Download or read book Environmental Contaminants and Endocrine Health written by Oliana Carnevali and published by Elsevier. This book was released on 2023-05-30 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat. This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas. - Includes important foundational coverage of the endocrine system, definitions of EDC sources and descriptions, model examples and mechanisms of action biological effects - Provides coverage of EDC effects in humans and animals, from metabolic alterations to epidemiological studies of fertility and metabolism - Presents insights into the confirmed and suspected human diseases spectrum with origins linked to EDC exposure, including cancers, intellectual disabilities, autism, birth defects of the urethra (hypospadias), decreased sperm count, increased rates of miscarriage, obesity, type 2 diabetes, and more

Download or read book Health Impacts of Developmental Exposure to Environmental Chemicals written by Reiko Kishi and published by Springer Nature. This book was released on 2019-12-13 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.

Download or read book Toxicoepigenetics written by Shaun D. McCullough and published by Academic Press. This book was released on 2018-11-02 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. - Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology - Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds - Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

Download or read book Pneumopedics And Craniofacial Epigenetics Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing written by G Dave Singh and published by World Scientific. This book was released on 2021-03-05 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive introduction to the novel concepts of pneumopedics and craniofacial epigenetics. Clinically, these mechanisms are delivered through biomimetic oral appliance therapy. The text, therefore, covers both genetics and epigenetics of craniofacial development, as well as growth and development of the craniofacial architecture. Despite being complex subjects, the style of writing allows the general reader to assimilate this information and sets the scene for how these principles might best be utilized. For example, the clinical application of biomimetic tooth movement achieved through epigenetic orthodontics is presented. Prior to pneumopedic treatment, the significance of craniofacial diagnostics and treatment planning is discussed, before detailing the principles of designing a biomimetic oral appliance. Next, the book goes over the practicalities of clinical adjustments of oral biomimetic devices. Moving onto patient selection and management, the book also provides an overview and introduction to pediatric craniofacial epigenetics, which touches upon the preventive aspects of healthcare, including nutrition. This section is followed by an introduction to sleep and sleep disordered breathing in both children and adults, which includes a comprehensive approach to the potential elimination of obstructive sleep apnea. Finally, clinical biomimetic correction is illustrated with examples of non-surgical upper airway remodeling using various cases. The book also contains a Glossary containing definitions of common terms as well as an Appendix of documents that might be useful for both implementation and further study.

Download or read book Pharmacokinetics and Toxicokinetic Considerations Vol II written by Rakesh Kumar Tekade and published by Academic Press. This book was released on 2022-02-05 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. - Allows readers to systematically integrate up-to-date research findings into their laboratory work - Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment - Provides clinical applications of concepts

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Download or read book Endocrine Disrupting Chemicals induced Metabolic Disorders and Treatment Strategies written by Muhammad Sajid Hamid Akash and published by Springer. This book was released on 2021-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.

Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

Download or read book Edible Medicinal and Non Medicinal Plants written by T. K. Lim and published by Springer. This book was released on 2016-02-11 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers such plants with edible modified storage subterranean stems (corms, rhizomes, stem tubers) and unmodified subterranean stem stolons, above ground swollen stems and hypocotyls, storage roots (tap root, lateral roots, root tubers), and bulbs, that are eaten as conventional or functional food as vegetables and spices, as herbal teas, and may provide a source of food additive or neutraceuticals. This volume covers selected plant species with edible modified stems, roots and bulbs in the families Iridaceae, Lamiaceae, Marantaceae, Nelumbonaceae, Nyctaginaceae, Nymphaeaceae, Orchidaceae, Oxalidaceae, Piperaceae, Poaceae, Rubiaceae and Simaroubaceae. The edible species dealt with in this work include wild and underutilized crops and also common and widely grown ornamentals. To help in identification of the plant and edible parts coloured illustrations are included. As in the preceding ten volumes, topics covered include: taxonomy (botanical name and synonyms); common English and vernacular names; origin and distribution; agro-ecological requirements edible plant parts and uses; plant botany; nutritive, medicinal and pharmacological properties with up-to-date research findings; traditional medicinal uses; other non-edible uses; and selected/cited references for further reading. This volume has separate indices for scientific and common names; and separate scientific and medical glossaries.

Download or read book The Obesogen Effect written by Bruce Blumberg and published by Grand Central Life & Style. This book was released on 2018-03-20 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: An eye-opening account of the landmark research into the hidden chemicals that are endangering our health and keeping us fat. Being overweight is not just the result of too many cheeseburgers or not enough exercise. According to leading-edge science, a new group of silent saboteurs in our daily lives is contributing greatly to our obesity epidemic: obesogens. These weight-inducing offenders, most of which are chemicals, disrupt our hormonal systems, altering how we create and store fat, and changing how we respond to dietary choices and caloric intake. Because they are largely unregulated, obesogens lurk all around us-in food, furniture, plastic products such as water bottles and food storage containers, and other surprising exposure points. Even worse: research has shown that the effects of some obesogens can be passed on to future generations by irreversibly interfering with the expression of our genes. The good news is we can protect ourselves by becoming more informed consumers. In The Obesogen Effect, Dr. Bruce Blumberg explains how obesogens work, where they are found, and how we can minimize their effects. Dr. Blumberg offers a highly practical three-step solution for reducing exposures. He explains why one size does not fit all in a weight loss program, what harmful additives are in our household goods, and how we should shop for obesogen-free items we use every day-from vegetables and meats to canned soup as well as household cleaners, air fresheners, and personal care products. The Obesogen Effect, is an urgent call to action to protect your body, clean up your life, and set a straight course for better health.

Download or read book Microbial Biotechnology written by Jayanta Kumar Patra and published by Springer. This book was released on 2018-02-14 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, is a collection of 25 chapters describing the recent advancements in the application of microbial technology in the food and pharmacology sector. The main focus of this book is application of microbes, food preservation techniques utilizing microbes, probiotics, seaweeds, algae, enzymatic abatement of urethane in fermentation of beverages, bioethanol production, pesticides, probiotic biosurfactants, drought tolerance, synthesis of application of oncolytic viruses in cancer treatment, microbe based metallic nanoparticles, agro chemicals, endophytes, metabolites, antibiotics etc. This book highlighted the significant aspects of the vast subject area of microbial biotechnology and their potential applications in food and pharmacology with various topics from eminent experts around the World. This book would serve as an excellent reference book for researchers and students in the Food Science, Food Biotechnology, Microbiology and Pharmaceutical fields.

Download or read book Organic Pollutants written by M. Vasanthy and published by Springer Nature. This book was released on 2021-10-23 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment. The chapters present reviews on current applied toxicology research, occupational health hazards and green remedial solutions for pollution control in terrestrial and aquatic environments, with the aim of raising public awareness of these issues and providing chemists, toxicologists and environmental scientists with the knowledge to combat organic pollutants through sustainable means. Readers will learn about the multi-dimensional applications of materials and processes which harvest energy out of environmental remediation technologies, as well as the roles of biotechnology and nanotechnology in addressing high pollutant load. Specific attention is paid to technologies that draw energy through wastewater remediation, as this covers the primary means by which organic pollutants are introduced into the environment from industry and other sources. The book will be of use to pollution control boards, industry regulators, and students and researchers in the fields of biotechnology, biomedical science, hydrology and water chemistry.

Download or read book Childhood Obesity written by Michael I. Goran and published by CRC Press. This book was released on 2016-10-14 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Childhood obesity has reached epidemic proportions in the United States and continues to increase in prevalence in almost all countries in which it has been studied, including developed and developing countries around the globe. The causes of obesity are complex and multi-factorial. Childhood obesity becomes a life-long problem in most cases and is associated with long term chronic disease risk for a variety of diseases including type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, as well as psychosocial as issues and obesity seems to affect almost every organ system in the body. In recent years there has been tremendous progress in the understanding of this problem and in strategies for prevention and treatment in the pediatric years. Childhood Obesity: Causes, Consequences, and Intervention Approaches presents current reviews on the complex problem of obesity from the multi-level causes throughout early life before adulthood and the implications for this for long-term disease risk. It reviews numerous types of strategies that have been used to address this issue from conventional clinical management to global policy strategies attempting to modify the global landscape of food, nutrition, and physical activity. Each chapter is written by a global authority in his or her respective field with a focus on reviewing the current status and recent developments. The book features information on contributing factors to obesity, including developmental origins, social/family, birth cohort studies, influence of ethnicity, and global perspectives. It takes a life-course approach to the subject matter and includes exhaustive treatment of contributing factors to childhood obesity, such as assessment, environmental factors, nutrition and dietary factors, host factors, interventions and treatment, consequences, and further action for future prevention. This broad range of topics relevant to the rapidly changing field of childhood obesity is suitable for students, health care professionals, physicians, and researchers.

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-10-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Download or read book Phthalates and Cumulative Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2009-01-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

Download or read book Sirtuins written by Matthew D. Hirschey and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring a diverse array of model organisms and scientific techniques, Sirtuins: Methods and Protocols collects detailed contributions from experts in the field addressing this vital family of genes. Opening with methods to generate sirtuin biology tools, the book continues by covering methods to identify sirtuin substrates, to measure sirtuin activity, and to study sirtuin biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Sirtuins: Methods and Protocols presents detailed protocols for sirtuin research that can be followed directly or modified to investigate new areas of sirtuin biology.