Download or read book Bioactive Peptide Grafted Polyurethane Copolymers written by Horng-Ban Lin and published by . This book was released on 1992 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hybrid Block and Graft Copolymers Made from Macrolactones and amino Acids for Applications as Drug Delivery Nanosystems written by Ernesto Tinajero Díaz and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Naturally produced peptides or proteins can be regarded as highly refined polymers. When synthetic polymers are married to proteins or peptides, the resulting bioconjugates can synergistically combine the properties of the individual components and overcome their separate limitations. This Thesis is focused on the study of hybrid copolymers based on polypeptides and polymacrolactones. Block and graft copolymers have been synthesized by making use of the ring opening polymerization method (ROP) mainly and extensively characterized including both their chemical structure and their structure in the solid state. The self-assembly properties of the new copolymers have been preliminary examined regarding their potential application as nanocarriers for pharmaceutical compounds. This Thesis initially reports the ROP of w-pentadecalactone (PDL) using different amino-ended initiators and assisted by either organic or enzymatic catalysts. This method was then extended for the ROP of PDL using bisamino-ended poly(ethylene glycol) (PEG) for the preparation of poly(w-pentadecalactone)-b-poly(ethylene glycol)-b-poly(wpentadecalactone) [PPDLx-PEG-PPDLx] triblock copolymers. These amphiphilic ABA-type copolymers were able to selfassemble in water to form nanoparticles with diameters between 100 and 200 nm. Hybrid copolymers of poly(ester-peptide) or poly(ether-ester-peptide) type exhibiting different architectures (e.g. diblock, triblock, graft or triblock/grafted) respectively, were then synthesized using as building blocks: poly(w-pentadecalactone), poly(globalide) (PGl), PEG as well as polypeptides derived from the L-glutamic acid (Glu), L-lysine (Lys), L-alanine (Ala) and L-phenylalanine (Phe) a-amino acids. The hybrid copolymers were synthesized through several stages depending on the desired architecture. The first stage in the preparation of these copolymers was the synthesis of macroinitiators from PDL or PGl containing either an amino group at the end of the chain or multiple amine groups along their polymeric chain. In the second stage, such macroinitiators were used to trigger the polymerization of the a-amino acid N-carboxyanhyrides (NCA) with the COOH group of L-glutamic acid and NH2 of L-lysine duly protected as g-benzyl-L-glutamate (BLG) and eNcarbobenzoxy-L-lysine (ZLL) respectively. Some copolymers containing BLG or ZLL units were treated with acids to render copolymers bearing the amino acids residues with their COOH or NH2 functionalities in the free form. All of the synthesized copolymers were fully characterized through GPC and NMR spectroscopy. The thermal properties were studied by TGA and DSC techniques. The conformation adopted by the peptide-based copolymers in the solid-state was assessed by FTIR, and their crystalline structure was examined by X-ray diffraction using synchrotron radiation in most cases. The conformation in aqueous solution of water-soluble copolymers containing Glu or Lys residues in the free form was explored by circular dichroism. The self-assembly behavior in aqueous medium of all the amphiphilic copolymers was investigated with the purpose of obtaining nanoparticles with the appropriated diameters required for their application as biomedical nanocarriers. The nanoparticles were duly characterized by light scattering and SEM and TEM microscopies. Block and graft copolymers were able to load doxorubicin and release it under pH control. Copolymers containing L-lysine were shown to be able of condensing DNA. The potential of these copolymers as 31S of anticancer drugs and vectors for transfection have been evidenced.
Download or read book Polyurethanes in Biomedical Applications written by NinaM.K. Lamba and published by Routledge. This book was released on 2017-10-19 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyurethanes in Biomedical Applications studies the use of polyurethanes in implanted medical devices. This analysis describes the concepts of polymer science, the manufacture of polyurethanes, and the biological responses to implant polyurethanes, reflecting the developments in biomaterials science and the interdisciplinary nature of bioengineering.
Download or read book Comprehensive Biotechnology written by and published by Newnes. This book was released on 2011-08-26 with total page 5304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Biotechnology, Six Volume Set continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field
Download or read book Graft Copolymers written by H. A. J. Battaerd and published by . This book was released on 1967 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biopolymer Grafting Synthesis and Properties written by Vijay Kumar Thakur and published by Elsevier. This book was released on 2017-09-27 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymer Grafting: Synthesis and Properties presents the latest research and developments in fundamental of synthesis and properties of biopolymer-based graft copolymers. The book presents a broad overview of the biopolymer grafting process, along with trends in the field. It also introduces a range of grafting methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of these techniques. The book bridges the knowledge gap between the scientific principles and industrial applications of polymer grafting. This book covers synthesis and characterization of graft-copolymers of plant polysaccharides, functional separation membranes from grafted biopolymers, and polysaccharides in alternative methods for insulin delivery. Recent trends and advances in this area are discussed, assisting materials scientists and researchers in mapping out the future of these new "green" materials through value addition to enhance their use. Introduces polymer researchers to a promising, rapidly developing method for modifying naturally derived biopolymers Provides a one-stop shop covering synthesis, properties, characterization and graft copolymerization of bio-based polymeric materials Increases familiarity with a range of biopolymer grafting processes, enabling materials scientists and engineers to improve material properties and widen the range of potential biopolymer applications
Download or read book Biopolymer Grafting Applications written by Vijay Kumar Thakur and published by Elsevier. This book was released on 2017-09-19 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopolymer Grafting: Applications presents the latest research and developments in the practical application of these methods in industry, both to enable polymer scientists and engineers to keep up with the latest research trends, as well as to propose ideas for further research and application. Research into bio-based polymers has become increasingly prevalent. However, due to challenges related to the properties of these materials compared to synthetic polymers—such as their resistance to chemicals or weather—uptake has not dramatically increased yet. As a result, improvements in surface modification of bio-polymers through graft copolymerization are enormously important, because they will widen the scope of their applications. Relevant industries for application of these methods include automotive, construction, food, packaging, agriculture, textiles and paper. This book provides an overview of the developments made in the area of biopolymer-based graft polymers. Advantages, disadvantages and suggestions for future works are discussed, assisting materials scientists and researchers in mapping out the future of these new "green" materials through value addition to enhance their use. Helps researchers and product developers understand the applications and limitations of biopolymer copolymers or copolymers of natural polymers Offers a roadmap to future applications development in a range of different industries, including automotive, biomedical and packaging Increases familiarity with a range of biopolymer grafting processes, enabling materials scientists and engineers to improve material properties and widen the range of potential biopolymer applications
Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
Download or read book Block and Graft Copolymers written by R. J. Ceresa and published by . This book was released on 1962 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solid Phase Synthesis of Graft Copolymers of Poly thiophene s and Peptides Containing 3 thienylalanine written by David W. Flanagan and published by . This book was released on 2004 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Biodegradable Polymers written by Abraham J. Domb and published by CRC Press. This book was released on 1998-02-04 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Biodegradable Polymers, the seventh volume in the Drug Delivery and Targeting book series, provides a source manual for synthetic procedures, properties and applications of bioerodible polymers. The authors describe widely available materials such as polyactides, collagen and gelatin, as well as polymers of emerging importance, such as the genetically-engineered and elastin-based polymers which are either proprietary or in early stages of development. Section I addresses synthetic absorbable polymers, and Section 2 profiles natural, semi-synthetic and biosynthetic polymers. Section 3 discusses the surface characterization of degradable polymers, the modeling of biodegradation and non-medical polymers. This book is ideal for researchers from academia and industry as well as chemists, pharmacists and physicians who deal with biopolymers, drug delivery and targeting, bioengineering and implantable devices.
Download or read book Polymer Yearbook written by and published by . This book was released on 1995 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Pharmaceutical Design written by and published by . This book was released on 1997-12 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Polysaccharide Based Graft Copolymers written by Susheel Kalia and published by Springer Science & Business Media. This book was released on 2013-05-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Renowned experts give all essential aspects of the techniques and applications of graft copolymers based on polysaccharides. Polysaccharides are the most abundant natural organic materials and polysaccharide based graft copolymers are of great importance and widely used in various fields. Natural polysaccharides have recently received more attention due to their advantages over synthetic polymers by being non-toxic, biodegradable and available at low cost. Modification of polysaccharides through graft copolymerization improves the properties of polysaccharides. Grafting is known to improve the characteristic properties of the backbones. Such properties include water repellency, thermal stability, flame resistance, dye-ability and resistance towards acid-base attack and abrasion. Polysaccharides and their graft copolymers find extensive applications in diversified fields. Applications of modified polysaccharides include drug delivery devices, controlled release of fungicides, selective water absorption from oil-water emulsions, purification of water etc.
Download or read book Antioxidant Polymers written by Giuseppe Cirillo and published by John Wiley & Sons. This book was released on 2012-06-07 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antioxidant Polymers is an exhaustive overview of the recent developments in the field of polymeric materials showing antioxidant properties. This research area has grown rapidly in the last decade because antioxidant polymers have wide industry applications ranging from materials science to biomedical, pharmaceuticals and cosmetics.
Download or read book Cellulose Based Graft Copolymers written by Vijay Kumar Thakur and published by CRC Press. This book was released on 2015-04-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellulose-Based Graft Copolymers: Structure and Chemistry discusses the synthesis, characterization, and properties of multifunctional cellulose-based graft copolymers. Presenting the contributions of accomplished experts in the field of natural cellulosic polymers, this authoritative text: Offers an overview of cutting-edge technical accomplishments in natural cellulose-based graft polymers Addresses a separate biomaterial in each chapter, exploring composition as well as graft copolymerization chemistry Covers fundamentals and applications including toxic ion removal, biomedical engineering, biofuels, micro/nano composites, papermaking, building materials, and defense Cellulose-Based Graft Copolymers: Structure and Chemistry tackles several critical issues and provides suggestions for future work, supplying deeper insight into the state of the art of advanced cellulose-based graft copolymers.
