Download or read book Big Data in Omics and Imaging written by Momiao Xiong and published by CRC Press. This book was released on 2018-06-14 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases. FEATURES Provides a natural extension and companion volume to Big Data in Omic and Imaging: Association Analysis, but can be read independently. Introduce causal inference theory to genomic, epigenomic and imaging data analysis Develop novel statistics for genome-wide causation studies and epigenome-wide causation studies. Bridge the gap between the traditional association analysis and modern causation analysis Use combinatorial optimization methods and various causal models as a general framework for inferring multilevel omic and image causal networks Present statistical methods and computational algorithms for searching causal paths from genetic variant to disease Develop causal machine learning methods integrating causal inference and machine learning Develop statistics for testing significant difference in directed edge, path, and graphs, and for assessing causal relationships between two networks The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell –specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.
Download or read book Big Data in Omics and Imaging written by Momiao Xiong and published by CRC Press. This book was released on 2017-12-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data in Omics and Imaging: Association Analysis addresses the recent development of association analysis and machine learning for both population and family genomic data in sequencing era. It is unique in that it presents both hypothesis testing and a data mining approach to holistically dissecting the genetic structure of complex traits and to designing efficient strategies for precision medicine. The general frameworks for association analysis and machine learning, developed in the text, can be applied to genomic, epigenomic and imaging data. FEATURES Bridges the gap between the traditional statistical methods and computational tools for small genetic and epigenetic data analysis and the modern advanced statistical methods for big data Provides tools for high dimensional data reduction Discusses searching algorithms for model and variable selection including randomization algorithms, Proximal methods and matrix subset selection Provides real-world examples and case studies Will have an accompanying website with R code The book is designed for graduate students and researchers in genomics, bioinformatics, and data science. It represents the paradigm shift of genetic studies of complex diseases– from shallow to deep genomic analysis, from low-dimensional to high dimensional, multivariate to functional data analysis with next-generation sequencing (NGS) data, and from homogeneous populations to heterogeneous population and pedigree data analysis. Topics covered are: advanced matrix theory, convex optimization algorithms, generalized low rank models, functional data analysis techniques, deep learning principle and machine learning methods for modern association, interaction, pathway and network analysis of rare and common variants, biomarker identification, disease risk and drug response prediction.
Download or read book Big Data in Omics and Imaging Two Volume Set written by Taylor & Francis Group and published by . This book was released on 2018-06-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Big Data in Multimodal Medical Imaging written by Ayman El-Baz and published by CRC Press. This book was released on 2019-11-05 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an urgent need to develop and integrate new statistical, mathematical, visualization, and computational models with the ability to analyze Big Data in order to retrieve useful information to aid clinicians in accurately diagnosing and treating patients. The main focus of this book is to review and summarize state-of-the-art big data and deep learning approaches to analyze and integrate multiple data types for the creation of a decision matrix to aid clinicians in the early diagnosis and identification of high risk patients for human diseases and disorders. Leading researchers will contribute original research book chapters analyzing efforts to solve these important problems.
Download or read book Machine Learning With Radiation Oncology Big Data written by and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation oncology is uniquely positioned to harness the power of big data as vast amounts of data are generated at an unprecedented pace for individual patients in imaging studies and radiation treatments worldwide. The big data encountered in the radiotherapy clinic may include patient demographics stored in the electronic medical record (EMR) systems, plan settings and dose volumetric information of the tumors and normal tissues generated by treatment planning systems (TPS), anatomical and functional information from diagnostic and therapeutic imaging modalities (e.g., CT, PET, MRI and kVCBCT) stored in picture archiving and communication systems (PACS), as well as the genomics, proteomics and metabolomics information derived from blood and tissue specimens. Yet, the great potential of big data in radiation oncology has not been fully exploited for the benefits of cancer patients due to a variety of technical hurdles and hardware limitations. With recent development in computer technology, there have been increasing and promising applications of machine learning algorithms involving the big data in radiation oncology. This research topic is intended to present novel technological breakthroughs and state-of-the-art developments in machine learning and data mining in radiation oncology in recent years.
Download or read book Big Data in Medical Image Processing written by R. Suganya and published by CRC Press. This book was released on 2018-01-29 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of medical imaging seen rapid development over the last two decades and has consequently revolutionized the way in which modern medicine is practiced. Diseases and their symptoms are constantly changing therefore continuous updating is necessary for the data to be relevant. Diseases fall into different categories, even a small difference in symptoms may result in categorising it in a different group altogether. Thus analysing data accurately is of critical importance. This book concentrates on diagnosing diseases like cancer or tumor from different modalities of images. This book is divided into the following domains: Importance of big data in medical imaging, pre-processing, image registration, feature extraction, classification and retrieval. It is further supplemented by the medical analyst for a continuous treatment process. The book provides an automated system that could retrieve images based on user’s interest to a point of providing decision support. It will help medical analysts to take informed decisions before planning treatment and surgery. It will also be useful to researchers who are working in problems involved in medical imaging.
Download or read book Radiomics and Radiogenomics written by Ruijiang Li and published by CRC Press. This book was released on 2019-07-09 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation
Download or read book Big Data in Radiation Oncology written by Jun Deng and published by CRC Press. This book was released on 2019-03-07 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are: Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy. Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas. Discusses the fundamental principles and techniques for processing and analysis of big data. Address the use of big data in cancer prevention, detection, prognosis, and management. Provides practical guidance on implementation for clinicians and other stakeholders. Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale-New Haven Hospital. He has received numerous honors and awards such as Fellow of Institute of Physics in 2004, AAPM Medical Physics Travel Grant in 2008, ASTRO IGRT Symposium Travel Grant in 2009, AAPM-IPEM Medical Physics Travel Grant in 2011, and Fellow of AAPM in 2013. Lei Xing, Ph.D., is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. His research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, and applications of molecular imaging in radiation oncology. Dr. Xing is on the editorial boards of a number of journals in radiation physics and medical imaging, and is recipient of numerous awards, including the American Cancer Society Research Scholar Award, The Whitaker Foundation Grant Award, and a Max Planck Institute Fellowship.
Download or read book Machine Learning With Radiation Oncology Big Data written by Jun Deng and published by Frontiers Media SA. This book was released on 2019-01-21 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Systems Analytics and Integration of Big Omics Data written by Gary Hardiman and published by MDPI. This book was released on 2020-04-15 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: A “genotype" is essentially an organism's full hereditary information which is obtained from its parents. A "phenotype" is an organism's actual observed physical and behavioral properties. These may include traits such as morphology, size, height, eye color, metabolism, etc. One of the pressing challenges in computational and systems biology is genotype-to-phenotype prediction. This is challenging given the amount of data generated by modern Omics technologies. This “Big Data” is so large and complex that traditional data processing applications are not up to the task. Challenges arise in collection, analysis, mining, sharing, transfer, visualization, archiving, and integration of these data. In this Special Issue, there is a focus on the systems-level analysis of Omics data, recent developments in gene ontology annotation, and advances in biological pathways and network biology. The integration of Omics data with clinical and biomedical data using machine learning is explored. This Special Issue covers new methodologies in the context of gene–environment interactions, tissue-specific gene expression, and how external factors or host genetics impact the microbiome.
Download or read book Artificial Intelligence in Medical Imaging written by Erik R. Ranschaert and published by Springer. This book was released on 2019-01-29 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.
Download or read book Big Data in Multimodal Medical Imaging written by Ayman El-Baz and published by CRC Press. This book was released on 2019-11-05 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an urgent need to develop and integrate new statistical, mathematical, visualization, and computational models with the ability to analyze Big Data in order to retrieve useful information to aid clinicians in accurately diagnosing and treating patients. The main focus of this book is to review and summarize state-of-the-art big data and deep learning approaches to analyze and integrate multiple data types for the creation of a decision matrix to aid clinicians in the early diagnosis and identification of high risk patients for human diseases and disorders. Leading researchers will contribute original research book chapters analyzing efforts to solve these important problems.
Download or read book Big Data Analytics in Bioinformatics and Healthcare written by Wang, Baoying and published by IGI Global. This book was released on 2014-10-31 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: As technology evolves and electronic data becomes more complex, digital medical record management and analysis becomes a challenge. In order to discover patterns and make relevant predictions based on large data sets, researchers and medical professionals must find new methods to analyze and extract relevant health information. Big Data Analytics in Bioinformatics and Healthcare merges the fields of biology, technology, and medicine in order to present a comprehensive study on the emerging information processing applications necessary in the field of electronic medical record management. Complete with interdisciplinary research resources, this publication is an essential reference source for researchers, practitioners, and students interested in the fields of biological computation, database management, and health information technology, with a special focus on the methodologies and tools to manage massive and complex electronic information.
Download or read book Biocomputing 2022 Proceedings Of The Pacific Symposium written by Russ B Altman and published by World Scientific. This book was released on 2021-11-29 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB) 2022 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2022 will be held on January 3 - 7, 2022 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2022 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Download or read book Biomedical Image or Genomic Data Characterization and Radiogenomic Image omics written by Ming Fan and published by Frontiers Media SA. This book was released on 2022-09-27 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of the emphasis in discussions about personalized medicine has been focused on the molecular characterization of tissue samples using microarray technology. However, as genetic differ between and within tumors and are quite heterogeneous, these techniques are limited. Imaging is noninvasive and is often used in routine clinical practice for disease diagnosis, treatment, and prognosis. Imaging is useful to guide disease therapy by providing a more comprehensive view of the entire lesion and it can be used on an ongoing basis to monitor lesion growth and progression or its response to treatment. The imaging includes but not limited to ultrasound, X-ray, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET). Radiomics refers to the conversion of images to high dimensional data and the subsequent mining for characterization of biology and ultimately to improve disease management for patients. Radiogenomics investigates relationships between imaging features and genomics, which represents the correlation between the anatomical-histological level to the genomic level. With advanced artificial intelligence methods, especially deep learning, data processing, feature extraction and data integration have been greatly improved. The topic is about artificial intelligence methods in biomedical images and genomics data for disease diagnosis, treatment, and prognosis, as listed here: • Biomarker identification from biomedical images to predict disease diagnosis, treatment, and prognosis • Radiogenomics/image-omics in identifying imaging biomarkers associated with molecular characteristics of the disease. • Machine learning/deep learning methods in biomedical imaging or genomics for disease detection and precision medicine. • Prediction of histological characteristics of disease based on biomedical imaging. • Integration of radiomics and genomics features for disease diagnosis, prognosis, and prediction medicine • Multimodality images or multi-omics data integration methods
Download or read book Biotechnology written by Mehdi Khosrowpour and published by Medical Information Science Reference. This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology can be defined as the manipulation of biological process, systems, and organisms in the production of various products. With applications in a number of fields such as biomedical, chemical, mechanical, and civil engineering, research on the development of biologically inspired materials is essential to further advancement. Biotechnology: Concepts, Methodologies, Tools, and Applications is a vital reference source for the latest research findings on the application of biotechnology in medicine, engineering, agriculture, food production, and other areas. It also examines the economic impacts of biotechnology use. Highlighting a range of topics such as pharmacogenomics, biomedical engineering, and bioinformatics, this multi-volume book is ideally designed for engineers, pharmacists, medical professionals, practitioners, academicians, and researchers interested in the applications of biotechnology.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
