Download or read book Predictive Approaches in Drug Discovery and Development written by J. Andrew Williams and published by John Wiley & Sons. This book was released on 2012-04-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

Download or read book The Expression of Possession written by William McGregor and published by Walter de Gruyter. This book was released on 2009 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of nine original articles deals with the expression of possession at various levels of grammar, morphological, phrasal, and syntactic, and from a typologically diverse range of languages (including Germanic, Oceanic, Meso-American, and Australian Aboriginal). There are two main aims. The first is to reveal something of the range of constructions employed cross-linguistically in the expression of possession, and second, to present an understanding of the possessive relation itself as a cognitive and linguistic phenomenon. A guiding principle in the selection of contributors has.

Download or read book Building and Interpreting Possession Sentences written by Neil Myler and published by MIT Press. This book was released on 2024-02-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide-ranging generative analysis of the typology of possession sentences, solving long-standing puzzles in their syntax and semantics. A major question for linguistic theory concerns how the structure of sentences relates to their meaning. There is broad agreement in the field that there is some regularity in the way that lexical semantics and syntax are related, so that thematic roles (the different participant roles in an event: agent, theme, goal, etc.) are predictably associated with particular syntactic positions. In this book, Neil Myler examines the syntax and semantics of possession sentences, which are infamous for appearing to diverge dramatically from this broadly regular pattern. On the one hand, Myler points out, possession sentences have too many meanings; in any given language, the construction used to express archetypal possessive meanings (such as personal ownership) is also often used to express other apparently unrelated notions (body parts, kinship relations, and many others). On the other hand, possession sentences have too many surface structures; languages differ markedly in the argument structures used to convey the same possessive meanings. Myler argues that recent work on the syntax-semantics interface in the generative tradition has developed the tools needed to solve these puzzles. Examining and synthesizing ideas from the literature and drawing on data from many languages (including some understudied Quechua dialects), Myler presents a novel way to understand the apparent irregularity of possession sentences while preserving explanations of general cross-linguistic regularities, offering a unified approach to the syntax and semantics of possession sentences that can also be integrated into a general theory of argument structure.

Download or read book Quantitative Approaches to Plant Breeding Concepts Strategies and Practical Applications written by Suchismita Mondal and published by Frontiers Media SA. This book was released on 2022-08-31 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Critical Approaches to Science and Philosophy written by Mario Bunge and published by Routledge. This book was released on 2018-10-08 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays, written on four continents by scientists, philosophers and humanists, was initially presented to Karl R. Popper on his sixtieth birthday as a token of critical admiration and in recognition of his work. But the volume also stands on its own as a remarkable series of statements utilizing Popper's critical vision in the study of philosophy proper, logic, mathematics, science as method and theory, and finally to the study of society and history. What is remarkable is that Popper worked in all of these areas, not in a cursory or discursive way, but with the utmost clarity and rigor. . The core position of this volume and its contributors is that the progress of knowledge is not a linear accumulation of definitive acquisitions but a zigzagging process in which counterexamples and unfavorable evidence ruin generalizations and prompt the invention of more comprehensive and sometimes deeper generalizations, to be criticized in their turn. A critical approach to problems, procedures, and results in every field of inquiry is therefore a necessary condition for the continuance of progress. The title of this volume then is, in a sense, an homage to Popper's critical rationalism and critical empiricism. The essays are a tribute to his unceasing and uncompromising quest, not for final certainty, but for closer truth and increased clarity. Among the contributors are outstanding figures in philosophy and the exact sciences in their own right, including Herbert Feigl, R. M. Hare, J.O. Wisdom, Nicholas Rescher, David Bohm, Paul K. Feyerabend, F. A. Hayek, and Adolf Grunbaum. Social science contributions include Hans Albert on social science and moral philosophy, W. B. Gallie, on the critical philosophy of history, Pieter Geyl on The Open Society and its Enemies, and George H. Nadel on the philosophy of History.

Download or read book From the Computer to the Clinic Methods for the Prediction Validation and Characterization of Tumor Neo antigens for Applications in Cancer Immunotherapy written by Nikolaos G. Sgourakis and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Report of the Workshop Predictive Theoretical Computational and Experimental Approaches for Additive Manufacturing WAM 2016 written by Xu Guo and published by Springer. This book was released on 2017-10-23 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume focuses on theoretical and computational approaches and involves areas such as simulation-based engineering and science, integrated computational materials engineering, mechanics, material science, manufacturing processes, and other specialized areas. Most importantly, the state-of-the-art progress in developing predictive theoretical, computational and experimental approaches for additive manufacturing is summarized.

Download or read book New Approaches of Protein Function Prediction from Protein Interaction Networks written by Jingyu Hou and published by Academic Press. This book was released on 2017-01-13 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Approaches of Protein Function Prediction from Protein Interaction Networks contains the critical aspects of PPI network based protein function prediction, including semantically assessing the reliability of PPI data, measuring the functional similarity between proteins, dynamically selecting prediction domains, predicting functions, and establishing corresponding prediction frameworks. Functional annotation of proteins is vital to biological and clinical research and other applications due to the important roles proteins play in various biological processes. Although the functions of some proteins have been annotated via biological experiments, there are still many proteins whose functions are yet to be annotated due to the limitations of existing methods and the high cost of experiments. To overcome experimental limitations, this book helps users understand the computational approaches that have been rapidly developed for protein function prediction. Provides innovative approaches and new developments targeting key issues in protein function prediction Presents heuristic ideas for further research in this challenging area

Download or read book Computational Methods in Inferring Cancer Tissue of Origin and Cancer Molecular Classification Volume I written by Min Tang and published by Frontiers Media SA. This book was released on 2021-04-01 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Predicting movie ratings and recommender systems written by Arkadiusz Paterek and published by Arkadiusz Paterek. This book was released on 2012-06-19 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 195-page monograph by a top-1% Netflix Prize contestant. Learn about the famous machine learning competition. Improve your machine learning skills. Learn how to build recommender systems. What's inside:introduction to predictive modeling,a comprehensive summary of the Netflix Prize, the most known machine learning competition, with a $1M prize,detailed description of a top-50 Netflix Prize solution predicting movie ratings,summary of the most important methods published - RMSE's from different papers listed and grouped in one place,detailed analysis of matrix factorizations / regularized SVD,how to interpret the factorization results - new, most informative movie genres,how to adapt the algorithms developed for the Netflix Prize to calculate good quality personalized recommendations,dealing with the cold-start: simple content-based augmentation,description of two rating-based recommender systems,commentary on everything: novel and unique insights, know-how from over 9 years of practicing and analysing predictive modeling.

Download or read book Handbook of Research Methods and Applications in Experimental Economics written by Arthur Schram and published by Edward Elgar Publishing. This book was released on 2019 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive review of experimental methods in economics. Its 21 chapters cover theoretical and practical issues such as incentives, theory and policy development, data analysis, recruitment, software and laboratory organization. The Handbook includes separate parts on procedures, field experiments and neuroeconomics, and provides the first methodological overview of replication studies and a novel set-valued equilibrium concept. As a whole, the combination of basic methods and current developments will aid both beginners and advanced experimental economists.

Download or read book Recent Technological Advances in Engineering and Management written by Dalia Younis and published by CRC Press. This book was released on 2024-09-26 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is with immense pleasure that we extend a warm welcome to all of you to the recently concluded conference, international conference on Advances in Science, Technology and Management (ICOSTEM 2023) which took place from November 24 – 27, 2023, in the picturesque Maldives, Male. This significant event focused on the “Recent Technological Advances in Engineering and Management” with special sessions on Applied Sciences, Management and Engineering.

Download or read book Toward a New Approach to Predicting Text Comprehensibility Using Inside and Outside the head Information and a Nomograph written by Beverley Lois Zakaluk and published by . This book was released on 1985 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Strategic Business Forecasting A Structured Approach to Shaping the Future of Your Business written by Simon Ramo and published by McGraw Hill Professional. This book was released on 2009-03-07 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A helpful read not just for corporate strategists but for almost anyone looking ahead.” Los Angeles Times What's Your Next Big Move? At the turn of the century, Western Union passed on the chance to dominate the telephone industry. Later, General Electric concluded that a new invention called television was doomed to fail. And very recently, decision makers at the highest level were taken off-guard when the global economy dropped from under their feet--and took their companies with it. Today, only those business leaders with the power of long-term foresight will seize and hold true competitive advantage. But can managers really predict the future? Yes, to a greater extent than one might expect. Strategic Business Forecasting shows how to identify and quantify possible events that may affect your business. Applying creativity, personal experience, and the lessons of history, you can use such forecasting to develop plans that will help your organization compete. Drs. Simon Ramo and Ronald Sugar, two giants of the aerospace industry, share their Four-Measures Rating system to help you explore the world of possibilities--thoroughly and systematically. Under their tutelage, you will be equipped to: Create a comprehensive list of possible scenarios concerning your business Utilize a scoring system to rate each scenario's merit as a serious and useful prediction Develop an effective plan that strategically shapes the future of your organization The authors provide vivid illustrations of the Four-Measures system at work with real-world examples of both forecasting failures and successes. No one can predict perfectly, and the authors don't promise magic. With the approach described in Strategic Business Forecasting, however, you can ensure your organization is better poised to seize future opportunities, avoid pitfalls, and handle anything the increasingly volatile global economy throws your way.

Download or read book Social Structure Space and Possession in Tongan Culture and Language written by Svenja Völkel and published by John Benjamins Publishing. This book was released on 2010 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This interdisciplinary study investigates the relationship between culture, language and cognition based on the aspects of social structure, space and possession in Tonga, Polynesia. Grounded on extensive field research, Volkel explores the subject from an anthropological as well as from a linguistic perspective. The book provides new insights into the language of respect, an honorific system which is deeply anchored in the societal hierarchy, spatial descriptions that are determined by socio-cultural and geocentric parameters, kinship terminology and possessive categories that perfectly express the system of social status inequalities among relatives. These examples impressively show that language is deeply anchored in its cultural context. Moreover, the linguistic structures reflect the underlying cognitive frame of its speakers. Just as several cultural practices (sitting order, access to land and gift exchange processes) the linguistic means are not only expressions of stratified social networks but also tools to maintain or negotiate the underlying socio-cultural system."

Download or read book Bayesian Economics Through Numerical Methods written by Jeffrey H. Dorfman and published by Springer Science & Business Media. This book was released on 2006-03-31 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing researchers in economics, finance, and statistics with an up-to-date introduction to applying Bayesian techniques to empirical studies, this book covers the full range of the new numerical techniques which have been developed over the last thirty years. Notably, these are: Monte Carlo sampling, antithetic replication, importance sampling, and Gibbs sampling. The author covers both advances in theory and modern approaches to numerical and applied problems, and includes applications drawn from a variety of different fields within economics, while also providing a quick overview of the underlying statistical ideas of Bayesian thought. The result is a book which presents a roadmap of applied economic questions that can now be addressed empirically with Bayesian methods. Consequently, many researchers will find this a readily readable survey of this growing topic.

Download or read book Annual Reports in Medicinal Chemistry written by and published by Elsevier. This book was released on 2011-08-09 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. * Critical reviews of the previous year’s literature in many topics of interest to medicinal chemists * Highlights major developments in medicinal chemistry * Includes a comprehensive set of cumulative indexes to easily locate topics in all published volumes