Download or read book Biochemistry of Platelets written by David Phillips and published by Elsevier. This book was released on 2012-12-02 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.
Download or read book Biochemistry and Pharmacology of Platelets written by Katherine Elliott and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Download or read book The Platelets written by Gesina Longenecker and published by Elsevier. This book was released on 2012-12-02 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet a-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease.
Download or read book Biochemistry of Blood Platelets written by Federation of European Biochemical Societies and published by Academic Press. This book was released on 1967 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Platelets written by Alan D. Michelson and published by Elsevier. This book was released on 2011-08-29 with total page 1386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. First edition won Best Book in Medical Science Award from the Association of American Publishers Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references
Download or read book The Circulating Platelet written by Shirley A. Johnson and published by Elsevier. This book was released on 2012-12-02 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Circulating Platelet focuses on the biochemistry and physiology of platelets. Composed of contributions of authors, the compilation starts with the discussions on the origin, discovery, production, and life span of blood platelets. The discussions continue with the morphology of platelets. Concerns include peripheral, sol-gel, and organelle zones and the membrane systems. The book also looks at the energy metabolism of thrombocytes and highlights the presence of glycoproteins in blood platelets. These include polysaccharides, glucosaminoglycans, and glycoproteins. The text also discusses the properties, functions, and the physiological value of thrombosthenin. The compilation further discusses platelet aggregation and functions of platelets. Concerns include collection and processing of platelets; preparation of homogenates; and the agents that influence platelet aggregation. The role of platelets in blood clots and fibrinolysis is emphasized. The selection ends with discussions on the immunological reactions of platelets; the clinical diseases related to blood platelets; and blood transfusion and preservation. The text is vital for researchers interested in studying blood platelets.
Download or read book Williams Hematology Hemostasis and Thrombosis written by Kenneth Kaushansky and published by McGraw Hill Professional. This book was released on 2018-01-12 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemostasis and Thrombosis as only Williams can cover them A Doody’s Core Title for 2019! Featuring content derived from Williams Hematology, Ninth Edition. this concise, full-color resource delivers comprehensive and current coverage of hemostasis and thrombosis, and platelet and megakaryocyte disorders. More than a sectional reprint, the book includes updated science and treatment recommendations not found in the 2015 release of Williams Hematology, Ninth Edition. Perfect for use at the point of care, Williams Hemostasis and Thrombosis offers the most current evaluation and treatment options for patients with bleeding and thrombotic disorders. •Covers the latest advances in hemostasis and thrombosis •A handy quick summary appears at the beginning of each chapter •Discusses the physiologic basis for hemostasis and thrombosis
Download or read book Handbook of Platelet Physiology and Pharmacology written by Gundu H.R. Rao and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology, and function. It provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs.
Download or read book Biochemistry of Platelets written by David R. Phillips and published by . This book was released on 1986 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Platelet Membrane Glycoproteins written by James N. George and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was just about ten years ago that platelet membrane glycoproteins were first charac terized and their abnormalities in congenital bleeding disorders first recognized. Dur ing this decade there has been a remarkable growth in our understanding of the structure and membrane organization of the platelet surface glycoproteins, their in teractions with external ligands during the process of hemostasis, and their defects causing hemorrhagic disease. These studies have advanced the knowledge of platelet involvement in hemostasis from a cellular to a molecular level, and they have provided a model for contact interactions among other cell types. This seemed a proper time to ask those who contributed major observations and insights during these past years to review their progress and to assess the state of our present knowledge. We have planned this volume to begin with the biochemistry of platelet membrane glycoproteins themselves and proceed through their involvement in platelet function to the final considerations of the platelet's role in maintaining the integrity of the vascular system. Our aim was an integrated presentation on the blood platelet from the perspective of its highly specialized and reactive cell surface. James N. George Alan T. Nurden David R. Phillips vii Contents I. INTRODUCTION 1. Plasma Membrane Receptors and Platelet Response Ernst F. Wscher 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Platelet Receptor Functions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . 2. 1. Receptors Involved in Platelet Adhesion and in Cell-Cell Contact. . . 5 2. 2. Receptors Involved in Platelet Activation. . . . . . . . . . . . . . . . . . . 6 . . . . 3. Conclusion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 II.
Download or read book Biochemistry and Physiopathology of Platelet Membrane written by Gérard Marguerie and published by . This book was released on 1988 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Manual of Blood Platelets Morphology Physiology and Pharmacology written by Gundu HR Rao and published by Jaypee Brothers Medical Publishers. This book was released on 2018-11-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets are tiny blood cells that help the body form clots to stop bleeding. Antiplatelet medications, such as aspirin and clopidogrel, are commonly used to thin the blood which limits clotting and reduces the risk of heart attack. This book is a comprehensive guide to blood platelets for haematologists. Beginning with discussion on platelet structure, morphology, function and physiology, the next chapters cover the role of calcium in platelet activation and calcium modulation by cyclic nucleotides. The following sections explain the pharmacology of antiplatelet drugs, antiplatelet therapies, aspirin resistance, and the association of diabetes mellitus with major platelet dysfunction. The book concludes with chapters on acute coronary problems, interaction between endothelial cells and platelets, and blood biocompatibility studies. Authored by a Minneapolis-based expert in the field, the text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to blood platelets for haematologists Extensive coverage of antiplatelet drugs and resistance Recognised author from University of Minnesota Highly illustrated with clinical photographs, diagrams and tables
Download or read book Platelets written by Alan D. Michelson and published by Academic Press. This book was released on 2013-01-09 with total page 1399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. Highly Commended BMA Medical Book Award 2013: Internal Medicine Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists Integrates the entire field of platelet biology, pathophysiology, and clinical medicine Full color reference comprising 64 chapters, 1400 pages, and 16,000 references Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo
Download or read book Platelet Heterogeneity written by John Martin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Battle is a practical and sometimes lasting way of solving man's problems. It relies on the strength of the combatants and ignores the truth of the dispute. Discussion face to face can dissolve attitudes which have incorrectly determined judgements. The most striking example of this that I know is a Battle in Ireland in the eleventh century, where the king of Leinster fought a Viking prince. The Icelanders had raided Ireland for several generations in search of women, which they lacked since most of the population of Iceland were men who had arrived there by rowing long-boats from Norway. The prince was leading such a raid for the first time. Standing in the prow of the leading boat he saw Irish cavalry galloping along the beach to meet them. As they approached the shore the Irish king rode out of the band to challenge single combat. The Icelander jumped into the surf to meet him. As they raised their swords each realized that the other's face was like his own. When the Irish king spoke the other recognized the language. It had been spoken in Iceland by his grandmother who had been captured and taken there from Ireland. Swords were dropped and replaced by drinking horns. It was soon established that they were cousins. The battle gave way to a life-time of close co-operation.
Download or read book Platelet Function and Thrombosis written by Pier Mannuccio Mannucci and published by Springer. This book was released on 1973-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fondazione Lorenzini has been sponsoring Postgraduate Courses for physicians and specialists, in Italy, since 1970. Its aim, as an institution, has been that of promoting post graduate medical education. In these years, recent advances in a wide range of medical fields have been discussed by distinguished experts from many countries throughout the world. Courses dealing with methodo logies and technical problems have been designed to include practical demonstrations of the various methods and techniques in the relevant fields. The Postgraduate Course on "Platelets and Thrombosis: Methods of Study" was held in Milan, at the Fondazione Lorenzini, from February 24th to 26th, 1972. This volume contains the edited and somewhat extended papers presented at the Course, which was sponsored and organized by the Italian Society for the Study of Atherosclerosis. The special contribution of the present volume is that of gathering a large amount of up-to-date information on the formidable problem of the methods used for testing platelet function in thrombosis.
Download or read book Mechanisms of Platelet Activation and Control written by Kalwant S. Authi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K. ), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.
Download or read book Williams Hematology 9E written by Kenneth Kaushansky and published by McGraw Hill Professional. This book was released on 2015-12-23 with total page 2528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2019! Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.