field such as genetic diversity, genome structure, genetic cloning, forensic genetics, and more Includes full-color illustrations and topical examples Presents material in an accessible, user-friendly style, requiring no expertise in genomics Discusses past discoveries, current research, and future possibilities in the field Sponsored by the American Museum of Natural History, Welcome to the Genome: A User's Guide to the Genetic Past, Present, and Future is a must-read book for anyone interested in the scientific foundation for understanding the development and evolutionary heritage of all life.
Download or read book Data Centric Biology written by Sabina Leonelli and published by University of Chicago Press. This book was released on 2016-11-18 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades, digital access to data has revolutionized research methods and ways of doing science in the biological and biomedical fields. Prominent scientists have characterized this shift as leading to a new, data-intensive paradigm for research, encompassing innovative ways to produce, store, disseminate, and interpret huge masses of data. In this book Sabina Leonelli explores the epistemological challenges this poses to how life is researched and understood. By following how data travels across research contexts, and the role played by standards, theories, models, and human agency in shaping their evidential value, she shows the conditions under which digitally available data further our understanding of life. Turning to how the characteristics of data-intensive science bear on philosophical debates, Leonelli explores the shifting criteria for what counts as scientific evidence and how data are transformed into new knowledge. In short, she argues that a philosophical characterization of how data and knowledge move from one context to another is of fundamental importance to a productive philosophical understanding of contemporary scientific practices."
Download or read book Computers and DNA written by Thomas Marr and published by Routledge. This book was released on 2018-02-20 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fields of molecular biology and genetics are faced with an enormous accumulation of information: DNA sequencing, associated sequences of amino acids in proteins, genetics, macromolecular structures and other sets have created a quantitative backlog of data which needs to be organized and analyzed. Moreover, the rate of data acquisitions is accelerating as improved technologies are used and as organized programs such as the Human Genome Initiative are established. Because of this data's importance, molecular biologists have turned to computational scientists for help in processing this mass of information.The Santa Fe Institute organized a workshop on "The Interface Between Computational Science and DNA Sequencing" in 1998 to address this information crisis. Approximately one hundred molecular biologists, computer scientists, mathematicians, and other scientists in diverse fields met to discuss how computational science can best keep pace with molecular biology. The papers presented at that meeting and included in this volume serve as a comprehensive introduction to the field and as a discussion of research on some of the current problems.
Download or read book Computing for Comparative Microbial Genomics written by David Wayne Ussery and published by Springer Science & Business Media. This book was released on 2008-12-16 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging these ? elds. The goal of this book is to p- vide a coherent set of tools and a methodological framework for starting with raw DNA sequences and producing fully annotated genome sequences, and then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Organization and Features The text is divided into four main parts: Introduction, Comparative Genomics, Transcriptomics and Proteomics, and ? nally Microbial Communities. The ? rst ? ve chapters are introductions of various sorts. Each of these chapters represents an introduction to a speci? c scienti? c ? eld, to bring all readers up to the same basic level before proceeding on to the methods of comparing genomes. First, a brief overview of molecular biology and of the concept of sequences as biological inf- mation are given.
Download or read book A Bibliography on Computational Molecular Biology and Genetics written by Sarah Barron and published by DIANE Publishing. This book was released on 1991 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive bibliographic review of the literature related to DNA mapping and sequence analysis, with a focus on computer and mathematical aspects of molecular biology and genetics. Over 2200 entries, arranged by author's name.
Download or read book Encyclopedia of Evolutionary Biology written by and published by Academic Press. This book was released on 2016-04-14 with total page 2138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Evolutionary Biology, Four Volume Set is the definitive go-to reference in the field of evolutionary biology. It provides a fully comprehensive review of the field in an easy to search structure. Under the collective leadership of fifteen distinguished section editors, it is comprised of articles written by leading experts in the field, providing a full review of the current status of each topic. The articles are up-to-date and fully illustrated with in-text references that allow readers to easily access primary literature. While all entries are authoritative and valuable to those with advanced understanding of evolutionary biology, they are also intended to be accessible to both advanced undergraduate and graduate students. Broad topics include the history of evolutionary biology, population genetics, quantitative genetics; speciation, life history evolution, evolution of sex and mating systems, evolutionary biogeography, evolutionary developmental biology, molecular and genome evolution, coevolution, phylogenetic methods, microbial evolution, diversification of plants and fungi, diversification of animals, and applied evolution. Presents fully comprehensive content, allowing easy access to fundamental information and links to primary research Contains concise articles by leading experts in the field that ensures current coverage of each topic Provides ancillary learning tools like tables, illustrations, and multimedia features to assist with the comprehension process
Download or read book Computational Genome Analysis written by Richard C. Deonier and published by Springer Science & Business Media. This book was released on 2005-12-27 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.
Download or read book Handbook of Computational Molecular Biology written by Srinivas Aluru and published by CRC Press. This book was released on 2005-12-21 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of
Download or read book Biological Sequence Analysis written by Richard Durbin and published by Cambridge University Press. This book was released on 1998-04-23 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
Download or read book Introduction to Computational Molecular Biology written by João Carlos Setubal and published by Pws Publishing Company. This book was released on 1997 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic concepts of molecular biology. Strings, graphs, and algorithms. Sequence comparasion and database search. Fragment assembly of DNA. Physical mapping of DNA. Phylogenetic trees. Genome rearrangements. Molecular structure prediction. epilogue: computing with DNA. Answers to selected exercises. References. index.
Download or read book A History of Genomics across Species Communities and Projects written by Miguel García-Sancho and published by Springer Nature. This book was released on 2023-03-31 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production.
Download or read book Dreamers Visionaries and Revolutionaries in the Life Sciences written by Oren Harman and published by University of Chicago Press. This book was released on 2018-07-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the conditions that foster true novelty and allow visionaries to set their eyes on unknown horizons? What have been the challenges that have spawned new innovations, and how have they shaped modern biology? In Dreamers, Visionaries, and Revolutionaries in the Life Sciences, editors Oren Harman and Michael R. Dietrich explore these questions through the lives of eighteen exemplary biologists who had grand and often radical ideas that went far beyond the run-of-the-mill science of their peers. From the Frenchman Jean-Baptiste Lamarck, who coined the word “biology” in the early nineteenth century, to the American James Lovelock, for whom the Earth is a living, breathing organism, these dreamers innovated in ways that forced their contemporaries to reexamine comfortable truths. With this collection readers will follow Jane Goodall into the hidden world of apes in African jungles and Francis Crick as he attacks the problem of consciousness. Join Mary Lasker on her campaign to conquer cancer and follow geneticist George Church as he dreams of bringing back woolly mammoths and Neanderthals. In these lives and the many others featured in these pages, we discover visions that were sometimes fantastical, quixotic, and even threatening and destabilizing, but always a challenge to the status quo.
Download or read book Bioinformatics in the Post genomic Era written by Jeffrey Augen and published by Addison-Wesley Professional. This book was released on 2005 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive treatment of the role of bioinformatics in the emerging world of molecular medicine, for anyone involved in this new field
Download or read book Computers and DNA written by Thomas Marr and published by Westview Press. This book was released on 1990-01-22 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fields of molecular biology and genetics are faced with an enormous accumulation of information: DNA sequencing, associated sequences of amino acids in proteins, genetics, macromolecular structures and other sets have created a quantitative backlog of data which needs to be organized and analyzed. Moreover, the rate of data acquisitions is accelerating as improved technologies are used and as organized programs such as the Human Genome Initiative are established. Because of this data's importance, molecular biologists have turned to computational scientists for help in processing this mass of information. The Santa Fe Institute organized a workshop on "The Interface Between Computational Science and DNA Sequencing" in 1998 to address this information crisis. Approximately one hundred molecular biologists, computer scientists, mathematicians, and other scientists in diverse fields met to discuss how computational science can best keep pace with molecular biology. The papers presented at that meeting and included in this volume serve as a comprehensive introduction to the field and as a discussion of research on some of the current problems.
Download or read book Biocomputing written by Phillip A. Laplante and published by Nova Publishers. This book was released on 2003 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the mid-1990s advances in DNA sequencing have enhanced our understanding of humanity and all living things. Driven by these advances, the closely related sciences of Bioinformatics and Biocomputing have become the ultimate interdisciplinary study areas, forever blurring the lines between engineering, biology and computer science and bringing together researchers who ordinarily wouldn't interact. While Bioinformatics largely focuses on the analysis, prediction, imaging and sequencing of genes, the broader, interdisciplinary field of Biocomputing includes the study of biological models of computing using traditional materials, genomic modelling and visualisation, biomaterials for non-traditional computer designs and computer architectures for those materials. In addition, Biocomputing uses the principles and tools of computer science to model or algorithmically specify complex biological information systems and computational systems with life-like capabilities. Biocomputing has manifested numerous government multi-agency programs, including the Human Genome Project, the High Performance Computing & Communications (HPCC) initiative, the Human Brain Project, and other related programs such as the National Information Infrastructure and Digital Libraries initiatives, which have strong bio-related components. This book brings together the latest research in this fast-growing field.
